Tal Patalon
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View article: Integrating Genetic Information into the Electronic Health Record: The Case of Adolescents’ Revelation of Misattributed Parentage
Integrating Genetic Information into the Electronic Health Record: The Case of Adolescents’ Revelation of Misattributed Parentage Open
In the near future, the electronic health record (EHR) is likely to include patients’ genetic information, in addition to other clinical information and administrative data. This warrants some preparatory thought. Presently, in many jurisd…
View article: Mean platelet volume and long-term cardiovascular outcomes in patients with type 2 diabetes mellitus
Mean platelet volume and long-term cardiovascular outcomes in patients with type 2 diabetes mellitus Open
View article: Treatment disparities and prognostic implications in octogenarians versus non-octogenarians with high-gradient severe aortic stenosis
Treatment disparities and prognostic implications in octogenarians versus non-octogenarians with high-gradient severe aortic stenosis Open
Background Aortic valve replacement (AVR) is considered one of the most potent disease-modifying procedures among patients with severe aortic stenosis (sAS). Accordingly, we have witnessed a consistent increase in the procedure rates in re…
View article: Observed-to-Expected Fetal Losses Following mRNA COVID-19 Vaccination in Early Pregnancy
Observed-to-Expected Fetal Losses Following mRNA COVID-19 Vaccination in Early Pregnancy Open
Background The clinical trials used to approve COVID-19 vaccines excluded pregnant women, and existing safety assessments of COVID-19 vaccination, particularly during early stages of pregnancy, are limited to observational studies prone to…
View article: Early-Life Exposure to Acid-Suppressive Therapy and the Development of Celiac Disease Autoimmunity
Early-Life Exposure to Acid-Suppressive Therapy and the Development of Celiac Disease Autoimmunity Open
Importance Early-life use of acid-suppressive therapy has increased over the past 2 decades. Although these medications are widely used, recent studies showed an association between early-life use of acid-suppressive therapy and various lo…
View article: Data from Strength in Numbers: Identifying a Significant Association between High Serum Ferritin Levels and Newly Diagnosed Malignancy in a Large Health Organization Cohort
Data from Strength in Numbers: Identifying a Significant Association between High Serum Ferritin Levels and Newly Diagnosed Malignancy in a Large Health Organization Cohort Open
Background:Ferritin, an iron storage protein and acute phase reactant, has been implicated in various aspects of human health and disease, including cancer. Previous studies have identified elevated serum ferritin (SF) levels in several ca…
View article: Table S3 - Bias in SF testing from Strength in Numbers: Identifying a Significant Association between High Serum Ferritin Levels and Newly Diagnosed Malignancy in a Large Health Organization Cohort
Table S3 - Bias in SF testing from Strength in Numbers: Identifying a Significant Association between High Serum Ferritin Levels and Newly Diagnosed Malignancy in a Large Health Organization Cohort Open
Comparison of MHS members who did or did not perform SF test, based on synthetic data of members who performed lab tests in 2016
View article: Table S1 - Sub-group Definition from Strength in Numbers: Identifying a Significant Association between High Serum Ferritin Levels and Newly Diagnosed Malignancy in a Large Health Organization Cohort
Table S1 - Sub-group Definition from Strength in Numbers: Identifying a Significant Association between High Serum Ferritin Levels and Newly Diagnosed Malignancy in a Large Health Organization Cohort Open
Detail on the different malignancies defining each sub-group used in the study
View article: Table S2 - Confounder ICD Codes from Strength in Numbers: Identifying a Significant Association between High Serum Ferritin Levels and Newly Diagnosed Malignancy in a Large Health Organization Cohort
Table S2 - Confounder ICD Codes from Strength in Numbers: Identifying a Significant Association between High Serum Ferritin Levels and Newly Diagnosed Malignancy in a Large Health Organization Cohort Open
ICD codes used in the study as confounding variables for the connection between SF and malignancy
View article: Table S5 - Sensitivity Analysis from Strength in Numbers: Identifying a Significant Association between High Serum Ferritin Levels and Newly Diagnosed Malignancy in a Large Health Organization Cohort
Table S5 - Sensitivity Analysis from Strength in Numbers: Identifying a Significant Association between High Serum Ferritin Levels and Newly Diagnosed Malignancy in a Large Health Organization Cohort Open
SF sensitivity analysis for the diagnosis of cancer
