Takeshi Iwasaki
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View article: Comprehensive Analysis of N6-Methyladenosine (m6A) RNA Methylation Regulators in Soft Tissue Leiomyosarcoma
Comprehensive Analysis of N6-Methyladenosine (m6A) RNA Methylation Regulators in Soft Tissue Leiomyosarcoma Open
N6-methyladenosine (m6A), a widespread RNA modification, plays a vital role in various biological processes, including carcinogenesis, tumor progression, and immune regulation. We conducted this study to investigate the relationship betwee…
View article: Multiscale Fusion Models With Genomic, Topological, and Pathomic Features to Predict Response to Radiation Therapy for Non–Small Cell Lung Cancer Patients
Multiscale Fusion Models With Genomic, Topological, and Pathomic Features to Predict Response to Radiation Therapy for Non–Small Cell Lung Cancer Patients Open
Artificial intelligence models with biomarkers to predict treatment responses to radiation would be necessary to maximize the treatment outcomes of individual patients, especially with histopathology images routinely obtained before treatm…
View article: Critical roles of chronic BCR signaling in the differentiation of anergic B cells into age-associated B cells in aging and autoimmunity
Critical roles of chronic BCR signaling in the differentiation of anergic B cells into age-associated B cells in aging and autoimmunity Open
Age-associated B cells (ABCs) with autoreactive properties accumulate with age and expand prematurely in autoimmune diseases. However, the mechanisms behind ABC generation and maintenance remain poorly understood. We show that continuous B…
View article: Differences in Tumor‐Infiltrating Lymphocyte Counts in the Peritumoral Area in Patients Undergoing Hepatic Resection After Lenvatinib and Atezolizumab Plus Bevacizumab Therapy for Hepatocellular Carcinoma
Differences in Tumor‐Infiltrating Lymphocyte Counts in the Peritumoral Area in Patients Undergoing Hepatic Resection After Lenvatinib and Atezolizumab Plus Bevacizumab Therapy for Hepatocellular Carcinoma Open
Aim With advances in systemic therapy, the number of patients with hepatocellular carcinoma (HCC) who can undergo hepatic resection has increased in recent years, but there are no reports evaluating the immune status in the peritumoral are…
View article: Impact of Tertiary Lymphoid Structure on Prognosis and Tumor Microenvironment in Undifferentiated Pleomorphic Sarcoma
Impact of Tertiary Lymphoid Structure on Prognosis and Tumor Microenvironment in Undifferentiated Pleomorphic Sarcoma Open
Undifferentiated pleomorphic sarcoma (UPS) has a favorable objective response rate to anti‐PD‐1 drugs compared with other sarcomas. Tertiary lymphoid structure (TLS) is a favorable prognostic factor and a biomarker for immune checkpoint in…
View article: Adjunctive diagnostic tool for histopathological classification of congenital mesoblastic nephroma based in molecular genetic findings
Adjunctive diagnostic tool for histopathological classification of congenital mesoblastic nephroma based in molecular genetic findings Open
View article: Loss of <scp>SMARCA4</scp> induces sarcomatogenesis through epithelial–mesenchymal transition in ovarian carcinosarcoma
Loss of <span>SMARCA4</span> induces sarcomatogenesis through epithelial–mesenchymal transition in ovarian carcinosarcoma Open
Ovarian carcinosarcoma (OCS) is a rare and aggressive tumor, and the development of its sarcomatous component is believed to be due to epithelial–mesenchymal transition (EMT). The SWIch/sucrose nonfermentable chromatin remodeling factor (C…
View article: Deep learning model to diagnose cardiac amyloidosis from haematoxylin/eosin-stained myocardial tissue
Deep learning model to diagnose cardiac amyloidosis from haematoxylin/eosin-stained myocardial tissue Open
Aims Amyloid deposition in myocardial tissue is a definitive feature for diagnosing cardiac amyloidosis, though less invasive imaging modalities such as bone tracer cardiac scintigraphy and cardiac magnetic resonance imaging have been esta…
View article: Clinical and pathological characteristics of immune checkpoint inhibitor-related fulminant myocarditis
Clinical and pathological characteristics of immune checkpoint inhibitor-related fulminant myocarditis Open
The advent of immune checkpoint inhibitors (ICIs) has significantly improved cancer treatment. With the increasing use of ICIs, ICI-related myocarditis has been recognized. However, an evidence-based therapeutic strategy has not been estab…
View article: Adjunctive diagnostic tool for histopathological classification in congenital mesoblastic nephroma
