Tanja Hyvärinen
YOU?
Author Swipe
View article: Microglia from patients with multiple sclerosis display a cell-autonomous immune activation state
Microglia from patients with multiple sclerosis display a cell-autonomous immune activation state Open
Aberrant and sustained activation of microglia is implicated in the progression and severity of multiple sclerosis (MS). However, whether intrinsic alterations in microglial function impact the pathogenesis of this disease remains unclear.…
View article: P02.29.B HYPOXIA SHAPES TUMOR IMMUNE MICROENVIRONMENT THROUGH CELL-TYPE DEPENDENT RESPONSES IN DIFFUSE ASTROCYTOMAS
P02.29.B HYPOXIA SHAPES TUMOR IMMUNE MICROENVIRONMENT THROUGH CELL-TYPE DEPENDENT RESPONSES IN DIFFUSE ASTROCYTOMAS Open
BACKGROUND Hypoxia is a critical driver of tumor aggressiveness in high-grade gliomas, yet its cell-type-specific effects on immune cell populations within the tumor microenvironment (TME) remain poorly understood. MATERIAL AND METHODS We …
View article: Abnormalities in the functional activity of neural networks in a human iPSC model of Dravet syndrome
Abnormalities in the functional activity of neural networks in a human iPSC model of Dravet syndrome Open
Dravet syndrome (DS) is a severe pediatric epilepsy primarily caused by de novo mutation in the SCN1A gene encoding the alpha subunit of the voltage-gated sodium channel. While early in vivo studies linked DS pathology to GABAergic disinhi…
View article: Modeling neuroinflammatory interactions between microglia and astrocytes in a human iPSC-based coculture platform
Modeling neuroinflammatory interactions between microglia and astrocytes in a human iPSC-based coculture platform Open
Background Microglia and astrocytes are central mediators of neuroinflammation in several neurodegenerative diseases. Their intricate crosstalk and contributions to pathogenesis remain elusive, highlighting the need for innovative in vitro…
View article: Abnormalities in the functional activity of neural networks in a human iPSC model of Dravet syndrome
Abnormalities in the functional activity of neural networks in a human iPSC model of Dravet syndrome Open
Dravet syndrome (DS) is a severe pediatric epilepsy with a limited response to current antiseizure medications. Majority of DS cases are caused by a de novo mutation in the SCN1A gene, encoding the alpha subunit of the voltage-gated sodium…
View article: Establishment of a human induced pluripotent stem cell line (TAUi008-A) derived from a multiple sclerosis patient
Establishment of a human induced pluripotent stem cell line (TAUi008-A) derived from a multiple sclerosis patient Open
Multiple sclerosis (MS) is a complex autoimmune disease of the central nervous system where the main pathogenetic events include demyelination and axonal degeneration. Here, we generated a human induced pluripotent stem cell (hiPSC) line f…
View article: Comparative microelectrode array data of the functional development of hPSC-derived and rat neuronal networks
Comparative microelectrode array data of the functional development of hPSC-derived and rat neuronal networks Open
View article: Directional Growth of Human Neuronal Axons in a Microfluidic Device with Nanotopography on Azobenzene‐Based Material
Directional Growth of Human Neuronal Axons in a Microfluidic Device with Nanotopography on Azobenzene‐Based Material Open
Axonal dysfunction and degeneration are important pathological features of central nervous system (CNS) diseases and traumas, such as Alzheimer's disease, traumatic brain injury, ischemic stroke and spinal cord injury. Engineered microflui…
View article: Covalent immobilization of luminescent oxygen indicators reduces cytotoxicity
Covalent immobilization of luminescent oxygen indicators reduces cytotoxicity Open
Luminescence-based oxygen sensing is a widely used tool in cell culture applications. In a typical configuration, the luminescent oxygen indicators are embedded in a solid, oxygen-permeable matrix in contact with the culture medium. Howeve…
View article: Transparent Microelectrode Arrays Fabricated by Ion Beam Assisted Deposition for Neuronal Cell In Vitro Recordings
Transparent Microelectrode Arrays Fabricated by Ion Beam Assisted Deposition for Neuronal Cell In Vitro Recordings Open
Microelectrode array (MEA) is a tool used for recording bioelectric signals from electrically active cells in vitro. In this paper, ion beam assisted electron beam deposition (IBAD) has been used for depositing indium tin oxide (ITO) and t…
View article: Building Neural in vitro Models with Human Pluripotent Stem Cells : Neuronal Functionality and the Role of Astrocytes in the Networks
Building Neural in vitro Models with Human Pluripotent Stem Cells : Neuronal Functionality and the Role of Astrocytes in the Networks Open
Ymmärryksemme ihmisaivojen kehityksestä ja toiminnasta on edelleen puutteellista. Valitettavasti neurotieteiden alalta puuttuu edustavia ihmisspesifisiä malleja, jotka täydentäisivät eläinmalleilla tehtäviä tutkimuksia. Ihmisaivokudoksen s…
View article: Functional characterization of human pluripotent stem cell-derived cortical networks differentiated on laminin-521 substrate: comparison to rat cortical cultures
Functional characterization of human pluripotent stem cell-derived cortical networks differentiated on laminin-521 substrate: comparison to rat cortical cultures Open
View article: Co-stimulation with IL-1β and TNF-α induces an inflammatory reactive astrocyte phenotype with neurosupportive characteristics in a human pluripotent stem cell model system
Co-stimulation with IL-1β and TNF-α induces an inflammatory reactive astrocyte phenotype with neurosupportive characteristics in a human pluripotent stem cell model system Open
View article: Microelectrode Array With Transparent ALD TiN Electrodes
Microelectrode Array With Transparent ALD TiN Electrodes Open
Low noise platinum black or sputtered titanium nitride (TiN) microelectrodes are typically used for recording electrical activity of neuronal or cardiac cell cultures. Opaque electrodes and tracks, however, hinder the visibility of the cel…
View article: Network Activity Development in Cultured Cortical Neurons: Comparison Between Rat Embryonic and Human Pluripotent Stem Cell -Derived Systems
Network Activity Development in Cultured Cortical Neurons: Comparison Between Rat Embryonic and Human Pluripotent Stem Cell -Derived Systems Open
Event Abstract Back to Event Network Activity Development in Cultured Cortical Neurons: Comparison Between Rat Embryonic and Human Pluripotent Stem Cell -Derived Systems Tanja Hyvärinen1*, Anu Hyysalo1, Emre Kapucu2, 3 and Susanna Narkilah…
View article: Functional epilepsy modelling – a novel platform for studying human stem cell -derived neuronal networks
Functional epilepsy modelling – a novel platform for studying human stem cell -derived neuronal networks Open
Event Abstract Back to Event Functional epilepsy modelling – a novel platform for studying human stem cell -derived neuronal networks Anssi Pelkonen1*, Lassi Sukki2, Tomi Ryynänen3, Tanja Hyvärinen1, Jukka Lekkala3, Pasi Kallio2 and Susann…
View article: Establishment Of Microfluidics Platform For Compartmentalized Neuronal Culture With Axonal Propagation Velocity Measurement
Establishment Of Microfluidics Platform For Compartmentalized Neuronal Culture With Axonal Propagation Velocity Measurement Open
Event Abstract Back to Event Establishment Of Microfluidics Platform For Compartmentalized Neuronal Culture With Axonal Propagation Velocity Measurement Mervi Ristola1*, Lassi Sukki2, Arla Tanner1, Tanja Hyvärinen1, Ali B. Rad1, Laura Ylä-…