Explanipedia

Biochemical Diagnosis of Phaeochromocytoma and Paraganglioma in Children and Adolescents: A Retrospective Cohort Study Open

Kristin Potthoff, Tamara Prodanov, Lara Knigge, Angela Hübner, Stefan R. Bornstein , et al. · 2025

Medicine

Introduction Currently, it is unclear whether plasma free or 24‐h urinary fractionated metanephrines are preferable for diagnosis of phaeochromocytoma/paraganglioma (PPGL) in children. Objectives To investigate whether measurements of plas…

A case series of three patients with extensive lung metastatic pheochromocytoma/paraganglioma: evaluation, treatment challenges, and outcomes Open

Kailah Charles, Matthew A. Nazari, Abhishek Jha, Sara Talvacchio, Mickey J. M. Kuo , et al. · 2024

Medicine Geology

Pheochromocytomas (PCCs) and paragangliomas (PGLs; together PPGLs) are uncommon neuroendocrine tumors arising from adrenal medullary chromaffin cells and sympathetic/parasympathetic paraganglia. Though PPGLs predominate in adult population…

8498 Nicardipine: Safe and Effective in Treating Catecholamine-Induced Hypertension? Open

Matthew A. Nazari, Rockyb Hasan, Tamara Prodanov, Kailah Charles, Abhishek Jha , et al. · 2024

Medicine

Disclosure: M. Nazari: None. R. Hasan: None. T. Prodanov: None. K. Charles: None. A. Jha: None. A. Park: None. S. Talvacchio: None. A. Derkyi: None. M. Kuo: None. M. Patel: None. A. Dey: None. A.S. Alzahrani: None. K. Pacak: None. Backgrou…

8338 A Case Series of 3 Patients with Unusual Miliary Lung Metastases in Paraganglioma: Diagnostic Workup, Treatment Challenges and Outcomes Open

Kailah Charles, Matt Nazari, Abhishek Jha, Alberta Derkyi, Sara Talvacchio , et al. · 2024

Medicine Geology

Disclosure: K.M. Charles: None. M.A. Nazari: None. A. Jha: None. A. Derkyi: None. S. Talvacchio: None. M.J. Kuo: None. M. Patel: None. T. Prodanov: None. A.S. Alzahrani: None. A. Chen: None. J. Glod: None. J. Del Rivero: None. A.M. Gharib:…

8338 A Case Series Of 3 Patients With Unusual Miliary Lung Metastases In Paraganglioma: Diagnostic Workup, Treatment Challenges And Outcomes Open

Kailah Charles, Matt Nazari, Abhishek Jha, Alberta Derkyi, Sara Talvacchio , et al. · 2024

Medicine Geology

Disclosure: K.M. Charles: None. M.A. Nazari: None. A. Jha: None. A. Derkyi: None. S. Talvacchio: None. M.J. Kuo: None. M. Patel: None. T. Prodanov: None. A.S. Alzahrani: None. A. Chen: None. J. Glod: None. J. Del Rivero: None. A.M. Gharib:…

Case Series: ATRX Variants in Four Patients with Metastatic Pheochromocytoma Open

Briana Cortez, Mickey J. M. Kuo, Abhishek Jha, Mayank Patel, Jorge A. Carrasquillo , et al. · 2024

Medicine Biology

Few reports have highlighted the rare presence of somatic ATRX variants in clinically aggressive, metastatic pheochromocytoma/paraganglioma (PCC/PGL); however, none have addressed detailed clinical presentation (including biochemistry and …

Multi-omic analysis of SDHB-deficient pheochromocytomas and paragangliomas identifies metastasis and treatment-related molecular profiles Open

Richard W. Tothill, Aidan Flynn, Andrew Pattison, Shiva Balachander, Emma Boehm , et al. · 2024

Biology Medicine

Hereditary SDHB-mutant pheochromocytomas (PC) and paragangliomas (PG) are rare tumours with a high propensity to metastasize although their clinical behaviour is unpredictable. To characterize the genomic landscape of these tumours and ide…

Diagnostic performance of [68Ga]DOTATATE PET/CT, [18F]FDG PET/CT, MRI of the spine, and whole-body diagnostic CT and MRI in the detection of spinal bone metastases associated with pheochromocytoma and paraganglioma Open

