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View article: The never-ending story: single versus dual venous anastomoses in microsurgical radial forearm free flap for head and neck reconstruction. A meta-analysis
The never-ending story: single versus dual venous anastomoses in microsurgical radial forearm free flap for head and neck reconstruction. A meta-analysis Open
The radial forearm free flap (RFFF) remains a cornerstone in head and neck reconstruction. Despite various venous anastomotic techniques, including single and dual anastomoses, venous compromise continues to be the leading cause of free fl…
View article: Management of Diabetes Mellitus and Hypertension During Hospitalization in Maxillofacial Departments
Management of Diabetes Mellitus and Hypertension During Hospitalization in Maxillofacial Departments Open
Background and Objectives: Diabetes mellitus (DM) and hypertension (HTN) continue to increase and pose a significant burden on the health system worldwide. These patients comprise a significant portion of the hospitalized Oral and Maxillof…
View article: Literature Review of Various Treatments in CNPAS and a Proposed Novel Clinical Treatment Algorithm
Literature Review of Various Treatments in CNPAS and a Proposed Novel Clinical Treatment Algorithm Open
Background: Congenital nasal pyriform aperture stenosis (CNPAS) is a rare disorder characterized by a narrowed pyriform aperture and nasal obstruction. Children with CNPAS often exhibit a bony ridge on the underside of the secondary palate…
View article: Using in-house 3D technology for optimal spatial positioning of elongation devices for distraction osteogenesis—a cost-effective alternative
Using in-house 3D technology for optimal spatial positioning of elongation devices for distraction osteogenesis—a cost-effective alternative Open
Introduction Mandibular distraction osteogenesis is globally accepted as the gold-standard surgical solution for various craniofacial deformities and syndromes. Stock device evolution has advanced into complex designs to achieve the most a…
View article: Digital planning and decision making for severe congenital oligodontia with Angle class-III malocclusion
Digital planning and decision making for severe congenital oligodontia with Angle class-III malocclusion Open
As maxillofacial surgery becomes increasingly digitized and the transformative impact of pre-surgical scanning and computer simulation is recognized, this clinical paper presents an algorithm for the selection of interventions in severe co…
View article: Epithelial RANKL Limits Experimental Periodontitis via Langerhans Cells
Epithelial RANKL Limits Experimental Periodontitis via Langerhans Cells Open
Due to its capacity to drive osteoclast differentiation, the receptor activator of nuclear factor kappa-β ligand (RANKL) is believed to exert a pathological influence in periodontitis. However, RANKL was initially identified as an activato…
View article: Real-time Reconstruction of Comminuted Mandibular Fractures Using 3D Printing
Real-time Reconstruction of Comminuted Mandibular Fractures Using 3D Printing Open
Background: Comminuted fractures of the jaws are complex injuries requiring special attention. In the past, treatment included closed reduction using maxillomandibular fixation. With advancements in technology and fixation systems, open re…
View article: Treatment of Facial Asymmetry Using Distraction Osteogenesis in a Mandible First Approach
Treatment of Facial Asymmetry Using Distraction Osteogenesis in a Mandible First Approach Open
Background: Facial asymmetry includes several etiologies, among them trauma to the condylar area during early childhood and congenital malformations such as hemifacial microsomia. This article describes the management of facial asymmetry i…
View article: A Comparative Study of Mucosal Wound Healing after Excision with a Scalpel, Diode Laser, or CO2 Laser
A Comparative Study of Mucosal Wound Healing after Excision with a Scalpel, Diode Laser, or CO2 Laser Open
Background: We aimed to compare the clinical and histological secondary healing effectiveness of various types of high-level laser versus scalpel excision in mucosa frenectomy. Methods: Forty-five Sprague Dawley rats were used in this stud…
View article: Evaluation of parental perceptions of lingual and labial frenectomy on their child: a comparison of CO2 laser and conventional scalpel
Evaluation of parental perceptions of lingual and labial frenectomy on their child: a comparison of CO2 laser and conventional scalpel Open
To evaluate parental reports of postoperative pain, improvement and satisfaction following frenectomy with scalpel versus carbon dioxide (CO2) laser treatment. Forty-nine patients aged 2–6 years with a short labial or lingual frenulum who …
View article: Patient-specific Implants for Treating Atrophic Mandibles
Patient-specific Implants for Treating Atrophic Mandibles Open
Summary: Extremely atrophic mandibles are difficult to treat. Most patients choose to live with removable dentures. However, what if the atrophy is so extreme that spontaneous fractures occur? The objective of this report is to offer a sin…
View article: Trends in cleft palate incidence in the era of obstetric sonography and early detection
Trends in cleft palate incidence in the era of obstetric sonography and early detection Open
Significant decrease was observed in the incidence of severe cleft palate cases in the last decade. Concurrently, we found a substantial increase in percentage of abortions performed due to physical malformations. We suggest that these cha…
View article: Early antitumor activity of oral Langerhans cells is compromised by a carcinogen
Early antitumor activity of oral Langerhans cells is compromised by a carcinogen Open
Significance Oral cancer is often diagnosed at late stages, resulting in a poor prognosis of this disease. Understanding early carcinogenic events taking place during the development of oral cancer is, therefore, an important unmet clinica…
