Explanipedia

Clinical effects of a selective urate reabsorption inhibitor dotinurad in patients with hyperuricemia and treated hypertension: a multicenter, prospective, exploratory study (DIANA) Open

Atsushi Tanaka, Isao Taguchi, Itaru Hisauchi, Hisako Yoshida, Michio Shimabukuro , et al. · 2023

Efficacy of Subcutaneous Implantable CardioVErter-Defibrillator ≤ 18 Year-Old CHILDREN: SAVE-CHILDREN Registry Open

Hitoshi Mori, Naokata Sumitomo, Kenta Tsutsui, Hideo Fukunaga, Hidemori Hayashi , et al. · 2022

Evaluation of the input site and characteristics of the antegrade fast pathway based on three-dimensional bi-atrial stimulus-ventricle mapping Open

Kazuhisa Matsumoto, Takeshi Tobiume, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose , et al. · 2021

Acute Hospital Mortality of Venous Thromboembolism in Patients With Cancer From Registry Data Open

Yuichiro Okushi, Kenya Kusunose, Yoshihiro Okayama, Robert Zheng, Michikazu Nakai , et al. · 2021

Background The prognosis of patients with cancer‐venous thromboembolism (VTE) is not well known because of a lack of registry data. Moreover, there is also no knowledge on how specific types are related to prognosis. We sought to evaluate …

Infective Endocarditis from Furuncle with Meningitis Complication Caused by Methicillin-resistant <i>Staphylococcus aureus</i> Open

Shusuke Yagi, Tomoko Takahashi, Keiji Murakami, Momoyo Azuma, Mikio Sugano , et al. · 2021

Infective endocarditis (IE) may be acquired in the community as community-acquired (CA) IE or in the healthcare setting. In Japan, cases of CA-methicillin-resistant Staphylococcus aureus (MRSA) infection as skin infection have been increas…

Activated Factor X Signaling Pathway via Protease-Activated Receptor 2 Is a Novel Therapeutic Target for Preventing Atrial Fibrillation Open

Tomomi Matsuura, Takeshi Soeki, Daiju Fukuda, Etsuko Uematsu, Takeshi Tobiume , et al. · 2021

The FXa-PAR2 signaling pathway might contribute to AF arrhythmogenesis associated with atrial inflammation. A direct FXa inhibitor, rivaroxaban, could prevent atrial inflammation and reduce AF inducibility, probably by inhibiting the pro-i…

Cardiac reserve by 6-minute walk stress echocardiography in systemic sclerosis Open

Miharu Arase, Kenya Kusunose, Sae Morita, N Yamaguchi, Yukina Hirata , et al. · 2021

Objectives There is a high prevalence of left ventricular diastolic dysfunction (LVDD) in systemic sclerosis (SSc) which is associated with high mortality. Thus, early detection of LVDD could be important in management of SSc. We hypothesi…

Association between Vitamin D and Heart Failure Mortality in 10,974 Hospitalized Individuals Open

Kenya Kusunose, Yuichiro Okushi, Yoshihiro Okayama, Robert Zheng, Miho Abe , et al. · 2021

A broad range of chronic conditions, including heart failure (HF), have been associated with vitamin D deficiency. Existing clinical trials involving vitamin D supplementation in chronic HF patients have been inconclusive. We sought to eva…

Antegrade slow pathway mapping of typical atrioventricular nodal reentrant tachycardia based on direct slow pathway capture Open

Takeshi Tobiume, Ritsushi Kato, Tomomi Matsuura, Kazuhisa Matsumoto, Motoki Hara , et al. · 2020

Background Radiofrequency (RF) ablation of typical atrioventricular nodal reentrant tachycardia (tAVNRT) is performed without revealing out the location of antegrade slow pathway (ASp). In this study, we studied a new electrophysiological …

Effects of L-/N-Type Calcium Channel Blockers on Angiotensin II–Renin Feedback in Hypertensive Patients Open

Yutaka Kawabata, Takeshi Soeki, Hiroyuki Ito, Tomomi Matsuura, Kenya Kusunose , et al. · 2020

