Takehiro Hashimoto
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Non-clostridial gas gangrene due to Anaerococcus tetradius following a cesarean section: A case report Open
A 25-year-old healthy woman was admitted to our hospital with fever and abdominal pain. Abdominal contrast-enhanced computed tomography revealed a fluid collection with foamy gas formation extending from both rectus abdominis muscles to th…
Long-Term Immunogenicity of Rabies Pre-Exposure Prophylaxis in Japanese Adult Travelers: Comparison of Dosing Regimens Open
Background/Objectives: Japan is a rabies-free country; therefore, pre-exposure prophylaxis (PrEP) is primarily recommended for travelers to rabies-endemic regions. However, no prior studies in Japan have assessed long-term immunogenicity a…
Wildlife Exposure Rates to Oz Virus vs. Severe Fever with Thrombocytopenia Syndrome Virus in Oita Prefecture, Japan Open
Oz virus (OZV) was first isolated from ticks in Japan in 2018, and human infections with OZV were reported in 2023. However, serosurveillance for OZV infections, compared with that for severe fever with thrombocytopenia syndrome (SFTS), is…
View article: Ampicillin sulbactam impacts serum potassium level comparable to piperacillin tazobactam
Ampicillin sulbactam impacts serum potassium level comparable to piperacillin tazobactam Open
Ampicillin/sulbactam (ABPC/SBT) and piperacillin/tazobactam (PIPC/TAZ) are important beta-lactam/beta-lactamase inhibitor combinations. Recently, PIPC/TAZ has been reported to decrease serum potassium level (SPL). To test the hypothesis th…
View article: Features of Carbapenem-resistant Gram-negative Bacterial Infections in Japan Based on the Setting of Onset
Features of Carbapenem-resistant Gram-negative Bacterial Infections in Japan Based on the Setting of Onset Open
Background Carbapenem-resistant Gram-negative bacilli (CR-GNB) are a major public health threat, traditionally linked to hospital settings. However, infections are increasingly reported in the community, and the clinical distinctions betwe…
View article: Multiplex PCR assay to identify clinically important <i>Aeromonas</i> species
Multiplex PCR assay to identify clinically important <i>Aeromonas</i> species Open
The genus Aeromonas is increasingly implicated in human infections. However, accurate species-level identification remains challenging, particularly in clinical microbiology laboratories. This study aimed to develop a multiplex polymerase …
View article: Molecular epidemiology and patient outcome of carbapenem-resistant <i>Enterobacterales, Pseudomonas aeruginosa</i> and <i>Acinetobacter baumannii</i> in Japan: a multicenter study from MultiDrug-Resistant organisms clinical research network
Molecular epidemiology and patient outcome of carbapenem-resistant <i>Enterobacterales, Pseudomonas aeruginosa</i> and <i>Acinetobacter baumannii</i> in Japan: a multicenter study from MultiDrug-Resistant organisms clinical research network Open
Background and objectives Carbapenem-resistant Gram-negative bacilli (CRGNB), especially Enterobacterales, Pseudomonas aeruginosa and Acinetobacter baumannii, are critical pathogens associated with excess morbidity and mortality. To elucid…
The Possibility of Ceftolozane/Tazobactam-Resistant Pseudomonas aeruginosa Emergence After Two Days of Antibiotic Therapy: A Case Report Open
Although antibiotic use is known to induce antimicrobial resistance, the duration of exposure necessary for resistance development remains uncertain. In this case, a patient was initially treated with tazobactam/piperacillin (TAZ/PIPC) for…
A case report of pulmonary paragonimiasis diagnosed via the deterioration of pulmonary cavities during high-dose corticosteroid therapy for chronic eosinophilic pneumonia Open
A 32-year-old Chinese woman with a cough and bloody sputum was diagnosed with chronic eosinophilic pneumonia. After starting corticosteroid therapy, chest radiography showed improvement in the bilateral infiltrative shadow. However, chest …
Exploring the Replication and Pathogenic Characteristics of Alpha, Delta, and Omicron Variants of SARS-CoV-2 Open
The variants of concern (VOCs) of SARS-CoV-2 have exhibited different phenotypic characteristics in clinical settings which are yet to be fully explored. This study aimed to characterize the viral replication features of major VOCs of SARS…
Rapid Detection of Severe Fever with Thrombocytopenia Syndrome Virus in the Acute Phase of Infection by Direct Real-Time Reverse Transcription without RNA Extraction Open
No specific treatment has been developed for severe fever with thrombocytopenia syndrome (SFTS). However, the prognosis can improve with early plasma exchange. Therefore, rapid and accurate detection of SFTS virus is important for diagnosi…
View article: Risk Factors for Teicoplanin-Associated Acute Kidney Injury in Patients with Hematological Malignancies: Focusing on Concomitant Use of Tazobactam/Piperacillin
Risk Factors for Teicoplanin-Associated Acute Kidney Injury in Patients with Hematological Malignancies: Focusing on Concomitant Use of Tazobactam/Piperacillin Open
Patients with hematological malignancies (HM) often receive tazobactam/piperacillin (TAZ/PIPC) and glycopeptide antibiotics for febrile neutropenia. The effect of concomitant use of TAZ/PIPC on risk of teicoplanin (TEIC)-associated acute k…
