Talia Hatkevich
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View article: Gonadal sex and temperature independently influence germ cell differentiation and meiotic progression in <i>Trachemys scripta</i>
Gonadal sex and temperature independently influence germ cell differentiation and meiotic progression in <i>Trachemys scripta</i> Open
In species with genetic sex determination (GSD), the sex identity of the soma determines germ cell fate. For example, in mice, XY germ cells that enter an ovary differentiate as oogonia, whereas XX germ cells that enter a testis initiate d…
View article: The RNA binding protein DND1 is elevated in a subpopulation of pro-spermatogonia and targets chromatin modifiers and translational machinery during late gestation
The RNA binding protein DND1 is elevated in a subpopulation of pro-spermatogonia and targets chromatin modifiers and translational machinery during late gestation Open
DND1 is essential to maintain germ cell identity. Loss of Dnd1 function results in germ cell differentiation to teratomas in some inbred strains of mice or to somatic fates in zebrafish. Using our knock-in mouse line in which a functional …
View article: A pathway for error-free non-homologous end joining of resected meiotic double-strand breaks
A pathway for error-free non-homologous end joining of resected meiotic double-strand breaks Open
Programmed DNA double-strand breaks (DSBs) made during meiosis are repaired by recombination with the homologous chromosome to generate, at selected sites, reciprocal crossovers that are critical for the proper separation of homologs in th…
View article: Metazoan tRNA introns generate stable circular RNAs in vivo
Metazoan tRNA introns generate stable circular RNAs in vivo Open
We report the discovery of a class of abundant circular noncoding RNAs that are produced during metazoan tRNA splicing. These transcripts, termed tRNA intronic circular (tric)RNAs, are conserved features of animal transcriptomes. Biogenesi…
View article: A pathway for error-free non-homologous end joining of resected meiotic double-strand breaks
A pathway for error-free non-homologous end joining of resected meiotic double-strand breaks Open
Programmed DNA double-strand breaks (DSBs) made during meiosis are repaired by recombination with the homologous chromosome to generate, at selected sites, reciprocal crossovers that are critical for the proper separation of homologs in th…
View article: Bloom Syndrome Helicase Promotes Meiotic Crossover Patterning and Homolog Disjunction
Bloom Syndrome Helicase Promotes Meiotic Crossover Patterning and Homolog Disjunction Open
In most sexually reproducing organisms, crossover formation between homologous chromosomes is necessary for proper chromosome disjunction during meiosis I. During meiotic recombination, a subset of programmed DNA double-strand breaks (DSBs…
View article: Centromeric SMC1 promotes centromere clustering and stabilizes meiotic homolog pairing
Centromeric SMC1 promotes centromere clustering and stabilizes meiotic homolog pairing Open
During meiosis, each chromosome must selectively pair and synapse with its own unique homolog to enable crossover formation and subsequent segregation. How homolog pairing is maintained in early meiosis to ensure synapsis occurs exclusivel…
View article: Meiotic MCM Proteins Promote and Inhibit Crossovers During Meiotic Recombination
Meiotic MCM Proteins Promote and Inhibit Crossovers During Meiotic Recombination Open
Crossover formation as a result of meiotic recombination is vital for the proper segregation of homologous chromosomes at the end of meiosis I. In many organisms, crossovers are generated through two crossover pathways: Class I and Class I…
View article: Centromere clustering stabilizes meiotic homolog pairing
Centromere clustering stabilizes meiotic homolog pairing Open
During meiosis, each chromosome must selectively pair and synapse with its own unique homolog to enable crossover formation and subsequent segregation. How homolog pairing is maintained in early meiosis to ensure synapsis occurs exclusivel…
View article: Meiotic MCM proteins promote and inhibit crossovers during meiotic recombination
Meiotic MCM proteins promote and inhibit crossovers during meiotic recombination Open
Crossover formation as a result of meiotic recombination is vital for proper segregation of homologous chromosomes at the end of meiosis I. In many organisms, crossovers are generated through two crossover pathways: Class I and Class II. T…
View article: Bloom syndrome helicase in meiosis: Pro‐crossover functions of an anti‐crossover protein
Bloom syndrome helicase in meiosis: Pro‐crossover functions of an anti‐crossover protein Open
The functions of the Bloom syndrome helicase (BLM) and its orthologs are well characterized in mitotic DNA damage repair, but their roles within the context of meiotic recombination are less clear. In meiotic recombination, multiple repair…
View article: Naringenin Inhibits Proliferation and Survival of Tamoxifen‐ Resistant Breast Cancer Cells
Naringenin Inhibits Proliferation and Survival of Tamoxifen‐ Resistant Breast Cancer Cells Open
The majority of breast cancers are estrogen receptor positive (ER+) and utilize estrogen to promote cell proliferation. Thus, the ER has been the target of many therapies. While this strategy has been successful, the long‐term use of antie…
View article: Metazoan tRNA introns generate stable circular RNAs in vivo
Metazoan tRNA introns generate stable circular RNAs in vivo Open
We report the discovery of a class of abundant circular noncoding RNAs that are produced during metazoan tRNA splicing. These transcripts, termed tRNA intronic circular (tric)RNAs, are conserved features of animal transcriptomes. Biogenesi…