Eugene S.J. Tan
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View article: Left Atrial Myocardial Mechanics: Association With Cognitive Dysfunction, Cerebrovascular Disease, and Circulating Biomarkers
Left Atrial Myocardial Mechanics: Association With Cognitive Dysfunction, Cerebrovascular Disease, and Circulating Biomarkers Open
Background The relationship of left atrial ( LA ) strain with cognition in the absence of atrial fibrillation is poorly understood. We investigated the association of LA strain with cognitive impairment and its pathogenetic subtype (vascul…
View article: U-shaped association of resting heart rate with cognitive decline
U-shaped association of resting heart rate with cognitive decline Open
Reports of associations between bradycardia and elevated resting heart rate with cognitive decline are inconsistent, and the underlying mechanisms unclear. Resting heart rate was recorded in a prospective cohort of memory clinic subjects, …
View article: Associations of Circulating Platelet Endothelial Cell Adhesion Molecule‐1 Levels with Progression of Cerebral Small Vessel Disease, Cognitive Performance and Incident Dementia
Associations of Circulating Platelet Endothelial Cell Adhesion Molecule‐1 Levels with Progression of Cerebral Small Vessel Disease, Cognitive Performance and Incident Dementia Open
Background The association between platelet endothelial cell adhesion molecule‐1 (PECAM‐1) with cerebral small vessel disease (CSVD) and cognition in non‐demented subjects remains un‐investigated. Method A longitudinal, prospective cohort …
View article: Atrial function: Association with cerebrovascular disease and cognitive dysfunction
Atrial function: Association with cerebrovascular disease and cognitive dysfunction Open
Background The relationships of left atrial (LA) dysfunction with cognition are poorly understood. We investigated the associations of LA function with cognitive impairment, etiologic‐subtype (neurodegenerative vs. vascular[VCI]), neuroima…
View article: Associations of Circulating Platelet Endothelial Cell Adhesion Molecule‐1 Levels With Progression of Cerebral Small‐Vessel Disease, Cognitive Decline, and Incident Dementia
Associations of Circulating Platelet Endothelial Cell Adhesion Molecule‐1 Levels With Progression of Cerebral Small‐Vessel Disease, Cognitive Decline, and Incident Dementia Open
Background The association between platelet endothelial cell adhesion molecule‐1 (PECAM‐1) with cerebral small‐vessel disease and cognition in dementia‐free subjects remains uninvestigated. Methods and Results A prospective cohort of demen…
View article: Circulating Plasma Proteins in Aortic Stenosis: Associations With Severity, Myocardial Response, and Clinical Outcomes
Circulating Plasma Proteins in Aortic Stenosis: Associations With Severity, Myocardial Response, and Clinical Outcomes Open
Background Echocardiographic indexes of aortic stenosis may not comprehensively reflect disease morbidity. Plasma proteomic profiling may add prognostic value in these patients. Methods and Results Proximity extension assays (Olink) of 183…
View article: The relative associations of aortic and carotid artery stiffness with CeVD and cognition
The relative associations of aortic and carotid artery stiffness with CeVD and cognition Open
We examined the relative associations of aortic and carotid artery stiffness with cerebrovascular disease (CeVD), cognition, and dementia subtypes in a memory clinic cohort of 272 participants (mean age = 75.4, SD = 6.8). We hypothesized t…
View article: Feasibility, safety and outcomes of conduction system pacing for bradycardia amongst the very elderly
Feasibility, safety and outcomes of conduction system pacing for bradycardia amongst the very elderly Open
View article: The relative contributions of aortic and carotid artery stiffness to CeVD and cognition
The relative contributions of aortic and carotid artery stiffness to CeVD and cognition Open
Introduction: The relative contributions of aortic and carotid artery stiffness on cognitive impairment and dementia remain unknown. We examined the associations of aortic and carotid artery stiffness with cerebrovascular disease markers, …
View article: Differential Associations of A-/B-Type Natriuretic Peptides With Cardiac Structure, Function, and Prognosis in Heart Failure
Differential Associations of A-/B-Type Natriuretic Peptides With Cardiac Structure, Function, and Prognosis in Heart Failure Open
View article: The effects of carotid artery stiffness on cerebral small vessel disease and cognition
The effects of carotid artery stiffness on cerebral small vessel disease and cognition Open
Background Carotid artery stiffness is associated with cognitive impairment and dementia, however, the underlying mechanism remains unknown. We examined the association of carotid artery stiffness with cerebral small vessel disease (CSVD) …
View article: Conduction system versus biventricular pacing in heart failure with non‐left bundle branch block
Conduction system versus biventricular pacing in heart failure with non‐left bundle branch block Open
Introduction The benefits of cardiac resynchronization therapy (CRT) with biventricular pacing (BiV) is significantly lower when applied to heart failure (HF) patients with non‐left bundle branch block (LBBB) conduction delay. We investiga…
View article: Effects of Carotid Artery Stiffness on Cerebral Small‐Vessel Disease and Cognition
Effects of Carotid Artery Stiffness on Cerebral Small‐Vessel Disease and Cognition Open
Background Carotid artery stiffness is associated with cognitive impairment and dementia, but the underlying mechanisms remain unknown. We examined the associations of carotid artery stiffness with cerebral small‐vessel disease markers, co…
View article: Sex and ethnicity modified high 1-year mortality in patients in Singapore with newly diagnosed atrial fibrillation
Sex and ethnicity modified high 1-year mortality in patients in Singapore with newly diagnosed atrial fibrillation Open
Introduction: We investigated sex and ethnic differences in the incidence, clinical characteristics and 1-year mortality of patients with newly diagnosed AF in a multi-ethnic population. Method: This retrospective cohort study of patients …
View article: Repetitive loss of accessory pathway conduction: What is the mechanism?
