Tamara Rothenburger
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View article: Papaverine Targets STAT Signaling: A Dual‐Action Therapy Option Against SARS‐CoV‐2
Papaverine Targets STAT Signaling: A Dual‐Action Therapy Option Against SARS‐CoV‐2 Open
Papaverine (PV) has been previously identified as a promising candidate in SARS‐CoV‐2 repurposing screens. In this study, we further investigated both its antiviral and immunomodulatory properties. PV displayed antiviral efficacy against S…
View article: Repurposing of the antibiotic nitroxoline for the treatment of mpox
Repurposing of the antibiotic nitroxoline for the treatment of mpox Open
The antiviral drugs tecovirimat, brincidofovir, and cidofovir are considered for mpox (monkeypox) treatment despite a lack of clinical evidence. Moreover, their use is affected by toxic side‐effects (brincidofovir, cidofovir), limited avai…
View article: Omicron‐induced interferon signaling prevents influenza A H1N1 and H5N1 virus infection
Omicron‐induced interferon signaling prevents influenza A H1N1 and H5N1 virus infection Open
Recent findings in permanent cell lines suggested that SARS‐CoV‐2 Omicron BA.1 induces a stronger interferon response than Delta. Here, we show that BA.1 and BA.5 but not Delta induce an antiviral state in air‐liquid interface cultures of …
View article: Identification of novel antiviral drug candidates using an optimized SARS-CoV-2 phenotypic screening platform
Identification of novel antiviral drug candidates using an optimized SARS-CoV-2 phenotypic screening platform Open
Reliable, easy-to-handle phenotypic screening platforms are needed for the identification of anti-SARS-CoV-2 compounds. Here, we present caspase 3/7 activity as a readout for monitoring the replication of SARS-CoV-2 isolates from different…
View article: Repurposing of the antibiotic nitroxoline for the treatment of mpox
Repurposing of the antibiotic nitroxoline for the treatment of mpox Open
The antiviral drugs tecovirimat, brincidofovir, and cidofovir are considered for mpox (monkeypox) treatment despite a lack of clinical evidence. Moreover, their use is affected by toxic side-effects (brincidofovir, cidofovir), limited avai…
View article: Drug Sensitivity of Currently Circulating Mpox Viruses
Drug Sensitivity of Currently Circulating Mpox Viruses Open
suggest an increased incidence of ectopic pregnancy detected after abortion with the use of no-touch protocols. 5However, clinicians must maintain a high index of suspicion for ectopic pregnancy in persons presenting with suggestive sympto…
View article: Omicron-induced interferon signalling prevents influenza A virus infection
Omicron-induced interferon signalling prevents influenza A virus infection Open
Recent findings in permanent cell lines suggested that SARS-CoV-2 Omicron BA.1 induces a stronger interferon response than Delta. Here, we show that BA.1 and BA.5 but not Delta induce an antiviral state in air-liquid interface (ALI) cultur…
View article: Synergism of interferon-beta with antiviral drugs against SARS-CoV-2 variants
Synergism of interferon-beta with antiviral drugs against SARS-CoV-2 variants Open
View article: Synergism of interferon-beta with antiviral drugs against SARS-CoV-2 variants
Synergism of interferon-beta with antiviral drugs against SARS-CoV-2 variants Open
Omicron BA.1 variant isolates were previously shown to replicate less effectively in interferon-competent cells and to be more sensitive to interferon treatment than a Delta isolate. Here, an Omicron BA.2 isolate displayed intermediate rep…
View article: Identification of novel antiviral drug candidates using an optimized SARS-CoV-2 phenotypic screening platform
Identification of novel antiviral drug candidates using an optimized SARS-CoV-2 phenotypic screening platform Open
Reliable, easy-to-handle phenotypic screening platforms are needed for the identification of anti-SARS-CoV-2 compounds. Here, we present caspase 3/7 activity as a read-out for monitoring the replication of SARS-CoV-2 isolates from differen…
View article: SARS-CoV-2 Omicron variant virus isolates are highly sensitive to interferon treatment
SARS-CoV-2 Omicron variant virus isolates are highly sensitive to interferon treatment Open
