Kok Hian Tan
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View article: Transplacental transfer efficiency of environmental chemicals in association with gestational diabetes mellitus
Transplacental transfer efficiency of environmental chemicals in association with gestational diabetes mellitus Open
We found high TTRs for multiple short half-life chemicals and more recently introduced short-chain PFAS. Importantly, GDM was associated with increased transplacental efficiency of several classes of environmental chemicals, particularly c…
View article: Consensus statements on perinatal depression and anxiety in the Asia-Pacific region
Consensus statements on perinatal depression and anxiety in the Asia-Pacific region Open
These guidelines, developed for maternal and child health practitioners in the Asia-Pacific, promote a holistic approach-combining lifestyle changes, early screening, and tailored interventions-to improve perinatal mental health and enhanc…
View article: Championing maternal health and reducing maternal mortality: a global multidisciplinary imperative
Championing maternal health and reducing maternal mortality: a global multidisciplinary imperative Open
Maternal mortality is a vital indicator of the performance of healthcare systems. To address the challenges it faces, a multifaceted lens is required. In this editorial, we present eight studies addressing maternal health from various pers…
View article: Composition of the human milk microbiome in the GUSTO cohort is shaped by intrapartum antibiotic prophylaxis and breastfeeding exclusivity
Composition of the human milk microbiome in the GUSTO cohort is shaped by intrapartum antibiotic prophylaxis and breastfeeding exclusivity Open
Human milk contains a low biomass microbiome, which is thought to contribute to mammary and infant health. However, the determinants of the human milk microbiome across populations are poorly understood. Here, we characterized the microbio…
View article: Perinatal mental health in Singapore—prevalence, knowledge, attitudes, and practices
Perinatal mental health in Singapore—prevalence, knowledge, attitudes, and practices Open
Introduction There is limited data on perinatal depression and anxiety rates, as well as on knowledge, attitudes, and practices related to perinatal mental health (PMH), particularly in an urban Southeast Asian population. Methods From Sep…
View article: Endocrine disrupting chemicals in maternal and umbilical cord plasma and their associations with birthweight in the GUSTO cohort
Endocrine disrupting chemicals in maternal and umbilical cord plasma and their associations with birthweight in the GUSTO cohort Open
This study adds to the growing concern about the impact of EDCs, especially the newer chemicals on vulnerable groups such as the developing fetus, warranting further research on the potential effects of in-utero EDC exposure on child healt…
View article: Saliva as a non-invasive matrix for assessing xenobiotic metabolites and metabolomes: implications for maternal health and preeclampsia
Saliva as a non-invasive matrix for assessing xenobiotic metabolites and metabolomes: implications for maternal health and preeclampsia Open
Chemical exposure during prenatal development has significant implications for both maternal and child health. Compared to blood, saliva is a non-invasive and less resource-intensive, alternative. Given the temporal variability of xenobiot…
View article: Patient Safety Leaders’ Perception of Patient Safety Practices in Eight Asia-Pacific Countries: Survey Based on the Global Patient Safety Action Plan Framework
Patient Safety Leaders’ Perception of Patient Safety Practices in Eight Asia-Pacific Countries: Survey Based on the Global Patient Safety Action Plan Framework Open
Our study revealed substantial differences in perception of patient safety practices across healthcare facilities of Asia-Pacific countries and across the strategic objectives. This helped to establish a baseline of patient safety landscap…
View article: First Trimester Mean Glucose Level on Continuous Glucose Monitoring Is Associated with Infant Birth Weight
First Trimester Mean Glucose Level on Continuous Glucose Monitoring Is Associated with Infant Birth Weight Open
Background: Comparisons between continuous glucose monitoring (CGM) metrics during the first and second trimesters and conventional mid-pregnancy oral glucose tolerance test (OGTT) values in pregnant women without pre-existing diabetes for…
View article: Preterm birth trends and risk factors in a multi-ethnic Asian population: A retrospective study from 2017 to 2023, can we screen and predict this?
Preterm birth trends and risk factors in a multi-ethnic Asian population: A retrospective study from 2017 to 2023, can we screen and predict this? Open
Introduction: Preterm birth (PTB) remains a leading cause of perinatal morbidity and mortality worldwide. Understanding Singapore’s PTB trends and associated risk factors can inform effective strategies for screening and intervention. This…
View article: Sexual dimorphism in the association of umbilical cord blood lipidome with abdominal fat in early childhood
Sexual dimorphism in the association of umbilical cord blood lipidome with abdominal fat in early childhood Open
Our study reveals sexual dimorphism in the associations between cord blood lipidome and abdominal adiposity, suggesting depot-specific patterns in adipose tissue development and lipid metabolism in early life.
View article: High-Risk Consult Multidisciplinary Team in a Tertiary Maternity Unit: Changing Prevalence of Cases
High-Risk Consult Multidisciplinary Team in a Tertiary Maternity Unit: Changing Prevalence of Cases Open
CIRB Ref: 2022/2458.
