Tammy T. Hshieh
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View article: A Multimodal Approach for Study Diagnosis of MCI and Dementia in the Successful Aging after Elective Surgery (SAGES) Cohort
A Multimodal Approach for Study Diagnosis of MCI and Dementia in the Successful Aging after Elective Surgery (SAGES) Cohort Open
View article: Ethics of overtreatment and undertreatment in older adults with cancer
Ethics of overtreatment and undertreatment in older adults with cancer Open
View article: Delirium in Older Patients With COVID-19 Presenting to the Emergency Department
Delirium in Older Patients With COVID-19 Presenting to the Emergency Department Open
Importance: Delirium is common among older emergency department (ED) patients, is associated with high morbidity and mortality, and frequently goes unrecognized. Anecdotal evidence has described atypical presentations of coronavirus diseas…
View article: Better Assessment of Illness Study (BASIL) II for Delirium Severity: Study Design, Variables, and Methods
Better Assessment of Illness Study (BASIL) II for Delirium Severity: Study Design, Variables, and Methods Open
Purpose Delirium is a common yet preventable complication of hospitalization, surgery and illness that is associated with poor outcomes. Older adults with Alzheimer’s Disease and Related Dementias (ADRD) are especially vulnerable to deliri…
View article: Management of vasomotor symptoms in cancer patients
Management of vasomotor symptoms in cancer patients Open
Many cancer treatments can lead to reduced levels of sex hormones, which in turn may cause vasomotor symptoms (VMS) such as hot flashes. These symptoms are associated with impaired quality of life, as well as suboptimal tolerability of and…
View article: Between a Rock and a Hard Place
Between a Rock and a Hard Place Open
View article: Reserve and resilience: the cumulative risk of surgery on cognition and neurodegeneration in older individuals
Reserve and resilience: the cumulative risk of surgery on cognition and neurodegeneration in older individuals Open
View article: Incident dementia or cognitive decline after elective surgery in older adults: Highlighting the importance of shared decision‐making
Incident dementia or cognitive decline after elective surgery in older adults: Highlighting the importance of shared decision‐making Open
This editorial comments on the articles by Tang et al . and Reich et al . in this issue.
View article: Comparison of the frailty index and frailty phenotype and their associations with postoperative delirium incidence and severity
Comparison of the frailty index and frailty phenotype and their associations with postoperative delirium incidence and severity Open
Background Recent studies have reported an association between presurgical frailty and postoperative delirium. However, it remains unclear whether the frailty‐delirium relationship differs by measurement tool (e.g., frailty index vs. frail…
View article: Successful aging after elective surgery <scp>II</scp> : Study cohort description
Successful aging after elective surgery <span>II</span> : Study cohort description Open
Background The Successful Aging after Elective Surgery (SAGES) II Study was designed to examine the relationship between delirium and Alzheimer's disease and related dementias (AD/ADRD), by capturing novel fluid biomarkers, neuroimaging ma…
View article: Association of Loneliness With Change in Physical and Emotional Health of Older Adults During the COVID-19 Shutdown
Association of Loneliness With Change in Physical and Emotional Health of Older Adults During the COVID-19 Shutdown Open
View article: Marital status, frailty, and survival in older adults with blood cancer
Marital status, frailty, and survival in older adults with blood cancer Open
View article: Benefits and Barriers of Technology for Home Function and Mobility Assessment: Perspectives of Older Patients With Blood Cancers, Caregivers, and Clinicians
Benefits and Barriers of Technology for Home Function and Mobility Assessment: Perspectives of Older Patients With Blood Cancers, Caregivers, and Clinicians Open
PURPOSE Advances in digital health technology can overcome barriers to measurement of function and mobility for older adults with blood cancers, but little is known about how older adults perceive such technology for use in their homes. ME…
View article: One‐year Medicare costs associated with delirium in older hospitalized patients with and without Alzheimer's disease dementia and related disorders
One‐year Medicare costs associated with delirium in older hospitalized patients with and without Alzheimer's disease dementia and related disorders Open
Introduction One‐year health‐care costs associated with delirium in older hospitalized patients with and without Alzheimer's disease and related dementias (ADRD) have not been examined previously. Methods Medicare costs were determined pro…
View article: Successful aging after elective surgery <scp>II</scp> : <scp>S</scp> tudy design and methods
Successful aging after elective surgery <span>II</span> : <span>S</span> tudy design and methods Open
Background The Successful Aging after Elective Surgery (SAGES) II study was designed to increase knowledge of the pathophysiology and linkages between delirium and dementia. We examine novel biomarkers potentially associated with delirium,…
View article: Association of Polypharmacy and Potentially Inappropriate Medications With Frailty Among Older Adults With Blood Cancers
Association of Polypharmacy and Potentially Inappropriate Medications With Frailty Among Older Adults With Blood Cancers Open
