Takeaki Wajima
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View article: Structural basis for collagen recognition by the Streptococcus pyogenes M3 protein and its involvement in biofilm
Structural basis for collagen recognition by the Streptococcus pyogenes M3 protein and its involvement in biofilm Open
The M protein is an essential virulence factor of Streptococcus pyogenes, or group A streptococcus (GAS), one of the most common and dangerous human pathogens. Molecular and functional characterization of M protein variants and their inter…
View article: Author response: Structural basis for collagen recognition by the Streptococcus pyogenes M3 protein and its involvement in biofilm
Author response: Structural basis for collagen recognition by the Streptococcus pyogenes M3 protein and its involvement in biofilm Open
View article: Corrigendum: Genomic characterization of Haemophilus influenzae harbouring an exogenous resistance gene
Corrigendum: Genomic characterization of Haemophilus influenzae harbouring an exogenous resistance gene Open
View article: Genotyping and drug susceptibility patterns of Mycobacterium avium subsp. hominissuis isolates from different hosts
Genotyping and drug susceptibility patterns of Mycobacterium avium subsp. hominissuis isolates from different hosts Open
Mycobacterium avium subsp. hominissuis (MAH) causes mainly pulmonary infection in immunocompetent hosts, disseminated infection in immunocompromised hosts, such as individuals infected with human immunodeficiency virus (HIV), and infection…
View article: Additional biomarkers and emm types associated with group A streptococcal toxic shock syndrome: a Japanese nationwide observational study
Additional biomarkers and emm types associated with group A streptococcal toxic shock syndrome: a Japanese nationwide observational study Open
View article: Structural basis for collagen recognition by the Streptococcus pyogenes M3 protein and its involvement in biofilm
Structural basis for collagen recognition by the Streptococcus pyogenes M3 protein and its involvement in biofilm Open
The M protein is an essential virulence factor of Streptococcus pyogenes, or group A streptococci (GAS), one of the most common and dangerous human pathogens. Molecular and functional characterization of M protein variants and their intera…
View article: Structural basis for collagen recognition by the Streptococcus pyogenes M3 protein and its involvement in biofilm
Structural basis for collagen recognition by the Streptococcus pyogenes M3 protein and its involvement in biofilm Open
The M protein is an essential virulence factor of Streptococcus pyogenes, or group A streptococcus (GAS), one of the most common and dangerous human pathogens. Molecular and functional characterization of M protein variants and their inter…
View article: Author response: Structural basis for collagen recognition by the Streptococcus pyogenes M3 protein and its involvement in biofilm
Author response: Structural basis for collagen recognition by the Streptococcus pyogenes M3 protein and its involvement in biofilm Open
View article: Unique and Ingenious Mechanisms Underlying Antimicrobial Resistance and Spread of <i>Haemophilus influenzae</i>
Unique and Ingenious Mechanisms Underlying Antimicrobial Resistance and Spread of <i>Haemophilus influenzae</i> Open
Antimicrobial resistance (AMR) is a serious global concern. AMR pathogens are found in hospitals and communities. Haemophilus influenzae is a common pathogen associated with community-acquired infections. H. influenzae infections are usual…
View article: Longitudinal Trend in Antimicrobial Susceptibility among <i>Haemophilus influenzae</i>: A Single-Centre Study in Japan
Longitudinal Trend in Antimicrobial Susceptibility among <i>Haemophilus influenzae</i>: A Single-Centre Study in Japan Open
Haemophilus influenzae presents significant concerns regarding antimicrobial resistance. The circumstances surrounding H. influenzae have been changing owing to changes in antimicrobial usage. In the present study, to determine the current…
View article: Structural basis for collagen recognition by the <i>Streptococcus pyogenes</i> M3 protein and its involvement in biofilm