Adjunctive diagnostic tool for histopathological classification in congenital mesoblastic nephroma Open
Purpose: Congenital mesoblastic nephromas (CMN) are histologically classified into classical, cellular, and mixed subtypes. Most cellular CMNs harbor ETV6-NTRK3 gene fusions, and classic and mixed CMNs harbor EGFR internal tandem duplicati…
View article: Spatial dynamics of CD39+CD8+ exhausted T cell reveal tertiary lymphoid structures-mediated response to PD-1 blockade in esophageal cancer
Spatial dynamics of CD39+CD8+ exhausted T cell reveal tertiary lymphoid structures-mediated response to PD-1 blockade in esophageal cancer Open
Despite the success of immune checkpoint blockade (ICB) therapy for esophageal squamous cell cancer, the key immune cell populations that affect ICB efficacy remain unclear. Here, imaging mass cytometry of tumor tissues from ICB-treated pa…
View article: Cholesterol sulfate prevents maternal–fetal conflict by locally modulating immune reactivity
Cholesterol sulfate prevents maternal–fetal conflict by locally modulating immune reactivity Open
Although placental mammals are at high risk of maternal–fetal immune conflict, it is unclear how the semi-allogeneic fetus avoids rejection. Cholesterol sulfate (CS) is a bioactive metabolite that inhibits leukocyte migration and activatio…
View article: Genetic profiles and clinical features in subcutaneous panniculitis‐like T‐cell lymphomas
Genetic profiles and clinical features in subcutaneous panniculitis‐like T‐cell lymphomas Open
Subcutaneous panniculitis‐like T‐cell lymphoma (SPTCL) is a rare peripheral T‐cell lymphoma characterized by cutaneous lesions and immunologic manifestations. The five‐year survival rate of SPTCL has been reported to be over 80%, indicatin…
View article: Reappraisal of bone and soft tissue cytopathology classification using the modified Milan system
Reappraisal of bone and soft tissue cytopathology classification using the modified Milan system Open
Background A standardized reporting system for bone and soft tissue tumor cytopathology has not yet been established. The objective of this study was to explore the potential utility of a classification modified from the Milan System for S…
View article: Interstitial Pneumonia Associated with Nodal T-follicular Helper Cell Lymphoma
Interstitial Pneumonia Associated with Nodal T-follicular Helper Cell Lymphoma Open
Nodal T-follicular helper cell lymphoma (nTFHL), a hematologic neoplasm originating from T-follicular helper (TFH) cells, occasionally presents with pulmonary radiographic abnormalities, without neoplastic cellular infiltration. However, t…
View article: A case of neo-adjuvant BEP chemotherapy and total thymectomy for thymic lymphoepithelial carcinoma
A case of neo-adjuvant BEP chemotherapy and total thymectomy for thymic lymphoepithelial carcinoma Open
症例は17歳の男性.気管支炎で胸部レントゲンを撮影された際に右肺門部の縦隔陰影拡大を指摘された.翌年の検診でも同様の指摘をされ,当院へ紹介された.胸部CTでは前縦隔に10 cm大の辺縁不整な腫瘍を認め,両側腕頭静脈,上大静脈,右房を圧排し腫瘍の浸潤が疑われた.組織診断のため,腫瘍針生検を行った.組織は小型成熟リンパ球とやや大型の腫瘍細胞からなりc-kit強陽性,PLAPが弱染色像を示した点からセミノーマと診断された.化学療法(BEP療法3コース)が施行され,著明な腫瘍縮小効…
View article: Gene amplification of chromatin remodeling factor <i>SMARCC2</i> and low protein expression of ACTL6A are unfavorable factors in ovarian high‑grade serous carcinoma
Gene amplification of chromatin remodeling factor <i>SMARCC2</i> and low protein expression of ACTL6A are unfavorable factors in ovarian high‑grade serous carcinoma Open
Ovarian high-grade serous carcinoma (OHGSC) is the most common type of ovarian cancer worldwide. Genome sequencing has identified mutations in chromatin remodeling factors (CRFs) in gynecological cancer, such as clear cell carcinoma, endom…
View article: Impact of <i>TP53</i>‐induced glycolysis and apoptosis regulator on malignant activity and resistance to ferroptosis in intrahepatic cholangiocarcinoma
Impact of <i>TP53</i>‐induced glycolysis and apoptosis regulator on malignant activity and resistance to ferroptosis in intrahepatic cholangiocarcinoma Open
TP53 ‐induced glycolysis and apoptosis regulator ( TIGAR ) is an important gene that encodes a regulatory enzyme of glycolysis and reactive oxygen species (ROS) detoxification and is associated with worse prognosis in various cancers. Ferr…
View article: Upregulated Fcrl5 disrupts B cell anergy and causes autoimmune disease
Upregulated Fcrl5 disrupts B cell anergy and causes autoimmune disease Open
B cell anergy plays a critical role in maintaining self-tolerance by inhibiting autoreactive B cell activation to prevent autoimmune diseases. Here, we demonstrated that Fc receptor-like 5 (Fcrl5) upregulation contributes to autoimmune dis…