View article: Table S4 - Corrected p-values from Strength in Numbers: Identifying a Significant Association between High Serum Ferritin Levels and Newly Diagnosed Malignancy in a Large Health Organization Cohort
Table S4 - Corrected p-values from Strength in Numbers: Identifying a Significant Association between High Serum Ferritin Levels and Newly Diagnosed Malignancy in a Large Health Organization Cohort Open
FDR-Adjusted p values of subgroup analysis
View article: A machine learning tool for early identification of celiac disease autoimmunity
A machine learning tool for early identification of celiac disease autoimmunity Open
View article: Revealing misattributed parentage through the integration of genetic information into the electronic health record
Revealing misattributed parentage through the integration of genetic information into the electronic health record Open
The integration of genetic information (GI) into the electronic health record (EHR) seems inevitable as the mainstreaming of genomics continues. Such newly provided accessibility to GI could be beneficial for improving health care, as well…
View article: Changes in behavior and biomarkers during the diagnostic decision period for COVID-19, influenza, and group A streptococcus (GAS): a two-year prospective cohort study in Israel
Changes in behavior and biomarkers during the diagnostic decision period for COVID-19, influenza, and group A streptococcus (GAS): a two-year prospective cohort study in Israel Open
This work was supported by the European Research Council, project #949850, the Israel Science Foundation (ISF), grant No. 3409/19, within the Israel Precision Medicine Partnership program, and a Koret Foundation gift for Smart Cities and D…
View article: Vitamin D supplement for patients with early-stage chronic lymphocytic leukemia is associated with a longer time to first treatment
Vitamin D supplement for patients with early-stage chronic lymphocytic leukemia is associated with a longer time to first treatment Open
Low levels of vitamin D are associated with a shorter time to first treatment (TTFT) and inferior overall survival in patients with chronic lymphocytic leukemia (CLL). But whether vitamin D supplement affects the clinical course of patient…
View article: A Machine Learning Tool for Early Identification of Celiac Disease Autoimmunity
A Machine Learning Tool for Early Identification of Celiac Disease Autoimmunity Open
Identifying which patients should undergo serologic screening for celiac disease (CD) may help diagnose patients who otherwise often experience diagnostic delays or remain undiagnosed. Using anonymized outpatient data from the electronic m…
View article: From Exposure to Detection: Unraveling the Digital Signature of Infectious Diseases and Patient Behavior Using Smartwatches and Patient Self-Reporting
From Exposure to Detection: Unraveling the Digital Signature of Infectious Diseases and Patient Behavior Using Smartwatches and Patient Self-Reporting Open
View article: P459 The prevalence and characteristics of inflammatory bowel disease-related ocular involvement in children
P459 The prevalence and characteristics of inflammatory bowel disease-related ocular involvement in children Open
Background Ocular manifestations (OM) in patients with inflammatory bowel disease (IBD) are uncommon, particularly in children. We aimed to explore the prevalence, characteristics and risk factors of IBD associated OM in a large epidemiolo…
View article: An Outbreak of Parvovirus B19 in Israel
An Outbreak of Parvovirus B19 in Israel Open
Human parvovirus B19 (B19V) has a wide clinical spectrum, ranging from an asymptomatic infection to a life threatening one. During pregnancy, it can lead to fetal loss and hydrops fetalis. This retrospective study examined the incidence ra…
View article: Whole exome germline sequencing in early‐onset prostate cancer patients: Genomic findings and clinical outcomes
Whole exome germline sequencing in early‐onset prostate cancer patients: Genomic findings and clinical outcomes Open
Background Whole exome sequencing (WES) furthered our understanding of various tumors. We assessed the occurrence of germline likely pathogenic/pathogenic (LP/P) variants, disease features, and clinical outcomes in early‐onset prostate can…
View article: BNT162b2 mRNA COVID-19 Vaccine Effectiveness in Patients with Coeliac Disease Autoimmunity: Real-World Data from Mass Vaccination Campaign
BNT162b2 mRNA COVID-19 Vaccine Effectiveness in Patients with Coeliac Disease Autoimmunity: Real-World Data from Mass Vaccination Campaign Open
Background: Data on COVID-19 vaccine effectiveness among patients with coeliac disease are currently lacking because patients with immune conditions were excluded from clinical trials. We used our coeliac disease autoimmunity (CDA) cohort …
View article: P652: IMPROVED SURVIVAL OF PATIENTS WITH CHRONIC LYMPHOCYTIC LEUKEMIA BETWEEN 1998-2022, INCLUDING THE ERA OF TARGET THERAPIES WITH BCL2 AND BTK INHIBITORS.
