Daniela Ježová
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View article: Pro-Cognitive Effect of Royal Jelly Is Linked with Increased Burst Activity of Mesocorticolimbic Dopaminergic Neurons
Pro-Cognitive Effect of Royal Jelly Is Linked with Increased Burst Activity of Mesocorticolimbic Dopaminergic Neurons Open
Background: Royal jelly is a protein-rich honeybee secretion that is used in the nutrition of larvae and adult queens. Previous studies have reported that royal jelly had induced pro-cognitive, anxiolytic, and antidepressant-like effects i…
View article: Pro-Cognitive Effect of Royal Jelly Is Linked with Increased Burst Activity of Mesocorticolimbic Dopaminergic Neurons
Pro-Cognitive Effect of Royal Jelly Is Linked with Increased Burst Activity of Mesocorticolimbic Dopaminergic Neurons Open
Royal jelly is a protein-rich honeybee secretion that is used in the nutrition of larvae and adult queens. Previous studies reported that royal jelly had induced pro-cognitive, anxio-lytic, and antidepressant-like effects in laboratory rat…
View article: LIGANDS OF THE DELTA-OPIOID RECEPTOR AND TRACE AMINE ASSOCIATED RECEPTOR 1 EXERT SIMILAR EFFECTS ON MONOAMINERGIC TRANSMISSION IN RATS
LIGANDS OF THE DELTA-OPIOID RECEPTOR AND TRACE AMINE ASSOCIATED RECEPTOR 1 EXERT SIMILAR EFFECTS ON MONOAMINERGIC TRANSMISSION IN RATS Open
Background It has been reported in previous studies that the agonists of delta opioid receptor (DOR)[1] and trace amine associated receptor 1 (TAAR1)[2] have anxiolytic and antidepressant-like effects in rodents. It has been also suggested…
View article: EFFECTS OF PRENATAL AND POSTNATAL TREATMENT WITH A DELTA- OPIOID RECEPTOR LIGAND ON ANXIETY, COGNITION AS WELL AS MESOLIMBIC DOPAMINERGIC AND HIPPOCAMPAL GLUTAMATERGIC NEUROTRANSMISSION IN RATS
EFFECTS OF PRENATAL AND POSTNATAL TREATMENT WITH A DELTA- OPIOID RECEPTOR LIGAND ON ANXIETY, COGNITION AS WELL AS MESOLIMBIC DOPAMINERGIC AND HIPPOCAMPAL GLUTAMATERGIC NEUROTRANSMISSION IN RATS Open
Background Central neurotransmitters are well-known to be involved in the pathophysiological processes leading to mental disorders. It is suggested that activation of delta opioid receptors (DOR) may lead to anxiolytic and antidepressant-l…
View article: Reduced Hair and Salivary Cortisol Concentrations Associated with Improved Emotional Well-Being Following Repeated Forest Walking: A Randomized Intervention Trial in Older Adults
Reduced Hair and Salivary Cortisol Concentrations Associated with Improved Emotional Well-Being Following Repeated Forest Walking: A Randomized Intervention Trial in Older Adults Open
The main hypothesis of this study in older adults is that repeated walks in a forest but not an urban environment for one month lead to reduced chronic stress compared to the previous month without any intervention. This was achieved by th…
View article: Maternal treatment with a selective delta-opioid receptor agonist during gestation has a sex-specific pro-cognitive action in offspring: mechanisms involved
Maternal treatment with a selective delta-opioid receptor agonist during gestation has a sex-specific pro-cognitive action in offspring: mechanisms involved Open
Background: There is growing evidence that the treatment of several mental disorders can potentially benefit from activation of delta-opioid receptors. In the future, delta-agonists with a safe pharmacological profile can be used for the t…
View article: Forests serve vulnerable groups in times of crises: improved mental health of older adults by individual forest walking during the COVID-19 pandemic
Forests serve vulnerable groups in times of crises: improved mental health of older adults by individual forest walking during the COVID-19 pandemic Open
Understanding the effects of environment on the mental health of older adults is crucial in an aging society. Previous research concerning restorative benefits of forests almost entirely omitted older adults as the primary target group and…
View article: Treatment with Glycyrrhiza glabra Extract Induces Anxiolytic Effects Associated with Reduced Salt Preference and Changes in Barrier Protein Gene Expression
Treatment with Glycyrrhiza glabra Extract Induces Anxiolytic Effects Associated with Reduced Salt Preference and Changes in Barrier Protein Gene Expression Open
We have previously identified that low responsiveness to antidepressive therapy is associated with higher aldosterone/cortisol ratio, lower systolic blood pressure, and higher salt preference. Glycyrrhiza glabra (GG) contains glycyrrhizin,…
View article: Selected neuroendocrine factors as potential molecular biomarkers of early non-affective psychosis course in relation to treatment outcome: A pilot study
Selected neuroendocrine factors as potential molecular biomarkers of early non-affective psychosis course in relation to treatment outcome: A pilot study Open