View article: Mediation effect of dental caries in the relationship between parental locus of control and oral health related quality of life
Mediation effect of dental caries in the relationship between parental locus of control and oral health related quality of life Open
Objectives The study aims to assess the direct and indirect effect of parental locus of control (LoC) on child oral health related quality of life. Methods As part of the Growing Up in Singapore Towards healthy Outcomes (GUSTO) multicenter…
View article: Caregiver feeding practices for infants and toddlers and their eating behaviors in Singapore
Caregiver feeding practices for infants and toddlers and their eating behaviors in Singapore Open
Introduction Research on early childhood caregiver feeding practices and eating behaviors is limited, especially within Asian populations. This study examined these practices across key feeding domains of variety, autonomy, and mealtime se…
View article: Linking obesity-associated genotype to child language development: the role of early-life neurology-related proteomics and brain myelination
Linking obesity-associated genotype to child language development: the role of early-life neurology-related proteomics and brain myelination Open
Singapore National Research Foundation and Agency for Science, Technology and Research.
View article: Associations of fetal and postnatal growth trajectories with child cognition: the GUSTO cohort study
Associations of fetal and postnatal growth trajectories with child cognition: the GUSTO cohort study Open
Background Using longitudinal ultrasounds as an improved fetal growth marker, we aimed to investigate if increased postnatal growth following fetal abdominal circumference (AC) growth deceleration is associated with improved child cognitio…
View article: An Online Resource for Monitoring 24-Hour Activity in Children and Adolescents: Observational Analysis
An Online Resource for Monitoring 24-Hour Activity in Children and Adolescents: Observational Analysis Open
Background The Singapore integrated 24-hour activity guide for children and adolescents was introduced to promote healthy lifestyle behaviors, including physical activity, sedentary behavior, sleep, and diet, to enhance metabolic health an…
View article: Exploring multi-omics and clinical characteristics linked to accelerated biological aging in Asian women of reproductive age: insights from the S-PRESTO study
Exploring multi-omics and clinical characteristics linked to accelerated biological aging in Asian women of reproductive age: insights from the S-PRESTO study Open
Our findings provide a comprehensive analysis of aging-related factors across multiple platforms, delineating their complex interconnections. This study is the first to report novel signatures in lipidomics, gut microbiome and blood biomar…
View article: Ethnic-specific oral glucose tolerance (OGTT) phenotypes in women with hyperglycemia in pregnancy
Ethnic-specific oral glucose tolerance (OGTT) phenotypes in women with hyperglycemia in pregnancy Open
Introduction Ethnic differences associated with oral glucose tolerance test (OGTT) phenotypes is less studied in Southeast Asian ethnicities, especially in women with hyperglycemia in pregnancy (HIP). Research design and methods We retrosp…
View article: Dietary pattern trajectories in early childhood and their associations with patterns of maternal feeding practices in a multi-ethnic Asian cohort
Dietary pattern trajectories in early childhood and their associations with patterns of maternal feeding practices in a multi-ethnic Asian cohort Open
A small number of children in this multi-ethnic study showed high adherence to the 'healthy' or 'less healthy' DP trajectory groups, respectively, while the majority showed average adherence to either of these trajectories. The positive as…
View article: Maternal pregnancy diet quality, night eating, and offspring metabolic health: the GUSTO study
Maternal pregnancy diet quality, night eating, and offspring metabolic health: the GUSTO study Open
We demonstrated that maternal predominant night-eating behavior and low-quality diet are associated with higher offspring insulin resistance. Maternal low-quality diet and predominant night-eating behavior synergistically interact to influ…
View article: Association and Predictive Ability of ACTN3 C/T, ACE I/D and PPARGC1A A/G Polymorphisms on Jump Height of Elite Malaysian Footballers
Association and Predictive Ability of ACTN3 C/T, ACE I/D and PPARGC1A A/G Polymorphisms on Jump Height of Elite Malaysian Footballers Open
Footballing performance is a complicated phenotype influenced by various factors that include individual genetic makeup and environmental variables. Genetic association research in football is gaining significant interest but the majority …
View article: Sleep problems in preschool mediate the association between chronotype and socioemotional problems at school-age
Sleep problems in preschool mediate the association between chronotype and socioemotional problems at school-age Open
Our findings suggest addressing sleep problems during early development may reduce socioemotional problems at school-age, especially among evening-chronotype children.
View article: The prospective associations of 24-hour movement behaviors and domain-specific activities with executive function and academic achievement among school-aged children in Singapore
The prospective associations of 24-hour movement behaviors and domain-specific activities with executive function and academic achievement among school-aged children in Singapore Open
Background Physical activity (PA), sedentary behavior (SB), and sleep are collectively referred to as 24-h movement behaviors, which may be linked to cognitive development in children. However, most of the evidence was based on cross-secti…