Tanja R. Zijp
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View article: Hair analysis for monitoring adherence to inhaled respiratory medications: possibilities and limitations
Hair analysis for monitoring adherence to inhaled respiratory medications: possibilities and limitations Open
Purpose Non-adherence to inhaled medication poses a significant clinical and economic burden on patients with respiratory diseases. This narrative review provides an overview of key aspects of hair analysis, in general and specific for inh…
View article: Do women need a change in dose of prescription drugs with onset of menopause? Time to find out
Do women need a change in dose of prescription drugs with onset of menopause? Time to find out Open
View article: Plasma Versus Whole Blood Tacrolimus Concentrations and Health-Related Quality of Life in Kidney Transplant Recipients
Plasma Versus Whole Blood Tacrolimus Concentrations and Health-Related Quality of Life in Kidney Transplant Recipients Open
Background/Objectives: Tacrolimus dosing traditionally relies on therapeutic drug monitoring in whole blood, while assessment in plasma may better reflect its effect and reveal overdosing impacting health-related quality of life (HRQoL). M…
View article: Optimising tacrolimus treatment in solid organ transplant recipients
Optimising tacrolimus treatment in solid organ transplant recipients Open
Solid organ transplantation is an effective, life-saving intervention to restore organ function. Key concern is the prevention of allograft rejection, in which tacrolimus is used as cornerstone treatment for maintaining immunosuppression. …
View article: Medication Adherence Monitoring Using Alternative Sample Matrices: Bridging the Gap Between Analytical Validation and Clinical Interpretation
Medication Adherence Monitoring Using Alternative Sample Matrices: Bridging the Gap Between Analytical Validation and Clinical Interpretation Open
View article: A Joint Pharmacokinetic Model for the Simultaneous Description of Plasma and Whole Blood Tacrolimus Concentrations in Kidney and Lung Transplant Recipients
A Joint Pharmacokinetic Model for the Simultaneous Description of Plasma and Whole Blood Tacrolimus Concentrations in Kidney and Lung Transplant Recipients Open
Whole blood tacrolimus target ranges, currently used to guide TDM, were translated to plasma concentration ranges of 0.06-0.26 ng/mL and 0.10-0.93 ng/mL for kidney and lung transplant recipients, respectively.
View article: Ultra-high throughput dual channel liquid chromatography with tandem mass spectrometry for quantification of four immunosuppressants in whole blood for therapeutic drug monitoring
Ultra-high throughput dual channel liquid chromatography with tandem mass spectrometry for quantification of four immunosuppressants in whole blood for therapeutic drug monitoring Open
View article: Expeditious quantification of plasma tacrolimus with liquid chromatography tandem mass spectrometry in solid organ transplantation
Expeditious quantification of plasma tacrolimus with liquid chromatography tandem mass spectrometry in solid organ transplantation Open
View article: Combining digital adherence technology and therapeutic drug monitoring for personalised tuberculosis care
Combining digital adherence technology and therapeutic drug monitoring for personalised tuberculosis care Open
Tuberculosis (TB) is the world-leading cause of infectious disease related mortality, apart from COVID-19 presently [1]. Standard TB treatment for drug-susceptible (DS) TB takes 6–9 months and requires daily intake of multiple medications …
View article: Electronic Smart Blister Packages to Monitor and Support Medication Adherence: A Usability Study
Electronic Smart Blister Packages to Monitor and Support Medication Adherence: A Usability Study Open
EDP had good perceived usability, was well accepted, and differed significantly from other adherence measurement methods. This study provides input to further guide scale-up of the blister packages.
View article: Digital spacer data driven COPD inhaler adherence education: The OUTERSPACE proof-of-concept study
Digital spacer data driven COPD inhaler adherence education: The OUTERSPACE proof-of-concept study Open
Pressurized metered dose inhalers are recommended to be used in combination with spacers, yet inhaler technique and adherence are poor. A novel digital "smart" spacer can record spacer use and technique errors and could facilitate personal…
View article: Clinical Value of Emerging Bioanalytical Methods for Drug Measurements: A Scoping Review of Their Applicability for Medication Adherence and Therapeutic Drug Monitoring
Clinical Value of Emerging Bioanalytical Methods for Drug Measurements: A Scoping Review of Their Applicability for Medication Adherence and Therapeutic Drug Monitoring Open
View article: Enantiomer‐specific pharmacokinetics of D,L‐3‐hydroxybutyrate: Implications for the treatment of multiple <scp>acyl‐CoA</scp> dehydrogenase deficiency
Enantiomer‐specific pharmacokinetics of D,L‐3‐hydroxybutyrate: Implications for the treatment of multiple <span>acyl‐CoA</span> dehydrogenase deficiency Open
D,L‐3‐hydroxybutyrate (D,L‐3‐HB, a ketone body) treatment has been described in several inborn errors of metabolism, including multiple acyl‐CoA dehydrogenase deficiency (MADD; glutaric aciduria type II). We aimed to improve the understand…
View article: Important Interactions of Immunosuppressants With Experimental Therapies for Novel Coronavirus Disease (COVID-19): How to Act
Important Interactions of Immunosuppressants With Experimental Therapies for Novel Coronavirus Disease (COVID-19): How to Act Open
To the Editor: Transplant recipients are prone to experience severe illness when infected with the new coronavirus disease (COVID-19). Importantly, 2 of the initially proposed drug regimens for the experimental treatment of this disease, l…
View article: <p>User Acceptability and Technical Robustness Evaluation of a Novel Smart Pill Bottle Prototype Designed to Support Medication Adherence</p>
User Acceptability and Technical Robustness Evaluation of a Novel Smart Pill Bottle Prototype Designed to Support Medication Adherence Open
The SPBP was well accepted and this study provides data for further optimization and follow-up studies. Smart adherence technologies such as these may change the way healthcare professionals, trialists and patients manage medication adhere…
View article: Smart Medication Adherence Monitoring in Clinical Drug Trials: A Prerequisite for Personalised Medicine?
Smart Medication Adherence Monitoring in Clinical Drug Trials: A Prerequisite for Personalised Medicine? Open
The current era of personalised medicine promises us medications tailored to the individual patient, minimising adverse effects, and maximising effectiveness. Yet, medication is only effective when taken as prescribed, which in the 'real w…
View article: Effects of prophylactic antibiotics on patients with stable COPD: a systematic review and meta-analysis of randomized controlled trials
Effects of prophylactic antibiotics on patients with stable COPD: a systematic review and meta-analysis of randomized controlled trials Open
Prophylactic antibiotics were effective in preventing COPD exacerbations and improving quality of life among stable patients with moderate to severe COPD. The choice of prophylactic antibiotics should be analysed and considered case by cas…