Takeshi Yoshimoto
YOU?
Author Swipe
View article: CYP2C19 Polymorphism and Clopidogrel Efficacy in Long-Term Outcomes of Large-Artery Atherosclerotic Stroke
CYP2C19 Polymorphism and Clopidogrel Efficacy in Long-Term Outcomes of Large-Artery Atherosclerotic Stroke Open
In patients with LAA stroke, CYP2C19 PM/IMs had a significantly higher long-term recurrence rate of ischemic events than extensive metabolizers.
View article: Association Between Blood Free Fatty Acid Concentrations in Midlife and Cerebral Small Vessel Disease
Association Between Blood Free Fatty Acid Concentrations in Midlife and Cerebral Small Vessel Disease Open
Free fatty acids (FFAs) are a risk factor for recurrent ischemic stroke, primarily via the overproduction of reactive oxygen species. However, the association between FFA concentrations and cerebral small vessel disease (SVD), including la…
View article: Preoperative Neurological Changes on Outcomes in Large-Vessel Occlusion Due to Intracranial Atherosclerotic Disease
Preoperative Neurological Changes on Outcomes in Large-Vessel Occlusion Due to Intracranial Atherosclerotic Disease Open
BACKGROUND AND OBJECTIVES: We aimed to clarify the association between neurological deterioration pre-endovascular therapy (EVT) and outcome in patients with large-vessel occlusion due to intracranial atherosclerotic disease (ICAD-LVO) und…
View article: Once- versus twice-daily direct oral anticoagulants after ischemic stroke in atrial fibrillation – A post-hoc analysis of the ELAN trial
Once- versus twice-daily direct oral anticoagulants after ischemic stroke in atrial fibrillation – A post-hoc analysis of the ELAN trial Open
Introduction: Whether the risk-benefit profile of once-daily versus twice-daily direct oral anticoagulants (DOAC) differs after atrial fibrillation(AF)-associated ischemic stroke is unclear. We explored this in a post-hoc analysis of ELAN …
View article: RNF213-Related Vasculopathy: An Entity with Diverse Phenotypic Expressions
RNF213-Related Vasculopathy: An Entity with Diverse Phenotypic Expressions Open
Moyamoya disease (MMD) is primarily associated with genetic variants in RNF213. RNF213 p.R4810K (c.14429G>A, p.Arg4810Lys) is a founder variant predominantly found in East Asian populations and is strongly associated with MMD, a rare cereb…
View article: Real-Time Monitoring of Cerebrovascular Insufficiency due to Emergent Large Vessel Occlusion Using Near-Infrared Spectroscopy Based on the Modified Beer–Lambert Law: A Retrospective Study
Real-Time Monitoring of Cerebrovascular Insufficiency due to Emergent Large Vessel Occlusion Using Near-Infrared Spectroscopy Based on the Modified Beer–Lambert Law: A Retrospective Study Open
NIRS shows potential utility in detecting LVO in patients with suspected stroke. The results of this study provide a critical foundation for the future application of NIRS in the early identification and prehospital triage of LVO. Further …
View article: Impact of Stroke Severity and Vascular Risk Factors on Early Versus Late Anticoagulation in Patients With Stroke and Atrial Fibrillation
Impact of Stroke Severity and Vascular Risk Factors on Early Versus Late Anticoagulation in Patients With Stroke and Atrial Fibrillation Open
View article: Relationship Between <i>RNF213</i> p.R4810K and Echocardiographic Findings in Patients with Cerebrovascular Diseases: A Multicenter Prospective Cohort Study
Relationship Between <i>RNF213</i> p.R4810K and Echocardiographic Findings in Patients with Cerebrovascular Diseases: A Multicenter Prospective Cohort Study Open
Background RING finger protein 213 ( RNF213 ) p.R4810K is an established risk factor for moyamoya disease and intracranial artery stenosis in East Asian people. Recent evidence suggests its potential association with extracranial cardiovas…
View article: Recent Advances in Stroke Genetics—Unraveling the Complexity of Cerebral Infarction: A Brief Review
Recent Advances in Stroke Genetics—Unraveling the Complexity of Cerebral Infarction: A Brief Review Open
Background/Objectives: Recent advances in stroke genetics have substantially enhanced our understanding of the complex genetic architecture underlying cerebral infarction and other stroke subtypes. As knowledge in this field expands, healt…
View article: Long-Term Outcomes in the Pre-Moyamoya Stage of RNF213-Related Vasculopathy Presenting with Ischaemic Stroke or Transient Ischaemic Attack: Insights from the NCVC Genome Registry
