Explanipedia

C-REGS2—A multinational, high-quality comparative effectiveness study of Cerebrolysin in moderate acute ischemic stroke Open

Milan R. Voško, Daniel Šaňák, Young-Rok Do, J.A. Vatanagul, Tamer Roushdy , et al. · 2025

Background: The main objective of the Cerebrolysin REGistry Study in Stroke 2 (C-REGS2) was to systematically record the routine clinical use of Cerebrolysin in patients with moderate ischemic stroke (IS) following the principles of a pros…

Case Report: Decoding genetic risks of vascular parkinsonism: a case series Open

Ali Shalash, Sittana S. Elshafie, Peter M. George, Tamer Roushdy, Mai Fathy , et al. · 2025

Background Vascular parkinsonism (VaP) is a subtype of parkinsonism which needs better characterization of its risks and determinants. Objective The aim of this report is to present an understanding of genetic risks of vascular parkinsonis…

Clinical and radiological outcome of incidental cerebral small vessel disease using antiplatelet therapy: randomized pilot study Open

Y. H. Hamid, Eman Hamid, Mena Elerian, Hossam Shokri, Mai Fathy , et al. · 2025

Background Cerebral small vessel disease (CSVD) causes significant disability at increasing age, such as cognitive impairment, gait, and sphincteric problems affecting a person’s quality of life. That is why it is essential to be detected …

Developing a culturally adapted Cairene Egyptian Arabic–Western Aphasia Battery—Revised (CEA-WAB-R) Open

Iman Muhammad Ahmad Jomaa, Ramez Reda Moustafa, Wafaa Batran Wahba, Eman Hamid, Nevine El Nahas , et al. · 2025

Background It is estimated that 30% of acute stroke patients present with aphasia. Thus, proper analysis of aphasia through a valid and culturally adapted scale seems mandatory. The Western Aphasia Battery is a well-recognized scale used u…

Prehospital stroke care in low- and middle-income countries: A World Stroke Organization (WSO) scientific statement Open

Jackie Bosch, Radhika Lotlikar, Rita Melifonwu, Tamer Roushdy, Ivy Sebastian , et al. · 2025

Evidence-based prehospital stroke care is effective in reducing stroke-related mortality and morbidity. The crucial period from symptom awareness to presentation at the hospital, the first step in the World Stroke Organization Road Map to …

Retinal vessel density using optical coherence tomography angiography as a potential biomarker in patients with cerebral small vessel disease Open

Nevine El Nahas, Tamer Roushdy, Mona Mokhtar Wahid El Din, Mona Abdellatif, Sahar Gaber , et al. · 2025

Background Optical coherence tomography angiography (OCTA) is a quick, noninvasive modality that visualizes retinal microvasculature. The retina is known to be the mirror of the brain, thus it is pertinent to employ OCTA to study covert ce…

Regional Burden and Region-Specific Stroke Risk Factors in Lower and Middle-Income Countries Open

Zhe Kang Law, Sarah Shali Matuja, Mirjam R. Heldner, Tamer Roushdy, Ayush Agarwal , et al. · 2025

In this chapter, we outline the trends in incidence, prevalence, and the burden of stroke in developing countries (lower- and middle-income countries—LMICs) over recent decades. We highlight the changes in risk factors and types of stroke …

Implementing Acute Stroke Services in Sub-Saharan Africa: Steps, Progress, and Perspectives from the Tanzania Stroke Project Open

Sarah Shali Matuja, Christine Tunkl, Tamer Roushdy, Linxin Li, Menglu Ouyang , et al. · 2025

Introduction: Stroke is a leading cause of morbidity and mortality globally, with Africa bearing a disproportionately high burden of poor outcomes. In sub-Saharan Africa, acute stroke care remains inconsistent, with organized stroke units …

Stroke awareness in Egypt: a survey-based study Open

Tamer Roushdy, Nevine El Nahas, Mai Fathy, Hossam Shokri, Hany Aref , et al. · 2025

