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View article: Diagnostic Utility of Comprehensive Balance Function Testing in Patients with Vertigo and the Role of Database Development for Future AI Integration
Diagnostic Utility of Comprehensive Balance Function Testing in Patients with Vertigo and the Role of Database Development for Future AI Integration Open
View article: Inability of α-cyclodextrins to accommodate cholesterol potentially underlies their lack of efficacy and ototoxicity in Niemann-Pick disease type C treatment
Inability of α-cyclodextrins to accommodate cholesterol potentially underlies their lack of efficacy and ototoxicity in Niemann-Pick disease type C treatment Open
View article: A Case of Vestibular Migraine Successfully Managed by Improving Medication Compliance and Environmental Adjustment
A Case of Vestibular Migraine Successfully Managed by Improving Medication Compliance and Environmental Adjustment Open
View article: Development of a vestibular implant for otolith stimulation: A mouse model study
Development of a vestibular implant for otolith stimulation: A mouse model study Open
Our findings indicated that targeted stimulation of the utricle and saccule via a vestibular implant can partially restore otolithic function, reduce trunk deviation, and improve gait stability in a mouse model of BVH. Despite the promisin…
View article: Outcomes of the Regenerative Treatment for more than 200 patients with Tympanic Membrane Perforation
Outcomes of the Regenerative Treatment for more than 200 patients with Tympanic Membrane Perforation Open
View article: Mitochondrial Hearing Loss: Genetic Variants and Clinical Progression
Mitochondrial Hearing Loss: Genetic Variants and Clinical Progression Open
Mitochondrial diseases can affect multiple organ systems including the auditory pathway, leading to sensorineural hearing loss (SNHL). Although several mitochondrial DNA (mtDNA) mutations are linked to progressive hearing impairment, the u…
View article: Influence of melanin and macrophage activation on hearing loss in SLC26A4 deficient mice.
Influence of melanin and macrophage activation on hearing loss in SLC26A4 deficient mice. Open
View article: Vestibular Neuritis Associated With COVID-19 Infection: A Case Report and Literature Review on the Time Course and Recovery
Vestibular Neuritis Associated With COVID-19 Infection: A Case Report and Literature Review on the Time Course and Recovery Open
View article: Postural Sway Characteristics in Patients With Persistent Postural-Perceptual Dizziness: A Comparative Study Between Psychogenic Vertigo Patients and Healthy Controls
Postural Sway Characteristics in Patients With Persistent Postural-Perceptual Dizziness: A Comparative Study Between Psychogenic Vertigo Patients and Healthy Controls Open
This study aimed to compare postural sway characteristics and evaluate postural sway as a potential biomarker for persistent postural-perceptual dizziness (PPPD) to clarify diagnostic boundaries. A total of 36 participants were enrolled, i…
View article: Post-earthquake dizziness syndrome (PEDS): A comprehensive review of recent advances
Post-earthquake dizziness syndrome (PEDS): A comprehensive review of recent advances Open
Earthquakes pose significant health challenges, including post-earthquake dizziness syndrome (PEDS), which is characterized by dizziness, vertigo, imbalance, nausea, and motion sensations. This review aimed to examine the intricate relatio…
View article: Mitochonic acid 5 mitigates age-related hearing loss progression by targeting defective 2-methylthiolation in mitochondrial transfer RNAs
Mitochonic acid 5 mitigates age-related hearing loss progression by targeting defective 2-methylthiolation in mitochondrial transfer RNAs Open
Introduction Age-related hearing loss (ARHL) is linked to dementia, with mitochondrial dysfunction playing a key role in its progression. Deficient mitochondrial tRNA modifications impair protein synthesis and energy metabolism, accelerati…
View article: A Single-Blind, Placebo-Controlled Crossover Study of the Sedative Effects of Yokukansan in Healthy Adults Assessed by Saccadic Eye Movement Analysis
