Tamsin Sharp
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View article: Maternal intimate partner violence exposure is associated with differences in cortical structure in 2-to-3-year-old children: A prospective investigation from the Drakenstein Child Health Study (DCHS)
Maternal intimate partner violence exposure is associated with differences in cortical structure in 2-to-3-year-old children: A prospective investigation from the Drakenstein Child Health Study (DCHS) Open
The adverse impacts of psychological stress during pregnancy are well established, with negative outcomes reported for both mothers and children. Intimate partner violence (IPV) represents a significant stressor, with high prevalence in lo…
View article: Prospective biomarkers of posttraumatic stress disorder in children and adolescents: a systematic review and meta-analysis
Prospective biomarkers of posttraumatic stress disorder in children and adolescents: a systematic review and meta-analysis Open
Trauma exposure in children and young people (CYP) can lead to the development of posttraumatic stress disorder (PTSD). Identification of biomarkers prospectively associated with PTSD can provide critical insight into the mechanisms underp…
View article: Systematic review and meta-analysis: do best-evidenced trauma-focused interventions for children and young people with PTSD lead to changes in social and interpersonal domains?
Systematic review and meta-analysis: do best-evidenced trauma-focused interventions for children and young people with PTSD lead to changes in social and interpersonal domains? Open
Objective: Young people with post-traumatic stress disorder experience difficulties in social and interpersonal domains. We examined whether the best-evidenced treatments of PTSD for children and young people (Trauma-focussed Cognit…
View article: Social support and (complex) posttraumatic stress symptom severity: does gender matter?
Social support and (complex) posttraumatic stress symptom severity: does gender matter? Open
Background: Perceived social support is an established predictor of post-traumatic stress disorder (PTSD) after exposure to a traumatic event. Gender is an important factor that could differentiate responses to social support, yet t…
View article: Post-traumatic stress disorder symptoms following exposure to acute psychological trauma in children aged 8–16 years in South Africa: protocol for the Sinethemba longitudinal study
Post-traumatic stress disorder symptoms following exposure to acute psychological trauma in children aged 8–16 years in South Africa: protocol for the Sinethemba longitudinal study Open
Introduction Children exposed to trauma are vulnerable to developing post-traumatic stress disorder (PTSD) and other adverse mental health outcomes. In low-and middle-income countries (LMICs), children are at increased risk of exposure to …
View article: Genetics impact risk of Alzheimer’s disease through mechanisms modulating structural brain morphology in late life
Genetics impact risk of Alzheimer’s disease through mechanisms modulating structural brain morphology in late life Open
Background Alzheimer’s disease (AD)-related neuropathological changes can occur decades before clinical symptoms. We aimed to investigate whether neurodevelopment and/or neurodegeneration affects the risk of AD, through reducing structural…
View article: Post-traumatic stress disorder symptoms following exposure to acute psychological trauma in children aged 8-16 years in South Africa: the Sinethemba longitudinal study
Post-traumatic stress disorder symptoms following exposure to acute psychological trauma in children aged 8-16 years in South Africa: the Sinethemba longitudinal study Open
IntroductionChildren exposed to trauma are vulnerable to developing posttraumatic stress disorder (PTSD) and other adverse mental health outcomes. In research conducted in high-income countries (HIC), psychosocial and psychobiological pred…
View article: Data-driven digital health technologies in the remote clinical care of diabetic foot ulcers: a scoping review
Data-driven digital health technologies in the remote clinical care of diabetic foot ulcers: a scoping review Open
Background The availability and effectiveness of Digital Health Technologies (DHTs) to support clinicians, empower patients, and generate economic savings for national healthcare systems are growing rapidly. Of particular promise is the ca…
View article: Sex-Based Contributors to and Consequences of Post-traumatic Stress Disorder
Sex-Based Contributors to and Consequences of Post-traumatic Stress Disorder Open
View article: The subcortical correlates of autistic traits in school-age children: a population-based neuroimaging study
The subcortical correlates of autistic traits in school-age children: a population-based neuroimaging study Open
Background There is emerging evidence that the neuroanatomy of autism forms a spectrum which extends into the general population. However, whilst several studies have identified cortical morphology correlates of autistic traits, it is not …
View article: Psychotherapeutic interventions for childhood posttraumatic stress disorder: an update
Psychotherapeutic interventions for childhood posttraumatic stress disorder: an update Open
Purpose of the review We review treatment outcome studies and systematic reviews for childhood and adolescent posttraumatic stress disorder (PTSD) between January 2020 and August 2022, including studies involving younger children and diffe…
View article: The subcortical morphology correlates of autistic traits in school-age children: a population-based neuroimaging study
The subcortical morphology correlates of autistic traits in school-age children: a population-based neuroimaging study Open
Background There is emerging evidence that the neuroanatomy of autism forms a spectrum which extends into the general population. However, whilst several studies have identified cortical morphology correlates of autistic traits, it is not …
View article: The bidirectional causal effects of brain morphology across the life course and risk of Alzheimers disease: A cross-cohort comparison and Mendelian randomization meta-analysis
The bidirectional causal effects of brain morphology across the life course and risk of Alzheimers disease: A cross-cohort comparison and Mendelian randomization meta-analysis Open
Neuropathological changes associated with Alzheimers disease (AD) can occur decades before clinical symptoms. We investigated whether neurodevelopment and/or neurodegeneration affects the risk of AD, through reducing structural brain reser…
View article: Population neuroimaging: generation of a comprehensive data resource within the ALSPAC pregnancy and birth cohort
Population neuroimaging: generation of a comprehensive data resource within the ALSPAC pregnancy and birth cohort Open
Neuroimaging offers a valuable insight into human brain development by allowing in vivo assessment of structure, connectivity and function. Multimodal neuroimaging data have been obtained as part of three sub-studies within the Avon Longit…