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View article: <i>PKD1</i> and <i>PKD2</i> mRNA cis-inhibition drives polycystic kidney disease progression
<i>PKD1</i> and <i>PKD2</i> mRNA cis-inhibition drives polycystic kidney disease progression Open
Autosomal dominant polycystic kidney disease (ADPKD), among the most common human genetic conditions and a frequent etiology of kidney failure, is primarily caused by heterozygous PKD1 mutations. Kidney cyst formation ensues when the PKD1 …
View article: Discovery and preclinical evaluation of anti-miR-17 oligonucleotide RGLS4326 for the treatment of polycystic kidney disease
Discovery and preclinical evaluation of anti-miR-17 oligonucleotide RGLS4326 for the treatment of polycystic kidney disease Open
Autosomal dominant polycystic kidney disease (ADPKD), caused by mutations in either PKD1 or PKD2 genes, is one of the most common human monogenetic disorders and the leading genetic cause of end-stage renal disease. Unfortunately, treatmen…
View article: Melanin-concentrating hormone in peripheral circulation in the human
Melanin-concentrating hormone in peripheral circulation in the human Open
Melanin-concentrating hormone (MCH) is a hypothalamic neuropeptide with a well-characterised role in energy homeostasis and emergent roles in diverse physiologic functions such as arousal, mood and reproduction. Work to date has predominan…