Repetitive loss of accessory pathway conduction: What is the mechanism? Open
View article: Atrial Fibrillation and the Prognostic Performance of Biomarkers in Heart Failure
Atrial Fibrillation and the Prognostic Performance of Biomarkers in Heart Failure Open
Background Consideration of circulating biomarkers for risk stratification in heart failure (HF) is recommended, but the influence of atrial fibrillation (AF) on prognostic performance of many markers is unclear. We investigated the influe…
View article: The diabetes-atrial fibrillation paradox
The diabetes-atrial fibrillation paradox Open
To the Editor We appreciate the editorial by Burden and Timpson1 highlighting collider bias as a potential explanation for our findings of a differential association between diabetes and atrial fibrillation (AF) by ethnicity as well as by …
View article: Ethnic differences in atrial fibrillation in patients with heart failure from Asia-Pacific
Ethnic differences in atrial fibrillation in patients with heart failure from Asia-Pacific Open
Objective Ethnic differences in the prevalence of atrial fibrillation (AF) in heart failure (HF) remain unclear. We compared the prevalence and clinical correlates of AF among different ethnicities in an Asian-Pacific population with HF. M…
View article: Optimal duration and predictors of diagnostic utility of patient-activated ambulatory ECG monitoring
Optimal duration and predictors of diagnostic utility of patient-activated ambulatory ECG monitoring Open
Objective We studied the optimal duration of ambulatory event monitors for symptomatic patients and the predictors of detected events. Methods Patients with palpitations or dizziness received a patient-activated handheld event monitor whic…
View article: Sleep study–guided multidisciplinary therapy (SGMT) for patients with acute coronary syndrome: Trial rationale and design
Sleep study–guided multidisciplinary therapy (SGMT) for patients with acute coronary syndrome: Trial rationale and design Open
Obstructive sleep apnea (OSA) is an emerging risk marker for acute coronary syndrome (ACS). This randomized trial aims to determine the effects of sleep study–guided multidisciplinary therapy (SGMT) comprising overnight sleep study, contin…
View article: Quality Reference Framework (QRF) for the Quality of Massive Open Online Courses (MOOCs): Developed by MOOQ in close collaboration with all interested parties worldwide
Quality Reference Framework (QRF) for the Quality of Massive Open Online Courses (MOOCs): Developed by MOOQ in close collaboration with all interested parties worldwide Open
This document contains the Quality Reference Framework (QRF) developed by the European Alliance for the Quality of Massive Open Online Courses (MOOCs), called MOOQ. The Quality Reference Framework consists of three dimensions: Dimension 1:…
View article: ABSTRACT Oral Presentation (2)
ABSTRACT Oral Presentation (2) Open
Introduction: Patient-activated ambulatory ECG monitors have been widely used in the outpatient setting for patients with infrequent symptoms.The optimal duration for diagnosis and the predictors of detection remain unclear.Methods: Patien…
View article: Orchestrating Learning Scenarios for the Borderless Classroom
Orchestrating Learning Scenarios for the Borderless Classroom Open
This part of the symposium focuses on the design of seamless learning experiences in a borderless classroom. There are two parts to this symposium. We start with unpacking various theoretical approaches that inform the instructional design…
View article: 1-g model tests of tunnels with a surrounding cement-treated soil ring
1-g model tests of tunnels with a surrounding cement-treated soil ring Open
The construction of large diameter tunnels can be challenging, especially in soft soil conditions. Stability intervention by means of ground improvement has been identified as a possible method to allow for the safe construction of such tu…
View article: Electrocardiographic Criteria for Left Ventricular Hypertrophy in Asians Differs from Criteria Derived from Western Populations—Community-based Data from an Asian Population
Electrocardiographic Criteria for Left Ventricular Hypertrophy in Asians Differs from Criteria Derived from Western Populations—Community-based Data from an Asian Population Open
Introduction: Electrocardiographic (ECG) criteria for left ventricular hypertrophy (LVH), such as the Cornell and Sokolow-Lyon voltage criteria were derived from Western populations. However, their utility and accuracy for diagnosing echoc…