Yi Tan
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View article: The Clinical Utility of the Objective Measures for Diagnosing and Monitoring Attention-Deficit and Hyperactivity Disorder (ADHD) in Adults: A Systematic Review
The Clinical Utility of the Objective Measures for Diagnosing and Monitoring Attention-Deficit and Hyperactivity Disorder (ADHD) in Adults: A Systematic Review Open
Background: Clinical practice suggests that objective assessment tools are needed to assess adults with inattention or hyperactivity, informed by the underlying pathophysiology of attention-deficit and hyperactivity disorder (ADHD). This s…
View article: Intestinal Neutral Ceramidase Deficiency Triggers Regulatory T Cell Response via Gd3 to Protect the Host from Intestinal Inflammation
Intestinal Neutral Ceramidase Deficiency Triggers Regulatory T Cell Response via Gd3 to Protect the Host from Intestinal Inflammation Open
Sphingolipids play a crucial role in gut inflammation. Neutral ceramidase (NcDase) serves as a pivotal regulator of ceramide, the central intermediate in sphingolipid metabolism. The contribution of intestinal epithelial cells (IEC) NcDase…
View article: Right ventricular dysfunctions in type 1 diabetic mice: A longitudinal study
Right ventricular dysfunctions in type 1 diabetic mice: A longitudinal study Open
BACKGROUND Diabetes has become a widespread metabolic disease affecting multiple organs. Among diabetic complications, cardiovascular complications are the main cause of patient morbidity and mortality. Diabetic cardiomyopathy is a diabete…
View article: Commensal bacterial glycosylation at the interface of host–bacteria interactions
Commensal bacterial glycosylation at the interface of host–bacteria interactions Open
Commensal bacteria produce a diverse array of glycosylated molecules, including glycoproteins, glycolipids, peptidoglycan, capsular polysaccharides, and exopolysaccharides, which play fundamental roles in host-microbe interactions. Recent …
View article: Injectable Functional Porous Carbon‐Loaded Hydrogel with Long‐Term Retention and Synergistic Anti‐Tumor Properties for Tumor Therapy
Injectable Functional Porous Carbon‐Loaded Hydrogel with Long‐Term Retention and Synergistic Anti‐Tumor Properties for Tumor Therapy Open
In situ therapies show significant promise for the treatment of unresectable tumors that lack tumor supply vessels. However, it remains a tremendous challenge to achieve precise delivery and sustained release of anti‐tumor agents with syne…
View article: Essential Gene Dynamics across Distinct Growth Conditions in <i>Xanthomonas citri</i>
Essential Gene Dynamics across Distinct Growth Conditions in <i>Xanthomonas citri</i> Open
Essential genes are crucial for bacterial growth and the pathogenicity. However, how gene essentiality varies under distinct growth conditions and its role in virulence remains poorly understood. In this study, we constructed high-saturati…
View article: High-Fat Diet Differentially Regulates Fibroblast Growth Factor Expression in Metabolic Tissues of Young and Aged Male Mice
High-Fat Diet Differentially Regulates Fibroblast Growth Factor Expression in Metabolic Tissues of Young and Aged Male Mice Open
Context Fibroblast growth factors (FGFs) play critical roles in metabolism, yet their tissue-specific expression in response to obesity and aging remains unclear. Objective We investigated the mRNA expression profiles of FGFs along with th…
View article: Plasma Metabolic Profiles of Chronic and Recurrent Uveitis Treated by Artesunate in Lewis Rats
Plasma Metabolic Profiles of Chronic and Recurrent Uveitis Treated by Artesunate in Lewis Rats Open
Background/Objectives: Identifying effective and safe treatment options for non-infectious uveitis remains challenging due to chronic and relapsing ocular inflammation. Previous studies have shown that artesunate (ART) plays an immunosuppr…
View article: Sedative Effect of White Noise on Prefrontal Cortex Lobe: A Randomized Controlled Study Based on Functional Near-Infrared Spectroscopy
Sedative Effect of White Noise on Prefrontal Cortex Lobe: A Randomized Controlled Study Based on Functional Near-Infrared Spectroscopy Open
Background: White noise has attracted widespread attention due to its potential effects on psychological and physiological states, particularly in promoting relaxation. The prefrontal cortex, a critical region of the brain responsible for …
View article: Diabetic cardiomyopathy: Importance of direct evidence to support the roles of NOD-like receptor protein 3 inflammasome and pyroptosis
