Tak‐Ho Chu
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View article: Limited Myelination Capacity in Human Schwann Cells in Experimental Models in Comparison to Rodent and Porcine Schwann Cells
Limited Myelination Capacity in Human Schwann Cells in Experimental Models in Comparison to Rodent and Porcine Schwann Cells Open
Schwann cells (SCs) play a crucial role in peripheral nerve repair by supporting axonal regeneration and remyelination. While extensive research has been conducted using rodent SCs, increasing attention is being directed toward human SCs d…
View article: Inferior Reinnervation of Reverse End-to-Side Nerve Transfer in a Delayed Nerve Repair Rat Model
Inferior Reinnervation of Reverse End-to-Side Nerve Transfer in a Delayed Nerve Repair Rat Model Open
Objective Reverse end-to-side (RETS) nerve transfer is a recent surgical technique to augment injured nerve function by supplying a dispensable donor motor nerve to the side of the distal injured nerve. Although clinical studies have sugge…
View article: <i>Etv5</i> Is Required for Peripheral Nerve Function and the Injury Response
<i>Etv5</i> Is Required for Peripheral Nerve Function and the Injury Response Open
The development of Schwann cells, which myelinate axons in the peripheral nervous system, is critically dependent on MEK/ERK signaling. While Ets-domain transcription factors ( Etv1 , Etv4 , Etv5 ) are downstream effectors of this pathway,…
View article: Predegenerating donor nerve for grafting using focused ultrasound neurotomy
Predegenerating donor nerve for grafting using focused ultrasound neurotomy Open
Early experimental evidence suggests that predegenerated nerve graft enhance axonal growth compared to freshly harvested nerve graft in nerve gap repair. However, the practicality of surgically pre-conditioning nerves for grafting remains …
View article: Knockout of the ING5 epigenetic regulator confirms roles in stem cell maintenance and tumor suppression in vivo
Knockout of the ING5 epigenetic regulator confirms roles in stem cell maintenance and tumor suppression in vivo Open
INhibitor of Growth (ING1-5) proteins are epigenetic readers that target histone acetyltransferase (HAT) or histone deacetylase (HDAC) complexes to the H3K4Me3 mark of active transcription. ING5 targets Moz/Morf and HBO1 HAT complexes that…
View article: Novel AAV variants with improved tropism for human Schwann cells
Novel AAV variants with improved tropism for human Schwann cells Open
View article: A Multi-Stage Bioprocess for the Expansion of Rodent Skin-Derived Schwann Cells in Computer-Controlled Bioreactors
A Multi-Stage Bioprocess for the Expansion of Rodent Skin-Derived Schwann Cells in Computer-Controlled Bioreactors Open
Regenerative therapies for the treatment of peripheral nerve and spinal cord injuries can require hundreds of millions of autologous cells. Current treatments involve the harvest of Schwann cells (SCs) from nerves; however, this is an inva…
View article: Erratum to “Comparison of human skin‐ and nerve‐derived Schwann cells reveals many similarities and subtle genomic and functional differences”
Erratum to “Comparison of human skin‐ and nerve‐derived Schwann cells reveals many similarities and subtle genomic and functional differences” Open
View article: Functional Gait Assessment Using Manual, Semi-Automated and Deep Learning Approaches Following Standardized Models of Peripheral Nerve Injury in Mice
Functional Gait Assessment Using Manual, Semi-Automated and Deep Learning Approaches Following Standardized Models of Peripheral Nerve Injury in Mice Open
Objective: To develop a standardized model of stretch–crush sciatic nerve injury in mice, and to compare outcomes of crush and novel stretch–crush injuries using standard manual gait and sensory assays, and compare them to both semi-automa…
View article: Utilization of focused ultrasound for opening of the blood-nerve barrier
Utilization of focused ultrasound for opening of the blood-nerve barrier Open
Objective . Focused ultrasound (FUS) use with and without microbubbles (MB) for investigation of the blood-nerve barrier (BNB) within the peripheral nervous system (PNS) has been performed in this study. We evaluate the feasibility of BNB …
View article: Insights Into the Role and Potential of Schwann Cells for Peripheral Nerve Repair From Studies of Development and Injury
Insights Into the Role and Potential of Schwann Cells for Peripheral Nerve Repair From Studies of Development and Injury Open
Peripheral nerve injuries arising from trauma or disease can lead to sensory and motor deficits and neuropathic pain. Despite the purported ability of the peripheral nerve to self-repair, lifelong disability is common. New molecular and ce…
View article: Comparative Behavioral Assessment of Lewis and Nude Rats after Peripheral Nerve Injury
Comparative Behavioral Assessment of Lewis and Nude Rats after Peripheral Nerve Injury Open
Cell therapy has shown potential in the field of peripheral nerve repair, and research using rodents is a critical and essential step toward clinical development of this approach. Traditionally, most experimental peripheral nerve injuries …
View article: Droplet Barcoding-Based Single Cell Transcriptomics of Adult Mammalian Tissues
Droplet Barcoding-Based Single Cell Transcriptomics of Adult Mammalian Tissues Open
The analysis of single cell gene expression across thousands of individual cells within a tissue or microenvironment is a valuable tool for identifying cell composition, discrimination of functional states, and molecular pathways underlyin…
View article: Axonal and myelinic pathology in 5xFAD Alzheimer’s mouse spinal cord
Axonal and myelinic pathology in 5xFAD Alzheimer’s mouse spinal cord Open
As an extension of the brain, the spinal cord has unique properties which could allow us to gain a better understanding of CNS pathology. The brain and cord share the same cellular components, yet the latter is simpler in cytoarchitecture …
View article: Unique spectral signatures of the nucleic acid dye acridine orange can distinguish cell death by apoptosis and necroptosis
Unique spectral signatures of the nucleic acid dye acridine orange can distinguish cell death by apoptosis and necroptosis Open
Cellular injury and death are ubiquitous features of disease, yet tools to detect them are limited and insensitive to subtle pathological changes. Acridine orange (AO), a nucleic acid dye with unique spectral properties, enables real-time …
View article: Reactivated astrocytes as a possible source of oligodendrocyte precursors for remyelination in remitting phase of experimental autoimmune encephalomyelitis rats.
Reactivated astrocytes as a possible source of oligodendrocyte precursors for remyelination in remitting phase of experimental autoimmune encephalomyelitis rats. Open
Multiple sclerosis (MS) is ademyelinating disease in the central nervous system (CNS). Majority of the MS patients show relapsing-remitting disease course. Evidences show that oligodendrocyte precursor cells (OPCs), which remain relatively…
View article: Catalpol induces oligodendrocyte precursor cell-mediated remyelination in vitro.
Catalpol induces oligodendrocyte precursor cell-mediated remyelination in vitro. Open
In demyelinating diseases such as multiple sclerosis, one of the treatment strategies includes remyelination using oligodendrocyte precursor cells (OPC). Catalpol, the extract of radix rehmanniae, is neuroprotective. Using an OPC culture m…