Túlio M. Lima
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View article: A Thermostable nasal spray dried COVID vaccine candidate
A Thermostable nasal spray dried COVID vaccine candidate Open
A nasal dry powder adjuvanted subunit COVID vaccine candidate was manufactured via spray drying and evaluated for physicochemical stability and aerosol performance over the course of 10 months under accelerated conditions. A nanoliposomal …
View article: Clinical characteristics of 2025 Chikungunya outbreak in Chattogram, Bangladesh
Clinical characteristics of 2025 Chikungunya outbreak in Chattogram, Bangladesh Open
Introduction and Objectives Chikungunya fever became as a major outbreak in the year 2025 in Chattogram, Bangladesh. Objectives of the present study is to document the clinical profile of the Chikungunya affected patients in Chattogram, Ba…
View article: UM ESTUDO DOS DESAFIOS E DO POTENCIAL DE APRENDIZAGEM SIGNIFICATIVA DE GRADUANDOS EM ADMINISTRAÇÃO DURANTE A PANDEMIA DO CORONAVÍRUS
UM ESTUDO DOS DESAFIOS E DO POTENCIAL DE APRENDIZAGEM SIGNIFICATIVA DE GRADUANDOS EM ADMINISTRAÇÃO DURANTE A PANDEMIA DO CORONAVÍRUS Open
A partir da análise do processo de adaptação de graduandos de uma Universidade Federal brasileira durante o período de migração de um ensino cem por cento presencial para um ensino cem por cento remoto durante a pandemia do coronavírus e, …
View article: Events supposedly attributable to vaccination or immunization of COVID-19 vaccines in Brazil: a cross-sectional study
Events supposedly attributable to vaccination or immunization of COVID-19 vaccines in Brazil: a cross-sectional study Open
COVID-19 vaccines effectively reduce morbidity and mortality but are associated with Events Supposedly Attributable to Vaccination or Immunization (ESAVI). This cross-sectional study examined the incidence and characteristics of ESAVI in B…
View article: A Thermostable Nasal Spray Dried Covid Vaccine Candidate
A Thermostable Nasal Spray Dried Covid Vaccine Candidate Open
View article: Exploring Photobiomodulation Therapy for Long COVID Xerostomia: A Randomized Controlled Pilot Trial
Exploring Photobiomodulation Therapy for Long COVID Xerostomia: A Randomized Controlled Pilot Trial Open
Aims: To investigate the effects of a photobiomodulation protocol in the treatment of long COVID-19 xerostomia Study Design: This is a single-center, randomized, controlled, double-blind pilot clinical trial. Methodology: 10 patients with …
View article: Efeitos vasomotores do vírus da dengue em pediatria: um relato de caso
Efeitos vasomotores do vírus da dengue em pediatria: um relato de caso Open
Introdução: Dengue é uma das doenças virais mais prevalentes em todo o mundo, representando um desafio significativo para a saúde pública, especialmente em regiões tropicais. Objetivos: realizar uma revisão sistemática da literatura dos úl…
View article: Mental Health, the COVID-19 Pandemic and Social Inequalities: An Integrative Review
Mental Health, the COVID-19 Pandemic and Social Inequalities: An Integrative Review Open
View article: Antibody response and soluble mediator profile in the first six months following acute SARS-CoV-2 infection
Antibody response and soluble mediator profile in the first six months following acute SARS-CoV-2 infection Open
The COVID-19 pandemic has caused a severe global health and economic crisis, with significant consequences for human mortality and morbidity. Therefore, there is an urgent need for more studies on the immune response to SARS-CoV-2 infectio…
View article: SARS-CoV-2 Nosocomial Outbreak in Campinas City, Brazil
SARS-CoV-2 Nosocomial Outbreak in Campinas City, Brazil Open
Coronavirus disease (COVID-19) caused by Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a cause of concern in the hospital environment due to nosocomial transmission among healthcare workers (HCWs) and patients. During the…
View article: Conformational stability of SARS-CoV-2 glycoprotein spike variants
Conformational stability of SARS-CoV-2 glycoprotein spike variants Open
