Tamara Pérez-Jeldres
YOU?
Author Swipe
View article: Prediction of Extraintestinal Manifestations in Inflammatory Bowel Disease Using Clinical and Genetic Variables with Machine Learning in a Latin IBD Group
Prediction of Extraintestinal Manifestations in Inflammatory Bowel Disease Using Clinical and Genetic Variables with Machine Learning in a Latin IBD Group Open
Extraintestinal manifestations (EIMs) significantly increase morbidity in inflammatory bowel disease (IBD) patients. In this study, we examined clinical and genetic factors associated with EIMs in 414 Latin IBD patients, utilizing machine …
View article: Impact of Amerindian ancestry on clinical outcomes in Crohn’s disease and ulcerative colitis in a Latino population
Impact of Amerindian ancestry on clinical outcomes in Crohn’s disease and ulcerative colitis in a Latino population Open
Research in Inflammatory Bowel Disease (IBD) assessing the genetic structure and its association with IBD phenotypes is needed, especially in IBD-underrepresented populations such as the South American IBD population. Aim. We examine the c…
View article: P1298 The Paradoxical Impact of Amerindian Ancestry on Clinical Phenotypes in Crohn’s Disease and Ulcerative Colitis: A Study in a South American Population
P1298 The Paradoxical Impact of Amerindian Ancestry on Clinical Phenotypes in Crohn’s Disease and Ulcerative Colitis: A Study in a South American Population Open
Background Inflammatory bowel disease (IBD) is on the rise in South America, but this population remains underrepresented in IBD genetic studies. Moreover, the genetic structure varies across South American countries, highlighting the need…
View article: P1297 Family History of Inflammatory Bowel Disease: Prevalence and Its Relationship with Clinical and Genetics Factors in Patients with Ulcerative Colitis and Crohn’s Disease in a SouthAmerican Cohort
P1297 Family History of Inflammatory Bowel Disease: Prevalence and Its Relationship with Clinical and Genetics Factors in Patients with Ulcerative Colitis and Crohn’s Disease in a SouthAmerican Cohort Open
Background Relatives of inflammatory bowel disease (IBD) patients have a higher risk of developing the condition than the general population. Approximately 12% of IBD cases are familial. We aim to evaluate the prevalence of family history …
View article: P1305 Prediction of extraintestinal manifestations in inflammatory bowel disease using clinical and genetic variables with machine learning
P1305 Prediction of extraintestinal manifestations in inflammatory bowel disease using clinical and genetic variables with machine learning Open
Background Patients with inflammatory bowel diseases (IBD) may develop extraintestinal manifestations (EIM) that increase their morbidity. We investigated clinical and genetic factors associated with EIM, analyzing an IBD cohort between 20…
View article: The Paradoxical Influence of Amerindian Ancestry on Clinical Outcomes in Crohn’s Disease and Ulcerative Colitis: Insights from a Chilean Cohort.
