Takehito Ouchi
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View article: Piezo1 negatively regulates proliferation, but enhances mineralization in human cementoblasts
Piezo1 negatively regulates proliferation, but enhances mineralization in human cementoblasts Open
Piezo1 suppresses colony formation, but activates HCEM-mediated mineralization, suggesting that Piezo1-induced Ca2+ signaling plays an important role in cementum mineralization and deposition by cementoblasts.
View article: Activation of G protein‐coupled parathyroid hormone receptors in rat incisor odontoblasts promotes mineralization via cyclic adenosine monophosphate, not Ca<sup>2+</sup> signalling: In vitro study
Activation of G protein‐coupled parathyroid hormone receptors in rat incisor odontoblasts promotes mineralization via cyclic adenosine monophosphate, not Ca<sup>2+</sup> signalling: In vitro study Open
Aim Parathyroid hormone (PTH) and its Gα s ‐coupled receptors, PTH receptor, mediate odontoblast differentiation; however, the detailed intracellular adenylyl cyclase‐mediated signalling pathway mediated by the PTH–PTH receptor axis remain…
View article: Dasatinib and Quercetin Mitigate Age‐Related Alveolar Bone Inflammaging and Neutrophil Infiltration
Dasatinib and Quercetin Mitigate Age‐Related Alveolar Bone Inflammaging and Neutrophil Infiltration Open
Objective Age‐related alveolar bone resorption poses a major dental health challenge, yet its mechanisms and treatments are poorly understood. This study investigates the impact of dasatinib and quercetin (D + Q) treatment on senescent cel…
View article: Pericytes Are Odontoblast Progenitor Cells Depending on ER Stress
Pericytes Are Odontoblast Progenitor Cells Depending on ER Stress Open
Odontoblasts are terminally differentiated cells that exhibit mechanosensitivity and mineralization capacity. Mechanosensitive ion channels such as Piezo1 are present in odontoblasts and are associated with their physiological functions vi…
View article: Negative feedback between PTH1R and IGF1 through the Hedgehog pathway in mediating craniofacial bone remodeling
Negative feedback between PTH1R and IGF1 through the Hedgehog pathway in mediating craniofacial bone remodeling Open
Regeneration of orofacial bone defects caused by inflammation-related diseases or trauma remains an unmet challenge. Parathyroid hormone 1 receptor (PTH1R) signaling is a key mediator of bone remodeling whereas the regulatory mechanisms of…
View article: Intracellular cAMP signaling-induced Ca2+ influx mediated by calcium homeostasis modulator 1 (CALHM1) in human odontoblasts
Intracellular cAMP signaling-induced Ca2+ influx mediated by calcium homeostasis modulator 1 (CALHM1) in human odontoblasts Open
In odontoblasts, intracellular Ca 2+ signaling plays key roles in reactionary dentin formation and generation of dentinal pain. Odontoblasts also express several G s protein-coupled receptors that promote production of cyclic AMP (cAMP). H…
View article: Upregulation of Amy1 in the salivary glands of mice exposed to a lunar gravity environment using the multiple artificial gravity research system
Upregulation of Amy1 in the salivary glands of mice exposed to a lunar gravity environment using the multiple artificial gravity research system Open
Introduction: Space is a unique environment characterized by isolation from community life and exposure to circadian misalignment, microgravity, and space radiation. These multiple differences from those experienced on the earth may cause …
View article: The Potential Role and Therapeutic Relevance of Cellular Senescence in Skeletal Pathophysiology
The Potential Role and Therapeutic Relevance of Cellular Senescence in Skeletal Pathophysiology Open
Biological aging profoundly impairs the homeostasis of the skeletal system. Cellular senescence, a hallmark of biological aging, plays an instrumental role in bone disease. The underlying mechanisms of cellular senescence, triggered by bot…
View article: Etiology of Oral Potentially Malignant Disorders and Squamous Cell Carcinoma Based on Cellular Stress Regulation and Matrix Stiffness
Etiology of Oral Potentially Malignant Disorders and Squamous Cell Carcinoma Based on Cellular Stress Regulation and Matrix Stiffness Open
The oral cavity serves as the initial segment of the digestive system and is responsible for both nutritional supplementation and the mechanical breakdown of food. It comprises distinct hard and soft tissues; the oral mucosa is subject to …
View article: A <scp>single‐cell</scp> transcriptomic atlas characterizes <scp>age‐related</scp> changes of murine cranial stem cell niches
A <span>single‐cell</span> transcriptomic atlas characterizes <span>age‐related</span> changes of murine cranial stem cell niches Open
The craniofacial bones provide structural support for the skull and accommodate the vulnerable brain tissue with a protective cavity. The bone tissue undergoes constant turnover, which relies on skeletal stem cells (SSCs) and/or mesenchyma…
View article: Intracellular cAMP Signaling Pathway via Gs Protein-Coupled Receptor Activation in Rat Primary Cultured Trigeminal Ganglion Cells
Intracellular cAMP Signaling Pathway via Gs Protein-Coupled Receptor Activation in Rat Primary Cultured Trigeminal Ganglion Cells Open
G protein-coupled receptors in trigeminal ganglion (TG) neurons are often associated with sensory mechanisms, including nociception. We have previously reported the expression of P2Y12 receptors, which are Gi protein-coupled receptors, in …
View article: Cellular Signaling for Dental Physiological Functions
Cellular Signaling for Dental Physiological Functions Open
Teeth are unique and multifaceted tissues that are necessary for routine functions, such as crushing food and constructing articulated sounds, as well as for esthetic symbols [...]
