Takeshi Mizutani
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View article: Precise staging of beetle horn formation in Trypoxylus dichotomus reveals the pleiotropic roles of doublesex depending on the spatiotemporal developmental contexts
Precise staging of beetle horn formation in Trypoxylus dichotomus reveals the pleiotropic roles of doublesex depending on the spatiotemporal developmental contexts Open
Many scarab beetles have sexually dimorphic exaggerated horns that are an evolutionary novelty. Since the shape, number, size, and location of horns are highly diverged within Scarabaeidae, beetle horns are an attractive model for studying…
View article: Rhinoceros beetle horn development reveals deep parallels with dung beetles
Rhinoceros beetle horn development reveals deep parallels with dung beetles Open
Beetle horns are attractive models for studying the evolution of novel traits, as they display diverse shapes, sizes, and numbers among closely related species within the family Scarabaeidae. Horns radiated prolifically and independently i…
View article: Outpatient chemotherapy for patients with unresectable or metastatic bone sarcomas
Outpatient chemotherapy for patients with unresectable or metastatic bone sarcomas Open
Background: Outpatient chemotherapy (OC) is one of the treatment options for patients with unresectable or metastatic bone sarcomas, but data regarding the clinical experience with it are few. Methods: We reviewed consecutive 18 patients w…
View article: Six-month results of intravitreal ranibizumab for macular edema after branch retinal vein occlusion in a single-center prospective study: visual outcomes and microaneurysm formation
Six-month results of intravitreal ranibizumab for macular edema after branch retinal vein occlusion in a single-center prospective study: visual outcomes and microaneurysm formation Open
Prompt initiation of IVR injection provided a better visual prognosis at month 6 and suppressed the microaneurysm formation.
View article: <i>doublesex</i>regulates sexually dimorphic beetle horn formation by integrating spatial and temporal developmental contexts in the Japanese rhinoceros beetle<i>Trypoxylus dichotomus</i>
<i>doublesex</i>regulates sexually dimorphic beetle horn formation by integrating spatial and temporal developmental contexts in the Japanese rhinoceros beetle<i>Trypoxylus dichotomus</i> Open
Many scarab beetles have sexually dimorphic exaggerated horns that are an evolutionary novelty. Since the shape, number, size, and location of horns are highly diverged within Scarabaeidae, beetle horns are an attractive model for studying…
View article: Tissue Plasminogen Activator as an Antiangiogenic Agent in Experimental Laser-Induced Choroidal Neovascularization in Mice
Tissue Plasminogen Activator as an Antiangiogenic Agent in Experimental Laser-Induced Choroidal Neovascularization in Mice Open
Intravitreal injection of tPA suppressed fibrin/fibrinogen expression and laser-induced CNV. The current results suggested that tPA may be a potential therapeutic adjuvant for treating CNV.
View article: Persistent choroidal neovascularization in high myopia detected by optical coherence tomography angiography
Persistent choroidal neovascularization in high myopia detected by optical coherence tomography angiography Open
View article: Intravenous immune globulin suppresses angiogenesis in mice and humans
Intravenous immune globulin suppresses angiogenesis in mice and humans Open
View article: Human IgG1 antibodies suppress angiogenesis in a target-independent manner
Human IgG1 antibodies suppress angiogenesis in a target-independent manner Open
View article: Nucleoside Reverse Transcriptase Inhibitors Suppress Laser-Induced Choroidal Neovascularization in Mice
Nucleoside Reverse Transcriptase Inhibitors Suppress Laser-Induced Choroidal Neovascularization in Mice Open
Multiple clinically relevant NRTIs suppressed laser-induced CNV and downregulated VEGF-A, via P2X7.
View article: Environmental chemicals active as human antiandrogens do not activate a stickleback androgen receptor but enhance a feminising effect of oestrogen in roach
Environmental chemicals active as human antiandrogens do not activate a stickleback androgen receptor but enhance a feminising effect of oestrogen in roach Open