Takuro Kubozono
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View article: Associations Between the Diverse Aspects of Psychological Frailty and Health‐Related Outcomes in Community‐Dwelling Older Adults: A Cross‐Sectional Study
Associations Between the Diverse Aspects of Psychological Frailty and Health‐Related Outcomes in Community‐Dwelling Older Adults: A Cross‐Sectional Study Open
Background Psychological frailty (PsF), encompassing cognitive and emotional vulnerabilities, remains understudied despite its potential impact on health outcomes in older adults. This cross‐sectional study aimed to explore the characteris…
View article: Current updates on latest basic research of scientific relevance in hypertensive dementia
Current updates on latest basic research of scientific relevance in hypertensive dementia Open
View article: QT prolongation and excessive variability predicts new-onset atrial fibrillation in the health screening data of Japanese adults
QT prolongation and excessive variability predicts new-onset atrial fibrillation in the health screening data of Japanese adults Open
Background A prolonged QT interval (QTc) is associated with the development of atrial fibrillation. However, reports linking QTc variability and atrial fibrillation are limited. Purpose To investigate the relationship linking prolongation …
View article: Association between toothbrushing habits and hypertension in the general population
Association between toothbrushing habits and hypertension in the general population Open
Periodontitis has been linked to cardiovascular disease (CVD), suggesting that oral care may play a role in CVD prevention. In contrast, hypertension has been linked to oral health; however, its association with toothbrushing habits is unc…
View article: Characteristics of Myocardial Work Indices in Patients with Aortic Valve Stenosis
Characteristics of Myocardial Work Indices in Patients with Aortic Valve Stenosis Open
No reports compared four indices of myocardial work based on aortic valve stenosis (AS) severity. This study aimed to characterize the four myocardial work indices and global longitudinal strain (GLS) in AS with left ventricular ejection f…
View article: Combinations of intrinsic capacity and frailty and their associations with self-rated health in community-dwelling older adults
Combinations of intrinsic capacity and frailty and their associations with self-rated health in community-dwelling older adults Open
View article: Targeting a systolic blood pressure of <130 mmHg is beneficial in adults with hypertension aged ≥75 years: a systematic review and meta-analysis
Targeting a systolic blood pressure of <130 mmHg is beneficial in adults with hypertension aged ≥75 years: a systematic review and meta-analysis Open
View article: Association between Cardio-Ankle Vascular Index and Heart Failure Outcomes: Insights from a Prospective Multicenter Cohort
Association between Cardio-Ankle Vascular Index and Heart Failure Outcomes: Insights from a Prospective Multicenter Cohort Open
Elevated CAVI independently associated with HF-related hospitalizations and cardiovascular death and modestly improved risk prediction beyond conventional risk factors. However, the discriminative ability remained limited, and further stud…
View article: Association between malnutrition and low tongue pressure in community-dwelling older people: a population-based cohort study
Association between malnutrition and low tongue pressure in community-dwelling older people: a population-based cohort study Open
View article: Deep Learning for Cardiac Overload Estimation ― Predicting B-Type Natriuretic Peptide (BNP) Levels From Heart Sounds and Electrocardiogram ―
Deep Learning for Cardiac Overload Estimation ― Predicting B-Type Natriuretic Peptide (BNP) Levels From Heart Sounds and Electrocardiogram ― Open
The eBNP model demonstrated strong potential for non-invasive and rapid HF screening. Its simplicity and objectivity make it ideally suited for point-of-care testing, offering a promising approach for early HF diagnosis and detection monit…
View article: Impact of Angiotensin‐Converting Enzyme Inhibitor on Coronary Artery Calcification Evaluated by Intravascular Ultrasound: A Retrospective Cohort Study
Impact of Angiotensin‐Converting Enzyme Inhibitor on Coronary Artery Calcification Evaluated by Intravascular Ultrasound: A Retrospective Cohort Study Open
Background and Aims Coronary artery calcification (CAC) is a predictor of poor prognosis after percutaneous coronary intervention (PCI), and its treatment depends on calcification severity assessed by intravascular imaging such as intravas…
View article: Development of risk prediction equations for 5-year diabetes incidence using Japanese health check-up data: a retrospective cohort study
Development of risk prediction equations for 5-year diabetes incidence using Japanese health check-up data: a retrospective cohort study Open
Objectives This study aimed to develop risk prediction equations for the 5-year incidence of diabetes among the Japanese population using health check-up data. We hypothesised that demographic and laboratory data from health check-ups coul…
View article: Association between defecation status and the habit of eating vinegar-based dishes in community-dwelling Japanese individuals: a cross-sectional study
Association between defecation status and the habit of eating vinegar-based dishes in community-dwelling Japanese individuals: a cross-sectional study Open
View article: Association Between Cognitive Impairment and Poor Oral Function in Community-Dwelling Older People: A Cross-Sectional Study
Association Between Cognitive Impairment and Poor Oral Function in Community-Dwelling Older People: A Cross-Sectional Study Open
Background/Objectives: The population of Japan has a high life expectancy, but there is room for improvement in terms of the country’s healthy life expectancy. The long period of care dependency among Japan’s elderly is also a major econom…
View article: Risk prediction score and equation for progression of arterial stiffness using Japanese longitudinal health examination data
Risk prediction score and equation for progression of arterial stiffness using Japanese longitudinal health examination data Open
The brachial-ankle pulse wave velocity (baPWV) is useful for evaluating arterial stiffness. No longitudinal studies have examined the association between multiple arterial stiffness risk factors and increased baPWV. We sought to identify f…
View article: Blood pressure elevations post-lenvatinib treatment in hepatocellular carcinoma: a potential marker for better prognosis
Blood pressure elevations post-lenvatinib treatment in hepatocellular carcinoma: a potential marker for better prognosis Open
Lenvatinib is a tyrosine kinase inhibitor that effectively inhibits vascular endothelial growth factor signaling and is used for treating hepatocellular carcinoma. However, angiogenesis inhibitors often cause hypertension. Although lenvati…
View article: Association between serum uric acid levels and left ventricular hypertrophy based on electrocardiographic findings: a sex-specific analysis across cardiometabolic diseases
Association between serum uric acid levels and left ventricular hypertrophy based on electrocardiographic findings: a sex-specific analysis across cardiometabolic diseases Open
View article: Subjective Memory Complaints Related to Satisfaction With Meaningful Activities Among Community-Dwelling Older Adults
Subjective Memory Complaints Related to Satisfaction With Meaningful Activities Among Community-Dwelling Older Adults Open
View article: Ambulatory blood pressure monitoring and left ventricular morphology
Ambulatory blood pressure monitoring and left ventricular morphology Open
View article: Impact of serum cholinesterase on calcified nodules in patients with stable coronary artery disease
Impact of serum cholinesterase on calcified nodules in patients with stable coronary artery disease Open
Background Calcified nodules (CNs) are an advanced stage of coronary calcification that can have significant clinical implications. We investigated factors associated with CNs, the etiology of which is not fully understood. Methods We retr…
View article: A Three-Year Longitudinal Follow-Up Study: Does Mild Cognitive Impairment Accelerate Age-Related Changes in Physical Function and Body Composition?
