Takumi Sato
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View article: Limitations of antimicrobial agent choice based on MIC value against Pseudomonas aeruginosa
Limitations of antimicrobial agent choice based on MIC value against Pseudomonas aeruginosa Open
Introduction. In antibiotic chemotherapy, an antimicrobial agent is selected based on MIC, which is determined by a test method using the principle of the broth microdilution. However, it does not provide a viable count in the mutant selec…
View article: Ceftazidime-Induced Overexpression of MexJK-OprM Confers Resistance to Ceftolozane/Tazobactam in an Isolate of Pseudomonas aeruginosa
Ceftazidime-Induced Overexpression of MexJK-OprM Confers Resistance to Ceftolozane/Tazobactam in an Isolate of Pseudomonas aeruginosa Open
This study demonstrated that overexpression of the MexJK-OprM efflux pump is a key mechanism underlying TAZ/CTLZ resistance. In addition, prior administration of CAZ contributed to the acquisition of resistance, highlighting the need to co…
View article: I-SVVS: integrative stochastic variational variable selection to explore joint patterns of multi-omics microbiome data
I-SVVS: integrative stochastic variational variable selection to explore joint patterns of multi-omics microbiome data Open
High-dimensional multi-omics microbiome data play an important role in elucidating microbial community interactions with their hosts and environment in critical diseases and ecological changes. Although Bayesian clustering methods have rec…
View article: Potential of histamine release factor for the utilization as a universal vaccine antigen against poultry red mites, tropical fowl mites, and northern fowl mites
Potential of histamine release factor for the utilization as a universal vaccine antigen against poultry red mites, tropical fowl mites, and northern fowl mites Open
Poultry red mites (PRMs, Dermanyssus gallinae), tropical fowl mites (TFMs, Ornithonyssus bursa), and northern fowl mites (NFMs, Ornithonyssus sylviarum) are hematophagous mites that are distributed worldwide which pose a serious challenge …
View article: Impact of high-speed nanodroplets on various pathogenic bacterial cell walls
Impact of high-speed nanodroplets on various pathogenic bacterial cell walls Open
Although the development of disinfection technologies with novel mechanisms has stagnated, we demonstrate the bactericidal effects and mechanisms of high-speed nanodroplet generation technology. The first development of this technology in …
View article: Cardiac Device-related Infective Endocarditis and Retrosternal Abscess Treated with Percutaneous Lead Extraction and Antimicrobials
Cardiac Device-related Infective Endocarditis and Retrosternal Abscess Treated with Percutaneous Lead Extraction and Antimicrobials Open
An 85-year-old man with a history of 2 open-heart surgeries [for aortic regurgitation and infective endocarditis (IE)] and pacemaker implantation for bradycardic atrial fibrillation presented with a fever. Transesophageal echocardiography …
View article: CTG repeat length underlying cardiac events and sudden death in myotonic dystrophy type 1
CTG repeat length underlying cardiac events and sudden death in myotonic dystrophy type 1 Open
Aims Myotonic dystrophy Type 1 (DM1) is caused by the expansion of CTG repeats (CTGn) in the DM1 protein kinase (DMPK) gene, while it remains unclear whether CTGn may be associated with the incidence of cardiac events or sudden death in Ja…
View article: A Case of an Ossifying Fibroma of the Mandible Suspected as a Static Bone Cavity
A Case of an Ossifying Fibroma of the Mandible Suspected as a Static Bone Cavity Open
Ossifying fibroma (OF) is a benign fibro-osseous lesion characterized by the proliferation of fibrous connective tissue containing immature bone and/or cementum-like hard tissue. Although the pathogenesis of OF remains unclear, trauma, pre…
View article: Alternating Bundle Branch Block in a Case of Kearns-Sayer Syndrome : Clinical Electrocardiographic Interpretation Assuming the Triple Pathway Longitudinal Dissociation in the His Bundle
Alternating Bundle Branch Block in a Case of Kearns-Sayer Syndrome : Clinical Electrocardiographic Interpretation Assuming the Triple Pathway Longitudinal Dissociation in the His Bundle Open