View article: SARS-CoV-2 Omicron variant virus isolates are highly sensitive to interferon treatment
SARS-CoV-2 Omicron variant virus isolates are highly sensitive to interferon treatment Open
Recently, we have shown that SARS-CoV-2 Omicron virus isolates are less effective at inhibiting the host cell interferon response than Delta viruses. Here, we present further evidence that reduced interferon-antagonising activity explains …
View article: Differences between intrinsic and acquired nucleoside analogue resistance in acute myeloid leukaemia cells
Differences between intrinsic and acquired nucleoside analogue resistance in acute myeloid leukaemia cells Open
View article: Differences between intrinsic and acquired nucleoside analogue resistance in acute myeloid leukaemia cells
Differences between intrinsic and acquired nucleoside analogue resistance in acute myeloid leukaemia cells Open
Summary Background SAMHD1 mediates resistance to anti-cancer nucleoside analogues, including cytarabine, decitabine, and nelarabine that are commonly used for the treatment of leukaemia, through cleavage of their triphosphorylated forms. H…
View article: Additional file 15 of Differences between intrinsic and acquired nucleoside analogue resistance in acute myeloid leukaemia cells
Additional file 15 of Differences between intrinsic and acquired nucleoside analogue resistance in acute myeloid leukaemia cells Open
Additional file 15: Supplementary Table 6. Concentrations that reduce the cell viability by 50% (IC50 values), determined by MTT assay after 96 h incubation.
View article: Additional file 13 of Differences between intrinsic and acquired nucleoside analogue resistance in acute myeloid leukaemia cells
Additional file 13 of Differences between intrinsic and acquired nucleoside analogue resistance in acute myeloid leukaemia cells Open
Additional file 13: Supplementary Table 4. Characteristics of AML patients analysed in the data presented in Fig. 3.
View article: SAMHD1 is a key regulator of the lineage-specific response of acute lymphoblastic leukaemias to nelarabine
SAMHD1 is a key regulator of the lineage-specific response of acute lymphoblastic leukaemias to nelarabine Open
View article: Long-term cultivation using ineffective MDM2 inhibitor concentrations alters the drug sensitivity profiles of PL21 leukaemia cells
Long-term cultivation using ineffective MDM2 inhibitor concentrations alters the drug sensitivity profiles of PL21 leukaemia cells Open
Acquired MDM2 inhibitor resistance is commonly caused by loss-of-function TP53 mutations. In addition to the selection of TP53 -mutant cells by MDM2 inhibitors, MDM2 inhibitor-induced DNA damage may promote the formation of TP53 mutations.…
View article: SAMHD1 is a key regulator of the lineage-specific response of acute lymphoblastic leukaemias to nelarabine
SAMHD1 is a key regulator of the lineage-specific response of acute lymphoblastic leukaemias to nelarabine Open
The nucleoside analogue nelarabine, the prodrug of arabinosylguanine (AraG), has been known for decades to be effective against acute lymphoblastic leukaemias of T-cell (T-ALL), but not of B-cell (B-ALL) origin. The mechanisms underlying t…
View article: Selective inactivation of hypomethylating agents by SAMHD1 provides a rationale for therapeutic stratification in AML
Selective inactivation of hypomethylating agents by SAMHD1 provides a rationale for therapeutic stratification in AML Open
Hypomethylating agents decitabine and azacytidine are regarded as interchangeable in the treatment of acute myeloid leukemia (AML). However, their mechanisms of action remain incompletely understood, and predictive biomarkers for HMA effic…
View article: <i>TP53</i>mutations and drug sensitivity in acute myeloid leukaemia cells with acquired MDM2 inhibitor resistance
<i>TP53</i>mutations and drug sensitivity in acute myeloid leukaemia cells with acquired MDM2 inhibitor resistance Open
Background: MDM2 inhibitors are under investigation for the treatment of acute myeloid leukaemia (AML) patients in phase III clinical trials. To study resistance formation to MDM2 inhibitors in AML cells, we here established 45 sub-lines o…