Explanipedia

<b>Gestational Diabetes Mellitus Alters Placental Pre-mRNA Splicing</b> Open

Eden Engal, A. A. Gershon, Aveksha Sharma, Hadas Ner‐Gaon, Yuval Nevo , et al. · 2025

Gestational diabetes mellitus (GDM) is defined as hyperglycemia first identified during pregnancy and can lead to adverse maternal and neonatal outcomes. The molecular mechanisms leading to these outcomes are currently poorly understood. W…

<b>Gestational Diabetes Mellitus Alters Placental Pre-mRNA Splicing</b> Open

Eden Engal, Aveksha Sharma, Gillian Kay, Ralf Dechend, Tal Shay · 2025

Gestational diabetes mellitus (GDM) is defined as hyperglycemia first identified during pregnancy and can lead to adverse maternal and neonatal outcomes. The molecular mechanisms leading to these outcomes are currently poorly understood. W…

The essential integration of sex and gender in immunological research Open

Marcus Altfeld, Camila Rosat Consiglio, Duffy Darragh, Molly A. Ingersoll, Cliona O’Farrelly , et al. · 2025

Comparison and development of cross-study normalization methods for inter-species transcriptional analysis Open

Sofya Feldman, Hadas Ner‐Gaon, Eran Treister, Tal Shay · 2024

Performing joint analysis of gene expression datasets from different experiments can present challenges brought on by multiple factors—differences in equipment, protocols, climate etc. “Cross-study normalization” is a general term for tran…

Microheterogeneity in the Kinetics and Sex-Specific Response to Type I IFN Open

Shani T. Gal-Oz, Alev Baysoy, Brinda Vijaykumar, Sara Mostafavi, Christophe Benoist , et al. · 2024

The response to type I IFNs involves the rapid induction of prototypical IFN signature genes (ISGs). It is not known whether the tightly controlled ISG expression observed at the cell population level correctly represents the coherent resp…

A telencephalon cell type atlas for goldfish reveals diversity in the evolution of spatial structure and cell types Open

Muhammad Tibi, Stav Biton Hayun, Hannah Hochgerner, Zhige Lin, Shachar Givon , et al. · 2023

Teleost fish form the largest group of vertebrates and show a tremendous variety of adaptive behaviors, making them critically important for the study of brain evolution and cognition. The neural basis mediating these behaviors remains elu…

Mapping the splicing landscape of the human immune system Open

Hadas Ner‐Gaon, Ronnie Peleg, Roi Gazit, Anat Reiner‐Benaim, Tal Shay · 2023

Most human genes code for more than one transcript. Different ratios of transcripts of the same gene can be found in different cell types or states, indicating differential use of transcription start sites or differential splicing. Such di…

Characterization of the Environmental Plasmidome of the Red Sea Open

Lucy Androsiuk, Tal Shay, S. Tal · 2023

Marine plasmids are understudied and hence underrepresented in databases. Plasmid functional annotation and characterization is complicated but, if successful, may provide a pool of novel genes and unknown functions. Newly discovered plasm…

A telencephalon cell type atlas for goldfish reveals diversity in the evolution of spatial structure and cell types Open

Muhammad Tibi, Stav Biton, Hannah Hochgerner, Zhige Lin, Shachar Givon , et al. · 2023

Teleost fish form the largest group of vertebrates, making them critically important for the study on the mechanisms of brain evolution. In fact, teleosts show a tremendous variety of adaptive behaviors similar to birds and mammals, howeve…

Supplementary Data from Adhesive Interactions Regulate Transcriptional Diversity in Malignant B Cells Open

Liat Nadav-Dagan, Tal Shay, Nili Dezorella, Elizabeth Naparstek, Eytan Domany , et al. · 2023

Supplementary Data from Adhesive Interactions Regulate Transcriptional Diversity in Malignant B Cells

Supplementary Data from Adhesive Interactions Regulate Transcriptional Diversity in Malignant B Cells Open

Liat Nadav-Dagan, Tal Shay, Nili Dezorella, Elizabeth Naparstek, Eytan Domany , et al. · 2023

Supplementary Data from Adhesive Interactions Regulate Transcriptional Diversity in Malignant B Cells

Data from Adhesive Interactions Regulate Transcriptional Diversity in Malignant B Cells Open

Liat Nadav-Dagan, Tal Shay, Nili Dezorella, Elizabeth Naparstek, Eytan Domany , et al. · 2023

The genetic profiling of B-cell malignancies is rapidly expanding, providing important information on the tumorigenic potential, response to treatment, and clinical outcome of these diseases. However, the relative contributions of inherent…

Data from Adhesive Interactions Regulate Transcriptional Diversity in Malignant B Cells Open

Liat Nadav-Dagan, Tal Shay, Nili Dezorella, Elizabeth Naparstek, Eytan Domany , et al. · 2023

The genetic profiling of B-cell malignancies is rapidly expanding, providing important information on the tumorigenic potential, response to treatment, and clinical outcome of these diseases. However, the relative contributions of inherent…

The interweaved signatures of common-gamma-chain cytokines across immunologic lineages Open

Alev Baysoy, Kumba Seddu, Tamara Salloum, Caleb A. Dawson, Juliana J. Lee , et al. · 2023

“γc” cytokines are a family whose receptors share a “common-gamma-chain” signaling moiety, and play central roles in differentiation, homeostasis, and communications of all immunocyte lineages. As a resource to better understand their rang…

