Explanipedia

Extending the duration of endocrine treatment for early breast cancer: patient-level meta-analysis of 12 randomised trials of aromatase inhibitors in 22 031 postmenopausal women already treated with at least 5 years of endocrine therapy Open

Jeremy Braybrooke, Rosie Bradley, Robert K. Hills, R Peto, Amanda Kerr , et al. · 2025

Different patterns of breast cancer-related lymphedema according to body mass index Open

Akiko Ogiya, Kiyomi Kimura, Takayuki Ueno, Takuji Iwase, Shinji Ohno · 2022

Purpose This study aimed to clarify how body mass index (BMI) affects the development of breast cancer-related lymphedema (BCRL) and to improve the postoperative follow-up for BCRL. Methods In this prospective study, patients with operable…

Postoperative Adjuvant Anastrozole for 10 Rather than 5 Years in Patients with Oestrogen Receptor-Positive Breast Cancer: AERAS, a Randomised Multicentre Open-Label Phase III Trial Open

Takuji Iwase, Shigehira Saji, Kotaro Iijima, Kenji Higaki, Shoichiro Ohtani , et al. · 2021

Clinicopathological features of breast cancer patients with internal mammary and/or supraclavicular lymph node recurrence without distant metastasis Open

Hitoshi Inari, Natsuki Teruya, Miki Kishi, Rie Horii, Futoshi Akiyama , et al. · 2020

Background Internal mammary and/or supraclavicular (IM–SC) lymph node (LN) recurrence without distant metastasis (DM) in patients with breast cancer is rare, and there have been few reports on its clinical outcomes. Methods We enrolled 423…

Survival in Cytologically Proven Node-Positive Breast Cancer Patients with Nodal Pathological Complete Response after Neoadjuvant Chemotherapy Open

Hitoshi Inari, Natsuki Teruya, Miki Kishi, Rie Horii, Futoshi Akiyama , et al. · 2020

Background: It is unknown whether patients with cytologically proven axillary node-positive breast cancer who achieve axillary pathological complete response (pCR) after neoadjuvant chemotherapy (NAC) have comparable prognosis to patients …

Prevalence of disease-causing genes in Japanese patients with BRCA1/2-wildtype hereditary breast and ovarian cancer syndrome Open

Tomoko Kaneyasu, Seiichi Mori, Hideko Yamauchi, Shozo Ohsumi, Shinji Ohno , et al. · 2020

Datasets and metadata supporting the published article: Prevalence of Disease-Causing Genes in Japanese Patients with BRCA1/2-Wildtype Hereditary Breast and Ovarian Cancer Syndrome Open

Tomoko Kaneyasu, Seiichi Mori, Hideko Yamauchi, Shozo Ohsumi, Shinji Ohno , et al. · 2020

Panel sequencing of susceptibility genes for hereditary breast and ovarian cancer (HBOC) syndrome has uncovered numerous germline variants; however, their pathogenic relevance and ethnic diversity remain unclear.In this study, the authors …

Additional file 2 of Clinicopathological features of breast cancer patients with internal mammary and/or supraclavicular lymph node recurrence without distant metastasis Open

Hitoshi Inari, Natsuki Teruya, Miki Kishi, Rie Horii, Futoshi Akiyama , et al. · 2020

Additional file 2.

Altered lymphatic drainage patterns in re-operative sentinel lymph node biopsy for ipsilateral breast tumor recurrence Open

Ayaka Sato, Takehiko Sakai, Takuji Iwase, Fumiko Kano, Kiyomi Kimura , et al. · 2019

Lymphatic drainage patterns altered in re-SLNB in patients with IBTR and previous ALND and RT were associated with alterations in lymphatic drainage patterns.

Usefulness of second-look ultrasonography using anatomical breast structures as indicators for magnetic resonance imaging-detected breast abnormalities Open

Ayumi Izumori, Yumi Kokubu, Kazuko Sato, Naoya Gomi, Hidetomo Morizono , et al. · 2019

Second-look US using anatomical breast structures as indicators and US-guided FNAC are useful for refining the diagnosis of suspicious breast lesions detected using MRI.