Objectives. Cilnidipine, an L-/N-type calcium channel blocker (CCB), has unique organ-protective properties due to suppression of hyperactivity in the sympathetic nervous system and renin-angiotensin system (RAS). In this study, we hypothe…

Toll-like receptor 9 is a novel therapeutic target to prevent atrial fibrillation Open

Takeshi Soeki, Kozo Matsumoto, Daiju Fukuda, Etsuko Uematsu, Tomomi Matsuura , et al. · 2020

Background Atrial fibrillation (AF) is the most common type of arrhythmia seen in clinical practice. Recent studies suggest that inflammation contributes to the pathogenesis of AF. On the other hand, several evidence suggests that toll-lik…

Association between Sarcopenia/Lower Muscle Mass and Short-Term Regression of Deep Vein Thrombosis Using Direct Oral Anticoagulants Open

Y Torii, Kenya Kusunose, Robert Zheng, Hirotsugu Yamada, Rie Amano , et al. · 2020

Advanced age, obesity, and muscle weakness are independent factors in the onset of deep vein thrombosis (DVT). Recently, an association between sarcopenia and DVT has been reported. We hypothesized that sarcopenia related factors, observed…

Atherosclerotic Coronary Plaque Is Associated With Adventitial Vasa Vasorum and Local Inflammation in Adjacent Epicardial Adipose Tissue in Fresh Cadavers Open

Hiroyuki Ito, Tetsuzo Wakatsuki, Koji Yamaguchi, Daiju Fukuda, Yutaka Kawabata , et al. · 2020

Lipid-rich coronary plaques are associated with adventitial VV and local inflammation in adjacent EAT in fresh cadavers. This study suggests that local inflammation of EAT is associated with coronary plaque progression via the VV.

Lambda-like J wave due to acute myocardial infarction of the diagonal branch Open

Shusuke Yagi, Rie Ueno, Kumiko Sutou, Tetsuzo Wakatsuki, Koji Yamaguchi , et al. · 2019

The culprit lesion of acute myocardial infarction could be predicted by electrocardiogram findings. However, we experienced some cases with coronary angiographic finding in the area of ST-T elevation that was different from that predicted.…

Association of Decreased Docosahexaenoic Acid Level After Statin Therapy and Low Eicosapentaenoic Acid Level with In-Stent Restenosis in Patients with Acute Coronary Syndrome Open

Shusuke Yagi, Daisuke Kondo, Takayuki Ise, Daiju Fukuda, Koji Yamaguchi , et al. · 2018

Statin therapy decreased the serum level of DHA with a parallel reduction in LDL-C level in patients with ACS. Decreased DHA level after statin therapy and low EPA level on admission are risk factors for ISR, indicating that in patients wi…

P2768Growth of vasa vasorum is associated with local inflammation around coronary plaque in fresh cadavers Open

Hiroyuki Ito, Tetsuzo Wakatsuki, Koji Yamaguchi, Daiju Fukuda, Yutaka Kawabata , et al. · 2018

P3732C-type natriuretic peptide improves left ventricular diastolic dysfunction and ischemia/reperfusion injury-associated ventricular arrhythmias Open

Takeshi Soeki, Etsuko Uematsu, Tomomi Matsuura, Takeshi Tobiume, Kenya Kusunose , et al. · 2018

106Gender disparities of distribution of epicardial adipose tissue and its impact on coronary artery disease Open

Gulinu Maimaituxun, M Shimabukuro, Daiju Fukuda, Shusuke Yagi, Yoichiro Hirata , et al. · 2018

Background: Patients with metabolically healthy obesity (MHO) are characterized by cardiovascular risk similar to that of lean individuals, but the underlying mechanisms remain poorly understood.We assumed that MHO has a distinct ectopic a…

Clinical, Electrocardiographic, and Echocardiographic Parameter Combination Predicts the Onset of Atrial Fibrillation Open

Takeshi Soeki, Tomomi Matsuura, Takeshi Tobiume, Sachiko Bando, Kazuhisa Matsumoto , et al. · 2018

A combined score that includes age, PAC count, maximum RR interval, and LAD could help characterize the risk of new-onset AF.

