Weiping Tang
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View article: Case analysis and literature review of liver cirrhosis combined with influenza A virus infection
Case analysis and literature review of liver cirrhosis combined with influenza A virus infection Open
This article presents a case of liver cirrhosis complicated by H1N1 influenza virus infection, and analyzes it in the context of medical literature since 2020. The patient, a 73-year-old male with decompensated cirrhosis of unknown origin,…
View article: Development of a Partial Proteolysis Targeting Chimera Library Based on Achiral Cereblon E3 Ligase Ligands and its Application for Bruton's Tyrosine Kinase Degraders
Development of a Partial Proteolysis Targeting Chimera Library Based on Achiral Cereblon E3 Ligase Ligands and its Application for Bruton's Tyrosine Kinase Degraders Open
Proteolysis targeting chimeras (PROTACs) offer a promising therapeutic approach by leveraging the ubiquitin–proteasome system (UPS) to degrade target proteins. These heterobifunctional molecules consist of a target protein ligand, an E3 li…
View article: Development of Potent and Selective RIPK1 Degraders Targeting Its Nonenzymatic Function for Cancer Treatment
Development of Potent and Selective RIPK1 Degraders Targeting Its Nonenzymatic Function for Cancer Treatment Open
Receptor-interacting protein kinase 1 (RIPK1) is a threonine/serine kinase that serves as a critical regulator of immune responses and cell death pathways, functioning through both its kinase activity and nonenzymatic scaffolding function.…
View article: Revealing the structure-activity relationship of Pt1/CeO2 with 17O solid-state NMR spectroscopy and DFT calculations
Revealing the structure-activity relationship of Pt1/CeO2 with 17O solid-state NMR spectroscopy and DFT calculations Open
Single-atom catalysts (SACs) have attracted significant interest due to their exceptional and tunable performance, enabled by diverse coordination environments achieved through innovative synthetic strategies. However, various local struct…
View article: Development of Prostate Cancer-Targeting BRD4 Intramolecular Bivalent Molecular Glue Degraders
Development of Prostate Cancer-Targeting BRD4 Intramolecular Bivalent Molecular Glue Degraders Open
Molecular glue degraders and PROTACs (proteolysis targeting chimeras) are promising therapeutic modalities by hijacking ubiquitin-proteasome pathway to degrade cellular proteins of interests (POIs). However, their clinical applications are…
View article: Development of Potent and Selective RIPK1 Degraders with In Vivo Efficacy for Cancer Treatment
Development of Potent and Selective RIPK1 Degraders with In Vivo Efficacy for Cancer Treatment Open
Receptor-interacting protein kinase 1 (RIPK1) is a threonine/serine kinase that serves as a critical regulator of immune re-sponses and cell death pathways, functioning through both its catalytic kinase activity and non-catalytic scaffold …
View article: Development of folate receptor targeting chimeras for cancer selective degradation of extracellular proteins
Development of folate receptor targeting chimeras for cancer selective degradation of extracellular proteins Open
Targeted protein degradation has emerged as a novel therapeutic modality to treat human diseases by utilizing the cell’s own disposal systems to remove protein target. Significant clinical benefits have been observed for degrading many int…
View article: Non-Markovian Dynamic Models Identify Non-Canonical KRAS-VHL Encounter Complex Conformations for Novel PROTAC Design
Non-Markovian Dynamic Models Identify Non-Canonical KRAS-VHL Encounter Complex Conformations for Novel PROTAC Design Open
Targeted protein degradation (TPD) is emerging as a promising therapeutic approach for cancer and other diseases, with an increasing number of programs demonstrating its efficacy in human clinical trials. One notable method for TPD is Prot…
View article: BCR::ABL1 Proteolysis-targeting chimeras (PROTACs): The new frontier in the treatment of Ph+ leukemias?