View article: Clinical significance of the expression of FOXP3 and TIGIT in Merkel cell carcinoma
Clinical significance of the expression of FOXP3 and TIGIT in Merkel cell carcinoma Open
The pathogenesis of 80% of Merkel cell carcinoma (MCC) cases is associated with Merkel cell polyomavirus (MCPyV). Forkhead helix transcription factor P3 (FOXP3) and the T cell immunoreceptor with immunoglobulin and immunoreceptor tyrosine-…
View article: <scp>MicroRNA</scp>‐326 negatively regulates <scp>CD155</scp> expression in lung adenocarcinoma
<span>MicroRNA</span>‐326 negatively regulates <span>CD155</span> expression in lung adenocarcinoma Open
Treatment with immune checkpoint inhibitors induces a durable response in some patients with non‐small‐cell lung cancer, but eventually gives rise to drug resistance. Upregulation of CD155 expression is implicated as one mechanism of resis…
View article: Chronic BCR signaling generates and maintains age-associated B cells from anergic B cells
Chronic BCR signaling generates and maintains age-associated B cells from anergic B cells Open
Accumulation of age-associated B cells (ABCs) with autoreactive properties contributes to the pathogenesis of autoimmune diseases 1–5 . However, the mechanisms whereby ABCs are generated and maintained are not understood 1, 2, 4 . Here, we…
View article: Upregulated Fcrl5 disrupts B cell anergy and causes autoimmunity
Upregulated Fcrl5 disrupts B cell anergy and causes autoimmunity Open
B cell anergy plays a critical role in maintaining self-tolerance by inhibiting autoreactive B cell activation to prevent autoimmune diseases. Here, we demonstrated that Fc receptor-like 5 (Fcrl5) upregulation contributes to autoimmune dis…
View article: Prognostic value of nuclear morphometry in myxoid liposarcoma
Prognostic value of nuclear morphometry in myxoid liposarcoma Open
Myxoid liposarcoma (MLS) accounts for 20%‐30% of liposarcoma and the round cell component (RCC) is believed to be a specific poor prognostic factor. However, the RCC assessment criteria are vaguely defined and, therefore, are inconsistentl…
View article: Spatial and single-cell transcriptomics decipher the cellular environment containing HLA-G+ cancer cells and SPP1+ macrophages in colorectal cancer
Spatial and single-cell transcriptomics decipher the cellular environment containing HLA-G+ cancer cells and SPP1+ macrophages in colorectal cancer Open
The cellular interactions in the tumor microenvironment of colorectal cancer (CRC) are poorly understood, hindering patient treatment. In the current study, we investigate whether events occurring at the invasion front are of particular im…
View article: Clinical significance of signal regulatory protein alpha and T cell immunoreceptor with immunoglobulin and immunoreceptor tyrosine-based inhibition motif domain expression in undifferentiated pleomorphic sarcoma
Clinical significance of signal regulatory protein alpha and T cell immunoreceptor with immunoglobulin and immunoreceptor tyrosine-based inhibition motif domain expression in undifferentiated pleomorphic sarcoma Open
View article: A case of pulmonary leiomyosarcoma achieving long-term survival after multiple metastasectomies
A case of pulmonary leiomyosarcoma achieving long-term survival after multiple metastasectomies Open
View article: TROP2 Expression in Sebaceous and Sweat Gland Carcinoma
TROP2 Expression in Sebaceous and Sweat Gland Carcinoma Open
Sebaceous carcinoma and sweat gland carcinoma (malignant tumors with apocrine and eccrine differentiation) are rare malignant skin adnexal tumors that differentiate toward sebaceous gland and eccrine and apocrine glands, respectively. Owin…
View article: Cytology of gynecologic perivascular epithelioid cell tumor (PEComa) with different clinical features
Cytology of gynecologic perivascular epithelioid cell tumor (PEComa) with different clinical features Open
背景：血管周囲類上皮細胞腫瘍（perivascular epithelioid cell tumor：PEComa）はまれな間葉系腫瘍である．婦人科領域に発生し，異なる臨床経過をとった PEComa の 2 例の経験を報告する．
View article: Merkel cell polyomavirus–negative Merkel cell carcinoma is associated with JAK‐STAT and MEK‐ERK pathway activation
Merkel cell polyomavirus–negative Merkel cell carcinoma is associated with JAK‐STAT and MEK‐ERK pathway activation Open
Merkel cell polyomavirus (MCPyV) is monoclonally integrated into the genomes of approximately 80% of Merkel cell carcinomas (MCCs). While the presence of MCPyV affects the clinicopathological features of MCC, the molecular mechanisms of MC…