Tamara Bucci
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View article: Schwann Cell Apoptosis in the Postnatal Axotomized Sciatic Nerve Is Mediated Via NGF through the Low-Affinity Neurotrophin Receptor
Schwann Cell Apoptosis in the Postnatal Axotomized Sciatic Nerve Is Mediated Via NGF through the Low-Affinity Neurotrophin Receptor Open
Schwann cell death is a developmentally regulated phenomenon and is also induced after peripheral nerve axotomy in neonatal rodents. In this study, we explored whether ligand-induced activation of the low-affinity neurotrophin receptor (p7…
View article: Induction of Postnatal Schwann Cell Death by the Low-Affinity Neurotrophin Receptor<i>In Vitro</i>and after Axotomy
Induction of Postnatal Schwann Cell Death by the Low-Affinity Neurotrophin Receptor<i>In Vitro</i>and after Axotomy Open
Schwann cells express the low-affinity neurotrophin receptor (p75), but no role for either the neurotrophins or their cognate receptors in Schwann cell development has been established. We have found that Schwann cells isolated from postna…
View article: Nerve Growth Factor Signaling through p75 Induces Apoptosis in Schwann Cells via a Bcl-2-Independent Pathway
Nerve Growth Factor Signaling through p75 Induces Apoptosis in Schwann Cells via a Bcl-2-Independent Pathway Open
Apoptosis is involved in the regulation of Schwann cell numbers during normal development and after axonal damage, but the molecular regulation of Schwann cell death remains unknown. We have used stably transfected rat Schwann cell lines t…
View article: Ligand for EPH-related Kinase (LERK) 7 Is the Preferred High Affinity Ligand for the HEK Receptor
Ligand for EPH-related Kinase (LERK) 7 Is the Preferred High Affinity Ligand for the HEK Receptor Open
HEK is a member of the EPH-like receptor tyrosine kinase family, which appear to have roles in development and oncogenesis. Recently, we purified a soluble HEK ligand which is also a ligand (AL1) for the HEK-related receptor EHK1. Promiscu…