Kearns-Sayre症候群(以下,KSS)は進行性外眼筋麻痺,網膜色素変性,心伝導ブロックを3主徴とする予後不良の疾患である.症例は現在27歳,KSSの男性である.19歳時にとられた心電図において,初めに洞調律,左軸偏位−70°,PR間隔0.16秒,QRS幅0.16秒で,完全右脚ブロック型【A】を示し,その数十秒後に左軸偏位−60°,PR時間0.15秒,QRS幅0.15秒の完全左脚ブロック型【B】を示す狭義の交代性脚ブロックを認めた.さらには,26歳時の心電図で,QRS…
View article: The Drug-Specific Propensity Regarding the Acquisition of Fluoroquinolone Resistance in Escherichia coli: An in vitro Challenge and DNA Mutation Analysis
The Drug-Specific Propensity Regarding the Acquisition of Fluoroquinolone Resistance in Escherichia coli: An in vitro Challenge and DNA Mutation Analysis Open
In our findings, fluoroquinolone resistance was not observed in the E. coli strain after 5- to 10-days of exposure. However, resistance acquisition was detected frequently after 15- to 25-days of exposure. Among fluoroquinolones, la…
View article: Suppressive modulation of host immune responses by Dermanyssus gallinae infestation
Suppressive modulation of host immune responses by Dermanyssus gallinae infestation Open
View article: Additional file 3 of Stochastic variational variable selection for high-dimensional microbiome data
Additional file 3 of Stochastic variational variable selection for high-dimensional microbiome data Open
Additional file 3: Table S1. The probability of microbiome species that are selected by SVVS in dataset A. The values are ordered in descending order (from largest to smallest). Table S2. The probability of microbiome species that are sele…
View article: High throughput method of 16S rRNA gene sequencing library preparation for plant root microbial community profiling
High throughput method of 16S rRNA gene sequencing library preparation for plant root microbial community profiling Open
Microbiota are a major component of agroecosystems. Root microbiota, which inhabit the inside and surface of plant roots, play a significant role in plant growth and health. As next-generation sequencing technology allows the capture of mi…
View article: Cefmetazole Resistance Mechanism for Escherichia Coli Including ESBL-Producing Strains
Cefmetazole Resistance Mechanism for Escherichia Coli Including ESBL-Producing Strains Open
Our results showed that the mRNA expression levels of genes encoding porin were decreased in the strains that acquired resistance due to CMZ exposure, and that ompF and ompC in particular were thought to be involved in the ac…
View article: The Risk of Emerging Resistance to Trimethoprim/Sulfamethoxazole in Staphylococcus aureus
The Risk of Emerging Resistance to Trimethoprim/Sulfamethoxazole in Staphylococcus aureus Open
The emergent risk was SXT exposure of 14 days or more.
View article: Temperature-Responsive Polysaccharide Microparticles Containing Nanoparticles: Release of Multiple Cationic/Anionic Compounds
Temperature-Responsive Polysaccharide Microparticles Containing Nanoparticles: Release of Multiple Cationic/Anionic Compounds Open
Most drug carriers used in pulmonary administration are microparticles with diameters over 1 µm. Only a few examples involving nanoparticles have been reported because such small particles are readily exhaled. Consequently, the development…
View article: Referral to Pain Specialists for Treatment of Intractable Mandibular Pain Caused by Osteonecrosis of the Jaw: A Case Series Report
Referral to Pain Specialists for Treatment of Intractable Mandibular Pain Caused by Osteonecrosis of the Jaw: A Case Series Report Open
Pain is a problematic symptom in patients with osteonecrosis of the jaws (ONJ). Effective pain management in patients with advanced ONJ still remains an unresolved issue. This case series report presents three patients who were referred to…
View article: Overproduction of Chromosomal <i>ampC</i> β-Lactamase Gene Maintains Resistance to Cefazolin in Escherichia coli Isolates
Overproduction of Chromosomal <i>ampC</i> β-Lactamase Gene Maintains Resistance to Cefazolin in Escherichia coli Isolates Open
This study is the first to demonstrate that mutations in the chromosomal- amp C attenuator region are responsible for the emergence of cefazolin resistance in Escherichia coli strains. The resistance was maintained even after culturing E. …
View article: Characterization of a Novel Cysteine Protease Inhibitor from Poultry Red Mites: Potential Vaccine for Chickens
Characterization of a Novel Cysteine Protease Inhibitor from Poultry Red Mites: Potential Vaccine for Chickens Open