BCR::ABL1 Proteolysis-targeting chimeras (PROTACs): The new frontier in the treatment of Ph+ leukemias? Open
View article: MBNL3 Acts as a Target of miR-302e to Facilitate Cell Proliferation, Invasion and Angiogenesis of Gastric Adenocarcinoma via AKT/VEGFA Pathway
MBNL3 Acts as a Target of miR-302e to Facilitate Cell Proliferation, Invasion and Angiogenesis of Gastric Adenocarcinoma via AKT/VEGFA Pathway Open
Gastric adenocarcinoma (GAC) is a common, malignant type of tumor in human, and is accompanied with higher mortality. Muscleblind-like 3 (MBNL3) was found to be a pivotal participator in aggravating this cancer's progression. However, the …
View article: Binary anion and cation co-doping enhance sulfide solid electrolyte performance for all-solid-state lithium batteries
Binary anion and cation co-doping enhance sulfide solid electrolyte performance for all-solid-state lithium batteries Open
Sulfide solid electrolytes are regarded as a pivotal component for all-solid-state lithium batteries (ASSLBs) due to their inherent advantages, such as high ionic conductivity and favorable mechanical properties. However, persistent challe…
View article: Development of Phenyl‐substituted Isoindolinone‐ and Benzimidazole‐type Cereblon Ligands for Targeted Protein Degradation
Development of Phenyl‐substituted Isoindolinone‐ and Benzimidazole‐type Cereblon Ligands for Targeted Protein Degradation Open
Thalidomide, pomalidomide and lenalidomide, collectively referred to as immunomodulatory imide drugs (IMiDs), are frequently employed in proteolysis‐targeting chimeras (PROTACs) as cereblon (CRBN) E3 ligase‐recruiting ligands. However, the…
View article: WNK1 facilitates cell proliferation, invasion and angiogenesis of gastric adenocarcinoma through AKT/VEGFA pathway through LINC00662/miR-103a-3p/WNK1 axis
WNK1 facilitates cell proliferation, invasion and angiogenesis of gastric adenocarcinoma through AKT/VEGFA pathway through LINC00662/miR-103a-3p/WNK1 axis Open
Gastric adenocarcinoma (GAC) is a very familiar malignant tumor in human accompanied with higher mortality. With-no-lysine kinase 1 (WNK1) have been discovered to be a pivotal participator to aggravate the cancers’ progression. However, th…
View article: Targeted degradation of extracellular secreted and membrane proteins
Targeted degradation of extracellular secreted and membrane proteins Open
View article: Development of Potent and Selective Coactivator-Associated Arginine Methyltransferase 1 (CARM1) Degraders
Development of Potent and Selective Coactivator-Associated Arginine Methyltransferase 1 (CARM1) Degraders Open
CARM1 is amplified or overexpressed in many cancer types, and its overexpression correlates with poor prognosis. Potent small-molecule inhibitors for CARM1 have been developed, but the cellular efficacy of the CARM1 inhibitors is limited. …
View article: CML-305 Discovery of a Selective PROTAC Degrading Untamable BCR::ABL1 Compound Mutants in Chronic Myelogenous Leukemia (CML)and Philadelphia Chromosome-Positive (Ph+) Acute Lymphoblastic Leukemia (ALL)
CML-305 Discovery of a Selective PROTAC Degrading Untamable BCR::ABL1 Compound Mutants in Chronic Myelogenous Leukemia (CML)and Philadelphia Chromosome-Positive (Ph+) Acute Lymphoblastic Leukemia (ALL) Open
View article: Dynamic Kinetic Stereoselective Glycosylation via Rh<sup>II</sup> and Chiral Phosphoric Acid‐Cocatalyzed Carbenoid Insertion to the Anomeric OH Bond for the Synthesis of Glycoconjugates
Dynamic Kinetic Stereoselective Glycosylation via Rh<sup>II</sup> and Chiral Phosphoric Acid‐Cocatalyzed Carbenoid Insertion to the Anomeric OH Bond for the Synthesis of Glycoconjugates Open
Chemical synthesis of glycoconjugates is essential for studying the biological functions of carbohydrates. We herein report an efficient approach for the stereoselective synthesis of challenging α‐linked glycoconjugates via a Rh II /chiral…
View article: A Modular Chemistry Platform for the Development of a Cereblon E3 Ligase‐Based Partial PROTAC Library
A Modular Chemistry Platform for the Development of a Cereblon E3 Ligase‐Based Partial PROTAC Library Open
Pr oteolysis ta rgeting c himeras (PROTACs) are a promising therapeutic strategy to selectively promote the degradation of protein targets by exploiting the ubiquitin‐proteasome system. Among the limited number of E3 ligase ligands discove…
View article: A platform for the rapid synthesis of molecular glues (Rapid-Glue) under miniaturized conditions for direct biological screening
A platform for the rapid synthesis of molecular glues (Rapid-Glue) under miniaturized conditions for direct biological screening Open
