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View article: <b>Differences in White Matter Microstructure in Children With Type 1 Diabetes Persist During Longitudinal Follow up: Relation to Dysglycemia</b>
<b>Differences in White Matter Microstructure in Children With Type 1 Diabetes Persist During Longitudinal Follow up: Relation to Dysglycemia</b> Open
Type 1 diabetes has detrimental effects in white matter microstructure. In a longitudinal study, we investigated if these reported findings change as children grow and enter puberty.143 children with type 1 diabetes and 71 non-diabetic con…
View article: Differences in White Matter Microstructure in Children With Type 1 Diabetes Persist During Longitudinal Follow-up: Relation to Dysglycemia
Differences in White Matter Microstructure in Children With Type 1 Diabetes Persist During Longitudinal Follow-up: Relation to Dysglycemia Open
Type 1 diabetes has detrimental effects in white matter microstructure. In a longitudinal study, we investigated whether these reported findings change as children grow and enter puberty. At study entry, there were 143 children with type 1…
View article: <b>Differences in White Matter Microstructure in Children With Type 1 Diabetes Persist During Longitudinal Follow up: Relation to Dysglycemia</b>
<b>Differences in White Matter Microstructure in Children With Type 1 Diabetes Persist During Longitudinal Follow up: Relation to Dysglycemia</b> Open
Type 1 diabetes has detrimental effects in white matter microstructure. In a longitudinal study, we investigated if these reported findings change as children grow and enter puberty.143 children with type 1 diabetes and 71 non-diabetic con…
View article: Many Pediatric Subspecialty Fellows Are Not Ready to Graduate From Fellowship in 2 Years
Many Pediatric Subspecialty Fellows Are Not Ready to Graduate From Fellowship in 2 Years Open
BACKGROUND AND OBJECTIVES The American Board of Pediatrics requires that proposed changes to the duration of pediatric subspecialty training must include a framework for competency assessment with a measurement component. We analyzed the c…
View article: Relationship between epa level of supervision with their associated subcompetency milestone levels in pediatric fellow assessment
Relationship between epa level of supervision with their associated subcompetency milestone levels in pediatric fellow assessment Open
Background Entrustable Professional Activities (EPA) and competencies represent components of a competency-based education framework. EPAs are assessed based on the level of supervision (LOS) necessary to perform the activity safely and ef…
View article: Executive Dysfunction in Klinefelter Syndrome: Associations With Brain Activation and Testicular Failure
Executive Dysfunction in Klinefelter Syndrome: Associations With Brain Activation and Testicular Failure Open
Context Executive dysfunction is a well-recognized component of the cognitive phenotype of Klinefelter syndrome (KS), yet the neural basis of KS-associated cognitive weaknesses, and their association with testicular failure is unknown. Obj…
View article: A self-guided curriculum on endocrinology standard of care for gender diverse youth, including ethical considerations
A self-guided curriculum on endocrinology standard of care for gender diverse youth, including ethical considerations Open
This is the first medical education curriculum in gender-affirming care created by pediatric endocrinologists grounded in the Endocrine Society practice guidelines. This study demonstrates medical knowledge gained in caring for gender dive…
View article: Review of Implant Gonadotrophin-Releasing Hormone Agonist Use: Experience in a Single Academic Center
Review of Implant Gonadotrophin-Releasing Hormone Agonist Use: Experience in a Single Academic Center Open
Background: Gonadotrophin-releasing hormone agonists (GnRHas) are used for puberty suppression in central precocious puberty (CPP) and gender dysphoria (GD). Guidelines on biochemical monitoring are not defined. Objectives: The aim of this…
View article: Fertility preservation in transgender and non-binary adolescents and young adults
Fertility preservation in transgender and non-binary adolescents and young adults Open
Although 37.5–51% of transgender adults state they would’ve considered freezing gametes before gender-affirming therapy if offered and 24–25.8% of transgender adolescents express interest in having biological children, less than 5% of tran…
View article: Fertility preservation in transgender and non-binary adolescents and young adults
Fertility preservation in transgender and non-binary adolescents and young adults Open
Although 37.5–51% of transgender adults state they would’ve considered freezing gametes before gender-affirming therapy if offered and 24–25.8% of transgender adolescents express interest in having biological children, less than 5% of tran…
View article: Impact of Type 1 Diabetes in the Developing Brain in Children: A Longitudinal Study
Impact of Type 1 Diabetes in the Developing Brain in Children: A Longitudinal Study Open
Objective: To assess whether previously observed brain and cognitive differences between children with type 1 diabetes and non-diabetic controls persist, worsen or improve as children grow into puberty, and whether differences are associat…
View article: Impact of Type 1 Diabetes in the Developing Brain in Children: A Longitudinal Study
Impact of Type 1 Diabetes in the Developing Brain in Children: A Longitudinal Study Open