The severe acute respiratory syndrome spread worldwide, causing a pandemic. SARS-CoV-2 mutations have arisen in the spike, a glycoprotein at the viral envelope and an antigenic candidate for vaccines against COVID-19. Here, we present comp…
View article: Intradermal Immunization of SARS-CoV-2 Original Strain Trimeric Spike Protein Associated to CpG and AddaS03 Adjuvants, but Not MPL, Provide Strong Humoral and Cellular Response in Mice
Intradermal Immunization of SARS-CoV-2 Original Strain Trimeric Spike Protein Associated to CpG and AddaS03 Adjuvants, but Not MPL, Provide Strong Humoral and Cellular Response in Mice Open
Despite the intramuscular route being the most used vaccination strategy against SARS-CoV-2, the intradermal route has been studied around the globe as a strong candidate for immunization against SARS-CoV-2. Adjuvants have shown to be esse…
View article: From a recombinant key antigen to an accurate, affordable serological test: Lessons learnt from COVID-19 for future pandemics
From a recombinant key antigen to an accurate, affordable serological test: Lessons learnt from COVID-19 for future pandemics Open
View article: Immunogenicity of SARS-CoV-2 Trimeric Spike Protein Associated to Poly(I:C) Plus Alum
Immunogenicity of SARS-CoV-2 Trimeric Spike Protein Associated to Poly(I:C) Plus Alum Open
The SARS-CoV-2 pandemic has had a social and economic impact worldwide, and vaccination is an efficient strategy for diminishing those damages. New adjuvant formulations are required for the high vaccine demands, especially adjuvant formul…
View article: Immunogenicity, Effectiveness, and Safety of Inactivated Virus (CoronaVac) Vaccine in a Two-Dose Primary Protocol and BNT162b2 Heterologous Booster in Brazil (Immunita-001): A One Year Period Follow Up Phase 4 Study
Immunogenicity, Effectiveness, and Safety of Inactivated Virus (CoronaVac) Vaccine in a Two-Dose Primary Protocol and BNT162b2 Heterologous Booster in Brazil (Immunita-001): A One Year Period Follow Up Phase 4 Study Open
Background Effective and safe vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are critical to controlling the COVID-19 pandemic and will remain the most important tool in limiting the spread of the virus long …
View article: Uncovering the structural flexibility of SARS-CoV-2 glycoprotein spike variants
Uncovering the structural flexibility of SARS-CoV-2 glycoprotein spike variants Open
The severe acute respiratory syndrome CoV-2 rapidly spread worldwide, causing a pandemic. After a period of evolutionary stasis, a set of SARS-CoV-2 mutations has arisen in the spike, the leading glycoprotein at the viral envelope and the …
View article: Immunogenicity, Effectiveness, and Safety of Inactivated Virus (CoronaVac) Vaccine in a Two-Dose Primary Protocol and BNT162b2 Heterologous Booster in Brazil (Immunita-001): A One Year Period Follow Up Phase 4 Study
Immunogenicity, Effectiveness, and Safety of Inactivated Virus (CoronaVac) Vaccine in a Two-Dose Primary Protocol and BNT162b2 Heterologous Booster in Brazil (Immunita-001): A One Year Period Follow Up Phase 4 Study Open
View article: Polyclonal F(ab’)2 fragments of equine antibodies raised against the spike protein neutralize SARS-CoV-2 variants with high potency
Polyclonal F(ab’)2 fragments of equine antibodies raised against the spike protein neutralize SARS-CoV-2 variants with high potency Open
We used the recombinant trimeric spike (S) glycoprotein in the prefusion conformation to immunize horses for the production of hyperimmune globulins against SARS-CoV-2. Serum antibody titers measured by ELISA were above 1:106, a…
View article: Development and Large-Scale Validation of A Highly Accurate SARS-COV-2 Serological Test Using Regular Test Strips for Autonomous and Affordable Finger-Prick Sample Collection, Transportation, and Storage
Development and Large-Scale Validation of A Highly Accurate SARS-COV-2 Serological Test Using Regular Test Strips for Autonomous and Affordable Finger-Prick Sample Collection, Transportation, and Storage Open