Long-Term Outcomes in the Pre-Moyamoya Stage of RNF213-Related Vasculopathy Presenting with Ischaemic Stroke or Transient Ischaemic Attack: Insights from the NCVC Genome Registry Open
View article: Early-onset cerebral infarction with psoriasis vulgaris and thromboangiitis obliterans as an athterosclerotic risk factor: a case report
Early-onset cerebral infarction with psoriasis vulgaris and thromboangiitis obliterans as an athterosclerotic risk factor: a case report Open
The patient is a 45-year-old male. He has psoriasis vulgaris and thromboangiitis obliterans (TAO) as a comorbidity and was transferred to our hospital with dysarthria and right hemiparesis. On arrival, he presented with right hemispatial n…
View article: Thrombus Age in Ischemic Stroke With Atrial Fibrillation: Impact on Mechanical Thrombectomy
Thrombus Age in Ischemic Stroke With Atrial Fibrillation: Impact on Mechanical Thrombectomy Open
View article: Detrimental Effect of Acute Hyperglycemia on the Outcomes of Large Ischemic Region Stroke
Detrimental Effect of Acute Hyperglycemia on the Outcomes of Large Ischemic Region Stroke Open
Background Although endovascular therapy (EVT) is effective for large ischemic region strokes, the impact of hyperglycemia remains unclear. Methods and Results We analyzed data from the RESCUE‐Japan LIMIT (Recovery by Endovascular Salvage …
View article: Association of perioperative P2Y12 inhibitor administration with outcomes for tandem occlusion: RESCUE AT-LVO sub-study
Association of perioperative P2Y12 inhibitor administration with outcomes for tandem occlusion: RESCUE AT-LVO sub-study Open
Background We aimed to clarify the association between intraoperative P2Y 12 inhibitor administration during EVT and clinical outcomes in patients with anterior circulation TO stroke. Methods Among consecutive patients with acute ischemic …
View article: Efficacy and safety of adrenomedullin for acute ischemic stroke (AMFIS): a phase 2, randomized, double-blinded, placebo-controlled, clinical trial
Efficacy and safety of adrenomedullin for acute ischemic stroke (AMFIS): a phase 2, randomized, double-blinded, placebo-controlled, clinical trial Open
View article: Blended Phenotype of <i>NOTCH3</i> and <i>RNF213</i> Variants With Accelerated Large and Small Artery Crosstalk
Blended Phenotype of <i>NOTCH3</i> and <i>RNF213</i> Variants With Accelerated Large and Small Artery Crosstalk Open
Temporal pole infarcts could represent a blended phenotype of both variants. This case highlights the importance of large and small artery crosstalk and the pivotal role of genetic analysis in determining the pathogenesis of stroke and dem…
View article: Endovascular therapy in patients with a large ischemic volume at presentation: An aggregate patient-level analysis
Endovascular therapy in patients with a large ischemic volume at presentation: An aggregate patient-level analysis Open
In this large, pooled-cohort study of AIS-LVO patients with infarct cores over 50cc at baseline, we demonstrated that successful recanalization was associated with a better functional outcome, lower mortality, and similar rates of symptoma…
View article: Optimizing endovascular therapy for large vessel occlusion using CYP2C19 genotype-guided antiplatelet therapy: a case report
Optimizing endovascular therapy for large vessel occlusion using CYP2C19 genotype-guided antiplatelet therapy: a case report Open
Ryoma Inui, Hiroyuki Ishiyama, Soichiro Abe, Takeshi Yoshimoto, Junji Fukumori, Yuji Kushi, Hirotoshi Imamura, Hiroharu Kataoka, Masafumi Ihara
View article: REsveratrol for VAscular cognitive impairment investigating cerebral Metabolism and Perfusion (REVAMP trial): a study protocol for a randomized, double-blind, placebo-controlled trial
REsveratrol for VAscular cognitive impairment investigating cerebral Metabolism and Perfusion (REVAMP trial): a study protocol for a randomized, double-blind, placebo-controlled trial Open
Background Carotid artery stenosis or occlusion (CASO) is a major cause of vascular cognitive impairment (VCI). There is currently no effective treatment for VCI induced by CASO. Resveratrol, a type of polyphenol, improves cognitive perfor…
View article: Tyrosine Kinase Inhibitor-induced Cerebrovascular Occlusion Presenting with Moyamoya Disease-like Stenosis of the Circle of Willis
Tyrosine Kinase Inhibitor-induced Cerebrovascular Occlusion Presenting with Moyamoya Disease-like Stenosis of the Circle of Willis Open
