Takayuki Nishimura
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View article: Low temperature abolishes human cellular circadian rhythm through Hopf bifurcation
Low temperature abolishes human cellular circadian rhythm through Hopf bifurcation Open
Circadian clocks orchestrate behavior, physiology, and metabolism in harmony with the Earth's 24-h cycle. Low temperatures are known to disrupt circadian clocks in plants and poikilotherms; however, their effects on human circadian rhythms…
View article: Erratum to “Parental axial lengths and prenatal conditions related to child axial length: The TMM BirThree Cohort Study” [Volume 2, Issue 1, April 2025, 100088]
Erratum to “Parental axial lengths and prenatal conditions related to child axial length: The TMM BirThree Cohort Study” [Volume 2, Issue 1, April 2025, 100088] Open
View article: Low temperature abolishes human cellular circadian rhythm through Hopf bifurcation
Low temperature abolishes human cellular circadian rhythm through Hopf bifurcation Open
SUMMARY Circadian clocks orchestrate behavior, physiology, and metabolism in harmony with the Earth’s 24-h cycle. Low temperatures are known to disrupt circadian clocks in plants and poikilotherms; however, their effects on human circadian…
View article: Recent updates on cold adaptation in population and laboratory studies, including cross-adaptation with nonthermal factors
Recent updates on cold adaptation in population and laboratory studies, including cross-adaptation with nonthermal factors Open
This review aims to update our understanding of human cold adaptation. First, an overview of the thermoregulatory response to cold is provided, with some recent updates in human brown adipose tissue (BAT). Variation in BAT activity and mul…
View article: Parental axial lengths and prenatal conditions related to child axial length: The TMM BirThree Cohort Study
Parental axial lengths and prenatal conditions related to child axial length: The TMM BirThree Cohort Study Open
View article: Urinary pentosidine as a potential biomarker of muscle and physical performance in young adult men
Urinary pentosidine as a potential biomarker of muscle and physical performance in young adult men Open
Pentosidine is representative of the cross-linked structure of advanced glycation end products (AGEs) and has been suggested as a biomarker to assess bone and muscle quality. As studies on pentosidine in young adult men remain limited, we …
View article: Sex differences in genotype frequency and the risk of polycythemia associated with rs13419896 and rs2790859 among Tibetan highlanders living in Tsarang, Mustang, Nepal
Sex differences in genotype frequency and the risk of polycythemia associated with rs13419896 and rs2790859 among Tibetan highlanders living in Tsarang, Mustang, Nepal Open
Background Tibetan highlanders have adapted to hypoxic environments through genetic mechanisms that avoid hemoglobin concentration increases and prevent polycythemia. Recently, sex differences in hemoglobin dynamics with age have been repo…
View article: Cell-cell interaction determines cell fate of mesoderm-derived cell in tongue development through Hh signaling
Cell-cell interaction determines cell fate of mesoderm-derived cell in tongue development through Hh signaling Open
Dysfunction of primary cilia leads to genetic disorder, ciliopathies, which shows various malformations in many vital organs such as brain. Multiple tongue deformities including cleft, hamartoma, and ankyloglossia are also seen in ciliopat…
View article: Cold adaptation in Upper Paleolithic hunter-gatherers of eastern Eurasia
Cold adaptation in Upper Paleolithic hunter-gatherers of eastern Eurasia Open
Previous genomic studies understanding the dispersal of Homo sapiens have suggested that present-day East Eurasians and Native Americans can trace their ancestry to migrations from Southeast Asia. However, ineluctable adaptations during th…
View article: Author response: Cell-cell interaction determines cell fate of mesoderm-derived cell in tongue development through Hh signaling
Author response: Cell-cell interaction determines cell fate of mesoderm-derived cell in tongue development through Hh signaling Open
View article: Genetic evidence for involvement of β2-adrenergic receptor in brown adipose tissue thermogenesis in humans
Genetic evidence for involvement of β2-adrenergic receptor in brown adipose tissue thermogenesis in humans Open
Background Sympathetic activation of brown adipose tissue (BAT) thermogenesis can ameliorate obesity and related metabolic abnormalities. However, crucial subtypes of the β-adrenergic receptor (AR), as well as effects of its genetic varian…
View article: Association between physical performance and bone mass in community-dwelling postmenopausal Japanese women: The Unzen study
Association between physical performance and bone mass in community-dwelling postmenopausal Japanese women: The Unzen study Open
Background Low bone mass is an independent risk factor for osteoporotic fractures. We examined the association between physical performance and bone mass using quantitative ultrasound in community-dwelling postmenopausal Japanese women. Me…
View article: Author Correction: Endocrine, inflammatory and immune responses and individual differences in acute hypobaric hypoxia in lowlanders
Author Correction: Endocrine, inflammatory and immune responses and individual differences in acute hypobaric hypoxia in lowlanders Open
View article: Endocrine, inflammatory and immune responses and individual differences in acute hypobaric hypoxia in lowlanders
Endocrine, inflammatory and immune responses and individual differences in acute hypobaric hypoxia in lowlanders Open
View article: Vasoreactivity of the optic nerve head, nailfold, and facial skin in response to cold provocation in normal-tension glaucoma patients
Vasoreactivity of the optic nerve head, nailfold, and facial skin in response to cold provocation in normal-tension glaucoma patients Open
View article: Endocrine, inflammatory and immune responses and individual differences in acute hypobaric hypoxia in lowlanders
Endocrine, inflammatory and immune responses and individual differences in acute hypobaric hypoxia in lowlanders Open
