Explanipedia

‘When Lightning Strikes Twice’—Preimplantation Genetic Testing for Two Indications in One Biopsy Open

Einav Kremer, Hagit Daum, Amy Solnica, Tamar Krisher, Assaf Ben Meir , et al. · 2025

Objective We aimed to investigate whether the clinical pregnancy and live birth rates in women undergoing preimplantation genetic testing for two indications (PGT2) differ from PGT for one autosomal dominant indication (PGT1). Method This …

Polycystic ovary syndrome and morphokinetic embryonic development: a case-control study evaluating 791 embryos Open

Gilad Karavani, Shira Shapira-Nass, Natali Schachter‐Safrai, Tal Imbar, Assaf Ben‐Meir · 2025

This study demonstrated comparable IVF outcomes in women with PCOS and non-PCOS controls. An analysis of time-lapse monitoring data from these patients showed no evidence that PCOS negatively affects embryonic development rate in women und…

Changes in Sperm Parameters with Time in Men with Normal and Abnormal Baseline Semen Analysis Open

Nir Cohen, Assaf Ben‐Meir, Tzuf Harlap, Tal Imbar, Gilad Karavani · 2024

What are the most common controversial clinical issues in fertility preservation? A content analysis of a collaborative professional online consultation group Open

Avi Tsafrir, Avi Ben‐Haroush, Jordana Hyman, Gilad Karavani, Tal Imbar · 2023

Research question Clinicians involved in fertility preservation (FP) are often required to make prompt and consequential decisions despite the absence of evidence-based data. We established a collaborative professional online consultation …

What are the most common controversial clinical issues in fertility preservation? A content analysis of a collaborative professional online consultation group Open

Avi Tsafrir, Avi Ben‐Haroush, Jordana Hyman, Gilad Karavani, Tal Imbar · 2023

Research Question Clinicians involved in fertility preservation (FP) are often required to make prompt and consequential decisions despite the absence of evidence-based data. We established a collaborative professional online consultation …

Pre-pubertal oocytes harbor altered histone modifications and chromatin configuration Open

Pe’era Wasserzug Pash, Gilad Karavani, Eli Reich, Lital Zecharyahu, Zehava Kay , et al. · 2023

Pre-pubertal oocytes are still dormant. They are arrested in a GV state and do not undergo meiotic divisions naturally. A multitude of molecular pathways are changed and triggered upon initiation of puberty. It is not yet clear which epige…

BNT162b2 COVID-19 Vaccine has no Adverse Effect on Women’s In Vitro Fertilization Outcomes and Fertility Open

M Safrai, A Rottenstreich, S Herzberg, Tal Imbar, B Reubinoff , et al. · 2022

Purpose: To investigate the effect of BNT162b2 COVID-19 vaccine on women’s fertility. Methods: We prospectively collected data of women patients undergoing In Vitro Fertilization (IVF) treatment after completion of 2 doses of BNT162b2 vacc…

Sperm quality is not affected by the BNT162b2 mRNA SARS-CoV-2 vaccine: results of a 6–14 months follow-up Open

Gilad Karavani, Henry H. Chill, Cherut Meirman, Einat Gutman‐Ido, Shmuel Herzberg , et al. · 2022

Pfizer SARS-CoV-2 BNT162b2 mRNA vaccination (BNT162b2) has no adverse effect on elective oocyte cryopreservation outcomes Open

Gilad Karavani, Henry H. Chill, Aharon Dick, Cherut Meirman, Einat Gutman‐Ido , et al. · 2022

Obstetric outcomes of young women following in-vitro fertilization: a case–control study Open

Gilad Karavani, Henry H. Chill, Aharon Dick, Marva Bergman, Tal Imbar , et al. · 2022

The BNT162b2 mRNA Covid-19 vaccine does not impair sperm parameters Open

Myriam Safrai, Shmuel Herzberg, Tal Imbar, Benjamin Reubinoff, Uri P. Dior , et al. · 2022