Background Awareness about stroke symptoms and management is an important and pivotal step in any stroke service as it will positively affect onset to door, which will affect rates of thrombolysis and thrombectomy, reduce mortality, and im…

Frequency, phenotypes, and neuroimaging of early post stroke movement disorders: a prospective study Open

Eslam Samra, Tamer Roushdy, Amr S. Zaki, Alia H. Mansour, Ahmed Elbassiouny , et al. · 2025

Background A prospective observational study recruited patients with acute stroke. Patients were assessed for the presence of post-stroke movement disorders PSMDs during the first week of stroke. This study aimed to identify the frequency,…

Revisiting Africa’s Stroke Obstacles and Services (SOS) Open

Tamer Roushdy, Ahmed Elbassiouny, Selma Kesraoui, Michael Temgoua, Kiatoko Ponte Nono , et al. · 2025

Background As one of the most common non-communicable diseases in Africa, Stroke ought to be dealt with properly with intensifying efforts to control its burden and to face obstacles in its management. Methods and Results In this follow-up…

From apoplexy in antiquities to cerebrovascular stroke in modernity: a narrative timeline and tale Open

Tamer Roushdy · 2024

Background Stroke is one of the commonest encountered brain and neurological disorders worldwide. Stroke management has had a major shift in the last 50 years and precisely since the discovery and approval of thrombolysis as an acute manag…

Telemedicine networks for acute stroke: An analysis of global coverage, gaps, and opportunities Open

Christine Tunkl, Ayush Agarwal, Emily Ramage, Faddi Saleh Velez, Tamer Roushdy , et al. · 2024

Background: Despite the proven efficacy of telestroke in improving clinical outcomes by providing access to specialized expertise and allowing rapid expert hyperacute stroke management and decision-making, detailed operational evidence is …

Pain Characteristics of Parkinson’s Disease Using Validated Arabic Versions of the King’s Parkinson’s Disease Pain Scale and Questionnaire: A Multicenter Egyptian Study Open

Ali Shalash, Salma Reda Mohamed, Marwa Y. Badr, Shimaa Elgamal, Shaimaa A. Elaidy , et al. · 2024

Objective Pain is one of the most common nonmotor symptoms in Parkinson’s disease (PD), with variable characteristics among populations. This multicenter Egyptian study aimed to translate and validate the King’s Parkinson’s Disease Pain Sc…

Whole exome sequencing in a sample of Egyptian patients with covert cerebral small vessel disease Open

Hany Aref, Mohamed Maged, Tamer Roushdy, Hossam Shokri, Eman Hamid , et al. · 2024

Background Covert cerebral small vessel disease (cCSVD) is associated with many age-related morbidities with little available data regarding the pathophysiology and role of genetics in it. This study aims to investigate the genetic load in…

The clinical and neuroimaging differences between vascular parkinsonism and Parkinson’s disease: a case-control study Open

Peter M. George, Tamer Roushdy, Mai Fathy, Eman Hamid, Yosra Abdelzaher Ibrahim , et al. · 2024

Differences in characteristics between patients from Egypt and Germany presenting with lacunar stroke Open

Mohamed Maged, Hany Aref, Nevine El Nahas, Eman Hamid, Mai Fathy , et al. · 2023

Applying the World Stroke Organization roadmap in planning a model for stroke service implementation in Matrouh Governorate-Egypt: a World Stroke Organization young future stroke leaders’ analytical study Open

Tamer Roushdy, Matías Alet, Radhika Lotlikar, Emily Ramage, Teresa Ullberg , et al. · 2023

Background The global incidence of stroke is on the rise, primarily due to an increase in the aging population and the prevalence of vascular risk factors among the elderly. However, stroke is a treatable condition if promptly recognized a…

The budget impact of alteplase in the treatment of acute ischemic stroke in Egypt Open