View article: Functional Expression of IP, 5-HT4, D1, A2A, and VIP Receptors in Human Odontoblast Cell Line
Functional Expression of IP, 5-HT4, D1, A2A, and VIP Receptors in Human Odontoblast Cell Line Open
Odontoblasts are involved in sensory generation as sensory receptor cells and in dentin formation. We previously reported that an increase in intracellular cAMP levels by cannabinoid 1 receptor activation induces Ca2+ influx via transient …
View article: Editorial: Stem cells in oral cavity: from development to regeneration, Volume II
Editorial: Stem cells in oral cavity: from development to regeneration, Volume II Open
EDITORIAL article Front. Cell Dev. Biol., 28 April 2023Sec. Stem Cell Research Volume 11 - 2023 | https://doi.org/10.3389/fcell.2023.1207744
View article: Piezo1-pannexin-1-P2X3 axis in odontoblasts and neurons mediates sensory transduction in dentinal sensitivity
Piezo1-pannexin-1-P2X3 axis in odontoblasts and neurons mediates sensory transduction in dentinal sensitivity Open
According to the “hydrodynamic theory,” dentinal pain or sensitivity is caused by dentinal fluid movement following the application of various stimuli to the dentin surface. Recent convergent evidence in Vitro has shown that plasma membran…
View article: Gαs-Coupled CGRP Receptor Signaling Axis from the Trigeminal Ganglion Neuron to Odontoblast Negatively Regulates Dentin Mineralization
Gαs-Coupled CGRP Receptor Signaling Axis from the Trigeminal Ganglion Neuron to Odontoblast Negatively Regulates Dentin Mineralization Open
An inflammatory response following dental pulp injury and/or infection often leads to neurogenic inflammation via the axon reflex. However, the detailed mechanism underlying the occurrence of the axon reflex in the dental pulp remains uncl…
View article: Glycosaminoglycans promote osteogenesis from human induced pluripotent stem cells via neural crest induction
Glycosaminoglycans promote osteogenesis from human induced pluripotent stem cells via neural crest induction Open
The stepwise development of bone is rigidly controlled from mesenchymal cells through osteoblasts. Dysregulation of this process causes various bone diseases, such as osteoporosis and osteogenesis imperfecta. Recently, it has been noted th…
View article: Mesenchymal Stem/Stromal Cell Senescence: Hallmarks, Mechanisms, and Combating Strategies
Mesenchymal Stem/Stromal Cell Senescence: Hallmarks, Mechanisms, and Combating Strategies Open
Aging is a multifaceted and complicated process, manifested by a decline of normal physiological functions across tissues and organs, leading to overt frailty, mortality, and chronic diseases, such as skeletal, cardiovascular, and cognitiv…
View article: Editorial: Stem Cells in Oral Cavity: From Development to Regeneration
Editorial: Stem Cells in Oral Cavity: From Development to Regeneration Open
EDITORIAL article Front. Cell Dev. Biol., 20 January 2022Sec. Stem Cell Research Volume 10 - 2022 | https://doi.org/10.3389/fcell.2022.840771
View article: Tissue Regeneration and Physiological Functional Recovery in Dental and Craniofacial Fields
Tissue Regeneration and Physiological Functional Recovery in Dental and Craniofacial Fields Open
Dental and oral tissues maintain homeostasis through potential reparative or regenerative processes [...]
View article: Mechanical Stimulation-Induced Calcium Signaling by Piezo1 Channel Activation in Human Odontoblast Reduces Dentin Mineralization
Mechanical Stimulation-Induced Calcium Signaling by Piezo1 Channel Activation in Human Odontoblast Reduces Dentin Mineralization Open
Odontoblasts play critical roles in dentin formation and sensory transduction following stimuli on the dentin surface. Exogenous stimuli to the dentin surface elicit dentinal sensitivity through the movement of fluids in dentinal tubules, …
View article: Cranial Suture Mesenchymal Stem Cells: Insights and Advances
Cranial Suture Mesenchymal Stem Cells: Insights and Advances Open
The cranial bones constitute the protective structures of the skull, which surround and protect the brain. Due to the limited repair capacity, the reconstruction and regeneration of skull defects are considered as an unmet clinical need an…
View article: Dental-Derived Mesenchymal Stem Cells: State of the Art
Dental-Derived Mesenchymal Stem Cells: State of the Art Open
Mesenchymal stem cells (MSCs) could be identified in mammalian teeth. Currently, dental-derived MSCs (DMSCs) has become a collective term for all the MSCs isolated from dental pulp, periodontal ligament, dental follicle, apical papilla, an…
View article: Diagnosing Trigeminal Neuralgia Based on Clinical Diagnostic Reasoning in an Elderly Patient
Diagnosing Trigeminal Neuralgia Based on Clinical Diagnostic Reasoning in an Elderly Patient Open
When pain adversely affects a patient's activities its diagnosis needs to be fast and accurate to allow effective treatment to be commenced as soon as possible. Difficulties may be found in achieving this, however, in elderly patients with…