Objective: To assess whether previously observed brain and cognitive differences between children with type 1 diabetes and non-diabetic controls persist, worsen or improve as children grow into puberty, and whether differences are associat…
View article: Impact of Type 1 Diabetes in the Developing Brain in Children: A Longitudinal Study
Impact of Type 1 Diabetes in the Developing Brain in Children: A Longitudinal Study Open
OBJECTIVE To assess whether previously observed brain and cognitive differences between children with type 1 diabetes and control subjects without diabetes persist, worsen, or improve as children grow into puberty and whether differences a…
View article: Brain function differences in children with type 1 diabetes: An fMRI study of working memory
Brain function differences in children with type 1 diabetes: An fMRI study of working memory Open
Glucose is a primary fuel source to the brain, yet the influence of dysglycemia on neurodevelopment in children with type 1 diabetes remains unclear. We examined brain activation using functional MRI in 80 children with type 1 diabetes (me…
View article: Brain function differences in children with type 1 diabetes: An fMRI study of working memory
Brain function differences in children with type 1 diabetes: An fMRI study of working memory Open
Glucose is a primary fuel source to the brain, yet the influence of dysglycemia on neurodevelopment in children with type 1 diabetes remains unclear. We examined brain activation using functional MRI in 80 children with type 1 diabetes (me…
View article: Brain Function Differences in Children With Type 1 Diabetes: A Functional MRI Study of Working Memory
Brain Function Differences in Children With Type 1 Diabetes: A Functional MRI Study of Working Memory Open
Glucose is a primary fuel source to the brain, yet the influence of dysglycemia on neurodevelopment in children with type 1 diabetes remains unclear. We examined brain activation using functional MRI in 80 children with type 1 diabetes (me…
View article: Agreement of Program Directors With Clinical Competency Committees for Fellow Entrustment
Agreement of Program Directors With Clinical Competency Committees for Fellow Entrustment Open
Objectives: Fellowship program directors (FPD) and Clinical Competency Committees (CCCs) both assess fellow performance. We examined the association of entrustment levels determined by the FPD with those of the CCC for 6 common pediatric s…
View article: Challenges with Patient Adoption of Automated Integration of Blood Glucose Meter Data in the Electronic Health Record
Challenges with Patient Adoption of Automated Integration of Blood Glucose Meter Data in the Electronic Health Record Open
Providers often encourage patients with type 1 diabetes (T1D) to contact them with blood glucose (BG) values between visits. However, patients and families find it cumbersome to share their BG values with clinical providers, creating a bar…
View article: Impact of Early Diabetic Ketoacidosis on the Developing Brain
Impact of Early Diabetic Ketoacidosis on the Developing Brain Open
OBJECTIVE This study examined whether a history of diabetic ketoacidosis (DKA) is associated with changes in longitudinal cognitive and brain development in young children with type 1 diabetes. RESEARCH DESIGN AND METHODS Cognitive and bra…
View article: Large Changes in Brain Volume Observed in an Asymptomatic Young Child With Type 1 Diabetes
Large Changes in Brain Volume Observed in an Asymptomatic Young Child With Type 1 Diabetes Open
This case was recorded during the Diabetes Research in Children Network (DirecNet) longitudinal study (1), in which children ( N = 214) had MRI scans at three time points over 5 years. During the analyses, we noted that one subject with di…
View article: Ketone production in children with type 1 diabetes, ages 4-14 years, with and without nocturnal insulin pump suspension
Ketone production in children with type 1 diabetes, ages 4-14 years, with and without nocturnal insulin pump suspension Open
Elevated morning blood ketones are more common in younger children with type 1 diabetes with or without nocturnal insulin suspension. Care providers need to be aware of the differences in ketogenesis in younger age children relative to var…
View article: Efficacy of an Overnight Predictive Low-Glucose Suspend System in Relation to Hypoglycemia Risk Factors in Youth and Adults With Type 1 Diabetes
Efficacy of an Overnight Predictive Low-Glucose Suspend System in Relation to Hypoglycemia Risk Factors in Youth and Adults With Type 1 Diabetes Open
Background: We developed a system to suspend insulin pump delivery overnight when the glucose trend predicts hypoglycemia. This predictive low-glucose suspend (PLGS) system substantially reduces nocturnal hypoglycemia without an increase i…
View article: Longitudinal Evaluation of Cognitive Functioning in Young Children with Type 1 Diabetes over 18 Months
Longitudinal Evaluation of Cognitive Functioning in Young Children with Type 1 Diabetes over 18 Months Open
Objectives: Decrements in cognitive function may already be evident in young children with type 1 diabetes (T1D). Here we report prospectively acquired cognitive results over 18 months in a large cohort of young children with and without T…
View article: Variations in Brain Volume and Growth in Young Children With Type 1 Diabetes
Variations in Brain Volume and Growth in Young Children With Type 1 Diabetes Open
Early-onset type 1 diabetes may affect the developing brain during a critical window of rapid brain maturation. Structural MRI was performed on 141 children with diabetes (4–10 years of age at study entry) and 69 age-matched control subjec…