Tanja Hoffmann
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View article: Serology- and Blood-PCR-Based Screening for Schistosomiasis in Pregnant Women in Madagascar—A Cross-Sectional Study and Test Comparison Approach
Serology- and Blood-PCR-Based Screening for Schistosomiasis in Pregnant Women in Madagascar—A Cross-Sectional Study and Test Comparison Approach Open
This work was conducted as a cross sectional study to define the disease burden of schistosomiasis in pregnant Madagascan women and to evaluate serological and molecular diagnostic assays. A total of 1154 residual EDTA blood samples from p…
View article: Differing Effects of Standard and Harsh Nucleic Acid Extraction Procedures on Diagnostic Helminth Real-Time PCRs Applied to Human Stool Samples
Differing Effects of Standard and Harsh Nucleic Acid Extraction Procedures on Diagnostic Helminth Real-Time PCRs Applied to Human Stool Samples Open
This study aimed to assess standard and harsher nucleic acid extraction schemes for diagnostic helminth real-time PCR approaches from stool samples. A standard procedure for nucleic acid extraction from stool and a procedure including bead…
View article: Study of enteric pathogens among children in the tropics and effects of prolonged storage of stool samples
Study of enteric pathogens among children in the tropics and effects of prolonged storage of stool samples Open
The study was performed to compare real-time PCR after nucleic acid extraction directly from stool samples as well as from samples stored and transported on Whatman papers or flocked swabs at ambient temperature in the tropics. In addition…
View article: TRICC-C: Nintedanib vs. placebo in patients receiving mFOLFOX6 for metastatic, chemorefractory colorectal cancer: Final results from the randomized phase II trial of the AIO
TRICC-C: Nintedanib vs. placebo in patients receiving mFOLFOX6 for metastatic, chemorefractory colorectal cancer: Final results from the randomized phase II trial of the AIO Open
Background: Anti-VEGF agents in combination with chemotherapy improve PFS of patients with mCRC in the 1st- and 2nd-line-setting. During anti-VEGF treatment tumour angiogenesis is driven by other factors but VEGF. Nintedanib is a triple an…
View article: Treatment Intensification in HIV-Infected Patients Is Associated With Reduced Frequencies of Regulatory T Cells
Treatment Intensification in HIV-Infected Patients Is Associated With Reduced Frequencies of Regulatory T Cells Open
In untreated HIV infection, the efficacy of T cell responses decreases over the disease course, resulting in disease progression. The reasons for this development are not completely understood. However, immunosuppressive cells are supposed…