Accurate serological tests are essential tools to allow adequate monitoring and control of COVID-19 spread. Production of a low-cost and high-quality recombinant viral antigen can enable the development of reliable and affordable serologic…
View article: The immunodominant antibody response to Zika virus NS1 protein is characterized by cross-reactivity to self
The immunodominant antibody response to Zika virus NS1 protein is characterized by cross-reactivity to self Open
Besides antigen-specific responses to viral antigens, humoral immune response in virus infection can generate polyreactive and autoreactive antibodies. Dengue and Zika virus infections have been linked to antibody-mediated autoimmune disor…
View article: Polyclonal F(ab’) <sub>2</sub> Fragments of Equine Antibodies Raised Against Recombinant SARS-CoV-2 Spike Protein Neutralize the P.1 and P.2 Strains with High Potency
Polyclonal F(ab’) <sub>2</sub> Fragments of Equine Antibodies Raised Against Recombinant SARS-CoV-2 Spike Protein Neutralize the P.1 and P.2 Strains with High Potency Open
View article: Sustained antibody response to ZIKV infection induced by NS1 protein is accompanied by the progressive appearance of autoreactive antibodies and cross-reactive B cell clones
Sustained antibody response to ZIKV infection induced by NS1 protein is accompanied by the progressive appearance of autoreactive antibodies and cross-reactive B cell clones Open
Besides antigen-specific responses to viral antigens, humoral immune response in virus infection can generate polyreactive and autoreactive antibodies. Dengue and Zika virus infections have been linked to antibody-mediated autoimmune disor…
View article: Production of yellow fever VLPs by perfusion cultivation of stable recombinant HEK293 cells
Production of yellow fever VLPs by perfusion cultivation of stable recombinant HEK293 cells Open
Yellow fever (YF) is a life-threatening viral disease endemic in large areas of Africa and Latin America. Although there is a very efficacious vaccine since the 1930s, YF still causes 29,000-60,000 annual deaths. During recent YF outbreaks…
View article: Potent neutralizing equine antibodies raised against recombinant SARS-CoV-2 spike protein for COVID-19 passive immunization therapy
Potent neutralizing equine antibodies raised against recombinant SARS-CoV-2 spike protein for COVID-19 passive immunization therapy Open
We used the trimeric spike (S) glycoprotein (residues 1-1208) in the prefusion conformation to immunize horses for production of hyperimmune globulins against SARS-CoV-2. Serum antibody titers measured by anti-spike ELISA were above 1:1,00…
View article: Development and large-scale validation of a highly accurate SARS-COV-2 serological test using regular test strips for autonomous and affordable finger-prick sample collection, transportation, and storage
Development and large-scale validation of a highly accurate SARS-COV-2 serological test using regular test strips for autonomous and affordable finger-prick sample collection, transportation, and storage Open
Accurate serological tests are essential tools to allow adequate monitoring and control of COVID-19 spread. Production of a low-cost and high-quality recombinant viral antigen can enable the development of reliable and affordable serologic…
View article: An Affordable Anti-SARS-COV-2 Spike Protein Elisa Test for Early Detection of IgG Seroconversion Suited for Large-Scale Surveillance Studies in Low-Income Countries
An Affordable Anti-SARS-COV-2 Spike Protein Elisa Test for Early Detection of IgG Seroconversion Suited for Large-Scale Surveillance Studies in Low-Income Countries Open
View article: Purification of flavivirus VLPs by a two-step chomatographic process
Purification of flavivirus VLPs by a two-step chomatographic process Open
Flaviviruses are enveloped viruses with positive-sense, single-stranded RNA, which are most commonly transmitted by infected mosquitoes. Zika virus (ZIKV) and yellow fever virus (YFV) are flaviviruses that have caused significant outbreaks…