Structural basis for collagen recognition by the <i>Streptococcus pyogenes</i> M3 protein and its involvement in biofilm Open
The M protein is an essential virulence factor of Streptococcus pyogenes , or group A streptococcus (GAS), one of the most common and dangerous human pathogens. Molecular and functional characterization of M protein variants and their inte…
View article: Molecular characterization of a novel putative pathogen, <i>Streptococcus nakanoensis</i> sp. nov., isolated from sputum culture
Molecular characterization of a novel putative pathogen, <i>Streptococcus nakanoensis</i> sp. nov., isolated from sputum culture Open
Reports of novel species of α-hemolytic Streptococcus have increased recently. However, limited information exists regarding the pathogenicity of these species, with the exception of Streptococcus pneumoniae and Streptococcus pseudopneumon…
View article: Clinical manifestations and biomarkers to predict mortality risk in adults with invasive Streptococcus dysgalactiae subsp. equisimilis infections
Clinical manifestations and biomarkers to predict mortality risk in adults with invasive Streptococcus dysgalactiae subsp. equisimilis infections Open
View article: Manifestations and Biomarkers to Predict Mortality Risk in Adults with Invasive Streptococcus dysgalactiae
Manifestations and Biomarkers to Predict Mortality Risk in Adults with Invasive Streptococcus dysgalactiae Open
Purpose: The incidence of invasive Streptococcus dysgalactiae subsp. equisimilis (iSDSE) infections is increasing in developed countries, but studies on the risk factors for death in iSDSE infection are scant. Here, we aimed to clarify ris…
View article: The Association between Transformation Ability and Antimicrobial Resistant Potential in <i>Haemophilus influenzae</i>
The Association between Transformation Ability and Antimicrobial Resistant Potential in <i>Haemophilus influenzae</i> Open
The prevalence of quinolone low-susceptible Haemophilus influenzae has increased in Japan. Low quinolone susceptibility is caused by point mutations in target genes; however, it can also be caused by horizontal gene transfer via natural tr…
View article: A CULTURE NEGATIVE ENDOCARDITIS CAUSED BY HYPERVIRULENT KLEBSIELLA PNEUMONIAE (ST23) DIAGNOSED FROM PCR OF VEGETATION
A CULTURE NEGATIVE ENDOCARDITIS CAUSED BY HYPERVIRULENT KLEBSIELLA PNEUMONIAE (ST23) DIAGNOSED FROM PCR OF VEGETATION Open
Intro: Hypervirulent Klebsiella pneumoniae (hvKp) has been recognized an emerging pathogen that can cause life-threading infections including liver abscess, and endophthalmitis in Eastern Asia. However, clinical feature of infective endoca…
View article: A Rapid Screening Assay for Clarithromycin-Resistant Mycobacterium avium Complex Using Melting Curve Analysis with Nonfluorescent Labeled Probes
A Rapid Screening Assay for Clarithromycin-Resistant Mycobacterium avium Complex Using Melting Curve Analysis with Nonfluorescent Labeled Probes Open
Since macrolide antibiotics such as clarithromycin or azithromycin are key drugs in multidrug therapy for Mycobacterium avium complex (MAC) lung diseases, the rapid detection of macrolide-resistant MAC strains has important implications fo…
View article: Prosthetic valve endocarditis due to highly beta-lactam-resistant Streptococcus oralis: a case report
Prosthetic valve endocarditis due to highly beta-lactam-resistant Streptococcus oralis: a case report Open
There are limited reports of patients with prosthetic valve infective endocarditis (IE) or recurrent IE due to highly beta-lactam-resistant viridans group streptococci. We present a case in which a patient with native valve IE due to beta-…
View article: Circulating immune-complexes and complement activation through the classical pathway in myeloperoxidase-ANCA-associated glomerulonephritis
Circulating immune-complexes and complement activation through the classical pathway in myeloperoxidase-ANCA-associated glomerulonephritis Open
These results suggest the involvement of immune-complex induced complement activation through the classical pathway in the pathogenesis of MPO-AAGN.
