Takenobu Yamamoto
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View article: Comparing immunopathogenesis of non‐human immunodeficiency virus immune reconstitution inflammatory syndrome and immune‐related adverse events: A prospective multicenter cohort study
Comparing immunopathogenesis of non‐human immunodeficiency virus immune reconstitution inflammatory syndrome and immune‐related adverse events: A prospective multicenter cohort study Open
The concept of immune reconstitution inflammatory syndrome (IRIS) has recently been applied to patients with non‐HIV infection with immune fluctuations. However, quantitative criteria to diagnose non‐HIV IRIS have not been established. Sim…
View article: A Case of Atypical Fibroxanthoma with Local Recurrence and Metastatic Progression to Pleomorphic Dermal Sarcoma
A Case of Atypical Fibroxanthoma with Local Recurrence and Metastatic Progression to Pleomorphic Dermal Sarcoma Open
View article: An exploratory study of the efficacy and safety of amenamevir for the treatment of herpes zoster in patients receiving immunosuppressive drugs
An exploratory study of the efficacy and safety of amenamevir for the treatment of herpes zoster in patients receiving immunosuppressive drugs Open
Amenamevir is an oral once‐daily antiherpesvirus drug that can be administered without dose adjustment in patients with impaired renal function. There are currently no clinical data on immunocompromised patients with herpes zoster treated …
View article: Sweat Protects against Contact Hypersensitivity: Transient Sweat Suppression Compromises Skin Barrier Function in Mice
Sweat Protects against Contact Hypersensitivity: Transient Sweat Suppression Compromises Skin Barrier Function in Mice Open
Although subtle barrier defects may facilitate allergen penetration, thereby enabling allergic sensitization, the relationship between sweating disturbance and skin barrier function is unknown. However, many studies on contact hypersensiti…
View article: Efficacy and safety of intravenous fosphenytoin for patients with acute herpes zoster‐associated pain: A placebo‐controlled randomized trial
Efficacy and safety of intravenous fosphenytoin for patients with acute herpes zoster‐associated pain: A placebo‐controlled randomized trial Open
Acute zoster‐associated pain develops in most patients with herpes zoster. Nonopioid analgesics are usually used to treat acute zoster‐associated pain but are frequently ineffective. We administered intravenous fosphenytoin, the prodrug of…
View article: Biomarkers for predicting immune reconstitution inflammatory syndrome in dipeptidyl peptidase‐4 inhibitor‐associated bullous pemphigoid: A retrospective observational study with a case series
Biomarkers for predicting immune reconstitution inflammatory syndrome in dipeptidyl peptidase‐4 inhibitor‐associated bullous pemphigoid: A retrospective observational study with a case series Open
Background The prognosis of dipeptidyl peptidase‐4 inhibitor‐associated bullous pemphigoid (DPP‐4i‐BP) is variable, with some cases showing spontaneous remission after drug cessation and others showing worsening BP or developing infectious…
View article: Dramatic deterioration or new‐onset dipeptidyl peptidase‐4 inhibitor‐associated bullous pemphigoid after COVID‐19 vaccination: A possible manifestation of immune reconstitution inflammatory syndrome
Dramatic deterioration or new‐onset dipeptidyl peptidase‐4 inhibitor‐associated bullous pemphigoid after COVID‐19 vaccination: A possible manifestation of immune reconstitution inflammatory syndrome Open
