Takeshi Yoshitomi
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View article: Effects of Trapezius Muscle Self-Stretching on Muscle Stiffness and Choroidal Circulatory Dynamics: An Evaluation Using Ultrasound Strain Elastography and Laser Speckle Flowgraphy
Effects of Trapezius Muscle Self-Stretching on Muscle Stiffness and Choroidal Circulatory Dynamics: An Evaluation Using Ultrasound Strain Elastography and Laser Speckle Flowgraphy Open
Background/Objectives: The relationship between upper trapezius muscle stiffness and choroidal circulatory dynamics remains unclear. This study aimed to examine changes in upper trapezius muscle stiffness and choroidal circulatory dynamics…
View article: Influence of artificial intelligence on ophthalmologists’ judgments in glaucoma
Influence of artificial intelligence on ophthalmologists’ judgments in glaucoma Open
Purpose To examine the influence of artificial intelligence (AI) on physicians’ judgments regarding the presence and severity of glaucoma on fundus photographs in an online simulation system. Methods Forty-five trainee and expert ophthalmo…
View article: Investigation of Choroidal Circulation Hemodynamics Using Laser Speckle Flowgraphy After Periocular Skin Warming
Investigation of Choroidal Circulation Hemodynamics Using Laser Speckle Flowgraphy After Periocular Skin Warming Open
View article: Findings of optical coherence tomography angiography of nasal optic disc hypoplasia
Findings of optical coherence tomography angiography of nasal optic disc hypoplasia Open
View article: Changes in Retinal Hemodynamics in the Optic Nerve Head of Healthy Participants Measured Using Laser Speckle Flowgraphy after a Cold Pressor Test
Changes in Retinal Hemodynamics in the Optic Nerve Head of Healthy Participants Measured Using Laser Speckle Flowgraphy after a Cold Pressor Test Open
Purpose: Autoregulation of retinal vessels is stronger than that of choroidal vessels. This study aimed to use laser speckle flowgraphy to determine the time course of changes in retinal hemodynamics of healthy eyes after a cold pressor te…
View article: Choroidal Thickness Increases During Parasympathetic Dominance After Immersion of the Foot in Warm Water
Choroidal Thickness Increases During Parasympathetic Dominance After Immersion of the Foot in Warm Water Open
View article: Choroidal Morphology and Systemic Circulation Changes During the Menstrual Cycle in Healthy Japanese Women
Choroidal Morphology and Systemic Circulation Changes During the Menstrual Cycle in Healthy Japanese Women Open
These findings indicate that choroidal thickness decreases during the mid-luteal phase in healthy Japanese women with normal menstrual cycles depending on systemic circulatory dynamics. However, since the difference in the SCT values betwe…
View article: Parasympathetic Dominance Decreases the Choroidal Blood Flow Velocity Measured Using Laser Speckle Flowgraphy
Parasympathetic Dominance Decreases the Choroidal Blood Flow Velocity Measured Using Laser Speckle Flowgraphy Open
These findings suggest that the dominant parasympathetic activity induced by warm water immersion at 40°C may lead to a reduction in the systemic circulation rate and choroidal blood flow rate in the macula. These findings may help prevent…
View article: Factors associated with visual field or structure progression occurring first in a prospective study on patients with untreated open-angle glaucoma with normal intraocular pressure
Factors associated with visual field or structure progression occurring first in a prospective study on patients with untreated open-angle glaucoma with normal intraocular pressure Open
View article: Differences in Factors Associated With Glaucoma Progression With Lower Normal Intraocular Pressure in Superior and Inferior Halves of the Optic Nerve Head
Differences in Factors Associated With Glaucoma Progression With Lower Normal Intraocular Pressure in Superior and Inferior Halves of the Optic Nerve Head Open
Different risk factors were identified in superior and inferior hemifields in NTG eyes.