View article: Development and Characterization of Third Generation MDM2 PROTACs for the Treatment of Acute Myeloid Leukemia Utilizing an Achiral Ligand for E3 Ligase Cereblon
Development and Characterization of Third Generation MDM2 PROTACs for the Treatment of Acute Myeloid Leukemia Utilizing an Achiral Ligand for E3 Ligase Cereblon Open
View article: Supplementary Figure S1 from Tumor-Suppressor Role of Notch3 in Medullary Thyroid Carcinoma Revealed by Genetic and Pharmacological Induction
Supplementary Figure S1 from Tumor-Suppressor Role of Notch3 in Medullary Thyroid Carcinoma Revealed by Genetic and Pharmacological Induction Open
Notch3 is able to autoregulate its own expression
View article: Supplementary Tables 1 through 3 from Tumor-Suppressor Role of Notch3 in Medullary Thyroid Carcinoma Revealed by Genetic and Pharmacological Induction
Supplementary Tables 1 through 3 from Tumor-Suppressor Role of Notch3 in Medullary Thyroid Carcinoma Revealed by Genetic and Pharmacological Induction Open
Supplementary Table 1: List of primary antibodies and their working dilutions, Supplementary Table 2: List of secondary antibodies and their working dilutions, Supplementary Table 3: List of qRT-PCR primers
View article: Supplementary Figure S1 from Tumor-Suppressor Role of Notch3 in Medullary Thyroid Carcinoma Revealed by Genetic and Pharmacological Induction
Supplementary Figure S1 from Tumor-Suppressor Role of Notch3 in Medullary Thyroid Carcinoma Revealed by Genetic and Pharmacological Induction Open
Notch3 is able to autoregulate its own expression
View article: Supplementary Figure S2 from Tumor-Suppressor Role of Notch3 in Medullary Thyroid Carcinoma Revealed by Genetic and Pharmacological Induction
Supplementary Figure S2 from Tumor-Suppressor Role of Notch3 in Medullary Thyroid Carcinoma Revealed by Genetic and Pharmacological Induction Open
AB3 induces full-length of Notch3 and NICD3 to the similar level
View article: Data from Tumor-Suppressor Role of Notch3 in Medullary Thyroid Carcinoma Revealed by Genetic and Pharmacological Induction
Data from Tumor-Suppressor Role of Notch3 in Medullary Thyroid Carcinoma Revealed by Genetic and Pharmacological Induction Open
Notch1-3 are transmembrane receptors that appear to be absent in medullary thyroid cancer (MTC). Previous research has shown that induction of Notch1 has a tumor-suppressor effect in MTC cell lines, but little is known about the biologic c…
View article: Supplementary Figure Legends from Tumor-Suppressor Role of Notch3 in Medullary Thyroid Carcinoma Revealed by Genetic and Pharmacological Induction
Supplementary Figure Legends from Tumor-Suppressor Role of Notch3 in Medullary Thyroid Carcinoma Revealed by Genetic and Pharmacological Induction Open
Legends for supplementary figures
View article: Supplementary Tables 1 through 3 from Tumor-Suppressor Role of Notch3 in Medullary Thyroid Carcinoma Revealed by Genetic and Pharmacological Induction
Supplementary Tables 1 through 3 from Tumor-Suppressor Role of Notch3 in Medullary Thyroid Carcinoma Revealed by Genetic and Pharmacological Induction Open
Supplementary Table 1: List of primary antibodies and their working dilutions, Supplementary Table 2: List of secondary antibodies and their working dilutions, Supplementary Table 3: List of qRT-PCR primers
View article: Data from Tumor-Suppressor Role of Notch3 in Medullary Thyroid Carcinoma Revealed by Genetic and Pharmacological Induction
Data from Tumor-Suppressor Role of Notch3 in Medullary Thyroid Carcinoma Revealed by Genetic and Pharmacological Induction Open
Notch1-3 are transmembrane receptors that appear to be absent in medullary thyroid cancer (MTC). Previous research has shown that induction of Notch1 has a tumor-suppressor effect in MTC cell lines, but little is known about the biologic c…
View article: Supplementary Figure S2 from Tumor-Suppressor Role of Notch3 in Medullary Thyroid Carcinoma Revealed by Genetic and Pharmacological Induction
Supplementary Figure S2 from Tumor-Suppressor Role of Notch3 in Medullary Thyroid Carcinoma Revealed by Genetic and Pharmacological Induction Open
AB3 induces full-length of Notch3 and NICD3 to the similar level
View article: Supplementary Figure Legends from Tumor-Suppressor Role of Notch3 in Medullary Thyroid Carcinoma Revealed by Genetic and Pharmacological Induction
Supplementary Figure Legends from Tumor-Suppressor Role of Notch3 in Medullary Thyroid Carcinoma Revealed by Genetic and Pharmacological Induction Open
Legends for supplementary figures