Background Many reports have described the development of bullous pemphigoid (BP) following COVID‐19 vaccination. In dipeptidyl peptidase‐4 inhibitor‐associated BP (DPP‐4i‐BP), cessation of DPP‐4i appears to have a paradoxical effect on th…
View article: A Case of Mucopolysaccharidosis II Caused by a Novel Variant with Skin Linear Hyperpigmented Streaks along Blaschko’s Lines
A Case of Mucopolysaccharidosis II Caused by a Novel Variant with Skin Linear Hyperpigmented Streaks along Blaschko’s Lines Open
We report a case of an eight-year-old boy with mucopolysaccharidosis (MPS) II with atypical skin lesions of hyperpigmented streaks along Blaschko’s lines. This case presented with mild symptoms of MPS such as hepatosplenomegaly, joint stif…
View article: Two Cases of phaeohyphomycosis on the fingers in immunocompromised patients
Two Cases of phaeohyphomycosis on the fingers in immunocompromised patients Open
黒色菌糸症は免疫不全患者の皮膚に好発する，黒色真菌による深在性真菌症である．今回，黒色菌糸症を2症例経験し，うち1症例で膿のKOH鏡検により迅速に診断を行えたので報告する．症例１は，87歳男性．肺小細胞癌(stageⅣB)に対して緩和治療中．初診の3か月前に転倒による外傷歴があり，抗菌薬による加療を受けたが，左環指基部腹側の発赤・腫脹が継続するため受診した．波動を触知し，超音波検査で皮下に境界明瞭な低エコー領域を認めた．膿汁の直接鏡検で多数の菌糸が観察された．症例2は，80…
View article: Anti-Cytomegalovirus Therapy: Whether and When to Initiate, Those Are the Questions
Anti-Cytomegalovirus Therapy: Whether and When to Initiate, Those Are the Questions Open
Cytomegalovirus (CMV) reactivation in patients with autoimmune bullous disease (AIBD) or severe drug eruption treated with immunosuppressive therapy was traditionally thought to be merely an epiphenomenon of the underlying immunosuppressio…
View article: Herpes zoster in lung cancer patients treated with PD-1/PD-L1 inhibitors
Herpes zoster in lung cancer patients treated with PD-1/PD-L1 inhibitors Open
There was no significant difference in the rate of HZ between lung cancer patients treated with ICI and those treated with cytotoxic chemotherapy alone. However, patients younger than 65 years treated with ICI might be at increased risk of…
View article: Neutrophil to lymphocyte ratio is predictive of severe complications and mortality in patients with dipeptidyl peptidase-4 inhibitor-associated bullous pemphigoid: A retrospective longitudinal observational study
Neutrophil to lymphocyte ratio is predictive of severe complications and mortality in patients with dipeptidyl peptidase-4 inhibitor-associated bullous pemphigoid: A retrospective longitudinal observational study Open
View article: Supplemental information for "Neutrophil to lymphocyte ratio is predictive of severe complications and mortality in patients with dipeptidyl peptidase-4 inhibitor-associated bullous pemphigoid: a retrospective longitudinal observational study.""
Supplemental information for "Neutrophil to lymphocyte ratio is predictive of severe complications and mortality in patients with dipeptidyl peptidase-4 inhibitor-associated bullous pemphigoid: a retrospective longitudinal observational study."" Open
Contents: Supplemental Methods and Legends Supplemental Fig 1 Supplemental Fig 2 Supplemental Fig 3
View article: Varicella Zoster Virus-Associated Meningitis as a Rebound Varicella Zoster Disease after Antiviral Discontinuation
Varicella Zoster Virus-Associated Meningitis as a Rebound Varicella Zoster Disease after Antiviral Discontinuation Open
Varicella zoster virus (VZV)-associated meningitis is usually progressive and can be fatal, and early diagnosis and aggressive treatment with intravenous antivirals such as acyclovir (ACV) are required in immunocompromised patients. Patien…
View article: Series: Diagnosis at a Glance
Series: Diagnosis at a Glance Open