Poultry red mite (PRM; Dermanyssus gallinae) is a hazardous, blood-sucking ectoparasite of birds that constitutes a threat to poultry farming worldwide. Acaricides, commonly used in poultry farms to prevent PRMs, are not effective because …
View article: In vitro evaluation of a cysteine protease from poultry red mites, Demanyssus gallinae, as a vaccine antigen for chickens
In vitro evaluation of a cysteine protease from poultry red mites, Demanyssus gallinae, as a vaccine antigen for chickens Open
Poultry red mites (PRMs, Dermanyssus gallinae) are hematophagous ectoparasites that negatively affect egg production, which causes serious economic losses to the poultry industry worldwide. Currently, the emergence of acaricide-resistant P…
View article: In vitro characterization of adipocyte plasma membrane-associated protein from poultry red mites, Dermanyssus gallinae, as a vaccine antigen for chickens
In vitro characterization of adipocyte plasma membrane-associated protein from poultry red mites, Dermanyssus gallinae, as a vaccine antigen for chickens Open
View article: Phosphorus is a critical factor of the <i>in vitro</i> monoxenic culture method for a wide range of arbuscular mycorrhizal fungi culture collections
Phosphorus is a critical factor of the <i>in vitro</i> monoxenic culture method for a wide range of arbuscular mycorrhizal fungi culture collections Open
Establishing an effective way to propagate a wide range of arbuscular mycorrhizal (AM) fungi species is desirable for mycorrhizal research and agricultural applications. Although the success of mycorrhizal formation is required for spore p…
View article: Simple amplicon sequencing library preparation for plant root microbial community profiling
Simple amplicon sequencing library preparation for plant root microbial community profiling Open
Microbiota are a major component of agroecosystems. Root microbiota, which inhabit the inside and surface of plant roots, play a significant role in plant growth and health. As next-generation sequencing technology allows the capture of mi…
View article: First record of swimming speed of the Pacific sleeper shark <i>Somniosus pacificus</i> using a baited camera array
First record of swimming speed of the Pacific sleeper shark <i>Somniosus pacificus</i> using a baited camera array Open
The Pacific sleeper shark Somniosus pacificus is one of the largest predators in deep Suruga Bay, Japan. A single individual of the sleeper shark (female, ~300 cm in total length) was observed with two baited camera systems deployed simult…
View article: Correction to: Radiofrequency identification tag system improves the efficiency of closed vitrification for cryopreservation and thawing of bovine ovarian tissues
Correction to: Radiofrequency identification tag system improves the efficiency of closed vitrification for cryopreservation and thawing of bovine ovarian tissues Open
View article: Citrus sudachi Peel Extract Suppresses Cell Proliferation and Promotes the Differentiation of Keratinocytes through Inhibition of the EGFR–ERK Signaling Pathway
Citrus sudachi Peel Extract Suppresses Cell Proliferation and Promotes the Differentiation of Keratinocytes through Inhibition of the EGFR–ERK Signaling Pathway Open
Citrus sudachi is a well-known fruit in Tokushima Prefecture, Japan, and its peels are rich in phytochemicals, including phenolic compounds. Although it is expected that the extract of the C. sudachi peel elicits various beneficial physiol…
View article: Which symptoms negatively affect the oral health–related quality of life in patients with osteonecrosis of the jaw?
Which symptoms negatively affect the oral health–related quality of life in patients with osteonecrosis of the jaw? Open
View article: In vitro exposure of chlorhexidine induce quinolone resistance in Pseudomonas aeruginosa
In vitro exposure of chlorhexidine induce quinolone resistance in Pseudomonas aeruginosa Open
View article: Analysis of the mechanisms of trimethoprim/sulfamethoxazole resistance in Staphylococcus aureus
Analysis of the mechanisms of trimethoprim/sulfamethoxazole resistance in Staphylococcus aureus Open
View article: The sterilization effect against Staphylococcus aureus and Pseudomonas aeruginosa on the contact lens using the Ultraviolet C irradiation
The sterilization effect against Staphylococcus aureus and Pseudomonas aeruginosa on the contact lens using the Ultraviolet C irradiation Open