Vascular occlusive events are notable adverse effects of tyrosine kinase inhibitors (TKIs), which are promising treatments for chronic myeloid leukemia (CML). We herein report the case of a patient with CML who developed cerebrovascular oc…
View article: Long-Term Resveratrol Intake for Cognitive and Cerebral Blood Flow Impairment in Carotid Artery Stenosis/Occlusion
Long-Term Resveratrol Intake for Cognitive and Cerebral Blood Flow Impairment in Carotid Artery Stenosis/Occlusion Open
Background and Purpose Carotid artery stenosis or occlusion (CASO) is a causative disease of vascular cognitive impairment (VCI) attributed to cerebral hypoperfusion, even without the development of symptomatic ischemic stroke. Preclinical…
View article: High pillow and spontaneous vertebral artery dissection: A case-control study implicating “Shogun pillow syndrome”
High pillow and spontaneous vertebral artery dissection: A case-control study implicating “Shogun pillow syndrome” Open
Introduction: The underlying causes of spontaneous vertebral artery dissection (sVAD) remain insufficiently understood. This study aimed to determine whether high-pillow usage is associated with an increased risk of sVAD and evaluate the f…
View article: Stent Retriever Angioplasty for Intracranial Atherosclerotic Disease-Related Medium Vessel Occlusion: A Case Report and Literature Review
Stent Retriever Angioplasty for Intracranial Atherosclerotic Disease-Related Medium Vessel Occlusion: A Case Report and Literature Review Open
SR angioplasty appears to be a safe option for managing MCA M2 segment occlusion.
View article: Detrimental effect of anemia after mechanical thrombectomy on functional outcome in patients with ischemic stroke
Detrimental effect of anemia after mechanical thrombectomy on functional outcome in patients with ischemic stroke Open
Background Anemia can occur due to an aspiration maneuver of blood with thrombi during mechanical thrombectomy (MT) for stroke. However, the association between postoperative anemia and stroke outcomes is unknown. Methods In a registry-bas…
View article: Abstract 205: Efficacy and Safety of Mechanical Thrombectomy for Primary MeVO with Disabling Deficit
Abstract 205: Efficacy and Safety of Mechanical Thrombectomy for Primary MeVO with Disabling Deficit Open
Introduction We aimed to evaluate the efficacy and safety of mechanical thrombectomy (MT) for medium vessel occlusion (MeVO) with the disabling deficit. Methods The study period was from January 2011 to December 2022. Inclusion criteria we…
View article: Mode of Imaging Study and Endovascular Therapy for a Large Ischemic Core: Insights From the RESCUE-Japan LIMIT
Mode of Imaging Study and Endovascular Therapy for a Large Ischemic Core: Insights From the RESCUE-Japan LIMIT Open
Background and Purpose Differences in measurement of the extent of acute ischemic stroke using the Alberta Stroke Program Early Computed Tomographic Score (ASPECTS) by non-contrast computed tomography (CT-ASPECTS stratum) and diffusion-wei…
View article: Association of thyroid peroxidase antibody with the RNF213 p.R4810K variant in ischemic stroke/transient ischemic attack
Association of thyroid peroxidase antibody with the RNF213 p.R4810K variant in ischemic stroke/transient ischemic attack Open
RNF213 is a susceptibility gene for moyamoya disease and vasospastic angina, with a second hit considered necessary for their development. Elevated thyroid peroxidase antibody (TPO-Ab) levels have been observed in both diseases, suggesting…
View article: Cardioembolism after thoracoscopic left atrial appendage clipping in a patient on oral anticoagulation therapy
Cardioembolism after thoracoscopic left atrial appendage clipping in a patient on oral anticoagulation therapy Open
View article: Tmax Mismatch Ratio to Identify Intracranial Atherosclerotic Stenosis‐Related Large‐Vessel Occlusion Before Endovascular Therapy
Tmax Mismatch Ratio to Identify Intracranial Atherosclerotic Stenosis‐Related Large‐Vessel Occlusion Before Endovascular Therapy Open
Background We aimed to clarify which time‐to‐maximum of the tissue residue function (Tmax) mismatch ratio is useful in predicting anterior intracranial atherosclerotic stenosis (ICAS)–related large‐vessel occlusion (LVO) before endovascula…
View article: RNF213 p.R4810K Variant Increases the Risk of Vasospastic Angina
RNF213 p.R4810K Variant Increases the Risk of Vasospastic Angina Open