Abhishek Jha, Mayank Patel, Alexander Ling, Ritu Shah, Clara C. Chen , et al. · 2024

Medicine

Objective To compare the diagnostic performance of [ 68 Ga]DOTATATE PET/CT, [ 18 F]FDG PET/CT, MRI of the spine, and whole-body CT and MRI for the detection of pheochromocytoma/paraganglioma (PPGL)–related spinal bone metastases. Materials…

SAT305 Clinical Characteristics And Outcomes Of Patient With Metastatic Pheochromocytoma/Paraganglioma (PPGL) And Extreme Elevated Biochemistry Open

Tamara Prodanov, Abhishek Jha, Sara Talvacchio, Matthew A. Nazari, Karel Pacák · 2023

Medicine Chemistry

Disclosure: T. Prodanov: None. A. Jha: None. S. Talvacchio: None. M. Nazari, MD: None. K. Pacak, MD, PhD: None. Background: Pheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrinetumors arising from chromaffin cells in adrenal…

Paediatric phaeochromocytoma and paraganglioma: A clinical update Open

Matthew A. Nazari, Abhishek Jha, Mickey J. M. Kuo, Mayank Patel, Tamara Prodanov , et al. · 2023

Medicine

Paediatric phaeochromocytomas and paragangliomas (PPGLs), though rare tumours, are associated with significant disability and death in the most vulnerable of patients early in their lives. However, unlike cryptogenic and insidious disease …

Data from MAX Mutations Cause Hereditary and Sporadic Pheochromocytoma and Paraganglioma Open

Nelly Burnichon, Alberto Cascón, Francesca Schiavi, Nicole Paes Morales, Iñaki Comino‐Méndez , et al. · 2023

Biology Medicine

Purpose: Pheochromocytomas (PCC) and paragangliomas (PGL) are genetically heterogeneous neural crest–derived neoplasms. Recently we identified germline mutations in a new tumor suppressor susceptibility gene, MAX (MYC-associated factor X),…

Supplementary Figures 1 - 3 from MAX Mutations Cause Hereditary and Sporadic Pheochromocytoma and Paraganglioma Open

Nelly Burnichon, Alberto Cascón, Francesca Schiavi, Nicole Paes Morales, Iñaki Comino‐Méndez , et al. · 2023

Medicine Biology

PDF file, 794KB, Supplementary figure S1. Gross MAX deletion analysis Supplementary figure S2. Immunohistochemical assessment. Supplementary figure S3. Pedigree of 3 families with affected relatives in more than one generation.

Supplementary Figures 1 - 3 from MAX Mutations Cause Hereditary and Sporadic Pheochromocytoma and Paraganglioma Open

Nelly Burnichon, Alberto Cascón, Francesca Schiavi, Nicole Paes Morales, Iñaki Comino‐Méndez , et al. · 2023

Biology Medicine

PDF file, 794KB, Supplementary figure S1. Gross MAX deletion analysis Supplementary figure S2. Immunohistochemical assessment. Supplementary figure S3. Pedigree of 3 families with affected relatives in more than one generation.

Data from MAX Mutations Cause Hereditary and Sporadic Pheochromocytoma and Paraganglioma Open

Nelly Burnichon, Alberto Cascón, Francesca Schiavi, Nicole Paes Morales, Iñaki Comino‐Méndez , et al. · 2023

Biology Medicine

Purpose: Pheochromocytomas (PCC) and paragangliomas (PGL) are genetically heterogeneous neural crest–derived neoplasms. Recently we identified germline mutations in a new tumor suppressor susceptibility gene, MAX (MYC-associated factor X),…

PSUN27 Largest Cohort of Cervical Spine Metastases of Pheochromocytoma/Paraganglioma in the Setting of SDHB Mutation Open

Karel Pacák, Tamara Prodanov, Abhishek Jha, Mayank Patel, Sara Talvacchio · 2022

Medicine Biology

Background Pheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors arising from chromaffin cells in adrenal or extra-adrenal locations, respectively. Overall, 10 to 20% of PPGLs are metastatic, with higher metastatic po…

Recurrent Disease in Patients With Sporadic Pheochromocytoma and Paraganglioma Open