When lowlanders are exposed to hypobaric hypoxia (HH) environments such as high mountains, hemodynamic changes occur to maintain oxygen levels in the body. However, changes to other physiological functions under such conditions have yet to…
View article: Dietary behaviours and related lifestyles according to the presence or absence of skipping breakfast in Japanese adults: the JPHC-NEXT study
Dietary behaviours and related lifestyles according to the presence or absence of skipping breakfast in Japanese adults: the JPHC-NEXT study Open
Objective: To assess dietary behaviours and related lifestyles according to the presence or absence of skipping breakfast. Design: We analysed the cross-sectional data from a baseline survey of a large-scale population-based cohort study i…
View article: Coordinated multiple cellular processes in tongue development
Coordinated multiple cellular processes in tongue development Open
Dysfunction of primary cilia leads to genetic disorder, ciliopathies, which shows various malformations in many vital organs such as brain. Multiple tongue deformities including cleft, hamartoma and ankyloglossia are also seen in ciliopath…
View article: Genetic Evidence for Involvement of β2-Adrenergic Receptor in Brown Adipocyte Thermogenesis in Humans
Genetic Evidence for Involvement of β2-Adrenergic Receptor in Brown Adipocyte Thermogenesis in Humans Open
View article: Association between sarcopenia and respiratory function in elderly orthopedic outpatients
Association between sarcopenia and respiratory function in elderly orthopedic outpatients Open
The relationship between sarcopenia and respiratory function has not been investigated in elderly Japanese orthopedic outpatients. This study aimed to assess the relationship between sarcopenia and respiratory function in elderly orthopedi…
View article: Association between Mothers’ Attachment Styles and Parenting Stress among Japanese Mothers with Toddlers
Association between Mothers’ Attachment Styles and Parenting Stress among Japanese Mothers with Toddlers Open
Parenting stress is affected by various factors, including maternal attachment; however, the number of studies focusing on Japanese samples is limited. As such, we explored the association between mothers’ attachment styles and parenting s…
View article: Individual variations and sex differences in hemodynamics and percutaneous arterial oxygen saturation (SpO2) in Tibetan highlanders of Tsarang in the Mustang district of Nepal
Individual variations and sex differences in hemodynamics and percutaneous arterial oxygen saturation (SpO2) in Tibetan highlanders of Tsarang in the Mustang district of Nepal Open
View article: Association between serum 25-hydroxyvitamin D and physical performance measures in middle-aged and old Japanese men and women: The Unzen study
Association between serum 25-hydroxyvitamin D and physical performance measures in middle-aged and old Japanese men and women: The Unzen study Open
Purpose Regarding epidemiological studies, the role of vitamin D in musculoskeletal functionality (muscle weakness and physical performance) among elderly people is still controversial. The purpose of the present study was to investigate t…
View article: Association Between Birth Weight and Risk of Pregnancy-Induced Hypertension and Gestational Diabetes in Japanese Women: JPHC-NEXT Study
Association Between Birth Weight and Risk of Pregnancy-Induced Hypertension and Gestational Diabetes in Japanese Women: JPHC-NEXT Study Open
We observed an increased risk of PIH among women born with lower birth weight albeit non-significant increased risk of GDM among Japanese women.
View article: Epidemiology of the association between serum 25-hydroxyvitamin D levels and musculoskeletal conditions among elderly individuals: a literature review
Epidemiology of the association between serum 25-hydroxyvitamin D levels and musculoskeletal conditions among elderly individuals: a literature review Open
Background Vitamin D deficiency is associated with osteoporosis, fracture, muscle weakness, falls, and osteoarthritis in adults. Elderly individuals are more likely to present with poor musculoskeletal conditions. Recently, several epidemi…
View article: Association between self-reported walking speed and calcaneal stiffness index in postmenopausal Japanese women
Association between self-reported walking speed and calcaneal stiffness index in postmenopausal Japanese women Open
View article: Association between self-reported walking speed and calcaneal stiffness index in postmenopausal Japanese women
Association between self-reported walking speed and calcaneal stiffness index in postmenopausal Japanese women Open
Background; Osteoporosis and related fractures, a worldwide public health issue of growing concern, is characterized by compromised bone strength and an increased risk of fracture. Here we show an association between self-reported walking …
View article: Individual variations and sex differences in hemodynamics with percutaneous arterial oxygen saturation (SpO2) in young Andean highlanders in Bolivia
Individual variations and sex differences in hemodynamics with percutaneous arterial oxygen saturation (SpO2) in young Andean highlanders in Bolivia Open
View article: Implications of human activities for (re)emerging infectious diseases, including COVID-19
Implications of human activities for (re)emerging infectious diseases, including COVID-19 Open
Since 1980, the world has been threatened by different waves of emerging disease epidemics. In the twenty-first century, these diseases have become an increasing global concern because of their health and economic impacts in both developed…
View article: Association between self-reported walking speed and calcaneal stiffness index in postmenopausal Japanese women
Association between self-reported walking speed and calcaneal stiffness index in postmenopausal Japanese women Open
Background; Osteoporosis and related fractures, a worldwide public health issue of growing concern, is characterized by compromised bone strength and an increased risk of fracture. Here we show an association between self-reported walki…