View article: 371. Clinical Characteristics and Prognoses for Carbapenem-Resistant Bacterial Infections in Patients with Cancer in Japan: A Multicenter Study from the Multi-Drug Resistant Organisms Clinical Research Network (MDRnet)
371. Clinical Characteristics and Prognoses for Carbapenem-Resistant Bacterial Infections in Patients with Cancer in Japan: A Multicenter Study from the Multi-Drug Resistant Organisms Clinical Research Network (MDRnet) Open
Background Carbapenem-resistant bacteria in patients with cancer are concerning due to the high risk of infection and mortality rates; however, the characteristics and prognoses of carbapenem-resistant infections in this population are cur…
View article: Comparison of Incidence of Hyponatremia between Linezolid and Vancomycin by Propensity Score Matching Analysis
Comparison of Incidence of Hyponatremia between Linezolid and Vancomycin by Propensity Score Matching Analysis Open
Several cases of severe hyponatremia induced by linezolid (LZD) were reported. However, severe infections could also cause hyponatremia by increasing vasopressin secretion. To prove that hyponatremia is associated with LZD rather than infe…
<i>Bacillus subtilis</i> Bacteremia from Gastrointestinal Perforation after Natto Ingestion, Japan Open
We report a case of Bacillus subtilis variant natto bacteremia from a gastrointestinal perforation in a patient who ingested natto. Genotypic methods showed the bacteria in a blood sample and the ingested natto were the same strains. Older…
View article: Effectiveness of cefmetazole versus meropenem for invasive urinary tract infections caused by extended-spectrum β-lactamase-producing <i>Escherichia coli</i>
Effectiveness of cefmetazole versus meropenem for invasive urinary tract infections caused by extended-spectrum β-lactamase-producing <i>Escherichia coli</i> Open
Cefmetazole is active against extended-spectrum β-lactamase-producing Escherichia coli (ESBLEC) and is a potential candidate for carbapenem-sparing therapy. This multicenter, observational study included patients hospitalized for invasive …
Perception of overseas experiences among medical students in Japan: a national online survey Open
Background Data on the perceptions of medical students on international experience in non-English-speaking high-income countries (HICs) are very limited. This study aimed to assess the perceptions of medical students in Japan toward overse…
Evaluation of a real-time mobile PCR device (PCR 1100) for the detection of the rabies gene in field samples Open
Background The Philippines is ranked among the top countries with 200–300 annual deaths due to rabies. Most human rabies cases have been reported in remote areas, where dog surveillance is inadequate. Therefore, a strategy to effectively i…
658. Evaluation of Effectiveness of Cefmetazole vs Meropenem for Invasive Urinary Tract Infections Caused by ESBL-Producing <i>Escherichia coli</i>: A Prospective Multicenter Observational Study Open
Background ESBL-producing E. coli (ESBLEC) continues to increase worldwide. For the infection due to ESBLEC, no antimicrobial agent has clearly demonstrated therapeutic effectiveness comparable to that of carbapenem. Overuse of carbapenems…
Dengue Infections during COVID-19 Period: Reflection of Reality or Elusive Data Due to Effect of Pandemic Open
The outbreak of coronavirus disease 2019 (COVID-19) devastated the overall health management strategy of most countries. In this scenario, the present study provided insights into the possible impact of the COVID-19 pandemic on dengue infe…
Pneumocystis Pneumonia Mimicking Atypical Pneumonia in a Patient With Human Immunodeficiency Virus Infection Open
We report a case of pneumocystis pneumonia (PCP) that mimicked atypical pneumonia in a patient with human immunodeficiency virus (HIV) infection. A 44-year-old Japanese man with persistent fever and dyspnea for a month was diagnosed with a…
View article: Impact of Inflammation on Intra-individual Variation in Trough Voriconazole Concentration in Patients with Hematological Malignancies
Impact of Inflammation on Intra-individual Variation in Trough Voriconazole Concentration in Patients with Hematological Malignancies Open
The pharmacokinetics of voriconazole shows large intra-individual and inter-individual variability and is affected by various factors. Recently, inflammation has been focused as a significant factor affecting the variability. This study ai…
Distribution of Severe Fever with Thrombocytopenia Syndrome Virus and Antiviral Antibodies in Wild and Domestic Animals in Oita Prefecture, Japan Open
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging life-threatening infectious disease caused by the tickborne SFTS virus (SFTSV), first identified in China in 2009 and then in Japan in 2013. Human SFTS cases were reported t…
<i>Campylobacter lari </i>Vertebral Osteomyelitis Open
We report a case of Campylobacter lari vertebral osteomyelitis with iliopsoas abscess. This is the first case report of vertebral osteomyelitis due to C. lari, which was identified from a vertebral biopsy sample collected using CT-guided p…
Presumed Septic Shock Caused by <i>Actinotignum schaalii</i> Bacteremia Open
We herein report a case of presumed septic shock due to Actinotignum schaalii bacteremia with urinary tract infection. A 65-year-old Japanese man suffering from a fever was diagnosed with septic shock due to urinary tract infection. A urin…