Tamara Tal
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View article: Identification of Neuroactive Chemicals in Crude Oil-Derived Water-Accommodated Fractions
Identification of Neuroactive Chemicals in Crude Oil-Derived Water-Accommodated Fractions Open
Crude oil-derived water-accommodated fractions (WAFs) are complex mixtures containing bioavailable constituents. We applied an automated zebrafish behavior-based assay to assess potential neuroactivity following exposure to WAF and chemica…
View article: The ENDOMIX project: an interdisciplinary approach to understanding how real-life chemical mixtures target the immune system to trigger disease
The ENDOMIX project: an interdisciplinary approach to understanding how real-life chemical mixtures target the immune system to trigger disease Open
The true impact of endocrine disrupting chemicals (EDCs) on human health is far from being understood. Humans are exposed to mixtures of chemicals throughout their lives, yet regulations and most studies focus on individual chemicals. END…
View article: Cross-taxa sublethal impacts of plant protection products on honeybee in-hive and zebrafish swimming behaviours at environmentally relevant concentrations
Cross-taxa sublethal impacts of plant protection products on honeybee in-hive and zebrafish swimming behaviours at environmentally relevant concentrations Open
Single and mixture exposure to plant protection products (PPPs) can affect non-target organisms at sublethal concentrations, yet the ecological relevance of behavioural effects remains underexplored. Behavioural disruptions can compromise …
View article: Perfluorooctanesulfonic acid (PFOS) antagonizes gamma-aminobutyric acid (GABA) receptors in larval zebrafish and mammalian models
Perfluorooctanesulfonic acid (PFOS) antagonizes gamma-aminobutyric acid (GABA) receptors in larval zebrafish and mammalian models Open
Per- and polyfluoroalkyl substances are a class of synthetic chemicals detected ubiquitously in the environment, humans, and wildlife. Perfluorooctanesulfonic acid (PFOS) is one prevalent chemical previously shown to cause adverse effects …
View article: Multi-behavioral phenotyping in early-life-stage zebrafish for identifying disruptors of non-associative learning
Multi-behavioral phenotyping in early-life-stage zebrafish for identifying disruptors of non-associative learning Open
These studies combined a series of behavior assays in a phenotypically rich, rapid, and inexpensive non-mammalian vertebrate test system to screen chemicals for neurotoxicity. Together with in silico target predictions and mouse- and human…
View article: Multi-behavioral fingerprints can identify potential modes of action for neuroactive environmental chemicals
Multi-behavioral fingerprints can identify potential modes of action for neuroactive environmental chemicals Open
There is a lack of confidence in the relevance of zebrafish-based behavior data for chemical risk assessment. We extended an automated Visual and Acoustic Motor Response (VAMR) new approach method (NAM) in 5-day post-fertilization (dpf) ze…
View article: Evaluating PFAS-Induced modulation of peripheral blood mononuclear cells (PBMCs) immune response to SARS-CoV-2 spike in COVID-19 Vaccinees
Evaluating PFAS-Induced modulation of peripheral blood mononuclear cells (PBMCs) immune response to SARS-CoV-2 spike in COVID-19 Vaccinees Open
The persistent nature of the environmental contaminants per- and polyfluoroalkyl substances (PFAS) has recently received considerable attention, particularly because of their adverse effects on immune system functionality in the context of…
View article: Developmental neurotoxicity (DNT): A call for implementation of new approach methodologies for regulatory purposes: Summary of the 5th International Conference on DNT Testing
Developmental neurotoxicity (DNT): A call for implementation of new approach methodologies for regulatory purposes: Summary of the 5th International Conference on DNT Testing Open
The 5th International Conference on Developmental Neurotoxicity (DNT) Testing (DNT5) took place in April 2024 in Konstanz, Germany, organized by CAAT-Europe, the University of Konstanz, and scientists from the US EPA, SCAHT, and CAAT at Jo…
View article: The ENDOMIX project: an interdisciplinary approach to understanding how real-life chemical mixtures target the immune system to trigger disease
The ENDOMIX project: an interdisciplinary approach to understanding how real-life chemical mixtures target the immune system to trigger disease Open
The true impact of endocrine disrupting chemicals (EDCs) on human health is far from being understood. Humans are exposed to mixtures of chemicals throughout their lives, yet regulations and most studies focus on individual chemicals. END…
View article: Multi-behavioral phenotyping in zebrafish identifies a novel disruptor of non-associative learning with environmental and human relevance
Multi-behavioral phenotyping in zebrafish identifies a novel disruptor of non-associative learning with environmental and human relevance Open
The vertebrate nervous system is vulnerable to chemical toxicity and the widespread release of chemicals into the environment outstrips the capacity to assess their safety. We devised a battery of automated behavior assays in larval zebraf…
View article: Investigation of Peroxisome Proliferator-Activated Receptor Genes as Requirements for Visual Startle Response Hyperactivity in Larval Zebrafish Exposed to Structurally Similar Per- and Polyfluoroalkyl Substances (PFAS)