View article: Identification and characterisation of a novel multidrug-resistant streptococcus, Streptococcus toyakuensis sp. nov., from a blood sample
Identification and characterisation of a novel multidrug-resistant streptococcus, Streptococcus toyakuensis sp. nov., from a blood sample Open
Our findings indicated that multidrug-resistant TP1632 is a novel species in the genus Streptococcus. Furthermore, antimicrobial resistance of this strain could transfer horizontally among α-haemolytic streptococci. These data indicated th…
View article: High-Level Quinolone-Resistant<i>Haemophilus haemolyticus</i>in Pediatric Patient with No History of Quinolone Exposure
High-Level Quinolone-Resistant<i>Haemophilus haemolyticus</i>in Pediatric Patient with No History of Quinolone Exposure Open
The prevalence of antimicrobial resistance among Haemophilus spp. is a critical concern, but high-level quinolone-resistant strains had not been isolated from children. We isolated high-level quinolone-resistant H. haemolyticus from the su…
View article: Salmonella fimbrial protein StcD induces cyclooxygenase-2 expression via Toll-like receptor 4
Salmonella fimbrial protein StcD induces cyclooxygenase-2 expression via Toll-like receptor 4 Open
StcD is a pathogen-associated molecular pattern of S. enterica serovar Typhimurium that is recognized by TLR4 and plays a significant role in the induction of COX-2 expression in macrophages.
View article: Adjunctive Rifampicin Increases Antibiotic Efficacy in Group A Streptococcal Tissue Infection Models
Adjunctive Rifampicin Increases Antibiotic Efficacy in Group A Streptococcal Tissue Infection Models Open
Biofilm has recently been highlighted as a complicating feature of necrotizing soft tissue infections (NSTI) caused by Streptococcus pyogenes (i.e., group A Streptococcus [GAS]) contributing to a persistence of bacteria in tissue despite p…
View article: In vitro growth-inhibitory effects of Portulaca oleracea L. formulation on intestinal pathogens
In vitro growth-inhibitory effects of Portulaca oleracea L. formulation on intestinal pathogens Open
Introduction. Empirical evidence suggests that Portulaca oleracea L. treats enteric infections, including dysentery, cholera, and acute infectious gastroenteritis. Aim. The aim of this study is to clarify the growth-inhibitory effects of P…
View article: Evaluation of the Antimicrobial Effects of a Novel Visible Light-driven Photocatalyst <i>in Vitro</i> and in the Environment
Evaluation of the Antimicrobial Effects of a Novel Visible Light-driven Photocatalyst <i>in Vitro</i> and in the Environment Open
Environmental microorganisms can cause several infections in humans, especially in compromised hosts. Since there are many compromised hosts in a hospital setting, it is important to control environmental pathogens in such scenarios. To di…
View article: Prevalence of antimicrobial-resistant staphylococci in nares and affected sites of pet dogs with superficial pyoderma
Prevalence of antimicrobial-resistant staphylococci in nares and affected sites of pet dogs with superficial pyoderma Open
Currently, antimicrobial-resistant staphylococci, particularly methicillin-resistant Staphylococcus pseudintermedius (MRSP), are frequently isolated from canine superficial pyoderma in Japan. However, little is known regarding the nasal pr…
View article: In vitro anti-biofilm effect of anti-methicillin-resistant Staphylococcus aureus (anti-MRSA) agents against the USA300 clone
In vitro anti-biofilm effect of anti-methicillin-resistant Staphylococcus aureus (anti-MRSA) agents against the USA300 clone Open
View article: First isolation of an IMP-1 metallo-β-lactamase-producing Kluyvera ascorbata in Japan
First isolation of an IMP-1 metallo-β-lactamase-producing Kluyvera ascorbata in Japan Open
View article: Whole-genome sequence of Haemophilus influenzae ST422 outbreak clone strain 2018-Y40 with low quinolone susceptibility isolated from a paediatric patient
Whole-genome sequence of Haemophilus influenzae ST422 outbreak clone strain 2018-Y40 with low quinolone susceptibility isolated from a paediatric patient Open
View article: A class A β-lactamase produced by borderline oxacillin-resistant Staphylococcus aureus hydrolyses oxacillin
A class A β-lactamase produced by borderline oxacillin-resistant Staphylococcus aureus hydrolyses oxacillin Open
Our findings strongly suggest that type A staphylococcal β-lactamase acts as an extended-spectrum β-lactamase and contributes to borderline resistance to oxacillin in S. aureus.