Takumi Hirabayashi
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View article: Myostatin antisense administration prevents sepsis‐induced muscle atrophy and weakness in male mice
Myostatin antisense administration prevents sepsis‐induced muscle atrophy and weakness in male mice Open
Muscle atrophy and weakness are serious problems associated with sepsis. However, only a few pharmacological interventions are available to date. In this study, myostatin antisense was used to prevent sepsis‐induced muscle atrophy and weak…
View article: Impact of preoperative beta-hydroxy-beta-methylbutyrate, arginine, and glutamine supplementation on inflammation in patients with cardiac surgery: A secondary analysis of a randomized controlled trial
Impact of preoperative beta-hydroxy-beta-methylbutyrate, arginine, and glutamine supplementation on inflammation in patients with cardiac surgery: A secondary analysis of a randomized controlled trial Open
Preoperative supplementation with a combination of HMB, glutamine, and arginine was effective in reducing preoperative TNF-α levels in older patients undergoing cardiac surgery, suggesting a potential anti-inflammatory effect. This anti-in…
View article: Effects of preoperative beta-hydroxy-beta-methylbutyrate, arginine, and glutamine supplementation on cardiac surgery: A randomized controlled trial
Effects of preoperative beta-hydroxy-beta-methylbutyrate, arginine, and glutamine supplementation on cardiac surgery: A randomized controlled trial Open
UMIN000030490 (UMINhttps://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000034773).
View article: Niacin supplementation attenuates the regression of three‐dimensional capillary architecture in unloaded female rat skeletal muscle
Niacin supplementation attenuates the regression of three‐dimensional capillary architecture in unloaded female rat skeletal muscle Open
Inactivity can lead to muscle atrophy and capillary regression in skeletal muscle. Niacin (NA), known for inducing hypermetabolism, may help prevent this capillary regression. In this study involving adult female Sprague–Dawley rats, the a…
View article: High Concentrations of Nucleotides Prevent Capillary Regression during Hindlimb Unloading by Inhibiting Oxidative Stress and Enhancing Mitochondrial Metabolism of Soleus Muscles in Rats
High Concentrations of Nucleotides Prevent Capillary Regression during Hindlimb Unloading by Inhibiting Oxidative Stress and Enhancing Mitochondrial Metabolism of Soleus Muscles in Rats Open
Prolonged inactivity in skeletal muscles decreases muscle capillary development because of an imbalance between pro- and antiangiogenic signals, mitochondrial metabolism disorders, and increased oxidative stress. Nucleotides have been show…
View article: Alternating current electromagnetic field exposure lessens intramyocellular lipid accumulation due to high-fat feeding via enhanced lipid metabolism in mice
Alternating current electromagnetic field exposure lessens intramyocellular lipid accumulation due to high-fat feeding via enhanced lipid metabolism in mice Open
Long-term high-fat feeding results in intramyocellular lipid accumulation, leading to insulin resistance. Intramyocellular lipid accumulation is related to an energy imbalance between excess fat intake and fatty acid consumption. Alternati…
View article: Mild Hyperbaric Oxygen Exposure Enhances Peripheral Circulatory Natural Killer Cells in Healthy Young Women
Mild Hyperbaric Oxygen Exposure Enhances Peripheral Circulatory Natural Killer Cells in Healthy Young Women Open
Mild hyperbaric oxygen (HBO) enhances oxygen absorption in blood, relieving fatigue without causing oxidative stress. The benefits of mild HBO have been recognized in the treatment of lifestyle-related diseases and hypertension, but no res…
View article: Exercise training
Exercise training Open
Background] Recently, the effectiveness of hyperbaric oxygen exposure has been reported in various studies, there are also possible disadvantages associated with higher oxygen concentrations.One such disadvantage is the possibility of an i…
View article: Protective effects of chlorogenic acid on capillary regression caused by disuse muscle atrophy
Protective effects of chlorogenic acid on capillary regression caused by disuse muscle atrophy Open
Inactivity causes muscle atrophy and capillary regression in skeletal muscle. Chlorogenic acid has an antioxidant capacity and may prevent capillary regression. Therefore, the protective effects of chlorogenic acid on inactivity-induced ca…
View article: Protective effects of <i>Enterococcus faecium</i> strain R30 supplementation on decreased muscle endurance under disuse in rats
Protective effects of <i>Enterococcus faecium</i> strain R30 supplementation on decreased muscle endurance under disuse in rats Open