Investigation of Peroxisome Proliferator-Activated Receptor Genes as Requirements for Visual Startle Response Hyperactivity in Larval Zebrafish Exposed to Structurally Similar Per- and Polyfluoroalkyl Substances (PFAS) Open
This work identifies a novel adverse outcome pathway for VSR hyperactivity in larval zebrafish. We demonstrate that developmental, but not acute, exposure to PFOS triggered persistent VSR hyperactivity that required ppard function. https:/…
View article: New approach methods to assess developmental and adult neurotoxicity for regulatory use: a PARC work package 5 project
New approach methods to assess developmental and adult neurotoxicity for regulatory use: a PARC work package 5 project Open
In the European regulatory context, rodent in vivo studies are the predominant source of neurotoxicity information. Although they form a cornerstone of neurotoxicological assessments, they are costly and the topic of ethical debate. While …
View article: Disruption of VEGFR signaling leading to developmental defects
Disruption of VEGFR signaling leading to developmental defects Open
The cardiovascular system is the first functional organ system to develop in the vertebrate embryo, reflecting its critical role during normal development and pregnancy. This Adverse Outcome Pathway focuses on the regulation and disruption…
View article: Innovative tools and methods for toxicity testing within PARC work package 5 on hazard assessment
Innovative tools and methods for toxicity testing within PARC work package 5 on hazard assessment Open
New approach methodologies (NAMs) have the potential to become a major component of regulatory risk assessment, however, their actual implementation is challenging. The European Partnership for the Assessment of Risks from Chemicals (PARC)…
View article: Additional file 1 of The AnimalAssociatedMetagenomeDB reveals a bias towards livestock and developed countries and blind spots in functional-potential studies of animal-associated microbiomes
Additional file 1 of The AnimalAssociatedMetagenomeDB reveals a bias towards livestock and developed countries and blind spots in functional-potential studies of animal-associated microbiomes Open
Supplementary Material 1
View article: Monoassociation with bacterial isolates reveals the role of colonization, community complexity and abundance on locomotor behavior in larval zebrafish
Monoassociation with bacterial isolates reveals the role of colonization, community complexity and abundance on locomotor behavior in larval zebrafish Open
Background Across taxa, animals with depleted intestinal microbiomes show disrupted behavioral phenotypes. Axenic (i.e., microbe-free) mice, zebrafish, and fruit flies exhibit increased locomotor behavior, or hyperactivity. The mechanism t…
View article: Additional file 2 of Monoassociation with bacterial isolates reveals the role of colonization, community complexity and abundance on locomotor behavior in larval zebrafish
Additional file 2 of Monoassociation with bacterial isolates reveals the role of colonization, community complexity and abundance on locomotor behavior in larval zebrafish Open
Additional file 2: Data files and R script used to generate figures and conduct statistical analyses.
View article: HumanMetagenomeDB: a public repository of curated and standardized metadata for human metagenomes
HumanMetagenomeDB: a public repository of curated and standardized metadata for human metagenomes Open
Metagenomics became a standard strategy to comprehend the functional potential of microbial communities, including the human microbiome. Currently, the number of metagenomes in public repositories is increasing exponentially. The Sequence …
View article: Evaluation of Developmental Toxicity, Developmental Neurotoxicity, and Tissue Dose in Zebrafish Exposed to GenX and Other PFAS
Evaluation of Developmental Toxicity, Developmental Neurotoxicity, and Tissue Dose in Zebrafish Exposed to GenX and Other PFAS Open
All emerging fluoroether PFAS tested were negative for evaluated outcomes. Two unique toxicity signatures were identified arising from structurally dissimilar PFAS. Among sulfonic acid aliphatic PFAS, chemical potencies were correlated wit…
View article: Triclosan-Selected Host-Associated Microbiota Perform Xenobiotic Biotransformations in Larval Zebrafish
Triclosan-Selected Host-Associated Microbiota Perform Xenobiotic Biotransformations in Larval Zebrafish Open
Microbiota regulate important physiologic processes during early host development. They also biotransform xenobiotics and serve as key intermediaries for chemical exposure. Antimicrobial agents in the environment may disrupt these complex …
View article: Investigating Tyrosine Phosphatases as Targets of Air Pollutants
Investigating Tyrosine Phosphatases as Targets of Air Pollutants Open
Exposure to ambient particulate matter (PM) is associated with elevated rates of morbidity and mortality. Inflammation is thought to be a central mechanism by which PM exposure induces adverse health effects. In lung epithelial cells, a pr…
View article: Development of a Zebrafish S1500+ Sentinel Gene Set for High-Throughput Transcriptomics
Development of a Zebrafish S1500+ Sentinel Gene Set for High-Throughput Transcriptomics Open
Sentinel gene sets have been developed with the purpose of maximizing the information from targeted transcriptomic platforms. We recently described the development of an S1500+ sentinel gene set, which was built for the human transcriptome…