Takeshi Hamada
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View article: Upregulation of the Mammalian Target of Rapamycin Complex 1 Pathway by Ras Homolog Enriched in Brain in Pancreatic β-Cells Leads to Increased β-Cell Mass and Prevention of Hyperglycemia
Upregulation of the Mammalian Target of Rapamycin Complex 1 Pathway by Ras Homolog Enriched in Brain in Pancreatic β-Cells Leads to Increased β-Cell Mass and Prevention of Hyperglycemia Open
OBJECTIVE Components of insulin/IGF-1 receptor–mediated signaling pathways in pancreatic β-cells have been implicated in the development of diabetes, in part through the regulation of β-cell mass in vivo. Studies in vitro have shown that t…
View article: Dropped Head Sign as the Only Symptom of Myasthenia Gravis
Dropped Head Sign as the Only Symptom of Myasthenia Gravis Open
Neck extensor muscle weakness and the dropped head sign are associated with various neuromuscular disorders. However, these symptoms are comparatively rare in myasthenia gravis (MG). We report a MG case that presented with dropped head sig…
View article: ‘Drug holiday’ effects of tandospirone in a patient with Machado–Joseph disease
‘Drug holiday’ effects of tandospirone in a patient with Machado–Joseph disease Open
Machado–Joseph disease (MJD) is an autosomal dominant spinocerebellar degeneration (SCD).1 Reports indicate that 5-hydroxytryptamine 1A (5-HT1A) agonists are efficacious for the treatment of cortical cerebellar atrophy2,3 but its effective…
View article: Beneficial effects of tandospirone on ataxia of a patient with Machado‐Joseph disease
Beneficial effects of tandospirone on ataxia of a patient with Machado‐Joseph disease Open
Tandospirone citrate (tandospirone) is an anti‐anxiety drug that acts by combining with serotonin receptor (5‐hydroxytryptamine‐1 A [5‐HT1A]). Recently, there have been a few reports of its potential role in the treatment of cerebellar ata…
View article: Qptico-spinal form of multiple sclerosis in Japanese.
Qptico-spinal form of multiple sclerosis in Japanese. Open
The clinical features of MS in Japanese are said to be characterized by high incidence of optico-spinal MS (OS-MS), although the frequency of it has recently decreased. The term OS-MS is used to describe a subgroup of patients diagnosed wi…
View article: Prevalence of Parkinson's Disease in Hokkaido, the Northernmost Island of Japan.
Prevalence of Parkinson's Disease in Hokkaido, the Northernmost Island of Japan. Open
The prevalence of Parkinson's disease (PD) was investigated in Hokkaido, the northernmost island of Japan. A pilot case-finding study was carried out to estimate the prevalence in the entire island of Hokkaido (population = 5,643,647) init…
View article: A case of an odontogenic keratocyst forming within a short period.
A case of an odontogenic keratocyst forming within a short period. Open
Odontogenic keratocyst is histologically and clinically distinct from other odontogenic cysts, especially with regard to its high recurrence rate and the remarkable growth capacity.We report a case of a 19-year-old man with an odontogenic …
View article: Molecular Epidemiology of Staphylococcus spp. Contamination in the Ward Environment: Study on mecA and femA Genes in Methicillin-Resistant Strains
Molecular Epidemiology of Staphylococcus spp. Contamination in the Ward Environment: Study on mecA and femA Genes in Methicillin-Resistant Strains Open
Staphylococcus spp. were isolated from the ward environment and antibiotic susceptibility tests were performed. Twenty-nine strains out of 274 isolates were S. aureus, and 41.4% of the S. aureus strains were methicillin resistant (MRSA). A…
View article: A case of epidermoid cyst in the mandible. Study of cytokeratin expression and cyst fluid analysis.
A case of epidermoid cyst in the mandible. Study of cytokeratin expression and cyst fluid analysis. Open
A case of epidermoid cyst in the mandible is reported in which the cystic lining epithelium was evaluated immunohistochemically with anti-keratin antibody. The patient was a 64-year-old man who was referred to our department due to swellin…
View article: Clinical and pathological studies on adenoid cystic carcinoma originating from the salivary gland. Recurrence and lymph node and distant metastases.
Clinical and pathological studies on adenoid cystic carcinoma originating from the salivary gland. Recurrence and lymph node and distant metastases. Open
Fifteen patients who were treated for adenoid cystic carcinoma in our departmentduring the 22 years between July 1971 and July 1993 were studied with respect to local recurrence, lymph node and the distant metastases and factors related to…
View article: A case of a congenital fibrolipoma of the median region of the maxilla.
A case of a congenital fibrolipoma of the median region of the maxilla. Open
Congenital lipoma in the oral cavity is very rare. A fibrolipama in the oral cavity of a 40-day-old female infant is reported. A pedunculated tumor measuring 25×15mm was noted at the region from the anterior palate to upper alveolar ridge.…
View article: A case of solitary neurofibroma of the tongue with Becker's nevus of the skin.
A case of solitary neurofibroma of the tongue with Becker's nevus of the skin. Open
A case of solitary neurofibroma of the tongue with Becker's nevus of the skin is reported.A 20-year old man was referred to our department with a chief complaint of swelling of the tongue. He had Becker's nevi on his shoulder and dorsum of…
View article: Evaluation of neck dissection with preservation of the internal jugular vein and accessory nerve in patients with squamous cell carcinoma of the oral cavity or maxillary sinus.
Evaluation of neck dissection with preservation of the internal jugular vein and accessory nerve in patients with squamous cell carcinoma of the oral cavity or maxillary sinus. Open
Neck dissection in which the sternocleidomastoid muscle was excised and the internal jugular vein and accessory nerve were preserved was performed in 73 patients with squamous cell carcinomas of the oral cavity or maxillary sinus. The diss…
View article: A case of plasma cell granuloma of the buccal mucosa probably caused by dental metal allergy.