P652: IMPROVED SURVIVAL OF PATIENTS WITH CHRONIC LYMPHOCYTIC LEUKEMIA BETWEEN 1998-2022, INCLUDING THE ERA OF TARGET THERAPIES WITH BCL2 AND BTK INHIBITORS. Open
Background: The treatment for Chronic Lymphocytic Leukemia (CLL) has undergone significant changes over the past two decades. Initially, chemotherapy was the primary treatment, it was later replaced by chemo-immunotherapy, and more recentl…
View article: P1532: CLINICAL OUTCOMES OF COVID-19 IN MYCOSIS FUNGOIDES AND SEZARY SYNDROME (MF/SS)
P1532: CLINICAL OUTCOMES OF COVID-19 IN MYCOSIS FUNGOIDES AND SEZARY SYNDROME (MF/SS) Open
Topic: 30. Infections in hematology (incl. supportive care/therapy) Background: Between 2020 and 2022, COVID-19 affected more than 70% of the Israeli population. It is now well known that haemato-oncologic patients are more susceptible to …
View article: The course of patients with hairy cell leukemia during the omicron surge of the Covid‐19 pandemic
The course of patients with hairy cell leukemia during the omicron surge of the Covid‐19 pandemic Open
In this study, we aim to explore the outcomes of Covid‐19 infection in patients with Hairy cell leukemia (HCL). The cohort is based on data obtained from electronic medical records. It includes 218 consecutive patients diagnosed with HCL b…
View article: Mpox Patient Journey in Israel
Mpox Patient Journey in Israel Open
Reports on Mpox have, thus far, characterized the disease, but mostly through a single timepoint view. The aim of this study was to characterize Mpox in the Israeli setting, in general, alongside compiling a detailed patient journey from m…
View article: Hybrid immunity against reinfection with SARS-CoV-2 following a previous SARS-CoV-2 infection and single dose of the BNT162b2 vaccine in children and adolescents: a target trial emulation
Hybrid immunity against reinfection with SARS-CoV-2 following a previous SARS-CoV-2 infection and single dose of the BNT162b2 vaccine in children and adolescents: a target trial emulation Open
View article: Immunosuppression as a Hub for SARS-CoV-2 Mutational Drift
Immunosuppression as a Hub for SARS-CoV-2 Mutational Drift Open
The clinical course of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), is largely determined by host factors, with a wide range of outcomes. Despite an extensive vaccination camp…
View article: Dynamics of Naturally Acquired Immunity Against Severe Acute Respiratory Syndrome Coronavirus 2 in Children and Adolescents
Dynamics of Naturally Acquired Immunity Against Severe Acute Respiratory Syndrome Coronavirus 2 in Children and Adolescents Open
View article: The Effectiveness of Bivalent mRNA Omicron Containing Booster Vaccines Among Patients with Hematological Neoplasms
The Effectiveness of Bivalent mRNA Omicron Containing Booster Vaccines Among Patients with Hematological Neoplasms Open
View article: Clinical Outcomes of COVID-19 in Mycosis Fungoides and Sezary Syndrome
Clinical Outcomes of COVID-19 in Mycosis Fungoides and Sezary Syndrome Open
Introduction: Haemato-oncologic patients are more susceptible to severe infections with SARS-CoV-2. We aimed to assess the clinical outcomes of SARS-CoV-2 infection among patients with Mycosis Fungoides and Sezary Syndrome (M…