Explanipedia

Effectiveness of self-assembling peptide in reducing bleeding after colorectal endoscopic submucosal dissection Open

Takeshi Yamamura, Masanao Nakamura, Masayuki Hiramatsu, Genta Uchida, Keisaku Yamada , et al. · 2025

The application of SAP significantly reduced the occurrence of hematochezia and DB after colorectal ESD. Furthermore, SAP was a significant factor associated with the reduction of hematochezia and DB. Therefore, SAP may be appropriate for …

Quantitative evaluation of upper gastrointestinal subepithelial lesions using endoscopic ultrasound-guided shear wave elastography. Open

Takahiro Marukawa, Kazuhiro Furukawa, Ryoji Miyahara, Kohei Funasaka, Takashi Hirose , et al. · 2025

Shear wave elastography provides quantitative data on tissue stiffness, but was not available for endoscopic ultrasound until recently. The present study investigated the utility of a newly developed endoscopic ultrasound-guided shear wave…

Ampullary tumors exhibit increased Fusobacterium in both the tumor surface and surrounding duodenal mucosa during carcinoma progression Open

Yoshihisa Takada, Kenta Yamamoto, Takuya Ishikawa, Kentaro Yamao, Yasuyuki Mizutani , et al. · 2025

A Novel Clip Device for Safer and Faster Suturing in Endoscopic Papillectomy: A Retrospective Study of 241 Procedures Open

Kosuke Takano, Kentaro Yamao, Takuya Ishikawa, Yoshihisa Takada, Yasuyuki Mizutani , et al. · 2025

Background and Aim Endoscopic papillectomy (EP) is a minimally invasive treatment for ampullary neoplasms. However, traditional endoscopic clips used for hemostasis and suturing during EP are often difficult to manipulate because of limita…

Efficacy of Mirikizumab in Patients with Prior Ustekinumab Exposure: A Case Series Open

Tsunaki Sawada, Masanao Nakamura, Takeshi Yamamura, Keiko Maeda, Eri Ishikawa , et al. · 2025

Lay Summary This series evaluates mirikizumab efficacy in 10 ulcerative colitis patients previously treated with ustekinumab. Seven achieved corticosteroid-free remission, highlighting potential benefits despite limited data for such cases…

Clinical and Medical Economic Value of Screening Colonoscopy before Laparoscopic Cholecystectomy Open

Tsuyoshi Igami, Masanao Nakamura, Takuya Ishikawa, Takeshi Yamamura, Kentaro Yamao , et al. · 2025

Objective: Clinical value of screening colonoscopy (SC) has been widely accepted; however, its clinical utility remains controversial in patients who undergo laparoscopic cholecystectomy (LC). The aim of this study was to evaluate the clin…

Usefulness of endoscopic ultrasonography for differentiating between non-functional pancreatic neuroendocrine neoplasm and intrapancreatic accessory spleen Open

Yuichi Kano, Takuya Ishikawa, Kentaro Yamao, Yasuyuki Mizutani, Tadashi Iida , et al. · 2025

In pancreatic hypervascular masses, it is often difficult to differentiate pancreatic neuroendocrine neoplasm (PanNEN) and intrapancreatic accessory spleen (IPAS) before surgery because of their similar features, such as a round shape and …

Diagnostic accuracy and cut-off values of serum leucine-rich alpha-2 glycoprotein for Crohn’s disease activity in the small bowel Open

Muneyori Okita, K Takenaka, Fumihito Hirai, Shinya Ashizuka, Hideki Iijima , et al. · 2025

Background Small bowel (SB) lesions in Crohn’s disease (CD) are often asymptomatic despite being highly active. Fecal calprotectin (FC) is the most widely used biomarker of CD activity, but its drawbacks include a large intra-individual sa…

High-quality welding of copper and aluminum by angled laser irradiation and insert metals Open

Yasuhiro Okamoto, Y. Yamada, Akira OKADA, Masaki Miyake, Takeshi Yamamura , et al. · 2025

Copper is an important material in order to use electricity effectively, and aluminum is also an attractive material to perform lightweight construction. Laser welding of copper and aluminum is required, and there are some reports to weld …

A newly proposed endoscopic score system to evaluate the entire small bowel and predict the prognosis in Crohn's disease. Open

Hitoshi Tanaka, Masanao Nakamura, Takeshi Yamamura, Keiko Maeda, Tsunaki Sawada , et al. · 2024

