Takehisa Watanabe
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View article: The Role of an Elevated Fibrosis‐4 Index in Neurocognitive Decline and Brain Volume Reduction in Older Adults With Metabolic Dysfunction‐Associated Steatotic Liver Disease
The Role of an Elevated Fibrosis‐4 Index in Neurocognitive Decline and Brain Volume Reduction in Older Adults With Metabolic Dysfunction‐Associated Steatotic Liver Disease Open
Aim Metabolic dysfunction‐associated steatotic liver disease (MASLD) is common in older adults and associated with systemic metabolic dysfunction, potentially contributing to cognitive decline and brain structural abnormalities. The fibros…
View article: Restoration of the gut-microbiota-liver axis after hepatitis C virus eradication
Restoration of the gut-microbiota-liver axis after hepatitis C virus eradication Open
This study offers significant insights into the gut-microbiota-liver axis in patients with chronic hepatitis C following a sustained virological response. The findings demonstrate that HCV eradication promotes partial restoration of the dy…
View article: Innovative Hepatitis C Screening: Clinical Utility of the HCV Antigen-Antibody Assay in Japan
Innovative Hepatitis C Screening: Clinical Utility of the HCV Antigen-Antibody Assay in Japan Open
The Elecsys® HCV Duo (HCV Duo) detects anti-HCV antibodies (Duo/anti-HCV) and HCV core antigen (Duo/HCV-Ag), offering an efficient, cost-effective, and rapid HCV screening. We evaluated HCV Duo's utility in Japan. We analyzed 37…
View article: Role of Regional Core Centers for Liver Disease Management in the Continuity of Activities of Hepatitis Medical Care Coordinators
Role of Regional Core Centers for Liver Disease Management in the Continuity of Activities of Hepatitis Medical Care Coordinators Open
Continuation of activities is important for the hepatitis medical care coordinators to fulfill their functions, which must be supported by regional core centers for liver disease management. Thus, we conducted a questionnaire survey among …
View article: Clinical usefulness of inside stents in anastomotic biliary strictures after liver transplantation
Clinical usefulness of inside stents in anastomotic biliary strictures after liver transplantation Open
Background Endoscopic biliary stenting is a standard treatment for biliary strictures after liver transplantation. Plastic stents are often replaced before stent dysfunction to prevent the development of cholangitis and jaundice. Therefore…
View article: Two cases of acute liver failure complicated by COVID-19 remarkably responded to anticoagulant therapy
Two cases of acute liver failure complicated by COVID-19 remarkably responded to anticoagulant therapy Open
症例1は83歳男性．前医でSARS-CoV-2陽性判明後，AST 4276 U/L，ALT 2247 U/Lと急激な肝酵素上昇を認めたため当院へ転院となった．PT 36 %，D-dimer 30.1 μg/mL，FDP 43.8 μg/mLと凝固異常を伴う急性肝不全非昏睡型で，未分画ヘパリンを開始したところ肝不全ならびに凝固異常は速やかに改善した．症例2は29歳男性．前医でSARS-CoV-2陽性判明後，AST 3027 U/L，ALT 2599 U/Lと急激な肝酵素上昇を…
View article: Possible Association of Mutations in the MEFV Gene with the Intestinal Phenotype of Behçet’s Disease and Refractoriness to Treatment
Possible Association of Mutations in the MEFV Gene with the Intestinal Phenotype of Behçet’s Disease and Refractoriness to Treatment Open
Background: Mediterranean fever (MEFV) gene mutations are responsible for familial Mediterranean fever (FMF) and associated with other inflammatory diseases. However, the effects of MEFV gene mutations on intestinal Behçet’s disease (BD) a…
View article: Hepatitis B core-related antigen: A novel and promising surrogate biomarker to guide anti-hepatitis B virus therapy
Hepatitis B core-related antigen: A novel and promising surrogate biomarker to guide anti-hepatitis B virus therapy Open
