Tanja Maier
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View article: Quantum doubles in symmetric blockade structures
Quantum doubles in symmetric blockade structures Open
Exactly solvable models of topologically ordered phases with non-abelian anyons typically require complicated many-body interactions which do not naturally appear in nature. This motivates the "inverse problem" of quantum many-body physics…
View article: Mitotane treatment of adrenocortical carcinoma induces tumoural secretion of GDF-15: impact on poor prognosis and impaired responsiveness to immunotherapy
Mitotane treatment of adrenocortical carcinoma induces tumoural secretion of GDF-15: impact on poor prognosis and impaired responsiveness to immunotherapy Open
Purpose Treatment options for adrenocortical carcinoma (ACC), where mitotane remains a mainstay of therapy, are unsatisfactory. Response rates of ACC to immune checkpoint inhibition (ICI) are disappointing, and immune cells are scarce in A…
View article: Tumoral glucocorticoids induce a phagocytic CD68+/CD163+/C1Q+ macrophage phenotype primed for IFNγ-driven CXCL9 secretion
Tumoral glucocorticoids induce a phagocytic CD68+/CD163+/C1Q+ macrophage phenotype primed for IFNγ-driven CXCL9 secretion Open
Glucocorticoids (GCs) play a multifaceted role in modulating immune responses in cancer. Adrenocortical carcinoma (ACC) is a rare endocrine malignancy that produces excessive glucocorticoids in ~ 60%, providing a unique model to study intr…
View article: Wnt/β-catenin pathway activation is associated with glucocorticoid secretion in adrenocortical carcinoma, but not directly with immune cell infiltration
Wnt/β-catenin pathway activation is associated with glucocorticoid secretion in adrenocortical carcinoma, but not directly with immune cell infiltration Open
Background In advanced adrenocortical carcinoma (ACC), the response rate to immune checkpoint inhibition (ICI) is only ~15%. Glucocorticoid (GC) secretion and the activation of the Wnt/β-catenin pathway have been suggested to contribute to…
View article: Best supportive care for patients with primary progressive multiple sclerosis (PPMS) in Germany prior to ocrelizumab treatment: Final results from the RETRO PPMS study
Best supportive care for patients with primary progressive multiple sclerosis (PPMS) in Germany prior to ocrelizumab treatment: Final results from the RETRO PPMS study Open
Background Best supportive care (BSC) measures are an essential component for the management of primary progressive multiple sclerosis (PPMS). Objectives RETRO PPMS (ML39631) is the first study to systematically analyze the therapeutic jou…
View article: Parylene C Coating Efficacy Studies: Enhancing Biocompatibility of 3D Printed Polyurethane Parts for Biopharmaceutical and CGT Applications
Parylene C Coating Efficacy Studies: Enhancing Biocompatibility of 3D Printed Polyurethane Parts for Biopharmaceutical and CGT Applications Open
Additive manufacturing, particularly Vat photopolymerization, presents a promising technique for producing complex, tailor-made structures, making it an attractive option for generating single-use components used in biopharmaceutical manuf…
View article: Dimethylsilanediol from silicone elastomers: Analysis, release from biopharmaceutical process equipment, and clearance studies
Dimethylsilanediol from silicone elastomers: Analysis, release from biopharmaceutical process equipment, and clearance studies Open
Polysiloxanes are considered one of the most important commercial families of synthetic elastomers. They are frequently employed in biopharmaceutical manufacturing equipment as flexible single-use solutions due to superior material propert…
View article: Equivalence study of extractables from single-use biopharmaceutical manufacturing equipment after X-ray or gamma irradiation
Equivalence study of extractables from single-use biopharmaceutical manufacturing equipment after X-ray or gamma irradiation Open
Single-use (SU) devices and assemblies used as manufacturing equipment in the biopharmaceutical industry require comprehensive qualifications. These qualifications include the assessment of compounds released from SU devices in contact wit…
View article: Mental but no bio-physiological long-term habituation to repeated social stress: A study on soldiers and the influence of mission abroad
Mental but no bio-physiological long-term habituation to repeated social stress: A study on soldiers and the influence of mission abroad Open
Soldiers regularly participate in missions abroad and subjectively adapt to this situation. However, they have an increased lifetime cardiovascular risk compared to other occupational groups. To test the hypothesis that foreign deployment …
View article: X‐ray sterilization of biopharmaceutical manufacturing equipment—Extractables profile of a film material and copolyester Tritan™ compared to gamma irradiation
X‐ray sterilization of biopharmaceutical manufacturing equipment—Extractables profile of a film material and copolyester Tritan™ compared to gamma irradiation Open
The biopharmaceutical industry gains enormous flexibility in production processes by using sterilized preassembled single‐use devices. Gamma irradiation is an established sterilization technology that may be restricted in the future by the…
View article: Formulation Development of Sublingual Cyclobenzaprine Tablets Empowered by Standardized and Physiologically Relevant Ex Vivo Permeation Studies
Formulation Development of Sublingual Cyclobenzaprine Tablets Empowered by Standardized and Physiologically Relevant Ex Vivo Permeation Studies Open
