Tanit L. Gabriel
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View article: Adipocytes harbor a glucosylceramide biosynthesis pathway involved in iNKT cell activation
Adipocytes harbor a glucosylceramide biosynthesis pathway involved in iNKT cell activation Open
View article: HEPES activates a MiT/TFE-dependent lysosomal-autophagic gene network in cultured cells: A call for caution
HEPES activates a MiT/TFE-dependent lysosomal-autophagic gene network in cultured cells: A call for caution Open
In recent years, the lysosome has emerged as a highly dynamic, transcriptionally regulated organelle that is integral to nutrient-sensing and metabolic rewiring. This is coordinated by a lysosome-to-nucleus signaling nexus in which MTORC1 …
View article: Elevation of glycoprotein nonmetastatic melanoma protein B in type 1 Gaucher disease patients and mouse models
Elevation of glycoprotein nonmetastatic melanoma protein B in type 1 Gaucher disease patients and mouse models Open
Gaucher disease is caused by inherited deficiency of lysosomal glucocerebrosidase. Proteome analysis of laser‐dissected splenic Gaucher cells revealed increased amounts of glycoprotein nonmetastatic melanoma protein B (gpNMB). Plasma gpNMB…
View article: Gpnmb Is a Potential Marker for the Visceral Pathology in Niemann-Pick Type C Disease
Gpnmb Is a Potential Marker for the Visceral Pathology in Niemann-Pick Type C Disease Open
Impaired function of NPC1 or NPC2 lysosomal proteins leads to the intracellular accumulation of unesterified cholesterol, the primary defect underlying Niemann-Pick type C (NPC) disease. In addition, glycosphingolipids (GSLs) accumulate in…