Diabetic cardiomyopathy: Importance of direct evidence to support the roles of NOD-like receptor protein 3 inflammasome and pyroptosis Open
Recently, the roles of pyroptosis, a form of cell death induced by activated NOD-like receptor protein 3 (NLRP3) inflammasome, in the pathogenesis of diabetic cardiomyopathy (DCM) have been extensively investigated. However, most studies h…
View article: Withaferin A as a Potential Therapeutic Target for the Treatment of Angiotensin II-Induced Cardiac Cachexia
Withaferin A as a Potential Therapeutic Target for the Treatment of Angiotensin II-Induced Cardiac Cachexia Open
In our previous studies, we showed that the generation of ovarian tumors in NSG mice (immune-compromised) resulted in the induction of muscle and cardiac cachexia, and treatment with withaferin A (WFA; a steroidal lactone) attenuated both …
View article: Role of non-coding RNA hsa_circ_0001495 in 16HBE cellular inflammation induced by PM<sub>2.5</sub>and O<sub>3</sub>combined exposure
Role of non-coding RNA hsa_circ_0001495 in 16HBE cellular inflammation induced by PM<sub>2.5</sub>and O<sub>3</sub>combined exposure Open
Background PM 2.5 and O 3 are the main air pollutants in China, and inflammation of the respiratory system is one of their main toxic effects. Cyclic RNAs are involved in many pathophysiological processes, but their relationship to the com…
View article: Mechanism through which the hsa-circ_0000992– hsa- miR- 936–AKT3 regulatory network promotes the PM2.5-induced inflammatory response in human bronchial epithelial cells
Mechanism through which the hsa-circ_0000992– hsa- miR- 936–AKT3 regulatory network promotes the PM2.5-induced inflammatory response in human bronchial epithelial cells Open
PM2.5 can induce the inflammatory response in 16HBE cells by activating the PI3K/AKT pathway. The expression of hsa_circ_0000992 increased when PM2.5 stimulated 16HBE cells,and the circRNA could then regulate the inflammatory response.Hsa_…
View article: An Efficient CRISPR/Cas9 Genome Editing System for a Ganoderma lucidum Cultivated Strain by Ribonucleoprotein Method
An Efficient CRISPR/Cas9 Genome Editing System for a Ganoderma lucidum Cultivated Strain by Ribonucleoprotein Method Open
The CRISPR/Cas9 system has become a popular approach to genome editing. Compared with the plasmid-dependent CRISPR system, the ribonucleoprotein (RNP) complex formed by the in vitro assembly of Cas9 and single-guide RNA (sgRNA) has many ad…
View article: Mechanism of Interaction between hsa_circ_0002854 and MAPK1 Protein in PM2.5-Induced Apoptosis of Human Bronchial Epithelial Cells
Mechanism of Interaction between hsa_circ_0002854 and MAPK1 Protein in PM2.5-Induced Apoptosis of Human Bronchial Epithelial Cells Open
Fine particulate matter (PM2.5) pollution increases the risk of respiratory diseases and death, and apoptosis is an important factor in the occurrence of respiratory diseases caused by PM2.5 exposure. In addition, circular RNAs (circRNAs) …
View article: Alterations of <scp>SIRT1</scp>/<scp>SIRT3</scp> subcellular distribution in aging undermine cardiometabolic homeostasis during ischemia and reperfusion
Alterations of <span>SIRT1</span>/<span>SIRT3</span> subcellular distribution in aging undermine cardiometabolic homeostasis during ischemia and reperfusion Open
Age‐related sensors Sirtuin1 (SIRT1) and Sirtuin3 (SIRT3) play an essential role in the protective response upon myocardial ischemia and/or reperfusion (I/R). However, the subcellular localization and co‐regulatory network between cardiac …
View article: Kalanchoë blossfeldiana naturally transformed with Rhizobium rhizogenes exhibits superior root phenotype
Kalanchoë blossfeldiana naturally transformed with Rhizobium rhizogenes exhibits superior root phenotype Open
Plant transformation with root oncogenic loci (rol) genes and open reading frames (ORFs) from Rhizobium rhizogenes have not yet targeted the underground root phenotype of these transformants. Hence, there is a need to develop plants with m…
View article: CXCR7 agonist TC14012 improves angiogenic function of endothelial progenitor cells via activating Akt/eNOS pathway and promotes ischemic angiogenesis in diabetic limb ischemia
CXCR7 agonist TC14012 improves angiogenic function of endothelial progenitor cells via activating Akt/eNOS pathway and promotes ischemic angiogenesis in diabetic limb ischemia Open
Purpose Endothelial progenitor cells (EPCs) play a critical role in repairing damaged vessels and triggering ischemic angiogenesis, but their number is reduced and function is impaired under diabetic conditions. Improving EPC function has …