Utility of Repeat Sentinel Lymph Node Biopsy for cN0 Ipsilateral Breast Tumor Recurrence in Patients Initially Treated with Breast-Conserving Surgery and Sentinel Lymph Node Biopsy Open

Akiko Ogiya, Ayaka Sato, Takehiko Sakai, Mitsuru Koizumi, Tomo Osako , et al. · 2019

Clinical outcomes and prognostic factors in patients with stage II-III breast cancer treated with neoadjuvant chemotherapy followed by surgery and postmastectomy radiation therapy in the modern treatment era Open

Naomi Nakajima, Masahiko Oguchi, Yasuko Kumai, Masahiro Yoshida, Hirotaka Inoda , et al. · 2018

A new molecular-based lymph node staging classification determines the prognosis of breast cancer patients Open

Tomo Osako, Takuji Iwase, Masaru Ushijima, Rika Yonekura, Shinji Ohno , et al. · 2017

The molecular-based pN classification determines the prognosis of breast cancer patients and could guide therapeutic decision making.

The early onset of peripheral neuropathy might be a robust predictor for time to treatment failure in patients with metastatic breast cancer receiving chemotherapy containing paclitaxel Open

Ippei Fukada, Yoshinori Ito, Kokoro Kobayashi, Tomoko Shibayama, Shunji Takahashi , et al. · 2017

The early onset of peripheral neuropathy might be a robust predictor for TTF in patients with metastatic breast cancer treated with paclitaxel.

Mutation status of RAD51C,PALB2 and BRIP1 in 100 Japanese familial breast cancer cases without BRCA1 and BRCA2 mutations Open

Katsutoshi Sato, Mio Koyasu, Sachio Nomura, Yuri Sato, Mizuho Kita , et al. · 2017

In addition to BRCA 1 and BRCA 2, RAD 51C , PALB 2 and BRIP 1 are known as breast cancer susceptibility genes. However, the mutation status of these genes in Japanese familial breast cancer cases has not yet been evaluated. To this end, we…

Cystoid Macular Edema during Treatment with Paclitaxel and Bevacizumab in a Patient with Metastatic Breast Cancer: A Case Report and Literature Review Open

Takamichi Yokoe, Ippei Fukada, Kokoro Kobayashi, Tomoko Shibayama, Yumi Miyagi , et al. · 2017

We present a case of a metastatic breast cancer patient with cystoid macular edema (CME) occurring during treatment with paclitaxel and bevacizumab. She had a history of neoadjuvant chemotherapy and partial mastectomy plus axillary lymph n…

Rainbow of KIBOU (ROK) study: a Breast Cancer Survivor Cohort in Japan Open

Yuri Mizota, Yasuo Ohashi, Takuji Iwase, Hiroji Iwata, Masataka Sawaki , et al. · 2017

The ROK study will provide much important evidence for breast cancer survivorship.

The prediction models for postoperative overall survival and disease‐free survival in patients with breast cancer Open

Daichi Shigemizu, Takuji Iwase, Masataka Yoshimoto, Y. Suzuki, Fuyuki Miya , et al. · 2017

The goal of this study is to establish a method for predicting overall survival ( OS ) and disease‐free survival ( DFS ) in breast cancer patients after surgical operation. The gene expression profiles of cancer tissues from the patients, …

Peking University - Juntendo University Joint Symposium on Cancer Research and Treatment Open

Masami Arai, Reiko Yoshida, Hidetaka Nomura, Dai Kitagawa, Eri Nakashima , et al. · 2017

Hereditary breast and ovarian cancer (HBOC) patients with BRCA1/2 mutation are estimated to be approximately 1,560,000 in Japan. But general doctors and medical staff do not fully recognize the significance of medical intervention for HBOC…

Ductal Carcinoma in situ Detected during Prospective MR Imaging Screening of a Woman with a BRCA2 Mutation: The First Case Report in Japan Open

Mitsuhiro Tozaki, Seigo Nakamura, Dai Kitagawa, Takuji Iwase, Rie Horii , et al. · 2017

The present case is the first report in Japan in which a breast cancer was discovered as a result of prospective magnetic resonance imaging (MRI) screening study for BRCA1/2 mutation carriers who were free of breast or ovarian cancer. This…

Actual circumstances of management of mammographic categories in breast cancer screening in Japan Open