The current requirement for biomarkers to detect hepatitis B virus (HBV) infection is polarized. One is a fully-automated and highly sensitive measurement system; the other is a simple system for point-of-care testing (POCT) in resource-li…
View article: Therapeutic Modifications without Discontinuation of Atezolizumab Plus Bevacizumab Therapy Are Associated with Favorable Overall Survival and Time to Progression in Patients with Unresectable Hepatocellular Carcinoma
Therapeutic Modifications without Discontinuation of Atezolizumab Plus Bevacizumab Therapy Are Associated with Favorable Overall Survival and Time to Progression in Patients with Unresectable Hepatocellular Carcinoma Open
We retrospectively evaluated the impact of therapeutic modifications of atezolizumab (Atezo) plus bevacizumab (Bev) therapy (Atezo/Bev), including the interruption or discontinuation of both Atezo and Bev, and the reduction or discontinuat…
View article: Drug Discovery Study Aimed at a Functional Cure for HBV
Drug Discovery Study Aimed at a Functional Cure for HBV Open
Hepatitis B virus (HBV) causes acute and, most importantly, chronic hepatitis B worldwide. Antiviral treatments have been developed to reduce viral loads but few patients with chronic hepatitis B (CHB) achieve a functional cure. The develo…
View article: Rapid Point-of-Care Test for Hepatitis B Core-Related Antigen to Diagnose High Viral Load in Resource-Limited Settings
Rapid Point-of-Care Test for Hepatitis B Core-Related Antigen to Diagnose High Viral Load in Resource-Limited Settings Open
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View article: Droplet digital PCR assay provides intrahepatic HBV cccDNA quantification tool for clinical application
Droplet digital PCR assay provides intrahepatic HBV cccDNA quantification tool for clinical application Open
View article: A female patient with GSD IXc developing multiple and recurrent hepatocellular carcinoma: a case report and literature review
A female patient with GSD IXc developing multiple and recurrent hepatocellular carcinoma: a case report and literature review Open
View article: Clusterin and Related Scoring Index as Potential Early Predictors of Response to Sorafenib in Hepatocellular Carcinoma
Clusterin and Related Scoring Index as Potential Early Predictors of Response to Sorafenib in Hepatocellular Carcinoma Open
Advanced hepatocellular carcinoma (HCC) remains a highly lethal malignancy, although several systemic therapeutic options are available, including sorafenib (SFN), which has been one of the standard treatment agents for almost a decade. As…
View article: Hepatitis B Core-Related Antigen and New Therapies for Hepatitis B
Hepatitis B Core-Related Antigen and New Therapies for Hepatitis B Open
The hepatitis B core-related antigen (HBcrAg) is an unprecedented novel HBV biomarker that plays an essential role in reflecting covalently closed circular DNA (cccDNA) in chronic hepatitis B (CHB) because its levels correlate with intrahe…
View article: A case of primary hepatic leiomyosarcoma treated with multi-line chemotherapy
A case of primary hepatic leiomyosarcoma treated with multi-line chemotherapy Open
67歳男性.右前胸部痛で前医を受診し,血清肝胆道系酵素値の上昇と腹部超音波検査にて肝後区域に約12 cm大の腫瘍を認め当科へ紹介となった.腹部造影CT・造影超音波検査の動脈相で辺縁部が濃染し,造影効果が遷延する多発肝腫瘍を両葉に認めた.PET-CTでは同部位にのみ集積を認めた.肝腫瘍生検の組織像は紡錘形の腫瘍細胞が束状に錯綜して増殖し,核分裂像が散見され,免疫染色ではαSMA,desminが陽性,c-Kit,CK7などが陰性であった.以上より原発性肝平滑筋肉腫と診断した.外…
View article: Modified albumin–bilirubin grade to predict eligibility for second-line therapies at progression on sorafenib therapy in hepatocellular carcinoma patients
Modified albumin–bilirubin grade to predict eligibility for second-line therapies at progression on sorafenib therapy in hepatocellular carcinoma patients Open
Modified ALBI grade in combination with CPs at the initiation of sorafenib therapy would be useful to predict eligibility for second-line therapies.
