Tal Cohen
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Formation of repeating bar‐flat bedforms in ephemeral gravel bed channels: 1. Field observations Open
Repeating fluvial macroforms are ubiquitous. The streamwise alternation of steeper, coarse‐grained, cobble/pebble bars and near‐horizontal, fine‐grained, sand/granule flats is characteristic of upland, single‐thread, dryland channels. We h…
Formation of repeating bar‐flat bedforms in ephemeral gravel bed channels: 2. Bridging mathematical modelling and field observations Open
Single‐ and multi‐thread gravel‐bed ephemeral channels in semi‐arid and arid regions have a characteristic repeating, channel‐wide pattern of low angle, fine‐grained ‘flats’ alternating with steeper, coarse‐grained ‘bars’. The genesis of t…
CAR-engineered lymphocyte persistence is governed by a FAS ligand–FAS autoregulatory circuit Open
Chimeric antigen receptor (CAR)-engineered lymphocytes treat B cell malignancies; however, limited persistence can restrain the full therapeutic potential of this approach. FAS ligand (FAS-L)/FAS interactions govern lymphocyte homeostasis.…
View article: Descriptive report of complex cystic renal mass fluid cytology: a cross-sectional analysis
Descriptive report of complex cystic renal mass fluid cytology: a cross-sectional analysis Open
Based on routine cytologic analysis, there is no clear pattern with the presence or absence of malignant cells in the fluid of complex renal cysts. More sophisticated testing may provide insight into the malignant potential of renal cyst f…
CAR-engineered lymphocyte persistence is governed by a FAS ligand/FAS auto-regulatory circuit Open
Chimeric antigen receptor (CAR)-engineered T and NK cells can cause durable remission of B-cell malignancies; however, limited persistence restrains the full potential of these therapies in many patients. The FAS ligand (FAS-L)/FAS pathway…
Inhibition of α4β1 Integrin Activity by Small Tellurium Compounds Regulates PD-L1 Expression and Enhances Antitumor Effects Open
Various cancer treatment approaches that inhibit the activity of the programmed death-1/programmed death-ligand 1 (PD-1/PD-L1) axis, a key player in tumor immune evasion, have been developed. We show that the immunomodulatory small telluri…
2891. Nebulized Phage Therapy for Patients with Cystic Fibrosis with Chronic <i>Pseudomonas aeruginosa</i> Pulmonary Infection: A Phase 1b/2a Randomized, Double-Blind, Placebo-Controlled, Multicenter Study Open
Background Pseudomonas aeruginosa (PsA) continues to cause difficult-to-treat pulmonary infections and hospitalizations in patients with cystic fibrosis (CF). Safer and targeted therapies are needed to minimize the morbidity and disease bu…
Exodus: sequencing-based pipeline for quantification of pooled variants Open
Summary Next-Generation Sequencing is widely used as a tool for identifying and quantifying microorganisms pooled together in either natural or designed samples. However, a prominent obstacle is achieving correct quantification when the po…
Mutant C. elegans mitofusin leads to selective removal of mtDNA heteroplasmic deletions across generations to maintain fitness Open
Background Mitochondrial DNA (mtDNA) is present at high copy numbers in animal cells, and though characterized by a single haplotype in each individual due to maternal germline inheritance, deleterious mutations and intact mtDNA molecules …
View article: Additional file 2 of Mutant C. elegans mitofusin leads to selective removal of mtDNA heteroplasmic deletions across generations to maintain fitness
Additional file 2 of Mutant C. elegans mitofusin leads to selective removal of mtDNA heteroplasmic deletions across generations to maintain fitness Open
Additional file 2. Individual data values. Spreadsheets of numerical data for Figures 1, 2, 3, 4 and 5 and Supplementary Figures S1-S4.
Mitochondrial gene expression in single cells shape pancreatic beta cells' sub-populations and explain variation in insulin pathway Open
Mitochondrial gene expression is pivotal to cell metabolism. Nevertheless, it is unknown whether it diverges within a given cell type. Here, we analysed single-cell RNA-seq experiments from human pancreatic alpha (N = 3471) and beta cells …
Mitochondrial and insulin gene expression in single cells shape pancreatic beta cells’ population divergence Open
Mitochondrial gene expression is pivotal to cell metabolism. Nevertheless, it is unknown whether it diverges within a given cell type. Here, we analysed single-cell RNA-seq experiments from ∼4600 human pancreatic alpha and beta cells, as w…
View article: Mutant <i>C. elegans</i> mitofusin leads to selective removal of mtDNA heteroplasmic deletions at different rates across generations
Mutant <i>C. elegans</i> mitofusin leads to selective removal of mtDNA heteroplasmic deletions at different rates across generations Open
Deleterious and intact mitochondrial DNA (mtDNA) mutations frequently co-exist (heteroplasmy). Such mutations likely survive and are inherited due to complementation via the intra-cellular mitochondrial network. Hence, we hypothesized that…
mtDNA eQTLs and the m1A 16S rRNA modification explain mtDNA tissue-specific gene expression pattern in humans Open
Expression quantitative trait loci (eQTLs) are instrumental in genome-wide identification of regulatory elements, yet were overlooked in the mitochondrial DNA (mtDNA). By analyzing 5079 RNA-seq samples from 23 tissues we identified associa…
Human primitive brain displays negative mitochondrial-nuclear expression correlation of respiratory genes Open
Oxidative phosphorylation (OXPHOS), a fundamental energy source in all human tissues, requires interactions between mitochondrial (mtDNA)- and nuclear (nDNA)-encoded protein subunits. Although such interactions are fundamental to OXPHOS, b…
Supplemental Dataset S2: Correlation matrices for expression patterns of OXPHOS genes and splice variants of OXPHOS genes in 48 human tissues.titled Item Open
Supplemental Dataset S2 of: Barshad G. et al (2018). Genome Research, 28(7): 952-967
Ancient Out-of-Africa Mitochondrial DNA Variants Associate with Distinct Mitochondrial Gene Expression Patterns Open
Mitochondrial DNA (mtDNA) variants have been traditionally used as markers to trace ancient population migrations. Although experiments relying on model organisms and cytoplasmic hybrids, as well as disease association studies, have served…