The Paradoxical Influence of Amerindian Ancestry on Clinical Outcomes in Crohn’s Disease and Ulcerative Colitis: Insights from a Chilean Cohort. Open
Background. Research in Inflammatory Bowel Disease (IBD) assessing the genetic structure and its association with IBD phenotypes is needed, especially in IBD-underrepresented populations such as the South American IBD population. Aim. We e…
View article: Amerindian ancestry proportion as a risk factor for inflammatory bowel diseases: results from a Latin American Andean cohort
Amerindian ancestry proportion as a risk factor for inflammatory bowel diseases: results from a Latin American Andean cohort Open
Background and aims Latin American populations remain underrepresented in genetic studies of inflammatory bowel diseases (IBDs). Most genetic association studies of IBD rely on Caucasian, African, and Asian individuals. These associations …
View article: Genotype Prevalence of Lactose Deficiency, Vitamin D Deficiency, and the Vitamin D Receptor in a Chilean Inflammatory Bowel Disease Cohort: Insights from an Observational Study
Genotype Prevalence of Lactose Deficiency, Vitamin D Deficiency, and the Vitamin D Receptor in a Chilean Inflammatory Bowel Disease Cohort: Insights from an Observational Study Open
Lactose intolerance (LI) and vitamin D deficiency (VDD) have been linked to inflammatory bowel disease (IBD). We conducted an observational study in 192 Chilean IBD patients to investigate the prevalence of a specific gene variant (LCT-139…
View article: Modulation of the Acute Inflammatory Response Induced by the Escherichia coli Lipopolysaccharide through the Interaction of Pentoxifylline and Florfenicol in a Rabbit Model
Modulation of the Acute Inflammatory Response Induced by the Escherichia coli Lipopolysaccharide through the Interaction of Pentoxifylline and Florfenicol in a Rabbit Model Open
Background: Experimental reports have demonstrated that florfenicol (FFC) exerts potent anti-inflammatory effects, improving survival in a murine endotoxemia model. Considering the anti-inflammatory and immunomodulatory properties of pento…
View article: P904 Genetic Variants in IBD Chilean Patients are related to clinical outcomes
P904 Genetic Variants in IBD Chilean Patients are related to clinical outcomes Open
Background IBD has emerged as a worldwide disease with an increased incidence in newly industrialized countries such as Chile. This population has been underrepresented in genome-wide association studies (GWAS) because IBD genetics studies…
View article: P906 Prevalence and CARD9 IBD risk variant rs4077515 in a Chilean IBD Cohort
P906 Prevalence and CARD9 IBD risk variant rs4077515 in a Chilean IBD Cohort Open
Background Genome-wide association studies (GWAS) have identified hundreds of polymorphisms associated with an increased risk of developing IBD. Among risk genes identified by GWAS, CARD9, a gene encoding an adapter molecule involved in th…
View article: P902 Native American Mapuche ancestry is related to higher IBD risk in Chileans
P902 Native American Mapuche ancestry is related to higher IBD risk in Chileans Open
Background Most genetic association studies rely on Caucasian, African and Asian individuals with inconsistent results depending on the population investigated, suggesting that genetic susceptibility to inflammatory bowel disease (IBD) may…
View article: CD4+-mediated colitis in mice is independent of the GPR183 and GPR18 pathways
CD4+-mediated colitis in mice is independent of the GPR183 and GPR18 pathways Open
Colitis is characterized by an exacerbated intestinal immune response, but the genetic and other mechanisms regulating immune activation remain incompletely understood. In order to identify new pathways leading to colitis, we sought to ide…
View article: Ethnicity influences phenotype and clinical outcomes: Comparing a South American with a North American inflammatory bowel disease cohort
Ethnicity influences phenotype and clinical outcomes: Comparing a South American with a North American inflammatory bowel disease cohort Open
Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn disease (CD), has emerged as a global disease with an increasing incidence in developing and newly industrialized regions such as South America. This global rise…
View article: P691 Influence of ethnicity on the phenotype and clinical outcomes in Inflammatory Bowel Disease; comparison of a South American with a North American population
P691 Influence of ethnicity on the phenotype and clinical outcomes in Inflammatory Bowel Disease; comparison of a South American with a North American population Open