A Single-Blind, Placebo-Controlled Crossover Study of the Sedative Effects of Yokukansan in Healthy Adults Assessed by Saccadic Eye Movement Analysis Open
View article: N1-methylnicotinamide promotes age-related cochlear damage via the overexpression of SIRT1
N1-methylnicotinamide promotes age-related cochlear damage via the overexpression of SIRT1 Open
Age-related hearing loss (ARHL) is a complex condition with genetic, aging, and environmental influences. Sirtuins, particularly SIRT1, are NAD-dependent protein deacetylases critical to aging and stress responses. SIRT1 is modulated by ni…
View article: Usefulness of emotional intelligence assessment in the treatment of chronic tinnitus
Usefulness of emotional intelligence assessment in the treatment of chronic tinnitus Open
View article: Tympanic Membrane Regeneration Therapy for Pediatric Tympanic Membrane Perforation
Tympanic Membrane Regeneration Therapy for Pediatric Tympanic Membrane Perforation Open
Objective To evaluate tympanic membrane regeneration therapy (TMRT) for pediatric tympanic membrane perforations (TMPs). Study Design Intervention study. Setting Research institute hospital. Patients In this study, 20 patients with chronic…
View article: Optimizing Tinnitus Management: The Important Role of Hearing Aids with Sound Generators
Optimizing Tinnitus Management: The Important Role of Hearing Aids with Sound Generators Open
Hearing aids (HAs), especially those with sound generators (SGs), are used in the management of tinnitus. However, their comparative efficacies and long-term outcomes remain unknown. Therefore, we investigated the efficacy and long-term ou…
View article: Evaluating the Efficacy of Omalizumab in Severe Cedar Seasonal Allergic Rhinitis in Japan
Evaluating the Efficacy of Omalizumab in Severe Cedar Seasonal Allergic Rhinitis in Japan Open
Traditional treatments for cedar seasonal allergic rhinitis include second-generation antihistamines, nasal corticosteroids, and sublingual immunotherapy (SLIT). Omalizumab (Xolair®), an anti-immunoglobulin E (IgE) monoclonal antibody, is …
View article: Comprehensive Equilibrium Function Tests for an Accurate Diagnosis in Vertigo: A Retrospective Analysis
Comprehensive Equilibrium Function Tests for an Accurate Diagnosis in Vertigo: A Retrospective Analysis Open
Background/Objectives: An accurate diagnosis of vertigo is crucial in patient care. Traditional balance function tests often fail to offer independent, conclusive diagnoses. This study aimed to bridge the gap between traditional diagnostic…
View article: A Study of Benign Paroxysmal Positional Vertigo Associated with Meniere’s Disease
A Study of Benign Paroxysmal Positional Vertigo Associated with Meniere’s Disease Open
Benign paroxysmal positional vertigo (BPPV) is a typical vertigo disease, and BPPV developing during the course of diseases causing peripheral vertigo, including Meniere's disease, is also known. Between June 2017 and March 2021, 29 (23%) …
View article: Gap Junction Beta-2 p.Val84Met Can Cause Autosomal Dominant Syndromic Hearing Loss With Keratoderma
Gap Junction Beta-2 p.Val84Met Can Cause Autosomal Dominant Syndromic Hearing Loss With Keratoderma Open
View article: Contribution of circulating monocytes in maintaining homeostasis of resident macrophages in postnatal and young adult mouse cochlea
Contribution of circulating monocytes in maintaining homeostasis of resident macrophages in postnatal and young adult mouse cochlea Open
The percentage of macrophage subpopulations based on their origins in the adult cochlea remains unclear. This study aimed to elucidate the origins of cochlear macrophages during the onset phase and development of auditory function. We used…
View article: A Case of Ocular Myoclonus Appearing After Pontine Hemorrhage
A Case of Ocular Myoclonus Appearing After Pontine Hemorrhage Open
View article: A Case of Inner Ear Hemorrhage Followed Up by Equilibrium Testing
A Case of Inner Ear Hemorrhage Followed Up by Equilibrium Testing Open
Introduction: Inner ear hemorrhage can manifest with symptoms such as dizziness, deafness, and tinnitus, and can be diagnosed by MRI, but it is relatively rare and the diagnosis may be overlooked.