Local Thickness of Epicardial Adipose Tissue Surrounding the Left Anterior Descending Artery Is a Simple Predictor of Coronary Artery Disease　― New Prediction Model in Combination With Framingham Risk Score ― Open

Gulinu Maimaituxun, Michio Shimabukuro, Daiju Fukuda, Shusuke Yagi, Yukina Hirata , et al. · 2018

The local fat thickness surrounding the LAD is a simple and useful surrogate marker for estimating the presence, severity, and extent of CAD, independent of classical cardiovascular risk factors.

Edoxaban improves acute venous thromboembolism while preserving protein C and protein S levels Open

Hiromu Yamazaki, Shusuke Yagi, Y Torii, Rie Amano, Yasuyuki Omichi , et al. · 2017

Canagliflozin reduces epicardial fat in patients with type 2 diabetes mellitus Open

Shusuke Yagi, Yukina Hirata, Takayuki Ise, Kenya Kusunose, Hirotsugu Yamada , et al. · 2017

Plasma brain natriuretic peptide levels are elevated in patients with cancer Open

Sachiko Bando, Takeshi Soeki, Tomomi Matsuura, Takeshi Tobiume, Takayuki Ise , et al. · 2017

In cancer patients, as well as colon cancer model mice, the plasma BNP levels were elevated, possibly due to cancer-related inflammation. The effect of cancer on the BNP levels should be considered when using BNP as an indicator of heart f…

Improved Exercise Capacity After Cardiac Rehabilitation Is Associated with Reduced Visceral Fat in Patients with Chronic Heart Failure Open

Yuriko Takagawa, Shusuke Yagi, Takayuki Ise, Ayumi Ishii, Nishikawa Koji , et al. · 2017

Participation in a comprehensive cardiac rehabilitation (CR) program has been shown to reduce mortality and improve exercise capacity and symptoms in patients with chronic heart failure (CHF). Reduced exercise capacity leads to a concomita…

Low Serum Levels of Eicosapentaenoic Acid and Docosahexaenoic Acid are Risk Factors for Cardiogenic Syncope in Patients with Brugada Syndrome Open

Shusuke Yagi, Takeshi Soeki, Ken‐ichi Aihara, Daiju Fukuda, Takayuki Ise , et al. · 2017

The n-3 polyunsaturated fatty acids (PUFAs), including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), have antiarrhythmic effects, possibly via modulation of the cardiac ion channels. Nevertheless, it is unknown whether low se…

Purulent Pericarditis Accompanying Pericardial Abscess Induced by <i>Nocardia</i> in an Immunocompromised Patient Open

Akira Takashima, Shusuke Yagi, Koji Yamaguchi, Syunsuke Watanabe, Nobuaki Yamamoto , et al. · 2016

Erratum to: ‘Reduced ratio of eicosapentaenoic acid and docosahexaenoic acid to arachidonic acid is associated with early onset of acute coronary syndrome’ Open

Shusuke Yagi, Ken‐ichi Aihara, Daiju Fukuda, Akira Takashima, Mika Bando , et al. · 2015

Corrigendum to “Expression of NLRP3 in subcutaneous adipose tissue is associated with coronary atherosclerosis” [Atherosclerosis 242 (2) (2015) 407–414] Open

Sachiko Bando, Daiju Fukuda, Takeshi Soeki, Sachiko Nishimoto, Etsuko Uematsu , et al. · 2015

Reduced ratio of eicosapentaenoic acid and docosahexaenoic acid to arachidonic acid is associated with early onset of acute coronary syndrome Open

Shusuke Yagi, Ken‐ichi Aihara, Daiju Fukuda, Akira Takashima, Mika Bando , et al. · 2015

Decreased EPA/AA and DHA/AA ratios may be risk factors for early onset of ACS, suggesting that reduced EPA/AA and DHA/AA may represent targets for preventing ACS in Japanese young people.

Characteristics and Catheter Ablation of Focal Atrial Tachycardia Originating From the Interatrial Septum Open

Yoshiaki Kaneko, Ritsushi Kato, Shiro Nakahara, Takeshi Tobiume, Itsuro Morishima , et al. · 2015

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