Takuya Yokoe
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View article: Developing a Simple Scoring System on CT Findings for Predicting Treatment Failure in <i>Mycobacterium avium</i> Complex Pulmonary Disease: The BCD (Bronchiectasis and Cavity Distribution) Score
Developing a Simple Scoring System on CT Findings for Predicting Treatment Failure in <i>Mycobacterium avium</i> Complex Pulmonary Disease: The BCD (Bronchiectasis and Cavity Distribution) Score Open
Background Optimal timing for treatment initiation in Mycobacterium avium complex pulmonary disease (MAC-PD) remains unclear due to lack of established rules for predicting treatment response. Methods A retrospective observational study wa…
View article: Intermittent Hypoxia Induces Cognitive Dysfunction and Hippocampal Gene Expression Changes in a Mouse Model of Obstructive Sleep Apnea
Intermittent Hypoxia Induces Cognitive Dysfunction and Hippocampal Gene Expression Changes in a Mouse Model of Obstructive Sleep Apnea Open
Obstructive sleep apnea syndrome (OSAS) is characterized by cycles of decreased blood oxygen saturation followed by reoxygenation due to transient apnea. Cognitive dysfunction is a complication of OSAS, but its mechanisms remain unclear. E…
View article: Intermittent Hypoxia Induces Cognitive Dysfunction and Hippocampal Gene Expression Changes in a Mouse Model of Obstructive Sleep Apnea
Intermittent Hypoxia Induces Cognitive Dysfunction and Hippocampal Gene Expression Changes in a Mouse Model of Obstructive Sleep Apnea Open
Obstructive sleep apnea syndrome (OSAS) is characterized by cycles of decreased blood oxygen saturation followed by reoxygenation due to transient apnea. Cognitive dysfunction is a complication of OSAS, but its mechanisms remain unclear. 8…
View article: An Emulsification Suction Irrigator for High-Viscosity Fluids
An Emulsification Suction Irrigator for High-Viscosity Fluids Open
Our new emulsification suction irrigator improved the removal efficiency of highly viscous liquids in artificial models.
View article: Lenvatinib plus pembrolizumab for advanced or recurrent endometrial cancer: A retrospective multi-institutional survey in the Kinki district of Japan
Lenvatinib plus pembrolizumab for advanced or recurrent endometrial cancer: A retrospective multi-institutional survey in the Kinki district of Japan Open
View article: Changes in Clinical Features and Severity of COVID-19 with the Emergence of Omicron Variants: A Shift Towards a Common Disease
Changes in Clinical Features and Severity of COVID-19 with the Emergence of Omicron Variants: A Shift Towards a Common Disease Open
The clinical characteristics of COVID-19 have become less distinct since the emergence of the Omicron variant, with CRP being the primary marker associated with a COVID-19 diagnosis. As COVID-19 continues to transition towards a more commo…
View article: Combination of rRT-PCR and Clinical Features to Predict Coronavirus Disease 2019 for Nosocomial Infection Control
Combination of rRT-PCR and Clinical Features to Predict Coronavirus Disease 2019 for Nosocomial Infection Control Open
Some clinical factors are useful to predict patients with COVID-19 among those with symptoms similar to COVID-19. This study suggests that at least two real-time reverse-transcription polymerase chain reactions of SARS-CoV-2 are recommende…
View article: Fertility-sparing radical resection of juvenile clear cell adenocarcinoma of the cervix by pneumovaginal endoscopic surgery
Fertility-sparing radical resection of juvenile clear cell adenocarcinoma of the cervix by pneumovaginal endoscopic surgery Open
View article: Detection of human coronavirus RNA in surgical smoke generated by surgical devices
Detection of human coronavirus RNA in surgical smoke generated by surgical devices Open
多くの外科医は電気メスや超音波メス等のエネルギーデバイスを使用する.これらの機器が生体組織を熱分解することで発生する煤煙はサージカルスモークと呼ばれ,この中には発癌性物質,患者由来の細菌・悪性細胞・ウイルスなどの有害物質が含まれていることが,数多くの研究で指摘されている.2019年にパンデミックになった新型コロナウイルス感染症(COVID-19)では,患者の呼吸器・糞便・血清中にウイルスRNAが存在することが示されている.そして,患者から生じたサージカルスモークによってウイ…
View article: Isolated port-site metastasis after laparoscopic hysterectomy for early-stage endometrial cancer: A case report
Isolated port-site metastasis after laparoscopic hysterectomy for early-stage endometrial cancer: A case report Open
Port-site metastasis (PSM) is specific and challenging complication that occurs after laparoscopic surgery for malignant tumor. Few cases of isolated PSM in patients with early-stage endometrial cancer have been reported; the management an…
View article: Pneumovaginoscopy-assisted radical hysterectomy for early-stage cervical cancer: a novel bidirectional approach for tumor spillage prevention and R0 resection
Pneumovaginoscopy-assisted radical hysterectomy for early-stage cervical cancer: a novel bidirectional approach for tumor spillage prevention and R0 resection Open
PVRH is a new fascia-oriented and nerve-sparing surgery for early-stage cervical cancer. Further, it has favorable operative outcomes and good prognoses, similar to those of adjacent pelvic surgery such as trans-anal total mesorectal excis…
View article: Significance of placental CD200 expression in patients with preeclampsia: Comparison between early‑ and late‑onset patients
Significance of placental CD200 expression in patients with preeclampsia: Comparison between early‑ and late‑onset patients Open
Preeclampsia, characterized by high blood pressure and proteinuria during pregnancy, causes serious complications in both the mother and the fetus. Although there have been several studies on the causes of preeclampsia, the detailed mechan…
View article: Laparoscopic hemostasis and drainage for postpartum retroperitoneal hematoma complicated with an infection: A case report and surgical video
Laparoscopic hemostasis and drainage for postpartum retroperitoneal hematoma complicated with an infection: A case report and surgical video Open
Laparoscopic surgery for postpartum retroperitoneal hematoma with infection was useful for both drainage and hemostasis.