Hany Aref, Nevine El Nahas, Gihan Hamdy Elsisi, Hossam Shokri, Tamer Roushdy · 2023

Introduction Stroke is the second leading cause of mortality worldwide. Five percent of all the disability-adjusted life years (DALYs) lost around the world are attributed to stroke. This study aimed to assess the economic burden of acute …

Do stroke services still show sex differences? A multicenter study Open

Nevine El Nahas, Hossam Shokri, Tamer Roushdy, Noha L. Dawood, Amr S. Zaki , et al. · 2023

Stroke services in MENA: What is there and what is needed Open

Hany Aref, Nevine El Nahas, Suhail Alrukn, Maria Khan, Selma Kesraoui , et al. · 2023

Objectives Stroke represents a health care challenge to most parts of the world including the Middle East and North Africa (MENA) region. The MENA represents 6% of the world population with an age-standardized stroke rate of 87.7 (78.2–97.…

Stroke in women: experience in a developing country Open

Nevine El Nahas, Hany Aref, Fatma Fathalla Kenawy, Shady S. Georgy, Eman M. Abushady , et al. · 2023

Background Several studies have addressed gender differences in stroke. Yet, results are diverse, and research is still required in different populations. So, this study investigates variation in stroke according to gender in a developing …

Gender disparity versus equality in acute stroke: a Middle Eastern country hospital-based study Open

John George, Hany Aref, Azza Abdel Nasser, Ayman Nasef, Ahmed Elbassiouny , et al. · 2023

NIHSS is deficient in acute stroke presenting with cortical deafness; clinical skills remain the backbone: a case report Open

Tamer Roushdy, Narges Wagih Mikhail, Shaimaa Ramadan Abdelaziz · 2023

A randomized pilot study of the efficacy and safety of loading ticagrelor in acute ischemic stroke Open

Hany Aref, Hala El-Khawas, Ahmed Elbassiouny, Hossam Shokri, Mohamed G. Zeinhom , et al. · 2022

SARS-CoV-2 and monkeypox: what is common and what is not in a present pandemic versus a potential one—a neuropsychiatric narrative review Open

Tamer Roushdy · 2022

Pandemic represents challenging medical emergency as it is usually associated with high rates of mortalities and morbidities. Along the last 2 and half years the world has faced the emergence of severe acute respiratory syndrome corona vir…

An Egyptian patient story: multilingual role in post-stroke aphasia recovery Open

Iman Muhammad Ahmad Jomaa, Wafaa Batran Wahba, Ramez Reda Moustafa, Tamer Roushdy · 2022

Background Ischemic strokes are common neurological disease and unless being managed fast enough within hours of onset a permanent deficit usually results. Such deficit impairs the patient independency to a great extent. Aphasia affects mo…

Did COVID-19 impact stroke services? A multicenter study Open

Hossam Shokri, Nevine El Nahas, Ahmed El Basiony, Thanh N. Nguyen, Mohamad Abdalkader , et al. · 2022

Background It has been reported that acute stroke services were compromised during COVID-19 due to various pandemic-related issues. We aimed to investigate these changes by recruiting centers from different countries. Methods Eight countri…

Peripheral magnetic theta burst stimulation to muscles can effectively reduce spasticity: a randomized controlled trial Open

Nevine El Nahas, Fatma Fathalla Kenawy, Eman Hamid, Tamer Roushdy, Shahinaz Helmy , et al. · 2022

Background Spasticity is a common complication of many neurological diseases and despite contributing much disability; the available therapeutic options are limited. Peripheral magnetic stimulation is one promising option . In this study, …

Venous and arterial cerebral thrombosis: a COVID-19 dual pathology and single possible etiology—a case report Open

Tamer Roushdy, Nouran K. Sharaf · 2022

Background Corona virus disease of the year 2019 (COVID-19) is still devastating the world for more than 19 months since its declaration as a pandemic by world health organization. Its manifestations does not stand at respiratory system bu…

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