Suitable ex vivo models are required as predictive tools of oromucosal permeability between in vitro characterizations and in vivo studies in order to support the development of novel intraoral formulations. To counter a lack of clinical r…
View article: Author response for "X‐ray Sterilization of Biopharmaceutical Manufacturing Equipment ‐ Extractables Profile of a Film Material and Copolyester Tritan™ Compared to Gamma Irradiation"
Author response for "X‐ray Sterilization of Biopharmaceutical Manufacturing Equipment ‐ Extractables Profile of a Film Material and Copolyester Tritan™ Compared to Gamma Irradiation" Open
View article: Longitudinal Profiles of Dietary and Microbial Metabolites in Formula- and Breastfed Infants
Longitudinal Profiles of Dietary and Microbial Metabolites in Formula- and Breastfed Infants Open
The early-life metabolome of the intestinal tract is dynamically influenced by colonization of gut microbiota which in turn is affected by nutrition, i.e. breast milk or formula. A detailed examination of fecal metabolites was performed to…
View article: Structural Equation Modeling of a Global Stress Index in Healthy Soldiers
Structural Equation Modeling of a Global Stress Index in Healthy Soldiers Open
Accumulation of stress is a prognostic trigger for cardiovascular disease. Classical scores for cardiovascular risk estimation typically do not consider psychosocial stress. The aim of this study was to develop a global stress index (GSI) …
View article: Social Stress-Induced Oxidative DNA Damage Is Related to Prospective Cardiovascular Risk
Social Stress-Induced Oxidative DNA Damage Is Related to Prospective Cardiovascular Risk Open
Psychosocial stress increases cardiovascular risk, which coincides with enhanced oxidative DNA damage. Increased sympathetic tone-related catecholamine release causes oxidative stress, which contributes to catecholamine-related cardiotoxic…
View article: Longitudinal profiles of dietary and microbial metabolites in formula- and breastfed infants
Longitudinal profiles of dietary and microbial metabolites in formula- and breastfed infants Open
The early-life metabolome of the intestinal tract is dynamically influenced by colonization of gut microbiota which in turn is affected by nutrition, i.e. breast milk or formula. A detailed examination of fecal metabolites was performed to…
View article: Impact of Dietary Resistant Starch on the Human Gut Microbiome, Metaproteome, and Metabolome
Impact of Dietary Resistant Starch on the Human Gut Microbiome, Metaproteome, and Metabolome Open
Diet can influence the composition of the human microbiome, and yet relatively few dietary ingredients have been systematically investigated with respect to their impact on the functional potential of the microbiome. Dietary resistant star…
View article: Proteomics_Analysis For Maier Et Al. 2017
Proteomics_Analysis For Maier Et Al. 2017 Open
This is an annotated proteomics data set used in the the paper "Impact of dietary resistant starch on the human gut microbiome, metaproteome and metabolome." mBio01343-17 Proteomics analysis was lead by Lang Ho Lee. Colin J. Brislawn is th…
View article: Proteomics_Analysis For Maier Et Al. 2017
Proteomics_Analysis For Maier Et Al. 2017 Open
This is an annotated proteomics data set used in the the paper "Impact of dietary resistant starch on the human gut microbiome, metaproteome and metabolome." mBio01343-17 Proteomics analysis was lead by Lang Ho Lee. Colin J. Brislawn is th…
View article: Mass spectrometry based metabolomics to follow the prebiotic and probiotic impact on the human gut microbiome
Mass spectrometry based metabolomics to follow the prebiotic and probiotic impact on the human gut microbiome Open
The human gastrointestinal tract and its microbiome is a complex ecosystem. It is involved in several functions in the human body. Nutrition affects the intestinal microbial community, whereas the metabolism is strongly affected as well. T…
View article: Novel biomarker and easy to perform ELISA for monitoring complement inhibition in patients with atypical hemolytic uremic syndrome treated with eculizumab
Novel biomarker and easy to perform ELISA for monitoring complement inhibition in patients with atypical hemolytic uremic syndrome treated with eculizumab Open
View article: High-urgency kidney transplantation in the Eurotransplant Kidney Allocation System: success or waste of organs? The Eurotransplant 15-year all-centre survey
High-urgency kidney transplantation in the Eurotransplant Kidney Allocation System: success or waste of organs? The Eurotransplant 15-year all-centre survey Open
Facing organ shortages, increasing wait times and considerable mortality on dialysis, we question the current policy of HU allocation and propose more restrictive criteria with regard to individuals with vascular complications or repeated …
View article: Transmediastinal Trachea Closure after Dilational Tracheotomy Positioned Too Low Down
Transmediastinal Trachea Closure after Dilational Tracheotomy Positioned Too Low Down Open
Dilational tracheotomy is a minimally invasive method that can be performed at the bedside on patients requiring long-term mechanical ventilation. In our 70-year-old male patient, percutaneous dilational tracheotomy (Ciaglia Blue Rhino, Co…
View article: Aquagenic Wrinkling of the Palms: Morphological Changes in Reflectance Confocal Microscopy and High-Definition Optical Coherence Tomography
Aquagenic Wrinkling of the Palms: Morphological Changes in Reflectance Confocal Microscopy and High-Definition Optical Coherence Tomography Open
Aquagenic wrinkling of the palms (AWP) is a rare condition, which is characterized by appearance of whitish papules and plaques, and an excessive wrinkling and swelling of the palmar skin after exposure to water. In most cases, young women…