Background: Polypharmacy and potentially inappropriate medications (PIMs) are common among older adults with blood cancers, but their association with frailty and how to manage them optimally remain unclear. Patients and Methods: From 2015…
View article: Virtual frailty assessment for older adults with hematologic malignancies
Virtual frailty assessment for older adults with hematologic malignancies Open
View article: Identifying Delirium in Persons With Moderate or Severe Dementia: Review of Challenges and an Illustrative Approach
Identifying Delirium in Persons With Moderate or Severe Dementia: Review of Challenges and an Illustrative Approach Open
View article: Patterns and Persistence of Perioperative Plasma and Cerebrospinal Fluid Neuroinflammatory Protein Biomarkers After Elective Orthopedic Surgery Using SOMAscan
Patterns and Persistence of Perioperative Plasma and Cerebrospinal Fluid Neuroinflammatory Protein Biomarkers After Elective Orthopedic Surgery Using SOMAscan Open
BACKGROUND: The neuroinflammatory response to surgery can be characterized by peripheral acute plasma protein changes in blood, but corresponding, persisting alterations in cerebrospinal fluid (CSF) proteins remain mostly unknown. Using th…
View article: Psychometric Properties of a Delirium Severity Score for Older Adults and Association With Hospital and Posthospital Outcomes
Psychometric Properties of a Delirium Severity Score for Older Adults and Association With Hospital and Posthospital Outcomes Open
These findings suggest that the delirium severity score provides an approach for measuring delirium severity that is associated with adverse clinical outcomes in a direct exposure-response association and that the delirium severity score m…
View article: Impact of Polypharmacy and Potentially Inappropriate Medications Among Older Adults With Blood Cancers
Impact of Polypharmacy and Potentially Inappropriate Medications Among Older Adults With Blood Cancers Open
View article: Domains of delirium severity in Alzheimer's disease and related dementias
Domains of delirium severity in Alzheimer's disease and related dementias Open
Background The ability to rate delirium severity is key to providing optimal care for persons with Alzheimer's Disease and Related Dementias (ADRD). Such ratings would allow clinicians to assess response to treatment, recovery time and pro…
View article: Randomized controlled trial of geriatric consultation versus standard care in older adults with hematologic malignancies
Randomized controlled trial of geriatric consultation versus standard care in older adults with hematologic malignancies Open
We conducted a randomized controlled trial in older adults with hematologic malignancies to determine the impact of geriatrician consultation embedded in our oncology clinic alongside standard care. From February 2015 to May 2018, transpla…
View article: From research to bedside: Incorporation of a <scp>CGA</scp> ‐based frailty index among multiple comanagement services
From research to bedside: Incorporation of a <span>CGA</span> ‐based frailty index among multiple comanagement services Open
The comprehensive geriatric assessment (CGA) is the core tool used by geriatricians across diverse clinical settings to identify vulnerabilities and estimate physiologic reserve in older adults. In this paper, we demonstrate the iterative …
View article: ED‐DEL: Development of a change package and toolkit for delirium in the emergency department
ED‐DEL: Development of a change package and toolkit for delirium in the emergency department Open
View article: Objective performance tests of cognition and physical function as part of a virtual geriatric assessment
Objective performance tests of cognition and physical function as part of a virtual geriatric assessment Open
View article: One-Year Medicare Costs Associated With Delirium in Older Patients Undergoing Major Elective Surgery
One-Year Medicare Costs Associated With Delirium in Older Patients Undergoing Major Elective Surgery Open
Importance Delirium is a common, serious, and potentially preventable problem for older adults, associated with adverse outcomes. Coupled with its preventable nature, these adverse sequelae make delirium a significant public health concern…
View article: Development and internal validation of a predictive model of cognitive decline 36 months following elective surgery
Development and internal validation of a predictive model of cognitive decline 36 months following elective surgery Open
Introduction Our goal was to determine if features of surgical patients, easily obtained from the medical chart or brief interview, could be used to predict those likely to experience more rapid cognitive decline following surgery. Methods…
View article: Association of CSF Alzheimer's disease biomarkers with postoperative delirium in older adults
Association of CSF Alzheimer's disease biomarkers with postoperative delirium in older adults Open
Introduction The interaction between delirium and dementia is complex. We examined if Alzheimer's disease (AD) biomarkers in patients without clinical dementia are associated with increased risk of postoperative delirium, and whether AD bi…
View article: Gait speed, survival, and recommended treatment intensity in older adults with blood cancer requiring treatment
Gait speed, survival, and recommended treatment intensity in older adults with blood cancer requiring treatment Open
Background Brief measures of physical function such as gait speed may be useful to optimize treatment intensity for older adults who have blood cancer; however, little is known about whether such assessments are already captured within onc…