View article: Study of Trans-tympanic Positive Pressure Therapy for Ménière’s Disease and Delayed Endolymphatic Hydrops
Study of Trans-tympanic Positive Pressure Therapy for Ménière’s Disease and Delayed Endolymphatic Hydrops Open
In September 2019, we introduced a tympanic membrane massage device for transtympanic positive-pressure therapy at our institution. This treatment is selected for patients definitively diagnosed as having Ménière's disease (Stage 4) or del…
View article: Diagnosing Middle Ear Malformation by Pure-Tone Audiometry Using a Three-Dimensional Finite Element Model: A Case-Control Study
Diagnosing Middle Ear Malformation by Pure-Tone Audiometry Using a Three-Dimensional Finite Element Model: A Case-Control Study Open
Background: Hearing loss caused by middle ear malformations is treated by tympanoplasty to reconstruct the acoustic conduction system. The mobility of the ossicles plays a crucial role in postoperative success. However, identifying the loc…
View article: Outcomes of regenerative treatment for over 200 patients with tympanic membrane perforation
Outcomes of regenerative treatment for over 200 patients with tympanic membrane perforation Open
Our results showed that RT-TMP had high success rates for TMP closure and good hearing improvement and produced no severe complications that could affect general health status. This novel therapy is simple, safe and minimally invasive, and…
View article: OC 69.4 Safety, Pharmacokinetics, and Pharmacodynamics of Single Subcutaneous Injection of NXT007, an Emicizumab-Based Next-Generation Bispecific Antibody, in Healthy Volunteers (NXTAGE Study)
OC 69.4 Safety, Pharmacokinetics, and Pharmacodynamics of Single Subcutaneous Injection of NXT007, an Emicizumab-Based Next-Generation Bispecific Antibody, in Healthy Volunteers (NXTAGE Study) Open
Figure 1: (abstract OC 59.5): Kinetics of platelet (A) and fibrin(ogen) (B) accumulation for n = 9 donors (shaded regions represent SEM).Fluorescence intensity is normalized by the maximum fluorescence intensity of the vehicle control.WB =…
View article: Characteristics of Vestibular Migraine Assessed Using the Emotional Intelligence Quotient Scale (EQS): A Pilot Study
Characteristics of Vestibular Migraine Assessed Using the Emotional Intelligence Quotient Scale (EQS): A Pilot Study Open
Vestibular migraine (VM) is a disorder characterized by recurrent headaches and vertigo. Meniere's disease (MD) is also characterized by similar symptoms, and it is often difficult to differentiate between the two conditions. Therefore, we…
View article: Different solubilizing ability of cyclodextrin derivatives for cholesterol in Niemann–Pick disease type C treatment
Different solubilizing ability of cyclodextrin derivatives for cholesterol in Niemann–Pick disease type C treatment Open
Background Niemann–Pick disease type C (NPC) is a fatal neurodegenerative disorder caused by abnormal intracellular cholesterol trafficking. Cyclodextrins (CDs), the most promising therapeutic candidates for NPC, but with concerns about ot…
View article: Arginine-Rich Cell-Penetrating Peptide-Mediated Transduction of Mouse Nasal Cells with FOXP3 Protein Alleviates Allergic Rhinitis
Arginine-Rich Cell-Penetrating Peptide-Mediated Transduction of Mouse Nasal Cells with FOXP3 Protein Alleviates Allergic Rhinitis Open
Intranasal corticosteroids are effective medications against allergic rhinitis (AR). However, mucociliary clearance promptly eliminates these drugs from the nasal cavity and delays their onset of action. Therefore, a faster, longer-lasting…