View article: Loss of skeletal muscle mass affects the incidence of minimal hepatic encephalopathy: a case control study
Loss of skeletal muscle mass affects the incidence of minimal hepatic encephalopathy: a case control study Open
Background Sarcopenia is a syndrome characterized by progressive and systemic decreases in skeletal muscle mass and muscle strength. The influence or prognosis of various liver diseases in this condition have been widely investigated, but …
View article: Loss of skeletal muscle mass affects the incidence of minimal hepatic encephalopathy: A case control study
Loss of skeletal muscle mass affects the incidence of minimal hepatic encephalopathy: A case control study Open
Background: Sarcopenia is a syndrome characterized by progressive and systemic decreases in skeletal muscle mass and muscle strength. The influence or prognosis of various liver diseases in this condition have been widely investigated, but…
View article: Loss of skeletal muscle mass affects the incidence of minimal hepatic encephalopathy: A case control study
Loss of skeletal muscle mass affects the incidence of minimal hepatic encephalopathy: A case control study Open
Background: Sarcopenia is a syndrome characterized by progressive and systemic decreases in skeletal muscle mass and muscle strength. The influence or prognosis of various liver diseases in this condition have been widely investigated, but…
View article: Prostaglandin E2-EP4 Axis Promotes Lipolysis and Fibrosis in Adipose Tissue Leading to Ectopic Fat Deposition and Insulin Resistance
Prostaglandin E2-EP4 Axis Promotes Lipolysis and Fibrosis in Adipose Tissue Leading to Ectopic Fat Deposition and Insulin Resistance Open
Lipolysis, the breakdown of triglyceride storage in white adipose tissue, supplies fatty acids to other tissues as a fuel under fasting conditions. In morbid obesity, fibrosis limits adipocyte expandability, resulting in enforced lipolysis…
View article: Loss of Skeletal Muscle Mass Affects the Incidence of Minimal Hepatic Encephalopathy: A Case Control Study
Loss of Skeletal Muscle Mass Affects the Incidence of Minimal Hepatic Encephalopathy: A Case Control Study Open
Background: Sarcopenia is a syndrome characterized by progressive and systemic decreases in skeletal muscle mass and muscle strength. The influence or prognosis of various liver diseases in this condition have been widely investigated, but…
View article: Melinjo seed extract increases adiponectin multimerization in physiological and pathological conditions
Melinjo seed extract increases adiponectin multimerization in physiological and pathological conditions Open
Melinjo seed extract (MSE) contains large amounts of polyphenols, including dimers of trans-resveratrol ( e.g. gnetin C, L, gnemonoside A, B and D), and has been shown to potentially improve obesity. However, there is no clinical evidence …
View article: <p>A Pilot Study Assessing the Possible Combined Effect of Physical Activity and <em>PNPLA3</em> rs738409 Polymorphism on the Risk for Non-Alcoholic Fatty Liver Disease in the Japanese Elderly General Population</p>
A Pilot Study Assessing the Possible Combined Effect of Physical Activity and <em>PNPLA3</em> rs738409 Polymorphism on the Risk for Non-Alcoholic Fatty Liver Disease in the Japanese Elderly General Population Open
The PNPLA3 rs738409 genotype may be associated with the beneficial effects of physical activity on the risk of NAFLD among elderly Japanese individuals. Further comprehensive investigations are therefore needed to verify the prelimi…
View article: Modeling of the Weight Status and Risk of Nonalcoholic Fatty Liver Disease in Elderly Individuals: The Potential Impact of the Disulfide Bond‐Forming Oxidoreductase A‐Like Protein (<i>DsbA‐L</i>) Polymorphism on the Weight Status
Modeling of the Weight Status and Risk of Nonalcoholic Fatty Liver Disease in Elderly Individuals: The Potential Impact of the Disulfide Bond‐Forming Oxidoreductase A‐Like Protein (<i>DsbA‐L</i>) Polymorphism on the Weight Status Open
Nonalcoholic fatty liver disease (NAFLD) is closely associated with obesity. Disulfide bond‐forming oxidoreductase A‐like protein (DsbA‐L) is known to be a key molecule in protection against obesity and obesity‐induced inflammation. In the…
View article: The Glucocorticoid Receptor Regulates the ANGPTL4 Gene in a CTCF-Mediated Chromatin Context in Human Hepatic Cells
The Glucocorticoid Receptor Regulates the ANGPTL4 Gene in a CTCF-Mediated Chromatin Context in Human Hepatic Cells Open
Glucocorticoid signaling through the glucocorticoid receptor (GR) plays essential roles in the response to stress and in energy metabolism. This hormonal action is integrated to the transcriptional control of GR-target genes in a cell type…
View article: Oral branched-chain amino acid granules improve structure and function of human serum albumin in cirrhotic patients
Oral branched-chain amino acid granules improve structure and function of human serum albumin in cirrhotic patients Open
View article: The longitudinal effect of the aldehyde dehydrogenase 2*2 allele on the risk for nonalcoholic fatty liver disease
The longitudinal effect of the aldehyde dehydrogenase 2*2 allele on the risk for nonalcoholic fatty liver disease Open
View article: The retrovirus HTLV-1 inserts an ectopic CTCF-binding site into the human genome
The retrovirus HTLV-1 inserts an ectopic CTCF-binding site into the human genome Open
Significance The retrovirus human T-lymphotropic virus type 1 (HTLV-1) causes inflammatory and malignant diseases in humans. To maintain latency and avoid immune detection in vivo, HTLV-1 minimizes expression of genes on the plus-strand of…
View article: Ledipasvir and sofosbuvir for recurrent hepatitis C after liver transplantation
Ledipasvir and sofosbuvir for recurrent hepatitis C after liver transplantation Open
Management of recurrent hepatitis C following liver transplantation still remains a challenge. Here, we report five patients who achieved viral responses following combined treatment with ledipasvir and sofosbuvir. All the patients receive…