Takayoshi Uematsu, Takuji Iwase, Koji Ohnuki, Yoshio Kasahara, Yukio Koibuchi , et al. · 2017

２０１５年に，日本乳癌学会検診関連委員会は日本の乳がん検診マンモグラフィカテゴリーに対するマネジメントの実情を把握する目的にてアンケート調査を行った。調査対象は日本乳癌学会評議員４０２人で回答率は７２％と良好であった。回答者の９１％が日本乳癌学会専門医を取得していた。アンケート結果からマンモグラフィカテゴリー判定とそのマネジメントに不一致が認められた。例えば，カテゴリー２の石灰化所見に要精査を施行した割合は６割あり，カテゴリー３症例に対する侵襲的検査の施行率（石灰化症例：７…

The management of contralateral axillary sentinel lymph nodes detected by lymphoscintigraphy in a patient of breast cancer that had never undergone breast related medical treatment Open

Hisako Ono, Masahiko Tanabe, Kiyomi Kimura, Yumi Miyagi, Rie Horii , et al. · 2017

In breast cancer, lymphoscintigraphy-based sentinel lymph node biopsy examinations usually show lymphatic drainage to the ipsilateral axilla, and sometimes to the extra-axillary regions. Drainage to the contralateral axilla is rarely obser…

Evaluation of ALDH1 expression in ipsilateral breast cancer recurrence Open

Tadahiko Shien, Takehiro Tanaka, Masahiko Tanabe, Yasuhiro Okumura, Norikazu Masuda , et al. · 2016

Aldehyde dehydrogenase 1 (ALDH1) is a cancer stem cell (CSC) marker that is easily evaluable. The expression and clinical significance of ALDH1 in ipsilateral breast tumor recurrence (IBTR) has yet to be investigated. In the present study,…

65PD Significance of preoperative fine-needle aspiration biopsy for suspected cases of lymph node metastasis in primary breast cancer Open

Akiko Ogiya, Takuji Iwase, Natsuki Teruya, Hiroaki Sakamoto, Eri Nakashima , et al. · 2016

Eribulin mesylate may improve the sensitivity of endocrine therapy in metastatic breast cancer Open

Kokoro Kobayashi, Yukako Ιtο, Tomoko Shibayama, Ippei Fukada, Naoki Ishizuka , et al. · 2016

Relapse patterns of Treatment for Primary Breast Lymphomas Open

Masahiko Oguchi, Ayaka Harada, Y. Terui, Kiyohiko Hatake, Kengo Takeuchi , et al. · 2016

Predictive Factors and Value of ypN+ after Neoadjuvant Chemotherapy in Clinically Lymph Node-Negative Breast Cancer Open

Ippei Fukada, Kazuhiro Araki, Kokoro Kobayashi, Tomoko Shibayama, Shunji Takahashi , et al. · 2016

The prognosis of clinically lymph node negative breast cancer depended on ypN+, which was associated with ypTinv and luminal subtype.

Imatinib could be a new strategy for pulmonary hypertension caused by pulmonary tumor thrombotic microangiopathy in metastatic breast cancer Open

Ippei Fukada, Kazuhiro Araki, Kokoro Kobayashi, Tomoko Shibayama, Masaru Hatano , et al. · 2016

Imatinib, which alleviated pulmonary hypertension, could be a new strategy for pulmonary tumor thrombotic microangiopathy in patient with metastatic breast cancer.

Eribulin-induced liver dysfunction as a prognostic indicator of survival of metastatic breast cancer patients: a retrospective study Open

Takayuki Kobayashi, Jyunichi Tomomatsu, Ippei Fukada, Tomoko Shibayama, Natsuki Teruya , et al. · 2016

Although EILD and fatty liver occurred at a relatively high frequency in our study, most of the patients did not experience severe adverse effects. Surprisingly, the development of EILD was positively associated with patient survival, espe…

Therapeutic effect of taxanes on metastatic breast cancer of various immunohistochemical subtypes Open

Ippei Fukada, Kazuhiro Araki, Kokoro Kobayashi, Takayuki Kobayashi, Rie Horii , et al. · 2016

Taxane drugs play a central role in chemotherapy for breast cancer. However, previous studies have reported that taxanes are relatively ineffective in patients with operable luminal breast cancer compared with other subtypes. Between Janua…

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