The aim of this pilot study was to find whether the dysregulation of neuroendocrine biomarker signaling pathways in the first episode of non-affective psychosis is a predictive factor of treatment outcome. Patients with the first episode o…
View article: Bridging the mood and stress hormone levels between mothers and their babies: The study design and first preliminary results
Bridging the mood and stress hormone levels between mothers and their babies: The study design and first preliminary results Open
The neurobiological mechanisms involved in the influence of post-partum maternal mood fluctuations on child development are far from being understood. Here we present the design of an ongoing study aimed to test the hypothesis that the men…
View article: Editorial: Stress, anxiety, and the synapse
Editorial: Stress, anxiety, and the synapse Open
EDITORIAL article Front. Behav. Neurosci., 21 November 2022Sec. Emotion Regulation and Processing https://doi.org/10.3389/fnbeh.2022.1085850
View article: A viewpoint on aldosterone and <scp>BMI</scp> related brain morphology in relation to treatment outcome in patients with major depression
A viewpoint on aldosterone and <span>BMI</span> related brain morphology in relation to treatment outcome in patients with major depression Open
An abundance of knowledge has been collected describing the involvement of neuroendocrine parameters in major depression. The hypothalamic–pituitary–adrenocortical (HPA) axis regulating cortisol release has been extensively studied; howeve…
View article: Effects of acute and chronic administration of trace amine-associated receptor 1 (TAAR1) ligands on in vivo excitability of central monoamine-secreting neurons in rats
Effects of acute and chronic administration of trace amine-associated receptor 1 (TAAR1) ligands on in vivo excitability of central monoamine-secreting neurons in rats Open
Trace amine-associated receptor 1 (TAAR1) has been recently identified as a target for the future antidepressant, antipsychotic, and anti-addiction drugs. Full (e.g. RO5256390) and partial (e.g. RO5263397) TAAR1 agonists showed antidepress…
View article: Stress Hormones Cortisol and Aldosterone, and Selected Markers of Oxidative Stress in Response to Long-Term Supplementation with Omega-3 Fatty Acids in Adolescent Children with Depression
Stress Hormones Cortisol and Aldosterone, and Selected Markers of Oxidative Stress in Response to Long-Term Supplementation with Omega-3 Fatty Acids in Adolescent Children with Depression Open
Late childhood and adolescence are crucial periods of brain development with high vulnerability to environmental insults. The aim of this study was to test the hypotheses that in adolescents with depression (a) 12 weeks-supplementation wit…
View article: Endocrine changes in women with a medically indicated abortion: the study design
Endocrine changes in women with a medically indicated abortion: the study design Open
A strongly psychosocially demanding situation in the life of a woman is the option of medically indicated abortion. Here we present the design of an ongoing study aiming to examine the stressfulness of life events related to medically indi…
View article: Psychotropic Drug Effects on Steroid Stress Hormone Release and Possible Mechanisms Involved
Psychotropic Drug Effects on Steroid Stress Hormone Release and Possible Mechanisms Involved Open
There is no doubt that chronic stress accompanied by adrenocortical stress hormone release affects the development and treatment outcome of several mental disorders. Less attention has been paid to the effects of psychotropic drugs on adre…
View article: Artificial intelligence and privacy
Artificial intelligence and privacy Open
At the current moment due to the enormous increase of digitalization the AI´s potential is starting to show its face. Many online applications used on daily basis (Facebook, Google, Netflix) are using AI technologies to improve their servi…
View article: Food Enrichment with Glycyrrhiza glabra Extract Suppresses ACE2 mRNA and Protein Expression in Rats—Possible Implications for COVID-19
Food Enrichment with Glycyrrhiza glabra Extract Suppresses ACE2 mRNA and Protein Expression in Rats—Possible Implications for COVID-19 Open
Angiotensin converting enzyme 2 (ACE2) is a key entry point of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus known to induce Coronavirus disease 2019 (COVID-19). We have recently outlined a concept to reduce ACE2 expre…
View article: Food Enrichment with Glycyrrhiza Glabra Extract Suppresses ACE2 mRNA and Protein Expression in Rats – Possible Implications for COVID-19
Food Enrichment with Glycyrrhiza Glabra Extract Suppresses ACE2 mRNA and Protein Expression in Rats – Possible Implications for COVID-19 Open
Angiotensin converting enzyme 2 (ACE2) is a key entry point of SARS-CoV-2 virus known to induce COVID-19. We have recently outlined the concept to reduce ACE2 expression by the administration of glycyrrhizin, a component of Glycyrrhiza gla…