Small bowel stenosis in patients with Crohn's disease leads to abdominal symptoms and can affect prognosis. The Simple Endoscopic Score for Crohn's Disease for the large bowel has been applied to the small bowel; however, stenosis scoring …

Predictors of the efficacy of vedolizumab in patients with ulcerative colitis. Open

Go Kajikawa, Tsunaki Sawada, Masanao Nakamura, Takeshi Yamamura, Keiko Maeda , et al. · 2024

Vedolizumab is a treatment option for ulcerative colitis but data on predictors of treatment response remain insufficient to establish personalized treatment strategies. We aimed to investigate the real-world effectiveness of vedolizumab i…

New drug-delivery balloon catheter for easy and fast injection of triamcinolone after esophageal endoscopic submucosal dissection Open

Takashi Hirose, Hiroyuki Shibata, Kazuhiro Furukawa, Takeshi Yamamura, Takuya Ishikawa , et al. · 2024

Esophageal endoscopic submucosal dissection (ESD) is a very common and useful endoscopic treatment for superficial esophageal cancer [1]. The most common delayed adverse event of esophageal ESD for extensive lesions is stenosis [2]. Local …

Clinical and medical economic value of screening colonoscopy before laparoscopic cholecystectomy Open

Tsuyoshi Igami, Masanao Nakamura, Takuya Ishikawa, Takeshi Yamamura, Kentaro Yamao , et al. · 2024

Purposes: Clinical value of screening colonoscopy (SC) has been widely accepted; however, its clinical utility remains controversial in patients who undergo laparoscopic cholecystectomy (LC). The aim of this study is to confirm the clinica…

Monoclonal Antibodies Against Mature Interleukin-18 Ameliorate Colitis and Repair Goblet Cell Function Open

Jingxi Mu, Keiko Maeda, Ayako Ohashi, Takeshi Urano, Yuko Nariai , et al. · 2024

Outcomes of surgical treatment for enterovesical fistula in Crohn's disease. Open

Norifumi Hattori, Goro Nakayama, Shinichi Umeda, Masanao Nakamura, Takeshi Yamamura , et al. · 2024

Enterovesical fistula (EVF) in Crohn's disease (CD) often does not improve with medical treatment and requires surgical treatment. The surgical treatment strategy for EVF in CD is definitive resection of the intestinal tract side, and perf…

Contents Open

T Farahvash, Yataro Kimoto, Hiroyasu Inoue, Yuto Shimamura, Daisuke Azuma , et al. · 2024

Efficacy of endoscopic submucosal resection with a ligation device for small rectal neuroendocrine tumor: study protocol of a multicenter open-label randomized control trial (BANDIT trial) Open

Kazunori Takada, Kenichiro Imai, Takanori Yamada, Ken Ohata, Takashi Kanesaka , et al. · 2024

Monoclonal Antibodies Against Mature Interleukin-18 Ameliorate Colitis and Repair Goblet Cell Function Open

Jingxi Mu, Keiko Maeda, Ayako Ohashi, Takeshi Urano, Yuko Nariai , et al. · 2024

Numerous biological interventions and small molecules are used to treat Crohn’s disease; however, the effectiveness of these treatments varies largely. Non-responsiveness to biological therapies is associated with interleukin (IL)-18 gene …

Current status of and future issues related to endoscopic papillectomy. Open

Hiroki Kawashima, Takuya Ishikawa, Kentaro Yamao, Yasuyuki Mizutani, Tadashi Iida , et al. · 2023

Endoscopic papillectomy is widely performed to treat duodenal papillary tumors, particularly at high-volume centers. It is indicated for adenomas without intraductal extension of the bile or pancreatic ducts. However, despite numerous repo…

Efficacy of endoscopic submucosal resection with a ligation device for small rectal neuroendocrine tumor: study protocol of a multicenter open-label randomized control trial (BANDIT trial) Open

Kazunori Takada, Kenichiro Imai, Takanori Yamada, Ken Ohata, Takashi Kanesaka , et al. · 2023

Background: Endoscopic resection is widely accepted as a local treatment for rectal neuroendocrine tumors sized ≤ 10 mm. However, there is no consensus on the best method for the endoscopic resection of rectal neuroendocrine tumors. As a s…

Clinical characteristics of Dieulafoy’s lesion in the small bowel diagnosed and treated by double-balloon endoscopy Open

Masanao Nakamura, Takeshi Yamamura, Keiko Maeda, Tsunaki Sawada, Eri Ishikawa , et al. · 2023

