Takehiro Ko
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An autopsy case of fulminant thrombotic thrombocytopenic purpura with a rapidly fatal course that responded poorly to plasma exchange therapy Open
血栓性血小板減少性紫斑病（TTP）は緊急に治療を必要とする致死的疾患である．TTPの診断基準はADAMTS13活性10％未満が必須であるが，結果が判明するまでに時間を要するため，病状によっては結果を待たずに治療を開始する必要がある．今回，後天性TTPに対し速やかに血漿交換を行うも急激な経過をたどり死亡した1例を経験したため報告する．症例は47歳の男性．感冒症状出現から約1週間後にCr 3.37 mg/dLと高度の腎機能低下とともに，血小板減少，破砕赤血球を認めた．TTPを強…
View article: Pembrolizumab-associated thrombotic microangiopathy in a patient with urothelial cancer: a case report and literature review
Pembrolizumab-associated thrombotic microangiopathy in a patient with urothelial cancer: a case report and literature review Open
Background Pembrolizumab, a highly selective humanized monoclonal IgG4κ isotype antibody against PD-1, is one of the immune checkpoint inhibitors approved for treatment of various cancers. The most frequent immune-related adverse events in…