Background Inflammatory Bowel Diseases (IBD) are chronic systemic inflammatory disorders, which affect the gastrointestinal tract. An increased incidence of IBD has been vastly reported in Europe, and North America, however, IBD has now em…
View article: Metabolic activation and colitis pathogenesis is prevented by lymphotoxin β receptor expression in neutrophils
Metabolic activation and colitis pathogenesis is prevented by lymphotoxin β receptor expression in neutrophils Open
Inflammatory bowel disease is characterized by an exacerbated intestinal immune response, but the critical mechanisms regulating immune activation remain incompletely understood. We previously reported that the TNF-superfamily molecule TNF…
View article: Inherent Immune Cell Variation Within Colonic Segments Presents Challenges for Clinical Trial Design
Inherent Immune Cell Variation Within Colonic Segments Presents Challenges for Clinical Trial Design Open
Background and Aims Intestinal biopsy sampling during IBD trials represents a valuable adjunct strategy for understanding drug responses at the tissue level. Given the length and distinctive embryonic origins of the proximal and distal col…
View article: Sphingosine-1-Phosphate Lyase Inhibition Alters the S1P Gradient and Ameliorates Crohn’s-Like Ileitis by Suppressing Thymocyte Maturation
Sphingosine-1-Phosphate Lyase Inhibition Alters the S1P Gradient and Ameliorates Crohn’s-Like Ileitis by Suppressing Thymocyte Maturation Open
Sphingosine-1-phosphate (S1P) receptor agonists are a promising therapeutic alternative to anti-integrin antibodies in inflammatory bowel disease. Here, we report that modulation of tissue S1P levels via inhibition of the S1P lyase might b…
View article: Targeting Cytokine Signaling and Lymphocyte Traffic via Small Molecules in Inflammatory Bowel Disease: JAK Inhibitors and S1PR Agonists
Targeting Cytokine Signaling and Lymphocyte Traffic via Small Molecules in Inflammatory Bowel Disease: JAK Inhibitors and S1PR Agonists Open
The inflammatory Bowel diseases (IBDs) are a chronic, relapsing inflammatory diseases of the gastrointestinal tract with heterogeneous behavior and prognosis. The introduction of biological therapies including anti-TNF, anti-IL-12/23, and …
View article: Cell Trafficking Interference in Inflammatory Bowel Disease: Therapeutic Interventions Based on Basic Pathogenesis Concepts
Cell Trafficking Interference in Inflammatory Bowel Disease: Therapeutic Interventions Based on Basic Pathogenesis Concepts Open
After 20 years of successful targeting of pro-inflammatory cytokines for the treatment of IBD, an alternative therapeutic strategy has emerged, based on several decades of advances in understanding the pathogenesis of IBD. The targeting of…
View article: Implementation of Mass Cytometry as a Tool for Mechanism of Action Studies in Inflammatory Bowel Disease
Implementation of Mass Cytometry as a Tool for Mechanism of Action Studies in Inflammatory Bowel Disease Open
Mass cytometry represents a unique tool for deep immunophenotyping intestinal cell composition. This technique has the potential to facilitate analysis of drug actions at the target tissue by identifying specific cellular subsets and their…
View article: Experience with Aerosolized Imipenem in Patients with Cystic Fibrosis and Achromobacter xylosoxidans
Experience with Aerosolized Imipenem in Patients with Cystic Fibrosis and Achromobacter xylosoxidans Open
Achromobacter xylosoxidans is a gram negative non-fermentative rod that infects adult cystic fibrosis patients with moderate to severe lung compromise. Its clinical implications are still to be determined. The aim of this study was to anal…
View article: Incidence, Clinical Characteristics, and Management of Psoriasis Induced by Anti-TNF Therapy in Patients with Inflammatory Bowel Disease
Incidence, Clinical Characteristics, and Management of Psoriasis Induced by Anti-TNF Therapy in Patients with Inflammatory Bowel Disease Open
The incidence rate of psoriasis induced by anti-TNF therapy is higher in women and in smokers/former smokers. In most patients, skin lesions were controlled with topical steroids. More than half of patients switching to another anti-TNF ag…
View article: P253. Incidental diagnosis of inflammatory bowel disease in a British bowel cancer-screening cohort: 6-year clinical outcome follow-up of the first reported cohort
P253. Incidental diagnosis of inflammatory bowel disease in a British bowel cancer-screening cohort: 6-year clinical outcome follow-up of the first reported cohort Open
dermatological, 31.2%(20) ophthalmological, 9.4% (6) nephrolithiasis, 7.8% (5) deep vein thrombosis, and 1.8% (1) vasculitis.Most initial EIM cases occurred in women (79.7%).Conclusions: EIM are common at the onset of IBD.The most frequent…