Takehito Seta
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View article: Size-reduced DREADD derivatives for AAV-assisted multimodal chemogenetic control of neuronal activity and behavior
Size-reduced DREADD derivatives for AAV-assisted multimodal chemogenetic control of neuronal activity and behavior Open
Designer receptors exclusively activated by designer drugs (DREADDs) are engineered G-protein-coupled receptors that afford reversible manipulation of neuronal activity in vivo. Here, we introduce size-reduced DREADD derivatives miniDq and…
View article: Minimal upstream open reading frame of Per2 mediates phase fitness of the circadian clock to day/night physiological body temperature rhythm
Minimal upstream open reading frame of Per2 mediates phase fitness of the circadian clock to day/night physiological body temperature rhythm Open
Body temperature in homeothermic animals does not remain constant but displays a regular circadian fluctuation within a physiological range (e.g., 35°C-38.5°C in mice), constituting a fundamental systemic signal to harmonize circadian cloc…
View article: <i>Nmu</i>/<i>Nms</i>/<i>Gpr176</i> Triple-Deficient Mice Show Enhanced Light-Resetting of Circadian Locomotor Activity
<i>Nmu</i>/<i>Nms</i>/<i>Gpr176</i> Triple-Deficient Mice Show Enhanced Light-Resetting of Circadian Locomotor Activity Open
The suprachiasmatic nucleus (SCN) is the master circadian clock in mammals and is properly entrained by environmental light cycle. However, the molecular mechanism(s) determining the magnitude of phase shift by light is still not fully und…