A case of plasma cell granuloma of the buccal mucosa probably caused by dental metal allergy. Open
Plasma cell granuloma is a pseudotumor characterized by aggregation of plasma cells. It rarely occurs in the oral cavity. A case of plasma cell granuloma of the buccal mucosa in a 42-year-old woman is reported. She suffered from repeated b…
View article: Sequential Magnetic Resonance Features of Encephalopathy Induced by Systemic Mastocytosis.
Sequential Magnetic Resonance Features of Encephalopathy Induced by Systemic Mastocytosis. Open
A 37-year-old man developed encephalopathy with prominent eosinophilia. Magnetic resonance imaging (MRI) revealed multiple T2-weighted high signal intensity lesions with dimeglumine gadopentetate (Gd-DTPA) enhancement on T1-weighted images…
View article: Germ Tube Formation and Proteinase Activity of Candida albicans in Relation to Virulence for Mice
Germ Tube Formation and Proteinase Activity of Candida albicans in Relation to Virulence for Mice Open
Standard strains and clinically isolated strains of Candida albicans were tested for their virulence for mice. Lethal effects of yeast forms of clinical isolates were stronger than those of germ tube-forming cells in all except one strain.…
View article: A case of cystic lymphangioma. OK-432 local injection therapy and application of a chin-cap.
A case of cystic lymphangioma. OK-432 local injection therapy and application of a chin-cap. Open
A 3-year-old boy was referred to our clinic with swelling of the neck, submandibular region and tongue. The patient had been previously treated in our clinic with local injection of bleomycin. We therefore resected the neck tumor and perfo…
View article: Correlation between gingival hyperplasia, the total dose of cyclosporin-A(Cy-A) and oral hygiene in patients administered Cy-A.
Correlation between gingival hyperplasia, the total dose of cyclosporin-A(Cy-A) and oral hygiene in patients administered Cy-A. Open
Recently, cyclosporin-A (Cy-A) induced gingival hyperplasia has been reported. We examined the oral condition of 8 patients with kidney transplants who were administered Cy-A at Tottori Prefectural Central Hospital, and found gingival hype…
View article: Multiple Sclerosis in Hokkaido, the Northernmost Island of Japan. Prospective Analyses of Clinical Features.
Multiple Sclerosis in Hokkaido, the Northernmost Island of Japan. Prospective Analyses of Clinical Features. Open
We analyzed the clinical features of multiple sclerosis (MS) prospectively seen between July 1986 and October 1989 on Hokkaido island, the northernmost part of Japan. Clinical features were generally considered to be intermediate between t…
View article: A clinical study of 52 salivary gland tumors.
A clinical study of 52 salivary gland tumors. Open
Fifty-two patients treated for salivary gland tumor in our hospital during the past 18 years from 1971 to 1989 were studied in this article.1. This study included 6 males and 11 females with benign and 15 males and 20 females with malignan…
View article: Chronic myelomonocytic leukemia with first manifestation of the submandibular swelling; A report of case.
Chronic myelomonocytic leukemia with first manifestation of the submandibular swelling; A report of case. Open
Chronic myelomonocytic leukemia has been classified into myelodysplastic syndromes according to FAB co-operative group proposal. A 76-year-old man was diagnosed chronic myelomonocytic leukemia according to the FAB criteria. Clinical featur…
View article: Pharmacokinetic studies on distribution of Latamoxef(LMOX) to oral tissues of human.
Pharmacokinetic studies on distribution of Latamoxef(LMOX) to oral tissues of human. Open
A dose of 2g LMOX was administered to 30 patients by one-shot intravenous injection. The distribution to oral tissues (maxillary bone, mandibular bone, gingiva, cyst wall) of LNIOX and its pharmacokinetic analysis were performed. The resul…
View article: A case of cranial chordoma with cheek invasion recurred 6 years after operation.
A case of cranial chordoma with cheek invasion recurred 6 years after operation. Open
Intracranial chordoma is very uncommon and rarely invasde the oral area.This is a report of a case with recurrent cranial chordoma, which is diagnosed from biopsy specimen of cheek tumor.A 43-year-old female visited the department of Denti…
View article: Metastatic embryonal carcinoma of upper and lower gingiva; A report of case and its review of the literature.
Metastatic embryonal carcinoma of upper and lower gingiva; A report of case and its review of the literature. Open
Oral metastatic tumor of testis is rare. Here we report a case of embryonal carcinoma of the left upper and lower gingiva in a 19-year-old man. His left testis gradually began swelling 13 months ago. Oral tumor surface was elastically soft…
View article: Clinical evaluation of Midecamycin acetate(MOM) in odontogenic infection. A comparative double-blind study with Josamycin.
Clinical evaluation of Midecamycin acetate(MOM) in odontogenic infection. A comparative double-blind study with Josamycin. Open
Clinical efficacy and safety of Midecamycin acetate (MOM) were compared with those of Josamycin (JM) in patients with oral and maxillofacial infections under multicentered double-blind controlled study, and the following results were obtai…
View article: Clinical evaluation cefbuperazone(CBPZ, keiperazone) to various infections in the field of oral surgery.
Clinical evaluation cefbuperazone(CBPZ, keiperazone) to various infections in the field of oral surgery. Open
Clinical evaluation of Cefbuperazone (CBPZ) in 63 cases of various infections inthe oro-facial region was carried out. Bacteria were isolated from the infectious lesions and their sensitivity to Cefbuperazone was tested. The results are su…