View article: A Case of Squamous Cell Carcinoma Occurring at the Ureterocutaneous Fistula as Metachronous Quadruple Cancers
A Case of Squamous Cell Carcinoma Occurring at the Ureterocutaneous Fistula as Metachronous Quadruple Cancers Open
74 歳，男性。既往に胃癌・食道癌があり，13 年前，右腎盂癌に対して右腎尿管膀胱全摘術および左尿管皮膚瘻増設術を施行し 13 年間カテーテルを留置されていた。2 カ月前から尿管皮膚瘻部の疼痛を認め，紅色結節が出現したため生検を施行された。組織は扁平上皮癌の所見で当科を受診した。PET/CT では結節部に集積を認め結節部から 10 mm 離して切除し，左腎尿管全摘除術を施行した。自験例は病変部以外の尿管，腎に異型細胞は認めず，皮膚尿管移行部の扁平上皮化生を認めたため，尿管皮…
View article: Hypercalcemia Associated with Extramammary Paget’s Disease
Hypercalcemia Associated with Extramammary Paget’s Disease Open
Hypercalcemia of malignancy occurs in up to one third of patients at some point during the course of their advanced stage. The majority of them is caused by humoral hypercalcemia of malignancy due to systemic secretion of parathyroid hormo…
View article: Severe oral stomatitis due to reactivation of herpes simplex virus type 1 in a methotrexate-treated patient with dermatomyositis
Severe oral stomatitis due to reactivation of herpes simplex virus type 1 in a methotrexate-treated patient with dermatomyositis Open
We herein report a case of a 79-year-old Japanese woman who developed severe oral stomatitis during methotrexate (MTX) treatment for dermatomyositis. She had been treated with MTX (12 mg/week) and prednisolone (5 mg/day) for dermatomyositi…
View article: A case of neonatal lupus erythematosus with fever in an infant born from an anti‐SSA/Ro and anti‐SSB/Lo antibody‐positive mother
A case of neonatal lupus erythematosus with fever in an infant born from an anti‐SSA/Ro and anti‐SSB/Lo antibody‐positive mother Open
Neonatal lupus erythematosus (NLE) is an uncommon syndrome, which is caused by the transplacental passage of maternal autoantibodies to anti-SSA/Ro antibody and/or anti-SSB/Lo antibody.1 In a 21-year-old woman, infiltrative annular erythem…
View article: Two Cases of Cerebral Infarction Associated with Herpes Zoster
Two Cases of Cerebral Infarction Associated with Herpes Zoster Open
症例 1 は左中大脳動脈領域の脳梗塞で当院に救急搬送され，搬送時にはすでに左第 2，3 頚神経領域の帯状疱疹が出現していた。症例 2 は右三叉神経第 3 枝領域の帯状疱疹でファムシクロビル内服，ビダラビン軟膏外用治療を受けていた。治療開始翌日に両側の大脳半球と小脳半球の多発脳梗塞で当院に救急搬送された。2 例とも脳梗塞発症時に帯状疱疹が出現していたが，高血圧症，糖尿病，高脂血症，心房細動など脳梗塞の危険因子はなかった。そのため，帯状疱疹関連脳梗塞と診断した。神経節に潜伏感染…
View article: Japanese Spotted Fever: A Rare Cause of Arthritis
Japanese Spotted Fever: A Rare Cause of Arthritis Open
View article: Cell-to-cell transmission of HSV-1 in differentiated keratinocytes promotes multinucleated giant cell formation
Cell-to-cell transmission of HSV-1 in differentiated keratinocytes promotes multinucleated giant cell formation Open
View article: IgA Vasculitis with Multiple Large Ulcers and Protracted Healing in an Elderly Woman
IgA Vasculitis with Multiple Large Ulcers and Protracted Healing in an Elderly Woman Open
IgA 血管炎は，皮膚，消化管，腎糸球体の小血管に IgA の沈着を認め，関節痛，糸球体腎炎を合併する疾患である。成人，特に高齢者の IgA 血管炎では小児よりも大型の紫斑，皮膚潰瘍や慢性腎不全を生じやすい。IgA 血管炎により下腿に潰瘍が多発した IgA 血管炎の 81 歳，女性例を報告する。蛍光抗体直接法にて血管壁に IgA，IgM，C3 の沈着がみられた。プレドニゾロン 30 mg/日の内服を行ったが，潰瘍が上皮化するのに約 3 カ月を要し，腎障害の改善も遷延した。病…
View article: A case of sitosterolemia due to compound heterozygous mutations in <i>ABCG5</i>: clinical features and treatment outcomes obtained with colestimide and ezetimibe
A case of sitosterolemia due to compound heterozygous mutations in <i>ABCG5</i>: clinical features and treatment outcomes obtained with colestimide and ezetimibe Open
Sitosterolemia is a rare, autosomal recessively inherited disorder of lipid metabolism caused by mutations in the "ATP-binding cassette, subfamily G" member 5 and 8 proteins (encoded by the ABCG5 and ABCG8 genes, respectively…