View article: Trends in Burn Injuries in Northern Israel During the COVID-19 Lockdown
Trends in Burn Injuries in Northern Israel During the COVID-19 Lockdown Open
Coronavirus disease 2019 obliged many countries to apply lockdown policies to contain the spread of infection. The restrictions in Israel included limitations on movement, reduction of working capacity, and closure of the educational syste…
View article: Direct on-the-spot detection of SARS-CoV-2 in patients
Direct on-the-spot detection of SARS-CoV-2 in patients Open
Many countries are currently in a state of lockdown due to the SARS-CoV-2 pandemic. One key requirement to safely transition out of lockdown is the continuous testing of the population to identify infected subjects. Currently, detection is…
View article: SARS-CoV-2 On-the-Spot Virus Detection Directly from Patients
SARS-CoV-2 On-the-Spot Virus Detection Directly from Patients Open
Many countries are currently in a lockdown state due to the SARS-CoV-2 pandemic. One key aspect to transition safely out of lockdown is to continuously test the population for infected subjects. Currently, detection is performed at points …
View article: Extramaxillary zygomatic implants: An alternative approach for the reconstruction of the atrophic maxilla
Extramaxillary zygomatic implants: An alternative approach for the reconstruction of the atrophic maxilla Open
Zygomatic implants allow for immediate loading of an atrophic maxilla. The emergence of the implant is prosthetically correct compared to the intrasinus approach, leading to better dental hygiene and decreased mechanical resistance. 96.1% …
View article: A Protocol for Simple, Rapid, and Direct Detection of SARS-CoV-2 from clinical samples, using Reverse Transcribed Loop-Mediated Isothermal Amplification (RT-LAMP)
A Protocol for Simple, Rapid, and Direct Detection of SARS-CoV-2 from clinical samples, using Reverse Transcribed Loop-Mediated Isothermal Amplification (RT-LAMP) Open
SARS-CoV-2 has quickly spread all around the globe causing illness and wide damages. Most countries were unprepared for such a rapid spread and crisis. This led to various strategies for effective control of the new pandemic. A key aspect …
View article: Bone Morphogenic Protein 2-Loaded Porous Silicon Carriers for Osteoinductive Implants
Bone Morphogenic Protein 2-Loaded Porous Silicon Carriers for Osteoinductive Implants Open
Bone morphogenetic proteins (BMPs) are probably the most important growth factors in bone formation and healing. However, the utilization of BMPs in clinical applications is mainly limited due to the protein poor solubility at physiologica…
View article: Impaired Differentiation of Langerhans Cells in the Murine Oral Epithelium Adjacent to Titanium Dental Implants
Impaired Differentiation of Langerhans Cells in the Murine Oral Epithelium Adjacent to Titanium Dental Implants Open
Peri-implantitis is a destructive inflammatory process affecting tissues surrounding dental implants and it is considered a new global health concern. Human studies have suggested that the frequencies of Langerhans cells (LCs), the main an…
View article: Multiple Regulatory Levels of Growth Arrest-Specific 6 in Mucosal Immunity Against an Oral Pathogen
Multiple Regulatory Levels of Growth Arrest-Specific 6 in Mucosal Immunity Against an Oral Pathogen Open
Growth arrest-specific 6 (GAS6) expressed by oral epithelial cells and dendritic cells (DCs) was shown to play a critical role in the maintenance of oral mucosal homeostasis. In this study, we demonstrate that the induction of pathogen-spe…
View article: Cell-intrinsic regulation of murine epidermal Langerhans cells by protein S
Cell-intrinsic regulation of murine epidermal Langerhans cells by protein S Open
Significance Langerhans cells (LCs) are the exclusive antigen-presenting cells of the epidermis, capable of mounting immunity and tolerance. LCs maintain themselves locally by self-renewing throughout life, a process that is regulated by b…
View article: Sequential BMP7/TGF-β1 signaling and microbiota instruct mucosal Langerhans cell differentiation
Sequential BMP7/TGF-β1 signaling and microbiota instruct mucosal Langerhans cell differentiation Open
Mucosal Langerhans cells (LCs) originate from pre–dendritic cells and monocytes. However, the mechanisms involved in their in situ development remain unclear. Here, we demonstrate that the differentiation of murine mucosal LCs is a two-ste…
View article: Protein S Negatively Regulates Neural Stem Cell Self-Renewal through Bmi-1 Signaling
Protein S Negatively Regulates Neural Stem Cell Self-Renewal through Bmi-1 Signaling Open
Revealing the molecular mechanisms underlying neural stem cell self-renewal is a major goal toward understanding adult brain homeostasis. The self-renewing potential of neural stem and progenitor cells (NSPCs) must be tightly regulated to …
View article: GAS6 is a key homeostatic immunological regulator of host–commensal interactions in the oral mucosa
GAS6 is a key homeostatic immunological regulator of host–commensal interactions in the oral mucosa Open
Significance Understanding the mechanisms by which the immune system and local microorganisms coexist in the oral cavity is important, as disruption of this delicate balance could cause oral and systemic diseases. We revealed that growth a…
View article: Porphyromonas gingivalis Promotes Unrestrained Type I Interferon Production by Dysregulating TAM Signaling via MYD88 Degradation
Porphyromonas gingivalis Promotes Unrestrained Type I Interferon Production by Dysregulating TAM Signaling via MYD88 Degradation Open
Whereas type I interferons (IFNs-I) were proposed to be elevated in human periodontitis, their role in the disease remains elusive. Using a bacterial-induced model of murine periodontitis, we revealed a prolonged elevation in IFN-I express…