View article: Salvage chemotherapy and maintenance therapy with poly adenosine diphosphate-ribose polymerase inhibitors for bevacizumab-resistant relapse of epithelial ovarian cancer
Salvage chemotherapy and maintenance therapy with poly adenosine diphosphate-ribose polymerase inhibitors for bevacizumab-resistant relapse of epithelial ovarian cancer Open
Adjuvant chemotherapy combined with bevacizumab, an angiogenesis inhibitor, can improve the survival of advanced epithelial ovarian cancer (EOC), but relapse during bevacizumab maintenance therapy may occur. Despite poly adenosine ribose-p…
View article: Combination of anti-glycopeptidolipid-core IgA antibody and clinical features for diagnosing potential nontuberculous mycobacterium pulmonary disease in routine practice
Combination of anti-glycopeptidolipid-core IgA antibody and clinical features for diagnosing potential nontuberculous mycobacterium pulmonary disease in routine practice Open
Background: The anti- Mycobacterium avium complex (MAC) antibody test measures levels of IgA antibody against the glycopeptidolipid (GPL) core in the bacterial cell walls and is a useful clinical indicator of nontuberculous mycobacterium p…
View article: Successful minimally invasive surgery for postpartum retroperitoneal hematoma complicated by an infection: Two case reports
Successful minimally invasive surgery for postpartum retroperitoneal hematoma complicated by an infection: Two case reports Open
Minimally invasive procedures involving laparoscopy could be beneficial for the management of postpartum retroperitoneal hematomas complicated by an infection.
View article: Detection of human coronavirus RNA in surgical smoke generated by surgical devices
Detection of human coronavirus RNA in surgical smoke generated by surgical devices Open
View article: Impact of the interferon-γ release assay and glomerular filtration rate on the estimation of active tuberculosis risk before bronchoscopic examinations: a retrospective pilot study
Impact of the interferon-γ release assay and glomerular filtration rate on the estimation of active tuberculosis risk before bronchoscopic examinations: a retrospective pilot study Open
IGRA test results are useful for predicting active TB before bronchoscopy. This strategy could identify patients who require antibiotic therapy to prevent TB or who are in the active phase of TB.
View article: Impact of the multidisciplinary antimicrobial stewardship team intervention focusing on carbapenem de‐escalation: A single‐centre and interrupted time series analysis
Impact of the multidisciplinary antimicrobial stewardship team intervention focusing on carbapenem de‐escalation: A single‐centre and interrupted time series analysis Open
The PPRF strategy implemented by the AST could improve the carbapenem usage by increasing the DE rate of carbapenem.