A Three-Year Longitudinal Follow-Up Study: Does Mild Cognitive Impairment Accelerate Age-Related Changes in Physical Function and Body Composition? Open
View article: Association of Combined Low Physical Activity and Low Dietary Diversity with Mild Cognitive Impairment among Community-Dwelling Japanese Older Adults
Association of Combined Low Physical Activity and Low Dietary Diversity with Mild Cognitive Impairment among Community-Dwelling Japanese Older Adults Open
Background: This study aimed to investigate the potential association between the combination of low physical activity and low dietary diversity with mild cognitive impairment (MCI) in older Japanese adults. Methods: Data from 600 older ad…
View article: Simple risk scoring using sinus rhythm electrocardiograms predicts the incidence of atrial fibrillation in the general population
Simple risk scoring using sinus rhythm electrocardiograms predicts the incidence of atrial fibrillation in the general population Open
View article: Does mild cognitive impairment accelerate age-related changes in physical function and body composition? A three-year longitudinal follow-up study
Does mild cognitive impairment accelerate age-related changes in physical function and body composition? A three-year longitudinal follow-up study Open
This prospective study examined the impact of mild cognitive impairment (MCI) on age-related changes in physical function and body composition among community-dwelling older adults. Older adults aged 70 years and above (n = 180) completed …
View article: Associations of Eating Out and Dietary Diversity with Mild Cognitive Impairment among Community-Dwelling Older Adults
Associations of Eating Out and Dietary Diversity with Mild Cognitive Impairment among Community-Dwelling Older Adults Open
Background: Dementia is a critical late-life health issue that occurs among members of aging societies. This study examined the relationships between eating out, dietary diversity, and mild cognitive impairment (MCI) among community-dwelli…
View article: Importance of Sustained Control of Multiple Risk Factors and Lifestyle Modifications for Cardiovascular Health
Importance of Sustained Control of Multiple Risk Factors and Lifestyle Modifications for Cardiovascular Health Open
Risk factors, such as high blood pressure, high cholesterol, obesity, smoking, and lack of exercise accelerate arteriosclerosis progression.When these factors are present simultaneously, their effects are synergistically amplified, causing…
View article: Colour tone of retinal arterioles imaged with a colour scanning laser ophthalmoscope can be an indicator of systemic arterial stiffness
Colour tone of retinal arterioles imaged with a colour scanning laser ophthalmoscope can be an indicator of systemic arterial stiffness Open
Objective Colour scanning laser ophthalmoscope (cSLO) offers several advantages, including improved image quality and better visualisation of the retinal structures compared with colour fundus photograph (CFP). This study aimed to identify…
View article: J-shaped association between serum uric acid levels and chronic kidney disease: a cross-sectional study using large health examination data
J-shaped association between serum uric acid levels and chronic kidney disease: a cross-sectional study using large health examination data Open
Introduction Hyperuricemia has been recognized as a risk for cardiovascular disease based on the results of many observational studies. On the other hand, a J-shaped association has been reported in which people with very low serum uric ac…
View article: Sex specific associations between serum uric acid levels and risk of hypertension for different reference values of high blood pressure
Sex specific associations between serum uric acid levels and risk of hypertension for different reference values of high blood pressure Open
Background Uric acid (UA) has been linked to the development of hypertension. However the sex specific associations between UA levels and different diagnostic blood pressure (BP) references is unknown. Purpose We aimed to ascertain the ass…
View article: VE/VCO2 slope in cardiopulmonary exercise testing was associated with left ventricular diastolic dysfunction in patients with reduced ejection fraction
VE/VCO2 slope in cardiopulmonary exercise testing was associated with left ventricular diastolic dysfunction in patients with reduced ejection fraction Open
Background Heart failure with reduced ejection fraction (EF) was well-known as a poor prognosis. VE/VCO2 slope and peak oxygen uptake (VO2) by cardiopulmonary exercise testing (CPET) is a useful parameter for predicting cardiovascular dise…