Explanipedia

Resistivity measurement for non-magnetic materials using high-order resonance mode of MFM-cantilever oscillation Open

Kazuma Okamoto, T. Imura, Satoshi Abo, Fujio Wakaya, K. Murakami , et al. · 2025

A method to measure the electrical resistivity of materials using magnetic-force microscopy (MFM) is discussed, where MFM detects the magnetic field caused by the tip-oscillation-induced eddy current. A high cantilever oscillation frequenc…

Toward nanoscale structural and chemical analysis of microbial surfaces Open

Ryo Kato, Keisuke Miyazawa, T. Imura, Takeo Minamikawa · 2024

Microbial surfaces play a critical role in various biological processes, including cell adhesion and biofilm formation. Understanding these surfaces at the nanoscale is essential for both fundamental and applied microbiology. This review e…

A Gelatin Hydrogel Nonwoven Fabric Enhances Subcutaneous Islet Engraftment in Rats Open

Ryusuke Saito, Akiko Inagaki, Yasuhiro Nakamura, T. Imura, Norifumi Kanai , et al. · 2023

Although subcutaneous islet transplantation has many advantages, the subcutaneous space is poor in vessels and transplant efficiency is still low in animal models, except in mice. Subcutaneous islet transplantation using a two-step approac…

A Gelatin Hydrogel Nonwoven Fabric Enhances Subcutaneous Islet Engraftment in Rats Open

Ryusuke Saito, Akiko Inagaki, Yasuhiro Nakamura, T. Imura, Norifumi Kanai , et al. · 2023

Although subcutaneous islet transplantation has many advantages, transplant efficiency is still low in animal models, except in mice. We previously reported the efficacy of pretreatment using gelatin hydrogel nonwoven fabric (GHNF) in a mo…

A Gelatin Hydrogel Nonwoven Fabric Improves Outcomes of Subcutaneous Islet Transplantation Open

Norifumi Kanai, Akiko Inagaki, Yasuhiro Nakamura, T. Imura, Hiroaki Mitsugashira , et al. · 2022

Subcutaneous islet transplantation is a promising treatment for severe diabetes; however, poor engraftment hinders its prevalence. We previously reported that a recombinant peptide (RCP) enhances subcutaneous islet engraftment. However, it…

Development of a novel method for measuring tissue oxygen pressure to improve the hypoxic condition in subcutaneous islet transplantation Open

Hiroaki Mitsugashira, T. Imura, Akiko Inagaki, Yukiko Endo, Takumi Katano , et al. · 2022

Use of Perfluorohexyloctane for Preservation of Rat Liver After Circulatory Death and a Prolonged Cold Preservation Model for Hepatocyte Transplantation Open

Muneyuki Matsumura, T. Imura, Akiko Inagaki, Hiroyuki Ogasawara, Shigehito Miyagi , et al. · 2022

LETTER TO THE EDITOR Transpl Int, 05 July 2022 https://doi.org/10.3389/ti.2022.10659

Short-term inhalation of isoflurane improves the outcomes of intraportal hepatocyte transplantation Open

Hiroyasu Nishimaki, Y Saitoh, Akiko Inagaki, Yasuhiro Nakamura, T. Imura , et al. · 2022

Optimization of dye solutions for detecting damaged pancreatic tissues during islet isolation procedures Open

T. Imura, Akiko Inagaki, Yasuhiro Igarashi, Masafumi Goto · 2021

We previously reported that dye was effective to prevent the leakage of enzyme solutions from pancreatic glands during an islet isolation procedure. However, the dye used for islet isolation has not yet been optimized. In this study, we fo…

KRP-203 Is a Desirable Immunomodulator for Islet Allotransplantation Open

Ibrahim Fathi, Ryuichi Nishimura, T. Imura, Akiko Inagaki, Norifumi Kanai , et al. · 2021

Background. The current standard immunosuppressive regimens, calcineurin inhibitors, have diabetogenic and anti-vascularization effects on islet grafts. KRP-203, a sphingosine-1-phosphate functional antagonist, exerts its immunomodulatory …

Improvement of hepatocyte engraftment by co‐transplantation with pancreatic islets in hepatocyte transplantation Open

Y Saitoh, Akiko Inagaki, Ibrahim Fathi, T. Imura, Hiroyasu Nishimaki , et al. · 2021

Because of the fragility of isolated hepatocytes, extremely poor engraftment of transplanted hepatocytes remains a severe issue in hepatocyte transplantation. Therefore, improving hepatocyte engraftment is necessary to establish hepatocyte…

A Simple and Effective Non-Human Primate Diabetic Model Combining Sub-Total Pancreatectomy and Low-Dose Streptozotocin Injection Open

Ibrahim Fathi, T. Imura, Kozue Imura, Megumi Goto, Yasuhiro Igarashi , et al. · 2019

Background: The existing non-human primate diabetic models, particularly those induced by total pancreatectomy or streptozotocin (STZ) injection, have several disadvantages, including a lengthy surgical procedure, the need for continual su…

A Simple and Useful Predictive Assay for Evaluating the Quality of Isolated Hepatocytes for Hepatocyte Transplantation Open

Muneyuki Matsumura, T. Imura, Akiko Inagaki, Hiroyuki Ogasawara, Kengo Fukuoka , et al. · 2019

The Optimization of the Prevascularization Procedures for Improving Subcutaneous Islet Engraftment Open

Satomi Uematsu, Akiko Inagaki, Yasuhiro Nakamura, T. Imura, Yasuhiro Igarashi , et al. · 2017

These results suggest that optimizing biomaterials to induce efficient prevascularization could be a novel strategy for improving subcutaneous islet transplantation.

The Optimization of Short-Term Hepatocyte Preservation Before Transplantation Open

Kengo Fukuoka, Akiko Inagaki, Yasuhiro Nakamura, Muneyuki Matsumura, Satoru Yoshida , et al. · 2017

Background No optimal methods for short-term hepatocyte preservation have been established. We have recently developed a prominent oxygen-permeable bag (Tohoku Device [TD]) for pancreatic islet culture and transplantation. In this study, w…

Collagen V Is a Potential Substrate for Clostridial Collagenase G in Pancreatic Islet Isolation Open

Hiroki Shima, Akiko Inagaki, T. Imura, Youhei Yamagata, Kimiko Watanabe , et al. · 2016

The clostridial collagenases, H and G, play key roles in pancreatic islet isolation. Collagenases digest the peptide bond between Yaa and the subsequent Gly in Gly-Xaa-Yaa repeats. To fully understand the pancreatic islet isolation process…

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