Background Obscure gastrointestinal bleeding refers to bleeding for which the source cannot be ascertained even through balloon-assisted endoscopy. In certain instances, Dieulafoy’s lesion in the small bowel is presumed to be the underlyin…

Real-world effectiveness of ustekinumab for patients with ulcerative colitis: a systematic review and meta-analysis. Open

Genta Uchida, Masanao Nakamura, Takeshi Yamamura, Tomoyuki Tsuzuki, Hiroki Kawashima · 2023

Ustekinumab has recently been approved for the treatment of ulcerative colitis (UC) based on data from clinical trials. However, the effectiveness of ustekinumab in patients with UC in a real-world setting remains unclear. Hence, in this m…

Multicenter prospective registration study of efficacy and safety of capsule endoscopy in Crohn’s disease in Japan (SPREAD-J study) Open

Toshiyuki Sakurai, Teppei Omori, Hiroki Tanaka, Takahiro Ito, Katsuyoshi Ando , et al. · 2023

Background Evidence of small-bowel capsule endoscopy (SBCE) for evaluating lesions in Crohn’s disease (CD) is lacking. We aimed to clarify the effectiveness and safety of SBCE in a large sample of patients with CD. Methods This multicenter…

Usefulness of Endoscopic Ultrasound Elastography and Contrast-Enhanced Endoscopic Ultrasound in the Diagnosis of Pancreatic Cancer of 10 mm or Less Open

Takuya Ishikawa, Eizaburo Ohno, Kentaro Yamao, Yasuyuki Mizutani, Tadashi Iida , et al. · 2023

Background Pancreatic cancers (PCs) are often detected late, limiting patient prognosis. Early detection and accurate diagnosis, especially for small PCs, are thus crucial. This study investigated the use of endoscopic ultrasound elastogra…

Issue Information Open

Rashid N. Lui, S T Wong, Ning Ding, Masao Sekiguchi, J. Yu , et al. · 2023

No abstract is available for this article.

Clinical characteristics of Dieulafoy’s Lesion in the Small Bowel Diagnosed and Treated by Double-Balloon Endoscopy Open

Masanao Nakamura, Takeshi Yamamura, Keiko Maeda, Tsunaki Sawada, Eri Ishikawa , et al. · 2023

BACKGROUNDS Obscure gastrointestinal bleeding indicates bleeding in which the source cannot be determined even by balloon-assisted endoscopy. In some cases, the cause is assumed to be a Dieulafoy’s lesion in the small bowel. AIM This retro…

Real-World Effectiveness and Risk Factors for Discontinuation of Ustekinumab in Ulcerative Colitis Open

Genta Uchida, Masanao Nakamura, Takeshi Yamamura, Keiko Maeda, Tsunaki Sawada , et al. · 2023

Introduction: Ustekinumab (UST) has been approved for the treatment of moderate-to-severe ulcerative colitis (UC). Real-world data showing the effectiveness and safety of UST are necessary to confirm the results of clinical trials for appl…

Supplementary Material for: Diagnostic Performance of Endocytoscopy for Esophageal Eosinophilia Open

Eisuke Hida, Kazuo Muroi, Naomi Kakushima, Satoshi Furune, Eri Ishikawa , et al. · 2023

Introduction: Eosinophils in the esophageal epithelium are unevenly distributed in eosinophilic esophagitis (EoE). Esophageal eosinophilia (EE) may be observable by endocytoscopy (EC). This study aimed to evaluate the diagnos…

Analysis of immunologic comorbidities in ulcerative colitis patients: a tool to prevent exacerbations in ulcerative colitis cases. Open

Miguel Ricardo Rodríguez Meza, Masanao Nakamura, Takeshi Yamamura, Keiko Maeda, Tsunaki Sawada , et al. · 2022

There have been previous studies, especially in Western countries and even in some areas in Asia, about extra-intestinal manifestations (EIMs) and its link with the outcome of inflammatory bowel disease (IBD), which includes Crohn's diseas…

The effects of ustekinumab on small intestinal lesions and stenotic lesions. Open

Hirotaka Wada, Kentaro Murate, Masanao Nakamura, Kazuhiro Furukawa, Naomi Kakushima , et al. · 2022

Crohn's disease patients suffer from symptoms originating from small bowel lesions, including strictures. As many of these patients also have a potential risk of surgery, it is important to consider various therapeutic strategies for small…

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