View article: 1. CPAP
1. CPAP Open
閉塞性睡眠時無呼吸は，脳心血管系疾患のリスクが高く，持続陽圧呼吸療法が標準的な治療法である．各種報告による治療効果を認めるためには，治療の継続と良好なアドヒアランスが重要であるが，治療継続率は5～8割程度，アドヒアランス良好な患者は4割程度と低い状態であり，40年以上の経過で進歩した機器の適切な使用と，アドヒアランス悪化に関連する各種問題への対応が必要である．
View article: Ovarian hyperstimulation syndrome following surgical removal of a complete hydatidiform mole: a case report
Ovarian hyperstimulation syndrome following surgical removal of a complete hydatidiform mole: a case report Open
Background Generally, ovarian hyperstimulation syndrome develops after superovulation caused by ovulation-inducing drugs in infertile patients. However, ovarian hyperstimulation syndrome associated with natural pregnancy is rare, and most …
View article: High burden of <i>Aspergillus fumigatus</i> infection among chronic respiratory diseases
High burden of <i>Aspergillus fumigatus</i> infection among chronic respiratory diseases Open
Aspergillus fumigatus (AF) is a ubiquitous fungus in our environment and causes severe airway disorders. Chronic respiratory diseases (CRDs) are a series of chronic airway and lung diseases. Although both are chronic disorders, however, th…
View article: Transactions of The Showa University Society : The 349<sup>th</sup> Meeting
Transactions of The Showa University Society : The 349<sup>th</sup> Meeting Open
Aspergillus fumigatus (Af) is a ubiquitous fungus in our environment that causes severe airway disorders.Chronic respiratory diseases (CRDs) comprise various upper and lower respiratory disorders ranging from asthma, chronic obstructive pu…
View article: Predicting future risk of exacerbations in Japanese patients with adult asthma: A prospective 1-year follow up study
Predicting future risk of exacerbations in Japanese patients with adult asthma: A prospective 1-year follow up study Open
View article: On-demand Inhaled Corticosteroid and Fast-onset Beta-2 Agonist Combination Therapy Versus Conventional Treatment for Mild to Moderate Asthma: A Non-inferiority, Network Meta-analysis
On-demand Inhaled Corticosteroid and Fast-onset Beta-2 Agonist Combination Therapy Versus Conventional Treatment for Mild to Moderate Asthma: A Non-inferiority, Network Meta-analysis Open
The aim of this study was to assess the non-inferiority of on-demand (OD) inhaled corticosteroid (ICS) and fast-onset beta-2 agonist (FOBA) combination therapy. Although the guidelines recommend regular inhalation of ICS and long-acting be…
View article: A Comparison of Adverse Effect Profiles of Two Anti-IL-5 Therapies in Adults with Uncontrolled Asthma
A Comparison of Adverse Effect Profiles of Two Anti-IL-5 Therapies in Adults with Uncontrolled Asthma Open
The aim of this study was to compare the adverse effect profiles of mepolizumab（MPZ）and benralizumab（BRZ）in adults with uncontrolled asthma. A network meta-analysis of phase 3 trials was conducted to compare the adverse effects of MPZ and …
View article: Comparing the Adverse Event Profiles of Nivolumab and Docetaxel in Previously-treated or Refractory Advanced Non-small Cell Lung Cancer: A Meta-analysis of Two Phase 3 Trials
Comparing the Adverse Event Profiles of Nivolumab and Docetaxel in Previously-treated or Refractory Advanced Non-small Cell Lung Cancer: A Meta-analysis of Two Phase 3 Trials Open
Nivolumab has recently been approved as a second-line treatment for squamous and non-squamous advanced non-small cell lung cancers (NSCLC). However, no studies have statistically evaluated the adverse event profiles for nivolumab and conve…
View article: On-Demand Inhaled Corticosteroid and Fast-Acting Beta-2 Agonist Combination Therapy Versus Regular Inhaled Corticosteroid Plus Rescue Bronchodilator in Adults with Mild Asthma: A Network Meta-Analysis
On-Demand Inhaled Corticosteroid and Fast-Acting Beta-2 Agonist Combination Therapy Versus Regular Inhaled Corticosteroid Plus Rescue Bronchodilator in Adults with Mild Asthma: A Network Meta-Analysis Open
The aim of this study was to assess the non-inferiority of on-demand (OD) inhaled corticosteroid (ICS) and fast-acting beta-2 agonist (FABA) combination therapy. Although regular inhalation of low-dose ICS and OD short-acting beta-2 agonis…
View article: Association between Casual Serum Triglyceride Levels and Bone Resorption Activity in Japanese Middle-aged and Elderly Women
Association between Casual Serum Triglyceride Levels and Bone Resorption Activity in Japanese Middle-aged and Elderly Women Open
High serum triglyceride (TG) levels may lower bone fracture risk, but the association between serum TG and bone resorption activity is unclear. The aim of the present study was to analyze this association using casual serum TG levels in pa…
View article: Meta-analysis of Low-versus High-dose Benralizumab in Adults with Uncontrolled Eosinophilic Asthma
Meta-analysis of Low-versus High-dose Benralizumab in Adults with Uncontrolled Eosinophilic Asthma Open
The aim of the present study was to assess the non-inferiority of low-dose benralizumab relative to high-dose benralizumab as a treatment option for uncontrolled eosinophilic asthma through a meta-analysis of efficacy and safety in randomi…