View article: Changes in Choroidal Circulation Hemodynamics Measured Using Laser Speckle Flowgraphy after a Cold Pressor Test in Young Healthy Participants
Changes in Choroidal Circulation Hemodynamics Measured Using Laser Speckle Flowgraphy after a Cold Pressor Test in Young Healthy Participants Open
Using laser speckle flowgraphy (LSFG), we investigated the time course of changes in choroidal circulation hemodynamics after a cold pressor test in healthy eyes. This prospective study included the right eye of 19 young healthy participan…
View article: Changes in Choroidal Blood Flow by Diurnal Variation in Healthy Young Adults
Changes in Choroidal Blood Flow by Diurnal Variation in Healthy Young Adults Open
Background: Little is known about the diurnal variation in choroidal circulatory dynamics in healthy eyes. Objective: This study aimed to clarify the diurnal variation in choroidal circulatory hemodynamic changes in healthy participants us…
View article: Prevalence of Glaucoma and Its Systemic Risk Factors in a General Japanese Population: The Hisayama Study
Prevalence of Glaucoma and Its Systemic Risk Factors in a General Japanese Population: The Hisayama Study Open
Systemic factors such as eGFR and diabetes must also be considered when implementing preventive measures against glaucoma.
View article: Changes in choroidal circulation hemodynamics during the menstrual cycle in young, healthy women
Changes in choroidal circulation hemodynamics during the menstrual cycle in young, healthy women Open
Purpose The current study aimed to investigate the time course of changes in choroidal circulation hemodynamics and their relationship to systemic circulation dynamics during the normal menstrual cycle in young, healthy women using laser s…
View article: The Enantiomer of Allopregnanolone Prevents Pressure-Mediated Retinal Degeneration Via Autophagy
The Enantiomer of Allopregnanolone Prevents Pressure-Mediated Retinal Degeneration Via Autophagy Open
In an ex vivo rat ocular hypertension (OHT) model, the neurosteroid allopregnanolone (AlloP) exerts neuroprotective effects via enhancement of both GABA A receptors and autophagy. We now examine whether its enantiomer ( ent- AlloP), which …
View article: Intraocular pressure-lowering effects of ripasudil in uveitic glaucoma, exfoliation glaucoma, and steroid-induced glaucoma patients: ROCK-S, a multicentre historical cohort study
Intraocular pressure-lowering effects of ripasudil in uveitic glaucoma, exfoliation glaucoma, and steroid-induced glaucoma patients: ROCK-S, a multicentre historical cohort study Open
View article: The occurrence of optic disc haemorrhage in primary open‐angle glaucoma eyes with lower normal pressure and its relating factors
The occurrence of optic disc haemorrhage in primary open‐angle glaucoma eyes with lower normal pressure and its relating factors Open
Purpose To report the occurrence probability of disc haemorrhage (DH) and risk factors for it in otherwise healthy Japanese normal‐tension glaucoma (NTG) patients who had lower normal intraocular pressure (IOP) and were followed without tr…
View article: The neurosteroid allopregnanolone protects retinal neurons by effects on autophagy and GABRs/GABA<sub>A</sub> receptors in rat glaucoma models
The neurosteroid allopregnanolone protects retinal neurons by effects on autophagy and GABRs/GABA<sub>A</sub> receptors in rat glaucoma models Open
In an ex vivo rat glaucoma model using dissected retinas, the neurosteroid allopregnanolone (AlloP) protects retinal ganglion cells (RGCs) via GABR/GABAA receptors. To determine the involvement of macroautophagy/autophagy…
View article: The neurosteroid allopregnanolone protects retinal neurons by effects on autophagy and GABRs/GABA<sub>A</sub> receptors in rat glaucoma models
The neurosteroid allopregnanolone protects retinal neurons by effects on autophagy and GABRs/GABA<sub>A</sub> receptors in rat glaucoma models Open
In an ex vivo rat glaucoma model using dissected retinas, the neurosteroid allopregnanolone (AlloP) protects retinal ganglion cells (RGCs) via GABR/GABAA receptors. To determine the involvement of macroautophagy/autophagy…
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View article: Epidemiologic and Clinical Characteristics of Optic Neuritis in Japan
Epidemiologic and Clinical Characteristics of Optic Neuritis in Japan Open
The present large-scale cohort study revealed the clinicoepidemiologic features of noninfectious optic neuritis in Japan. Anti-aquaporin-4 antibody-positive optic neuritis has poor visual outcome. In contrast, MOG-Ab positive cases manifes…
View article: Data for: Difference of the Retinal Nerve Fiber Layer Thickness Assessed on the Disc Center and Bruch’s Membrane Opening Center in Myopic Eyes
Data for: Difference of the Retinal Nerve Fiber Layer Thickness Assessed on the Disc Center and Bruch’s Membrane Opening Center in Myopic Eyes Open
This data contains retinal nerve fiber layer thickness measured on the disc center and Bruch's membrane opening center in myopic eyes.