New Findings What is the central question of this study? Does Enterococcus faecium strain R30 (R30), a new lactic acid bacterial strain for supplementation, attenuate shifts in the typology of whole muscle fibres from slow‐ to fast‐twitch …
View article: Reduced metabolic capacity in fast and slow skeletal muscle via oxidative stress and the energy‐sensing of AMPK/SIRT1 in malnutrition
Reduced metabolic capacity in fast and slow skeletal muscle via oxidative stress and the energy‐sensing of AMPK/SIRT1 in malnutrition Open
The effects of malnutrition on skeletal muscle result in not only the loss of muscle mass but also fatigue intolerance. It remains unknown whether the metabolic capacity is related to the fiber type composition of skeletal muscle under mal…
View article: Preventive effects of low‐intensity endurance exercise for severe hyperglycemia‐induced capillary regression in non‐obese type 2 diabetes rat skeletal muscle
Preventive effects of low‐intensity endurance exercise for severe hyperglycemia‐induced capillary regression in non‐obese type 2 diabetes rat skeletal muscle Open
Although endurance exercise is effective for reducing diabetes‐related capillary regression, it is difficult to prescribe high‐intensity endurance exercise due to the potential worsening of complications in patients with severe hyperglycem…
View article: Metabolism
Metabolism Open
Aims] Therapeutic effect of exosomes from skeletal muscles are getting to be focused for the inflammation regulation.The action of acoustic cavitation is reported to facilitate the exosome release from cells.The aim of this study was to in…
View article: Exercise training
Exercise training Open
Aims: Hyperbaric Oxygen has the effects of increasing oxygenation in the blood by dissolving oxygen into the blood plasma.This research investigated the effects of mild hyperbaric oxygen (mHBO) exposure on microcirculation in nailfold and …
View article: Preventive effects of medium-chain triglycerides supplementation on the oxidative capacity in skeletal muscle under cachectic condition
Preventive effects of medium-chain triglycerides supplementation on the oxidative capacity in skeletal muscle under cachectic condition Open
Cachexia is a multifactorial condition characterized by muscle mass loss and induces metabolic dysfunction of the skeletal muscles. The preventive effects of medium-chain triglycerides (MCT) supplementation on the oxidative capacity in ske…
View article: Protective Effects of Astaxanthin Supplementation against Ultraviolet-Induced Photoaging in Hairless Mice
Protective Effects of Astaxanthin Supplementation against Ultraviolet-Induced Photoaging in Hairless Mice Open
Ultraviolet (UV) induces skin photoaging, which is characterized by thickening, wrinkling, pigmentation, and dryness. Astaxanthin, a ketocarotenoid from Haematococcus pluvialis, has been extensively studied with respect to its possible eff…
View article: Protective Effects of Astaxanthin Supplementation against Ultraviolet-Induced Photoaging in Hairless Mice
Protective Effects of Astaxanthin Supplementation against Ultraviolet-Induced Photoaging in Hairless Mice Open
Ultraviolet (UV) induces skin photoaging, which is characterized by thickening, wrinkling, pigmentation, and dryness. Astaxanthin, a ketocarotenoid from Haematococcus pluvialis, has been extensively studied with respect to its possible eff…
View article: Nutrition and digestion
Nutrition and digestion Open
Aim] Paprika Xanthophyll (PX) has been reported to contain anti oxidants which maintains the deformability of red blood cells and improves oxygen transport efficiency.To examine the effects of PX intake on aerobic capacity.[Method] In a do…
View article: Transcutaneous carbon dioxide attenuates impaired oxidative capacity in skeletal muscle in hyperglycemia model
Transcutaneous carbon dioxide attenuates impaired oxidative capacity in skeletal muscle in hyperglycemia model Open
Hyperglycemia impairs oxidative capacity in skeletal muscle. Muscle oxidative capacity is regulated by peroxisome proliferator-activated receptor-γ co-activator-1α (PGC-1α). Transcutaneous carbon dioxide (CO2) enhances PGC-1α expression in…
View article: Nivolumab-induced chronic inflammatory demyelinating polyradiculoneuropathy mimicking rapid-onset Guillain–Barré syndrome: a case report
Nivolumab-induced chronic inflammatory demyelinating polyradiculoneuropathy mimicking rapid-onset Guillain–Barré syndrome: a case report Open
Nivolumab, an anti-programmed death-1-specific monoclonal antibody, has demonstrated a durable response and effect on overall survival and has become one of the standard treatments for patients with advanced melanoma. Reported herein is a …