Establishment of a controlled slow freezing-based approach for experimental clinical cryopreservation of human prepubertal testicular tissues Open

Doron Kabiri, Myriam Safrai, Michal Gropp, Guy Hidas, Talya Mordechai-Daniel , et al. · 2021

Reduced Endothelin-2 and Hypoxic Signaling Pathways in Granulosa-Lutein Cells of PCOS Women Open

Magdalena Szymańska, Ketan Shrestha, Eliezer Girsh, Avi Harlev, Iris Eisenberg , et al. · 2021

Granulosa-lutein cells (GLCs) from PCOS women display reduced HIF-1α and EDN2 levels, suggesting their role in PCOS etiology. Here, we investigated the mechanisms involved in aberrant EDN2 expression in PCOS, and its association with HIF-1…

Age-Dependent in vitro Maturation Efficacy of Human Oocytes – Is There an Optimal Age? Open

Gilad Karavani, Peera Wasserzug‐Pash, Talya Mordechai-Daniel, Dvora Bauman, Michael Klutstein , et al. · 2021

In vitro maturation of oocytes from antral follicles seen during tissue harvesting is a fertility preservation technique with potential advantages over ovarian tissue cryopreservation (OTC), as mature frozen and later thawed oocyte used fo…

Stopping the misinformation: BNT162b2 COVID-19 vaccine has no negative effect on women’s fertility Open

Myriam Safrai, Amihai Rottenstreich, Shmuel Herzberg, Tal Imbar, Benjamin Reubinoff , et al. · 2021

Objective To investigate the possible impact of Pfizer-BioNTech’s mRNA BNT162b2 COVID-19 vaccine on women’s fertility. Methods A retrospective single-center study examining women’s IVF treatment parameters and pregnancies before and after …

Chemotherapy-based gonadotoxicity risk evaluation as a predictor of reproductive outcomes in post-pubertal patients following ovarian tissue cryopreservation Open

Gilad Karavani, Amihai Rottenstreich, Natali Schachter‐Safrai, Adiel Cohen, Michael Weintraub , et al. · 2021

In vitro maturation rates in young premenarche patients Open

Gilad Karavani, Natali Schachter‐Safrai, Ariel Revel, Talya Mordechai-Daniel, Dvora Bauman , et al. · 2019

Antral follicle count recovery in women with menses after treatment with and without gonadotropin-releasing hormone agonist use during chemotherapy for breast cancer Open

Nikita Sinha, Joseph M. Letourneau, Kaitlyn Wald, Ping-Xiang Xiong, Tal Imbar , et al. · 2018

miR-210 and GPD1L regulate EDN2 in primary and immortalized human granulosa-lutein cells Open

Ketan Shrestha, Adepeju Esther Onasanya, Iris Eisenberg, Noa Wigoda, Simcha Yagel , et al. · 2018

Endothelin-2 (EDN2), expressed at a narrow window during the periovulatory period, critically affects ovulation and corpus luteum (CL) formation. LH (acting mainly via cAMP) and hypoxia are implicated in CL formation; therefore, we aimed t…

Random start ovarian stimulation for fertility preservation appears unlikely to delay initiation of neoadjuvant chemotherapy for breast cancer Open

Joseph M. Letourneau, Nikita Sinha, Kaitlyn Wald, Eve Harris, Molly M. Quinn , et al. · 2017

This study was supported by departmental research funding within the University of California, San Francisco Department of Obstetrics, Gynecology and Reproductive Sciences. There are no conflicts of interest to declare.

Is It Me or My Hormones? Neuroendocrine Activation Profiles to Visual Food Stimuli Across the Menstrual Cycle Open

Yardena Arnoni-Bauer, Atira Bick, Noa Raz, Tal Imbar, Shoshana Amos , et al. · 2017

Hormonal mechanisms affect the responses of women's homeostatic, emotional, and attentional brain regions to food cues. The relation of these findings to eating behavior throughout the cycle needs further investigation.

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