The transcriptional landscape of the giant freshwater prawn: Embryonic development and early sexual differentiation mechanisms Open

Nufar Grinshpan, Faiza Amterat Abu Abayed, Melody Wahl, Hadas Ner‐Gaon, Rivka Manor , et al. · 2022

The giant freshwater prawn pj Macrobrachium rosenbergii is one of the best studied species in aquaculture. However, the transcriptional changes associated with embryonic development and the sexual differentiation mechanism of M. rosenbergi…

Immune Sexual Dimorphism: Connecting the Dots Open

Shani T. Gal-Oz, Tal Shay · 2021

Despite numerous studies of immune sexual dimorphism, sexual differences are not rigorously mapped and dimorphic mechanisms are incompletely understood. Current immune research typically studies sex differences in specific cells, tissues, …

A microRNA expression and regulatory element activity atlas of the mouse immune system Open

Samuel A. Rose, Aleksandra Wroblewska, Maxime Dhainaut, Hideyuki Yoshida, Jonathan M. Shaffer , et al. · 2021

The neutrotime transcriptional signature defines a single continuum of neutrophils across biological compartments Open

Ricardo Grieshaber‐Bouyer, Felix A. Radtke, Pierre Cunin, Giuseppina Stifano, Anaïs Levescot , et al. · 2021

DoChaP: the domain change presenter Open

Shani T. Gal-Oz, Nimrod Haiat, Dana Eliyahu, Guy Shani, Tal Shay · 2021

Alternative splicing results in multiple transcripts of the same gene, possibly encoding for different protein isoforms with different domains. Whereas it is possible to manually determine the effect of alternative splicing on the domain c…

Gut CD4+ T cell phenotypes are a continuum molded by microbes, not by TH archetypes Open

Evgeny Kiner, Elijah Willie, Brinda Vijaykumar, Kaitavjeet Chowdhary, Hugo Schmutz , et al. · 2021

DoChaP: The Domain Change Presenter Open

Shani T. Gal-Oz, Nimrod Haiat, Dana Eliyahu, Guy Shani, Tal Shay · 2020

Alternative RNA splicing results in multiple transcripts of the same gene, possibly encoding for different protein isoforms with different protein domains and functionalities. Whereas it is possible to manually determine the effect of a sp…

Post-sepsis immunosuppression depends on NKT cell regulation of mTOR/IFN-γ in NK cells Open

Edy Y. Kim, Hadas Ner‐Gaon, Jack Varon, Aidan M. Cullen, Jingyu Guo , et al. · 2020

As treatment of the early, inflammatory phase of sepsis improves, post-sepsis immunosuppression and secondary infection have increased in importance. How early inflammation drives immunosuppression remains unclear. Although IFN-γ typically…

ImmGen report: sexual dimorphism in the immune system transcriptome Open

Shani T. Gal-Oz, Bárbara Maier, Hideyuki Yoshida, Kumba Seddu, Nitzan Elbaz , et al. · 2019

Author Correction: γδ T cells producing interleukin-17A regulate adipose regulatory T cell homeostasis and thermogenesis Open

Ayano C. Kohlgruber, Shani T. Gal-Oz, Nelson M. LaMarche, Moto Shimazaki, Danielle Duquette , et al. · 2019

Correction: CaSTLe - Classification of single cells by transfer learning: Harnessing the power of publicly available single cell RNA sequencing experiments to annotate new experiments Open

Yuval Lieberman, Lior Rokach, Tal Shay · 2018

[This corrects the article DOI: 10.1371/journal.pone.0205499.].

CaSTLe – Classification of single cells by transfer learning: Harnessing the power of publicly available single cell RNA sequencing experiments to annotate new experiments Open

Yuval Lieberman, Lior Rokach, Tal Shay · 2018

Single-cell RNA sequencing (scRNA-seq) is an emerging technology for profiling the gene expression of thousands of cells at the single cell resolution. Currently, the labeling of cells in an scRNA-seq dataset is performed by manually chara…

γδ T cells producing interleukin-17A regulate adipose regulatory T cell homeostasis and thermogenesis Open

Ayano C. Kohlgruber, Shani T. Gal-Oz, Nelson M. LaMarche, Moto Shimazaki, Danielle Duquette , et al. · 2018

Conservation and divergence in modules of the transcriptional programs of the human and mouse immune systems Open

Tal Shay, Vladimir Jojic, Or Zuk, Christophe Benoist, Daphne Koller , et al. · 2018

Studies in mouse have shed important light on human hematopoietic differentiation and disease. However, substantial differences between the two species often limit the translation of findings from mouse to human. Here, we compare previousl…

Salient experiences are represented by unique transcriptional signatures in the mouse brain Open

Diptendu Mukherjee, Bogna M. Ignatowska‐Jankowska, Eyal Itskovits, Ben J. Gonzales, Hagit Turm , et al. · 2018

It is well established that inducible transcription is essential for the consolidation of salient experiences into long-term memory. However, whether inducible transcription relays information about the identity and affective attributes of…

Author response: Salient experiences are represented by unique transcriptional signatures in the mouse brain Open

Diptendu Mukherjee, Bogna M. Ignatowska‐Jankowska, Eyal Itskovits, Ben J. Gonzales, Hagit Turm , et al. · 2018

Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods References Decision letter Author response Article and author information Metrics Abstract It is well established that inducible transcrip…

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