View article: Remodeled structure and reduced contractile responsiveness of ocular ciliary artery in spontaneously hypertensive rats
Remodeled structure and reduced contractile responsiveness of ocular ciliary artery in spontaneously hypertensive rats Open
Our results demonstrate that the structure and function of OCAs are altered in hypertension. OCAs from SHR are remodeled with decreased lumen diameter and increased media-to-lumen ratio. Moreover, the contractile responsiveness of OCAs fro…
View article: Differences in Retinal Nerve Fiber Layer Thickness as Assessed on the Disc Center and Bruch’s Membrane Opening Center in Myopic Eyes
Differences in Retinal Nerve Fiber Layer Thickness as Assessed on the Disc Center and Bruch’s Membrane Opening Center in Myopic Eyes Open
There was a significant amount of difference in the sectorial cpRNFLT acquired on the disc center and that acquired on the BMO center in the myopic eyes, which was considered to be derived from unique optic disc margin anatomy in these eye…
View article: Data for: Optic disc margin anatomy in myopic eyes with glaucoma with spectral domain optical coherence tomography
Data for: Optic disc margin anatomy in myopic eyes with glaucoma with spectral domain optical coherence tomography Open
These are all the data used in the analysis in the present study. It has the separate column for myopic eyes without glaucom (labled as "Myopic") and myopic eyes with open-angle glaucoma (labled as "OAG") that was used in the comparison be…
View article: Optic Disc Margin Anatomic Features in Myopic Eyes with Glaucoma with Spectral-Domain OCT
Optic Disc Margin Anatomic Features in Myopic Eyes with Glaucoma with Spectral-Domain OCT Open
View article: Additive neuroprotective effects of 24(S)-hydroxycholesterol and allopregnanolone in an ex vivo rat glaucoma model
Additive neuroprotective effects of 24(S)-hydroxycholesterol and allopregnanolone in an ex vivo rat glaucoma model Open
In a rat ex vivo acute glaucoma model, high pressure (75 mmHg) causes swelling of ganglion cell axons and elevates levels of the endogenous steroids 24(S)-hydroxycholesterol (24SH) and allopregnanolone (AlloP). Furthermore, 24SH (0.1 µM) a…
View article: Assessment of Central Visual Function in Patients with Retinitis Pigmentosa
Assessment of Central Visual Function in Patients with Retinitis Pigmentosa Open
In order to clarify the disease progression in retinitis pigmentosa (RP) and its related factors, reliable data on the changes in central visual function in RP are needed. In this longitudinal study, we examined 118 patients who were diagn…
View article: Assessment of Central Visual Function in Patients with Retinitis Pigmentosa
Assessment of Central Visual Function in Patients with Retinitis Pigmentosa Open
View article: Effects of brinzolamide on rabbit ocular blood flow in vivo and ex vivo
Effects of brinzolamide on rabbit ocular blood flow in vivo and ex vivo Open
Brinzolamide decreases IOP and increases ocular blood flow. The direct vasodilatory effect of brizolamide is mediated by suppression of Ca2+ release from intracellular calcium stores.